iosr-jmr   Volume-2 ~ Issue-2 ~ Mar. - Apr. 2025

ABSTRACT: Background: Bacterial resistance, particularly in strains of Staphylococcus aureus, poses a significant challenge in both veterinary and human medicine. The production of β-lactamases by these bacteria is one of the primary reasons for the ineffectiveness of β-lactam antibiotics. The use of β-lactamase inhibitors emerges as a promising strategy to restore the efficacy of these antibiotics.
Materials and Methods: This study conducted an in silico analysis of various β-lactamase inhibitors against the 1BLH protein of S. aureus. The crystal structure of the.....

Key Word: β-lactamase; inhibitors; DockThor; S. aureus

[1]. George CRR, Lahra MM, Nguyen T, Gatus B. Disc Test For Detecting Staphylococcus Aureus Strains Producing Type A And Type C Β-Lactamases. Microbiol Spectr. 2023 Aug 17;11(4):E0022023.
[2]. Wang G, Wen J, Tian Z, Zhou H, Peng X, Zhang P, Li Z. Piceatannol And Its Analogues Alleviate Staphylococcus Aureus Pathogenesis By Targeting Β-Lactamase Biofilms And Α-Hemolysin. Sci Rep. 2025 Feb 14;15(1):5551.
[3]. Bush K, Bradford PA. Epidemiology Of Β-Lactamase-Producing Pathogens. Clin Microbiol Rev. 2020 Feb 26;33(2):E00047-19.
[4]. Oliveira-Tintino CDM, Tintino SR, Justino De Araújo AC, Dos Santos Barbosa CR, Ramos Freitas P, Araújo Neto JB, Begnini IM, Rebelo RA, Silva LED, Mireski SL, Nasato MC, Krautler MIL, Barreto HM, Ribeiro-Filho J, De Menezes IRA, Coutinho HDM. Efflux Pump (Qaca, Qacb, And Qacc) And Β-Lactamase Inhibitors? An Evaluation Of 1,8-Naphthyridines Against Staphylococcus Aureus Strains. Molecules. 2023 Feb 15;28(4):1819.
[5]. Christaki E, Marcou M, Tofarides A. Antimicrobial Resistance In Bacteria: Mechanisms, Evolution, And Persistence. J Mol Evol. 2020 Jan;88(1):26-40.

ABSTRACT: Class II medical devices occupy a critical position in healthcare, requiring rigorous clinical evaluation to ensure safety, efficacy, and regulatory compliance. The European Union Medical Device Regulation (EU MDR 2017/745) and the U.S. Food and Drug Administration (FDA) emphasize the necessity of robust clinical data to support market approval and post-market surveillance. This paper explores the evolving landscape of clinical evaluation for Class II medical devices, focusing on data analysis methodologies and the integration of artificial intelligence (AI) in regulatory and clinical decision-making.....

Key Word:Clinical Evaluation, Class II medical devices, post-market surveillance, data analysis, artificial intelligence

[1] Elshikh MS, Alwahibi MS, Alexiou A, Papadakis M, Et Al. Soil Pollution: An Agricultural And Environmental Problem With Nanotechnological Remediation Opportunities And Challenges. Discover [Journal Name]. Springer; 2024.
[2] Kitonakis N, Kontis A. The Determinants Of Greek Foreign Direct Investments In Southeast European Countries. Southeast European And Black Sea Studies. Taylor & Francis; 2008.
[3] Kuo C, Liu X. The Integration Of AI And Machine Learning In Medical Device Clinical Evaluations. Med Device Regul Rev. 2020;16(2):99-112.
[4] Liakou CI, Papadakis M, Plytas M. Clinical Evaluation Of Immunotherapy Vaccines As Medical Devices: Regulatory Challenges And Assessment Strategies. Int J Eng Technol Res Manag. 2025;9(3):32. Available From: Https://Www.Ijetrm.Com/ [Accessed 8 Mar. 2025]. Also Available From: Https://Zenodo.Org/Records/14989436
[5] Liakou CI, Papadakis M, Plytas M. The Challenges For Manufacturers Of The Increased Clinical Evaluation Requirements Under The European Union Medical Device Regulations. Int J Eng Technol Res Manag. 2025;9(3). Available From:
Https://Www.Ijetrm.Com/ [Accessed 8 Mar. 2025]..

ABSTRACT: Introduction: as air pollution continues to be a major source of concern across the global community, epidemiological evidence of its effects on the cardiopulmonary health also continue to rise. It's then crucial that the proper awareness of its effect on the cardiopulmonary health be extensively studied as this will play a crucial role to alleviate the menace of air pollution while at the same time, improve how the global study aim: this study aimed to investigate the awareness of air pollution effect on cardiopulmonary health among student at university of sunderland......

[1] Abdul-Rahman, T., Roy, P., Bliss, Z. S. B., Mohammad, A., Corriero, A. C., Patel, N. T., ... & Gupta, R. (2024). The Impact Of Air Quality On Cardiovascular Health: A State Of The Art Review. Current Problems In Cardiology, 49(2), 102174.
[2] Agbokey F, Dwommoh R, Tawiah T, Ae-Ngibise KA, Mujtaba MN. (2019). Determining The Enablers And Barriers For The Adoption Of Clean Cookstoves In The Middle Belt Of Ghana—A Qualitative Study.Int. J. Environ. Res. Public Health 16(7):1207 Air Pollution Problem. Energy Policy, 57, 204-211. Https://Doi.Org/10.1016/J. Enpol.2013.01.042
[3] Ali N, Islam F. (2020) The Effects Of Air Pollution On COVID-19 Infection And Mortality-A Review On Recent Evidence. Front Public Health.;8:580057. PMID: 33324598; PMCID: PMC7725793.Doi: 10.3389/Fpubh.2020.580057. Amegah AK, Agyei-Mensah S. (2017)Urban Air Pollution In Sub-Saharan Africa: Time For Action. J. Environ. Pollut. 220:738–43. DOI: 10.1016/J.Envpol.2016.09.042
[4] Amegah AK, Damptey OK, Sarpong GA, Duah E, Vervoorn DJ, Jaakkola JJ. (2013). Malaria Infection, Poor Nutrition And Indoor Air Pollution Mediate Socioeconomic Differences In Adverse Pregnancy Outcomes In Cape Coast, Ghana. PLOS ONE 8:E69181
[5] Amegah AK, Jaakkola JJ. (2016). Household Air Pollution And The Sustainable Development Goals. J. Bull. World Health Organ. 94:215–21

ABSTRACT: Mobile Edge Computing (MEC) is a transformative paradigm that enhances computational efficiency by bringing processing and storage capabilities closer to the end-user. This significantly reduces latency and improves performance in applications such as IoT, augmented reality, and real-time data processing.
However, efficient resource management remains a critical challenge to optimize utilization, maintain Quality of Service (QoS), and ensure energy efficiency in dynamic and heterogeneous environments. This paper presents a comprehensive survey.....

Keywords: Mobile Edge Computing (MEC), Internet of Things (IoT), Augmented Reality (AR), Quality of Service (QoS), Deep Reinforcement Learning, Minimum Energy Consumption

[1] B. G. Chun, S. Ihm, P. Maniatis, M. Naik, And A. Patti, "Resource Management In Mobile Edge Computing," Eurosys, 2022.
[2] R. K. Balan Et Al., "Dynamic Priority Scheduling Based On Task Urgency And System Context," Ieee Cloud Computing, 2022.
[3] E. Cuervo Et Al., "Spacce: Capacity Calculation For Edge Computing," Mobisys, 2022.
[4] M. Satyanarayan, "Fundamental Challenges In Mobile Cloud Computing," Acm Podc, 2022.
[5] G. Huerta-Canepa, D. Lee, "A Virtual Cloud Computing Provider For Mobile Devices," Acm Mcs, 2023.

ABSTRACT: Background: Water is essential for life, and rivers play a key role as freshwater sources for ecosystems, agriculture, industry, and human use. The quality of river water is affected by both natural factors like geology and climate, as well as human activities such as urbanization, industrial discharge, and agricultural runoff. The Dhansiri river in Nagaland, important for drinking water, irrigation, and industrial use, faces challenges due to rapid urbanization and human activities......

Key words: Physicochemical parameters, pH levels, TDS, EC, water hardness, DO, alkalinity, ammonia, nitrate, phosphate, salinity, iron, calcium, Dhansiri River, Nagaland.

[1] Abbasi SA, 1998. Water Quality: Sampling And Analysis. Discovery Publishing House. American Public Health Association. 2005. Standard Methods For The Examination Of Water And Waste Water (12th Edition), Washington D.C, 98-152p. 4.
[2] Anbarasu K. And Anbuselvan G. – "Physico-Chemical Parameter Analysis Of Water In Musiri Taluk, Tamil Nadu, India", WNOFNS 6 (2017) 28-35.
[3] Antoniadis V, Golia EE, Shaheen SM, Rinklebe J, 2017. Bioavailability And Health Risk Assessment Of Potentially Toxic Elements In Thriasio Plain, Near Athens, Greece. Environ Geochem Health 39:319–330.
[4] Arivoli Appavu, Sathiamoorthi Thangavelu, Satheeshkumar Muthukannan, Joseph Sahayarayan Jesudoss And Boomi Pandi, Study Of Water Quality Parameters Of Cauvery River Water In Erode Region. J. Global Biosci. ISSN 2320-1355,5, (9),2016 ,Pp. 4556-4567.
[5] Asheesh Shrivastava, Shalini A Tandon, Rakesh Kumar, Water Quality Management Plan For Patalganga River For Drinking Purpose And Human Health Safety, Int. J.Scient.Res.Environ.Sci.3(2)(2015)71–87..

ABSTRACT: Today, mobile phones serve not only as communication tools but also as multifunctional devices capable of handling various tasks. Due to evolving customer needs and preferences, the mobile phone market remains highly competitive and constantly changing. This study identified and explored the factors associated with the mobile phone preference......

Keywords: Factor Analysis, Latent Class Analysis

[1] Boslaugh, S. (2012). Statistics In A Nutshell: A Desktop Quick Reference. " O'Reilly Media, Inc.".
[2] Charry, K., Coussement, K., Demoulin, N., & Heuvinck, N. (2016). Marketing Research With IBM® SPSS Statistics: A Practical Guide. Routledge.
[3] Corner, S. (2009). Choosing The Right Type Of Rotation In PCA And EFA. JALT Testing & Evaluation SIG Newsletter, 13(3), 20-25.
[4] Costello, A. B., & Osborne, J. (2005). Best Practices In Exploratory Factor Analysis: Four Recommendations For Getting The Most From Your Analysis . Practical Assessment, Research, And Evaluation, 7.
[5] Dien, J. (2010). Evaluating Two‐Step PCA Of ERP Data With Geomin, Infomax, Oblimin, Promax, And Varimax Rotations

ABSTRACT: This study explores the many perspectives that people who live in Bangalore, a busy city in the nearby state of Karnataka, have of Kasaragodu, a tranquil coastal district in the southern state of Kerala, India. Due to its historical significance, cultural richness, and natural beauty, Kasaragodu is frequently regarded as an exquisite travel destination. With a focus on historical......

Keywords: Kasaragodu, Bangaloreans, Perceptions, Cultural Diversity, Tourism, Historical Connections.

[1] Road To Kasaragod. (2010). My "Earthly" Experiences.Https://Nithinu.Blogspot.Com/2010/11/Road-To-Kasaragod.Html
[2] Pranav. (2018). A Drive From Bengaluru To Kasaragod. Native Planet. Https://Www.Nativeplanet.Com/Travel-Guide/A-Drive-From-Bengaluru-To-Kasaragod-003336.Html
[3] ET Spotligh. (2019, August 20). Love Travelling Over The Long Weekends? You're Not The Only One! The Economic Times. Https://Economictimes.Indiatimes.Com/Magazines/Travel/Love-Travelling-Over-The-Long-Weekends-Youre-Not-The-Only-One/Articleshow/70750460.Cms
[4] Lapelosova, K. (2020, April 8). The Psychology Of Escapism And Travel. Webmd.
Https://Www.Webmd.Com/Covid/Features/Travelers-Escapism-Stay-In-Place
[5] Onmanorama Staff. (2023, July 31). What Karnataka Deputy CM Shivakumar Said While On Holiday At Bekal Fort. Onmanorama. Https://Www.Onmanorama.Com/Travel/Kerala/2023/07/31/Karnataka-Deputy-Chief-Minister-Cm-Shivakumar-Bekal-Fort.Html.

ABSTRACT: Art therapy has gained recognition as an effective educational tool, integrating creative expression with psychological and cognitive development. This paper explores the applications, benefits, and limitations of art therapy in educational settings, highlighting its role in fostering emotional intelligence, social skills, and cognitive growth among students. Art therapy provides a......

Keywords: Art Therapy, Art-Based Interventions, Creative Therapy, Cognitive Development, Educational Psychology, Learning through Art, Mental Health in Education, Therapeutic Education.

[1] Malchiodi, C. A. (2012). The Handbook Of Art Therapy And Digital Technology. Guilford Press.
[2] Kramer, E. (1971). Art As Therapy With Children. Schocken Books.
[3] Naumburg, M. (1950). Psychodynamic Art Therapy: The Use Of Art In Psychotherapy With Children And Adults. Grune & Stratton.
[4] Rubin, J. A. (2016). Approaches To Art Therapy: Theory And Technique. Routledge.
Journal Articles & Empirical Studies
[5] Huss, E., & Samson, T. (2018). "Drawing On The Arts To Enhance Resilience Among At-Risk Children And Adolescents." Children And Youth Services Review, 84, 201-208..

ABSTRACT: The peer-to-peer (P2P) clothing rental concept presents a feasible solution to the environmental and economic problems related to fast fashion. This research examines the feasibility of P2P clothing rentals in India, especially among young urban consumers such as college students and working professionals. With a design thinking methodology, this study explores the most important factors contributing to adoption, such as cost, convenience, hygiene, and fashion choice. The research summarizes building a Minimum Viable Product (MVP) that entails a mobile......

Keywords: Peer-to-peer rental, sustainable fashion, fast fashion, circular economy, digital platforms, sharing economy

[1] Mcneill, L., & Moore, R. (2015). Sustainable Fashion Consumption And The Fast Fashion Conundrum: Fashionable Consumers And Attitudes To Sustainability In Clothing Choice. International Journal Of Consumer Studies, 39(3), 212-222.
Https://Doi.Org/10.1111/Ijcs.12156
[2] Pedersen, E. R., & Netter, S. (2015). Collaborative Consumption: Business Model Opportunities And Barriers For Fashion Libraries. Journal Of Fashion Marketing And Management, 19(3), 258-273. Https://Doi.Org/10.1108/JFMM-05-2013-0073
[3] Pwc India. (2022). The Rise Of The Sharing Economy In India: Business Trends And Market Outlook. Pricewaterhousecoopers (Pwc) India. Retrieved From Https://Www.Pwc.In
[4] Rana, J., & Paul, J. (2020). Consumer Behavior And Sustainability: A Review And Research Agenda. Journal Of Retailing And Consumer Services, 53, 101726. Https://Doi.Org/10.1016/J.Jretconser.2019.101726
[5] Statista. (2023). Online Fashion Rental Market In India: Growth Trends And User Preferences. Statista Reports. Retrieved From Https://Www.Statista.Com.

ABSTRACT: This study empirically examined the impact of bank lending rates on the financial performance of deposit money banks in Nigeria over a 14-year period (2010-2023). Specifically, it analyzed the influence of lending rates and the loan-to-deposit ratio on bank performance, using return on shareholder funds (RSF) as a proxy. The study applied the least square econometric method to explore the relationship between bank lending and bank performance in Nigeria. The findings revealed that lending rates have a negative effect on bank performance, while the loan-to-deposit.....

[1] Abayomi, T. O., & Adebayo, M. S. (2010). Determinants Of Interest Rates In Nigeria. Journal Of Economics And International Finance, 2(12), 261-271.
[2] Adedoyin, O., & Sobodun, U. N. (1996). Commercial Banks Lending Activities In Nigeria. Nigerian Financial Review, 9(3), 36-37.
[3] Adofu, M. I., & Audu, S. I. (2010). An Assessment Of The Effect Of Interest Rate Deregulation In Enhancing Agricultural Production In Nigeria. Current Research Journal Of Economic Theory, 2(2), 82-86.
[4] Adebiyi, M. A., & Babatope-Obasa, B. (2004). Institutional Framework, Interest Rate Policy And The Financing Of The Nigerian Manufacturing Sub-Sector. Paper Presented At The African Development And Poverty Reduction (The Macro-Macro Linkage) Conference, Lord Charles Hotel, Somerset West, South Africa, 13th-15th October.
[5] Akinwale, S. (2018). Bank Lending Rate And Economic Growth: Evidence From Nigeria. International Journal Of Academic Research In Economics And Management Sciences, 7(3), 112- 122.

ABSTRACT: Thiomargarita magnifica is a recently discovered, macroscopic, sulfur-oxidizing bacterium that challenges long-standing biological principles about bacterial morphology and cellular organization. This manuscript explores its unique biological features, ecological roles, and potential implications on human health, including its contribution to environmental detoxification, its role as a microbial indicator, and its prospective use in biotechnological innovations. While not pathogenic, understanding its physiology opens new doors in microbial ecology and human health monitoring.....

[1] Volland JM, Et Al. (2022). A Centimeter-Long Bacterium With DNA Compartmentalized In Membrane-Bound Organelles. Science, 376(6591), 1453–1458.
[2] Schulz HN, Jørgensen BB. (2001). Big Bacteria. Annual Review Of Microbiology, 55(1), 105–137.
[3] Callahan BJ, Et Al. (2023). Thiomargarita Spp. And The Sulfur Cycle: Insights From Macro-Scale Bacteria. Microbial Ecology Reports, 18(2), 71–84.
[4] CDC. (2021). Hydrogen Sulfide: Human Health Effects. Www.Cdc.Gov/Hydrogensulfide
[5] NASA Astrobiology Institute. (2023). Extremophiles And The Limits Of Life. Www.Nasa.Gov/Astrobiology/Extremophiles.

ABSTRACT: To explore the diverse experiences of women in wartime, this study analyzes their depiction in literature and the influence of societal and cultural norms on their roles and identities.While acknowledging the progress made in recognizing women's resilience and agency, the paper argues that persistent gender biases continue to marginalize their contributions to war and peace. The analysis draws on a comprehensive review of scholarly works, highlighting the diverse experiences of women as community leaders, armed combatants, and agents of change, as well as their crucial roles in conflict resolution and peacebuilding. This study contributes
to a deeper understanding of the intricate socio-political forces at play during armed conflicts and their broader societal ramifications by advocating for literary portrayals of women that reflect the diversity and complexity of.

Keywords- war literature, scholarly works, community leaders etc..

[1]. Adjei, M. (2019, February 7). Women's participation in peace processes: a review of literature. Taylor & Francis, 16(2), 133 -
154. https://doi.org/10.1080/17400201.2019.1576515
[2]. Bragin, M., Tosone, C., Akesson, B., Taaka, J., & Nzeyimana, G. (2021, April 1). To Live in Peace: Women Ex‐combatants in
Burundi and Northern Uganda Envision Psychosocial Well‐being. Wiley, 46(2), 183-207. https://doi.org/10.1111/pech.12452
[3]. Haeri, M., & Puechguirbal, N. (2010, March 1). From helplessness to agency: examining the plurality of women's experiences in
armed conflict. Cambridge University Press, 92(877), 103-122. https://doi.org/10.1017/s1816383110000044
[4]. Kinsella, H M. (2013, January 1). Sex & World Peace, Valerie M. Hudson, Bonnie Ballif-Spanvill, Mary Caprioli, and Chad F.
Emmett (New York: Columbia University Press, 2012), 304 pp., $26.50 cloth.. Cambridge University Press, 27(2), 228-230.
https://doi.org/10.1017/s0892679413000129
[5]. Onyejekwe, C J. (2005, June 1). Women, War, Peace‐building and Reconstruction. Wiley, 57(184), 277-283.
https://doi.org/10.1111/j.1468-2451.2005.550