Volume-1 ~ Issue-1

Abstract : Some new spiro β-Lactam and thiazolidinone derivatives were prepared from the reaction of 5 with different aromatic amine to give Schiff bases 6a-c followed by cycloaddition reaction with chloroacetyl chloride and/or mercaptoacetic acid to give spiro β-Lactam derivatives 7a-c and spiro thiazolidinone 8a-c. Also Isolated β-Lactam 11a-c and Isolated thiazolidinone were prepared by the reaction of Schiff bases 10a-c with chloroacetyl chloride and/or mercaptoacetic acid, pyrazolo 14,10a-c. Isoxazolo 16a-c, pyrimidino 17a c, pyrimidin thiono 18a-c Incorporating thieno pyrimidine 9 has been synthesized by cyclocondensation addition reaction of hydrazine hydrate, phenyl hydrazine, hydroxylamine hydrochloride, urea and thiourea
Keywords: Spiro β-Lactam, spiro thiazolidinone, thienopyrimidine. Schiff base ,Isolated β-Lactam.

[1] K. Haraguchi; Y. Kubota; H. Tanaka; J. Org. Chem. 69, 1831 (2004).
[2] M. Cushman; T. Sambaiah; G. Jin; B. Illarionov; M. Fischer; Bacher, A.J. Org. Chem. 69, 601 (2004).
[3] G. Depecker; N. Patino; C.D. Giorgio; R. Terreux; D. Cabrol-Bass; C. Bailly; A.M. Aubertin; R. Condom; Org. Biomol. Chem. 2, 74 (2004).
[4] S.F. Wnuk; E. Lewandowska; D.R. Companioni; P.I. Garcia; Jr.; J.A. Secrist; Org. Biomol. Chem. 2,120 (2004).
[5] A. Bendich; P.J. Russell; J.J. Fox; J.Am. Chem. Soc. 76, 6073 (1954).
[6] S. Kobayashi; Chem. Pharm. Bull. 21, 941 (1973).
[7] A. Ali; G.E. Taylor; D.W. Graham; Wo 0129045, (2001).
[8] S.A. Armstrong; J.M. Berge; P. Brown; J.S. Elder; A.K. Forrest; D.W. Hamprecht; R.L. Jervest; Wo 0071524, (2000).
[9] E.R. El-Bendary; F.A. Badria; Arch. Pharm. 333, 99 (2000).
[10] A. Tetsuya; M. Shogo; I. Fumio; Y. Masuo; N. Masafuml; EP 0733633, (1996).

Abstract: The level of macronutrients (nitrogen, phosphorus, potassium, calcium and magnesium) in African yam bean (Spheostylisnsternocarpa harms) collected at Ede ( latitude 7o44.952'N and longititude 4o26.114'E, elevation of 271.8m) in Osun State Nigeria, was investigated by studying the levels of nitrogen, phosphorus, potassium, calcium and magnesium in soil, leaves and the seed using standard methods. The highest level of nitrogen was obtained in the mature seed (3.37±0.26 %); soil sample had the highest phosphorus concentration (334±10mg/kg). Leaves had the highest potassium, calcium and magnesium concentration (11056±10mg/kg, 6576±19mg/kg and 1547±30 mg/kg respectively). The relative availability of nitrogen in the samples was seed > leaves > soil, for phosphorus, soil > leaves > seeds, for potassium, leaves > soil > seeds, for calcium, leaves > soil > seeds and magnesium, leaves >seeds > soil. Statistical analysis reveals a positive correlation of the macronutrients between leaves/seed except for nitrogen leaves/nitrogen seed (r = - 0.545) at p< 0.01. Significance difference was observed in the means of the macronutrients for samples analyzed at p< 0.05. African yam bean has the potential of boosting the nutrition of the greatest number of needful Africans.
Keywords: African yam bean, Assessment, Leaves, Macronutrient, Soil.

[1] G.Y.P. Klu, H.M. Amoatey, D. Bansa, and E.K.. Kumaya, Cultivation and use of African Yam Bean Sphenostylis stenocarpa in the Volta region of Ghana. Plant Genet. Newleft. 124, 2000, 13-16.
[2] D. Potter, Economic botany of Sphenostylis stenocarpa (Leguminosae). Econ. Bot. 46, 1992, 262-275.
[3] D.E.C. Corbridge, Phosphorous : An Outline of its Chemistry, Biochemistry and Technology, 5th ed. Elsevier Amsterdam. ISBN 0-444-89307-5, 1995.
[4] T. Campbell, and T. Campbell, The China study. Dallas Benella Books. ISBN 1932100385, 2005.
[5] S.E. Lakhan, and K.F. Vieira, Nutrition therapies for mental disorders. Nutri. J.7:2.doi:10.1186/1475-2891-7-2.PMID 18208598. PMC 2248201. http://www.nutritionJ. Com/content/7/1/2, 2008.
[6] D.L. Nelson, and M.M. Cox, Lehninger Principles of Biochemiatry,3rd ed. Worth Publishing, New York ISBN 1-57259-153-6, 2000.
[7] J.B. Jones, A guide for the hydroponic and soil-less culture grower. Timber Press, Beaverton, Oregon, 1983, 124.
[8] S.U. Reminson, Basic principles of crop physiology. Sadoh Press Nig. Limited. Benin City. 2005, 170.
[9] C.E Umebese, and Ade- O.E. Ademilua, and B.O . Olonisakin, Impact of combined industrial effluent on metal accumulation, nitrate reductase activity and yield of two cultivars of vigna unguiculata (L.) walp. J. Environ. Sci. Technol., 2, 2009, 146-152.
[10] K.O. Rachie, and L.M. Roberts, Grain legumes of the lowland tropics. Advances in Agronomy. 26, 1974, 1-32.

Abstract: The reaction of some newly synthesised compound 2, 4-diamino-lH-benz[g]quinolino-5,l0-dione 3-ethyl carboxylate 1 and 2,4-diamino-l ,2,3-trihydropiperpdino[2,3-b]benz[g]-1 ,2,3,4-tetrahydroquinolines-5,6,11-trione 3 ethylcarboxylate 2 with different aromatic aldehyde afforded the corresponding new Schiff bases derivatives 3a-c, 4a-c. The cycloaddition reaction of 3a-c, 4a-c with chloroacetyl chloride and thioglycolic acid give new isolated β-Lactams and thiazlidinone derivatives 5a-c, 7a-c and 6a-c, 8a-c. Compound 1, 2 undergo hydrolysis by NaOH to give carboxylic compound 9,10 which react with different aromatic aldehyde to give new Schiff bases 11a-c and 12a-c. The cycloaddition reaction of 11a-c, 12a-c with chloroacetylchloride and/or mercaptoacetic acid to give 13a-c, 15a-c and 14a-c, 16a-c.
Key Words: Schiff bases, Isolated β -lactam, Isolated thiazolidinone

[1] Harinath B.B. and Subba R.N.N., Proc. Indian Acad. Sci., 67A, 31, 1968.
[2] Wagner A., Beck W.; Diskus A., Austrain 220, 425, (26 March 1962); Chem. Abstr., 57, 3420f,1962
[3] Tsizin Yu. S.; Rubtsov M.V.; Khirn. Geterotsikl. Soedin, 637, 1970.
[4] Shellhammer C.W., Petersep S.; Dommagk G., Uspat. 3,084, 165 (2 April 1963); Chem. Abstr., 59, 13956, 1963.
[5] Shellbammer C.W.; Peterson S.; Dommagk G., Ger. 1, 114, 194 (Appl. 21 May 1959); Chem. Abstr., 56,4740, 1959.
[6] Liao, T.K ;.Nyberg, W.H.; Cheng, C.C.; Angew. Chem. (int. Edn.), 6, 82, 1967.
[7] Georg G.l., Recent Advances in the chemistry and Biology of -Lactam and -Lactam Antibiotics, Bioorg = Med. Chem. Letters (Symposia in print No. (8), 3, 2159, 1993.
[8] Durckeimer W., Blumbach J.; Lattrell R.; Scheunemann, Angew, Chem., Int. Ed. Engl., 24, 180, 1985.
[9] Berko A.H., Tetrahedron, 52,331, 1996.
[10] 10-Ren X.F., Konaklieva M.I., Shi H., Dickeys., Lim D.V.; Gonzalez J.; Turos E., J. Org. Chem.; 63, 8898, 1998.

Abstract : In an era of technological advancements, improved life style, more dietary intake with lowered physical activity, increased longevity of life and early onset of many non – communicable diseases including type 2 diabetic mellitus resulting in many health complications on functioning of cardiac, nervous, renal system. This study aims to minimize such complications among diabetic patients, provide better health care with an improved quality of life.
Keywords: Type 2 diabetes, Stability Ball

[1] Sicree R, Show J, Zimmet P, "Diabetes and impaired glucose tolerance, Ingand, editor diabetes atlas", International diabetes federation, 3rd edition, Belgium, 2006,Page: 15-103.
[2] Radha V, Mohan V, Genetic predisposition of Type 2 diabetes among Asian Indians. Indian J Med res 2007; 125; 259-74.
[3] Mohan V, Gokula Krishnan K, Deepa R, Shanthirani CS, Datta M, Association of physical inactivity with components of metabolic syndrome and coronary artery disease – The CUPS no;15, Diab Med 2005, 22; 1206-11.
[4] Wild S, Roglic G, Green A, Sicree R, King H, "Global Prevalence of diabetes: Estimates for the year 2000 and projections for 2030, diabetes care 2004; Volume- 27, Page: 1047-1053.
[5] Ramachandran A, Sanehlatac, Vinitha R, et al, Prevalence of overweight in urban Indian adolescent school children, Diab Res Cli Practical 2002; 57; 185-90.
[6] American Heart Association: Scientific statement on circulation 2009; 119; 3244-3262.
[7] American college of sports medicine and the American diabetic association; Exercise and Type 2 diabetes: Joint position statement, diabetes care; July 2010.
[8] Klans Banm et al, " Efficiency of vibration exercise for glycaemic control in Type 2 diabetes patients", International Journal of Medical sciences, 2007, Volume:4, Issue:3, Page: 159-163.
[9] Carmen castaneda et al, "A randomized controlled trial of resistance exercise training to improve glycaemic control in older adults with Type 2 diabetes", Diabetes care, 2002, Volume: 25, Number: 12, Page: 2335-2341.
[10] Erikson J, Taimela S, Erikson K, Assistance training in the treatment of Non – minsulin dependent diabetes mellitus, Int J. Sports Med, 1997; 18; 242-246.

Abstract: The studies on the effect of polymer-polymer interactions of Poly(Ethylene Glycol) [PEG] with Methyl Methacrylate and 2-Ethoxy Ethylmethacrylate(MMA/2-EOEMA) copolymer blends showed miscibility, compatibility and specific interaction due to hydrogen bond formation between hydroxyl group from PEG and ether, ester carbonyl oxygen atom from 2-EOEMA and MMA. The studies were carried out at various blend compositions with chloroform as common solvent using viscometric, FT-IR and DSC thermal analysis methods. From viscosity data based on sign convention involved in the criterion, the values of μ and α for PEG with MMA/2-EOEMA copolymer blends system was computed and found to be partially positive indicating it is partially miscible and compatible for all blends composition. The compatibility and miscibility of the blends were also supported by density measurement. The properties of specific and hydrogen bonding interactions of PEG with MMA/2-EOEMA copolymer blends are studied by spectroscopic techniques such as FT-IR and the obtained results were further confirmed by DSC thermal analysis. Spectral features from above all techniques revealed that site-specific interactions are present, consistent with a significant degree of mixing of the blend components which probes mixing on a macroscopic level, which in turn imparts the miscibility to these blends.
Keywords:Blend miscibility, Compatibility, MMA/EOEMA Copolymer, PEG, Specific Interactions

[1] Long Yu., Katherine Dean., Lin Li. 2006. Prog. Polym. Sci. 31, 576–602.
[2] Ramesh S., CW Liew., E Morris. 2010. Thermochimica Acta. Elsevier, 511, 1–2, 140–146.
[3] Mruthyunjaya Swamy T. M., Siddaramaiah. 2007. J. Applied Polymer Sci. 104, 3, 2048–2053.
[4] Ramesh S., A.H. Yahaya., A.K. Arof. 2002. Solid State Ionics 148, 483– 486.
[5] Chee K. K. 1990. European Polymer Journal, 26, 423-426.
[6] Sun, Z., Wang W., & Feng Z. 1992. European Polymer Journal, 51, 1259.
[7] Paladhi R. & Singh R. P. (1994a). European Polymer Journal, 51, 1559.
[8] Paladhi R. & Singh R. P. (1994b). Journalof Applied Polymer Science, 30, 25, 251.
[9] Varada Rajulu V & Mabusab P. 1996. European Polymer Journal, 32, 267-268.
[10] Changhua Liu & Chaobo Xiao. 2005. Journal of Applied Polymer Science, 95, 1405-1411.

Abstract: As the stock of fossil fuels are decreasing throughout the world and demands for energy based Comforts and mobility ever increasing, so there is a need to increase biodiesel production. Bio diesel is an alternative diesel fuel prepared from renewable resources and is most popular as an alternative energy sources because it is non toxic and biodegradable. India has great potential for production of biodiesel from non-edible oil seeds. From about 100 varieties of oil seeds, only 10-12 varieties have been tapped so far. The promising non-edible sources in India are Madhuca Indica (Mahua),Jatropha curcas(Ratan Jyot), Pongamia and pinnata (Karanja). This review paper assesses and integrates the biological, chemical and genetic attributes of the plant and describes about the different tree borne oilseeds in India,
Keywords:Tree borne oil seeds, Non edible oils, transesterification, and Bio diesel.

[1] N.S.Venkataraman, Chemical Industry Digest,pp.77(2004)
[2] Based Biodiesel-Opportunities and contents in developing countries like India, Chemical Industries News, (2004) p,p.79
[3] Azam A. M., and Nahar N. M., 2005. Biomass and Bioenergy. 2005 Article in Press.
[4] Ma F, Hanna MA. Biores Technol 1999;70: 1–15.
[5] Srivastava, A and Prasad, R, Oil Energy 2000; Rev.4:111-133
[6] Sihna S, Bhardwaj D, Gupta PK, Biomass and Bio energy. 2004 ; 13:501-505.
[7] Pramanik K, Srivani K, Chandra V, Indian chemical engineering congress. 2000;
[8] Altin R, Cetinkaya S, Yucesu HS. Energy Convers Manage 2001;42: 529–38.
[9] Agarwal AK, Das LM, Journal of engineering for For Turbines and power. 2001; 123:440- 447.
[10] Ram BVB, Ramanathan V, Phuan S, Vedaraman N, Indian chemical Engg. Journal. 2004; 14(2):12-15.

Abstract: Ginger root( Zingiber officinal Rose) was analysed to identify its nutritional and anti- nutritional contents. The results showed that Ginger has 34.13% crude protein, 4.07% Ether Extract, 4.02% crude fibre content, 13.75% moisture content, 7.64% Ash content and 1.036% vitamin C. Furthermore, ginger contains major minerals like: Zn 64.0 mg/l , Mn 5.90 mg/l, Fe 279.7 mg/l, Cu 8.80 mg/l, Ca 280.0 mg/l and P 8068.0 mg/l. The result obtained confirmed the usefulness of ginger root as a potential functional food and could be explored further in new product and formulation.

1. Altman C.D, Marcussen K.C (2001). Effect of a ginger extract on knee pain in patient with osteoarthritis. Arthritis Rheum, 44(11), 2531- 2538.
2 Chan E.W.C., Lim Y.Y and Omar M (2007) Antioxidant and antibacterial activity of levels of Etlingera species (Zingiberaceae) in peninsular Malaysia. Food Chemistry 104,1586- 1593.
3. Thomson M, Al Qattan K.K, Al sawan S.M(2002) The use of ginger( Zingiber officinale rose) as a potential antiflammatory and antithrombotic agent. Prostaglandins Leukot Essent Fatty Acids 67(6), 475-478.
4. Portnoi G, Chig L.A, Karim-Tabesh (2003) Prospective comparative study of the safety and effectiveness of ginger for the treatment of nausea and vomiting in pregnancy. Am J. obstet Gynecol. 189(5), 1374- 1377.
5. AOAC (1990) Official methods of Analysis (15th ed ) Washington DC. Association of Analytical chemistry
6. Bhat R., Kiran K., Arun A and Karim A. (2010). Determination of mineral composition and heavy metal content of some nutraceutically valued plant products. Food Analytical methods 3. 181-187.
7. Bhat R and Sridhar K.R (2008) Nutritional quality and evaluation of electron beam-irradiated lotus (Nelumbo nucifera) seed. Food chemistry 107, 174-184.
8. Belitz H.D., Grosch W and Schieberle P (2009) Food chemistry, New-york. Springer pg 1-1070

Abstract: Infrared red spectra of terbium stearate confirmed that stearic acid has a dimeric structure due to hydrogen bonding between two molecules of stearic acid, whereas metal to oxygen bond in terbium stearate have an ionic character but are not purely ionic. The double layer structure of terbium stearate is verified by X-ray diffraction study, with the molecular axis slightly inclined to the basal plane. In thermal analysis, the decomposition reaction of terbium stearate is found to be kinetically of zero order, with activation energies ranging from 14 to 16 kcal mol¯¹ on the basis of different equations.

Key Words: terbium stearate, IR spectra, X-ray studies, thermal analysis.

[1]. Chatfield H.W., Paint Manuf., 6,112, (1936).
[2]. Skellon J.H. and Spence J.W., J. Appl. Chem. London,3,10, (1953).
[3]. Skellon J.H. and Andrews K.E., J. Appl. Chem., London,5,245, (1955).
[4]. Solanki A.K., and Bhandari A.M., Tenside Detergents,18,34, (1984).
[5]. Gonen M., Ozturk S., Balkose S., Okur S. and Ulku S., Ind. Eng. Chem. Res.,49,4,1732, (2010).
[6]. Nene P.N., Adv Nat. Appl. Sci., 2(2), 73, (2008).

Abstract: The quest for sustainable methodologies in organic synthesis has propelled the development of novel catalysts that not only enhance reaction efficiency but also align with the principles of green chemistry. This study focuses on the design, synthesis, and application of innovative catalysts for asymmetric synthesis, aiming to address the dual challenges of environmental sustainability and the need for enantiomerically pure compounds in pharmaceuticals, agrochemicals, and materials science. Utilizing a multidisciplinary approach that combines organic synthesis, catalysis, and green chemistry, we have developed a series of novel catalysts that demonstrate.....

Key Words: Asymmetric Synthesis, Green Chemistry, Novel Catalysts, Enantioselectivity, Sustainable Practices

[1]. Knowles, William S., and Michael J. Sabacky. "Catalytic Asymmetric Hydrogenation." Chemical Communications, no. 22, 1968, pp. 1445-1446.
[2]. Noyori, Ryoji, and Hidemasa Takaya. "BINAP: A Versatile Ligand for Asymmetric Catalysis." Accounts of Chemical Research, vol. 20, no. 7, 1987, pp. 207-214.
[3]. Sharpless, K. Barry, et al. "Asymmetric Epoxidation of Allylic Alcohols: The Sharpless Epoxidation." Journal of the American Chemical Society, vol. 112, no. 12, 1990, pp. 4860-4877.
[4]. Jacobsen, Eric N., et al. "Asymmetric Diels-Alder Catalysis in Water." Journal of the American Chemical Society, vol. 112, no. 8, 1990, pp. 2801-2803.
[5]. Trost, Barry M. "Atom Economy—A Challenge for Organic Synthesis: Homogeneous Catalysis Leads the Way." Angewandte Chemie International Edition in English, vol. 30, no. 11, 1991, pp. 1315-1364