Volume-4 ~ Issue-6

Abstract: A green, safer , efficient , eco-friendly approach for the synthesis of novel compounds which reveal biological and spermicidal activity. The nature of the pharmacophore decides the physiological reactivity of the compound.

Keywords: Microbial, Microwave assisted, Solvent free, Spermicidal activity, Structure-activity relationship

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[3] S.Sharma, R.Jain, V.Sharma and C.Chawlal, J.Indian Chem.Soc,90,2013,221

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Abstract: The chromatographic behaviour of some cephalosporins has been studied on synthetic stannic arsenate layers using citrate and borate buffers as mobile phases. Several ternary and quaternary separations have been achieved. The utility of these separations has been demonstrated for estimation of cephalosporins in blood serum from patients.This method used is simple, rapid ,reproducible and can also be applied in the separation and determination of cephalosporins in other biological samples. The limit of detection was found to be 0.20 μg/l.

KeyWords: TLC, Cephalosporins, Stanic arsenate

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Abstract: Model using Iraqi limestone as an adsorbent has been investigated. The influences of equilibrium time, limestone dosage, limestone particle size, pH of solution, adsorption isotherms and temperature on adsorption performance have been experimentally verified by a batch method. The adsorbent used in this study exhibited a good adsorption potential at initial pH 10, temperatures 28ºC, particle size 75 μm, limestone dosage 0.1g for equilibrium time 140 min. The removal efficiency and distribution coefficient have also been determined for the adsorption system as a function of dosage of the adsorbent. The experimental results are described by Langmuir and Freundlich isotherm models. Experimental results show that the kinetic model of pseudo-second order provided a good description of the whole experimental data more than the kinetic of the Lagergren-first order.

Keyword: Batch adsorption, Methyl Violet, Thermodynamics and Kinetic models.

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Abstract: Solution Chemistry of some bivalent metal ions (viz. CoII , NiII ,CuII ,ZnII ) with β-amide α-aminosuccinate (Asparagine)/ α-aminoisoverate( Valine ) (A) and 5-methyl 2,4- dioxopyrimidine ( Thymine ) (B)ligands have been analyzed. Formation constant of quaternary metal complexes and complexation equilibria at 30±1ºC and at constant ionic strength (I=0.1M NaNO3 ) have been explored potentiometrically. Formation of quaternary species in addition to hydroxyl, protonated, binary and ternary species have been reported. Overall formation constant have been evaluated using SCOGS computer program.Species distribution curves of complexes have been plotted as a function of pH to visualize the equlibria system and was refined using ORIGIN program.The metal ligand formation constant of MA,MB,MAB and M1M2AB type of complexes follow Irving William order. The order of stability constants of quaternary systems have been observed as: Cu – Ni > Cu –Zn > Cu–Co > Ni – Zn > Ni – Co > Co –Zn. Solution structures of metal complexes with said ligands have been compared and discussed.

Keywords: Multinuclear complexes/ SCOGS/ Valine / Asparagine/ Thymine

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Abstract: The 3-methoxy-6-phenyl-6,6a-dihydro-[1]benzopyrano-[3,4-b][1]benzopyran has been synthesised according to eight-steps synthesis. The target compound was obtained using a synthetic route based on two key cyclisations steps including the platinum chlorides-catalysed of alkynones and intramolecular oxo-Michael addition.

Keywords - 3-methoxy-6-phenyl-6,6a-dihydro-[1]benzopyrano-[3,4-b][1]benzopyran, photochromic system, oxo-Michael addition.

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Abstract: Four Cu(II) and two Ni(II) complexes of azo carboxylate ligands were synthesized and characterized by conductivity ,UV-visible and Infrared spectroscopy. The comparison of IR spectra of uncoordinated ligands and their metal complexes indicated that ligands were coordinated to the metal through carboxylic oxygen atom in bidented fashion. The electronic spectral data suggested square planner geometry of the complexes. The conductivity study of the complexes indicated Cu(II) complexes are nonelectrolyte while Ni(II) complexes are electrolyte in nature. All the complexes were tested for their in vitro antibacterial and antifungal activity against different microbes and compared with standard drugs, Amphotericin-B and Ciprofloxacin. It was observed that Ni(II)complexes are more effective than the corresponding Cu(II)complexes.Cu(II) complexes were found to be inactive against the tested fungal species but they show moderate activity against the tested bacterial species. One of the Ni(II) complex was found to be active in both fungal and bacterial species and also found to be more effective than the other complexes.

Keywords: Azo-carboxylates, antimicrobial activity,conductivity, IR spectroscopy

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Abstract: Nanosized Iron oxide is prepared by using precipitation method from iron nitrate and liquid ammonia. Thermal analysis shows that synthesized iron oxide shows some weight loss and oxide undergoing decomposition, dehydration or any physical change from TGA curve we observe that Iron oxide shows stable weight loss above 4000C. In DTA curve also, there is exothermic and endothermic peak. Which shows phase transition, solid state reaction or any chemical reaction occurred during heating treatment. Morphology is observed by scanning electron microscopy (SEM) shows particles are nanosized. Further morphology observation by Transmission Electron Microscopy (TEM) revels that Iron Oxide has the corundum (Al2O3) structure. Magnetic measurements shows that iron oxide has five unpaired electron and strongly paramagnetic character.

Keywords: Corundum, Haematite, Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM).

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Abstract: Freshly harvested Moringa oleifera was authenticated and processed for its vegetable leaf protein concentrates and analysed for proximate composition, functional properties and mineral composition. The proximate analysis was evaluated using standard analytical procedures. The proximate analysis reveal the moisture content to be 9.00mg/100g, ash content 6.00mg/100g, crude fat 2.43mg/100g, crude fibre 5.43mg/100g, crude protein 39.13mg/100g and carbohydrate content is 38.21 mg/100g. The mineral content of the leaves indicated that Ca, Mg, Zn, Mn, and Na are the most abundant. The water absorption capacity, fat absorption capacity, emulsion capacity, foaming stability revealed good functional properties.

Keywords: Leaf Protein Concentrate, Proximate Analysis, Mineral Content, Functional Properties, Vegetable

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Abstract: Year 2011, has been specially important for teachers and students of chemistry, as after a gap of about 14 years at least five new elements were named and included in the periodic table. All these elements are synthetic and radioactive and some were actually made in 1999, but got their name and status by IUPAC, in July 2011. The total number of elements now in periodic table is 112, and scientists are trying their best to prepare elements with atomic numbers 118, 119 and 120 as well.

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Abstract: Amino acid composition as well as the seed protein solubility of (Hura crepitans) seeds was studied. The chemical scores for the determined amino acids of the seed in % showed tryptophan, leucine, methionine and isoleucine with 175.71, 175.00, 161.82 and 134.52 as the most abundant amino acids in that order while lysine and phenylalanine with 44.29 and 45.71 respectively were the most limiting amino acids. The ratio of percentage essential and non-essential amino acids in the seed was found to be 79: 21. All the values determined for amino acids were higher than the FAO/WHO standard except for lysine, cysteine and phenylalanine where lower values were obtained. Four solvents (0.1M each of NaOH, Na2CO3, NaHCO3 and NaCl) were used to test for solubility of the seed protein and out of these, 0.1M NaOH was found to be the most effective solvent compared to the deionized distilled water. The protein was found to be more soluble in the alkaline than the acidic medium with PH4 having the lowest protein solubility of 20% while PH8 have the highest solubility of 65% after which increasing pH do not increase solubility and a relative stability established. The outcome of this work is a useful indication of how well protein isolate would perform when they are applied to food and to the extent of protein denaturation due to chemical treatment,

Keywords: Amino acid, chemical score, solubility, protein, essential, non-essential, limiting.

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Abstract: Six new derivatives of carbonyl thiourea comprises of o-,m- and p-toluyl at one end of Nitrogen atom and p-methylpyridine or ethyl pyridine at another one end of Nitrogen atom has been synthesized. The compounds are, 2-methyl-N-[(4-methylpyridine-2-yl) carbamothiol] benzamide (I), 3-methyl-N-[(4-methylpyridine-2-yl) carbamothiol] benzamide (II) and 4-N-[(4-methylpyridine-2-yl) carbamothiol] benzamide (III) for Toluyl-MP while 2-methyl-N-[(2-pyridine-2-yl-ethyl) carbamothiol] benzamide (IV), 3- methyl-N-[(2-pyridine-2-yl-ethyl) carbamothiol] benzamide (V) and 4- methyl-N-[(2-pyridine-2-yl-ethyl) carbamothiol] benzamide (VI) for isomer Toluidal-AEP have been successfully synthesized and characterized by elemental analysis, Infrared Spectroscopy analysis (FT-IR), Nuclear Magnetic Resonance Spectroscopy (NMR) and Ultraviolet-visible (UV-vis). All products shown stretching modes of ν(N-H), ν(C=O), ν(C-N), and ν(C=S) around 3276 cm-1, 1671 cm-1, 1315cm-1 and 1148 cm-1 respectively. All products shown two maximum absorption around 262 nm and 290 nm respectively for carbonyl C=O and thione C=S chromophore. Those both values contributed by n -п* transition. 1H nuclear magnetic resonance spectrum showed presence of aromatic, methyl, methine and amide protons except for product III. All products showed presence of carbon thione in 13C nuclear magnetic resonance except for product III. Ionophor interpretation with acetate anion shows color changes by naked eye for compound (I) and (III).

Keywords: Carbonoylthiourea, Spectroscopy,chromoionophore.

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Abstract: This paper tries to find the effect of the different environmental changes of ( pH, ionic strength, and temperature) on their tertiary structure of hGH by using UV sepctoscopy. We found that the hormone affected by chemical reagents change its conformation and folding. The present study is an attempt to discover what could happen to GH molecule when the biochemistry of body is changed. The results reveal that tryptophyl residues are inside the hormone, whereas tyrosyl residues are on the surface.

Key words: hGH, UV spectroscopy, Urea, divalent cation, halides

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Abstract: Synthesis of 2-(1, 3- dihydro- 3 - oxo- 2H - pyridylpyrr- 2- ylidene)-1, 2-dihydro- 3H- pyridylpyrrol- 3- one, polycyclic bi-indolinedione vat dye was carried out using a heterocyclic compound, 2-aminopyridine, chlorinated ethanoic acid and sodium hydroxide. The aromatic glycine that resulted as an intermediate to this new polycyclic bi-indolinedione compound was fused with admixture sodamide: sodium hydroxide: potassium hydroxide and oxidized by acidified concentrated solution of ferric chloride using hydrochloric acid. This dye showed good fastness properties on cotton, polyester, dacron, silk, wool and paper. The spectral analysis was in agreement with the proposed structure of the compound. UV: (DMSO) λmax nm; 609. IR:(KBr) ʋ cm-1 ; 3402, 2251.66, 2078.00, 1650.25, 1398.18, 1005.50 825.37, 764.03, 627.00. 1H-NMR :( DMSO-d6) δppm; 6.6, 7.2, 8.0; 13C- NMR: (DMSO-d6) δppm; 190.11, 188.20, 157.01, 155.21, 149.60, 148.11, 136.02, 134.50, 130.0, 128.94, 27.53, 126.31, 124.30, 123.91. MS: m/z; 32, 77, 105,181, 264 (M+).
Keywords: fused, heterocyclic, oxidized, spectral analysis, vat dye

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