Abstract: Lipophilic phosphonium cations were used to investigate mitochondrial biology by delivering them in mitochondria in the late 1960s. Since then, these molecules have become useful for exploring mitochondrial bioenergetics and free radical biology. The cations moves rapidly and carry antioxidants to mitochondria the process is entirely based on membrane potential ( ΔΨ). Here the investigation is carried out to synthesize and delivered antioxidants to brain mitochondria using lipophilic triphenylphosphonium cation.
Key words: lipophilic phosphonium cations, membrane potential, antioxidants.
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