Volume-15 ~ Issue-7 ~ July 2022

Abstract: Five copper(II) complexes bearing aroylhydrazone Schiff base ligands were prepared and studied by spectroscopies which indicated that the ligands can act as dianionic tridentate chelates in enol forms. The obtained mass spectra data induced the hydrazone Schiff base copper(II) complexes as binuclear copper(II) complexes probably. The effective magnetic moments measured for these complexes are expected for one unpaired electron and distorted square-planar geometry around Cu(II) centers. The electrochemical properties of obtained complexes were conducted by cyclic voltammetric method. Their antibacterial and antifungal activity of all copper(II) complexes were examined on some Gram-positive strains, Gram-negative strains and a fungi. The obtained Cu(II) complexes were also tested for their anticancer activity against human breast cancer (MCF-7) and hepatocellular carcinoma (HepG-2).

Keywords. Hydrazones, copper(II) complexes, spectroscopy, electrochemical property, biological activity

[1]. Ali, Md. R.; Marella, A.; Alam, Md. T.; Naz, R.; Akhter, M.; Shaquiquzzaman, Md.; Saha, R.; Tanwar, O.; Alam, Md. M.; Hooda, J.Indonesian J. Pharm. 2012, 23(4), 193 – 202.
[2]. Sharma, P.C.; Sharma, D.; Sharma, A.; Saini, N.; Goyal, R.; Ola, M.; Chawla, R.; Thakur, V.K. Materials Today Chemistry, 2020, 18, 100349.
[3]. Verma, G.; Marella, A.; Shaquiquzzaman, Md.; Akhtar, M.; Ali, M.R.; Alam, M.M. J Pharm Bioall Sci., 2014, 6, 69-80.
[4]. Stadler, A.M.; Harrowfield, J. InorganicaChimicaActa, 2009, 362, 4298–4314.
[5]. Mandewale, M.C.; Thorat, B.; Shelke, D.; Yamgar, R. Bioinorg. Chem. & Appl.,2015, Article ID 153015, 14 pages; http://dx.doi.org/10.1155/2015/153015..

Abstract: Chemical investigation of the hydromethanolic fraction of ethanolic crude extract of Diplastrella sp. collected from Senegalese coast yielded a new tribrominated indole nucleoside. The compound was identified using HRMS and 1D and 2D NMR spectroscopic.

Keywords. Marine sponge, Diplastrella sp., indole nucleoside, marine metabolite.

[1]. Anjum K, Abbas, SQ, Shah SAA, Akhter N, Batool S, Hassan SSU. Marine Sponges as a Drug Treasure. Biomol. Ther. 2016, 24, 347-362.
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[3]. Hu Y, Chen J, Hu G, Yu J, Zhu X, Lin Y, Chen S, Yuan J.Statistical Research on the Bioactivity of New Marine Natural Products Discovered during the 28 Years from 1985 to 2012. Mar. Drugs. 2015; 13: 202-221.
[4]. Rao VK., Kasanah N, Wahyuono S, Tekwani BL, Schinazi RF, Hamann MT.Three new manzamine alkaloids froma common indonesian sponge and their activityagainst infectiousand tropical parasitic diseases. J. Nat. Prod. 2004; 67: 1314-1318.
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Abstract: Alligator pepper (Aframomum melegueta) is a spice from the Zingiberaceae family, a traditional snack with great pharmacological potentials. Its seeds components (proximate parameters, minerals and bioactive compounds) were determined in samples obtained from a market in Yenagoa the capital city of Bayelsa State, Nigeria. The proximate results were 66.58 % carbohydrate, 8.28 % fibre, 5.41 % protein, 8.91 % fat, 2.34 % ash and 8.53 % moisture content. Results for Minerals analyzed were 0.99 % K, 0.003 % Fe, 0.004 % Mn, 0.02 % Ca and 0.23 % P. The GC-MS analysis of the methanol extract of Aframomum melegueta revealed the presence of 15 bioactive.......

Keywords. Aframomum melegueta, proximate, minerals, bioactive compounds

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Abstract: Disinfection of water is generally accomplished by adding some form of chlorine, either as bubbled gas or aqueous solution of bleaching powders. In both cases chlorine behaves as a toxic and corrosive gas, for both the handlers as well as the consumers. It causes skin burns, eye irritations and gastro intestinal problems. Moreover, the commercial production of hypochlorite is tedious, expensive and an established environmental hazard. This contribution is in the initial stage of a two pronged study, first, on the composition and effective concentration of an organic biocide using raw cow urine as one of the ingredients and second, the effect of different concentrations of the formulation on spores of Giardia lamblia, Cryptosporidium, Streptococcus, Escherichia coli, Clostridium perfringens and some common bacterial strains found in swimming pools.

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Abstract: A backbone engineering study has been performed with isosorbide based organic semiconducting materials to modulate their physical and electronic properties through the incorporation of tetrazole groups. In this context, a novel polymer type PPV containing tetrazole groups was elaborated. It was prepared by chemical modification of cyano (CN) groups of the synthesized precursor polymer (CN-PPVIs) using click chemistry reaction. The structural, thermal and photophysical properties of the synthesized polymers were investigated and the structure-property correlations were established based on the conjugated system nature. The obtained results showed a significant effect on.......

Keywords: Semi-conducting Polymers; Click chemistry; DFT calculation; Optical properties; Space-charge limited current (SCLC)..

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4, 22332–22344..

Abstract: Background: In recent years, scientific communities have shown an increased interest in plant antioxidants which could be used as natural additives to replace synthetic ones. This upheaval involves a constant growing requirement of raw materials and new ingredients from natural sources. Phenolic compounds constitute one of the major groups of plant secondary metabolites, involved in the antioxidant defense. The present study consists of an exploration of the effect of solvent fractionation on the phenolic compound contents, their antioxidant activities and their chemical composition in P. denticulatum aerial parts. Materials and Methods: P. denticulatum was harvested during the flowering stage. Plant material was air dried then subjected to a differential extraction using different polarity solvents. Comparison of the effect of this parameter on the contents.......

Keywords: Pelargonium denticulatum; Phenolic compounds; Solvent fractionnation; Antioxidant activities; RP-HPLC.

[1]. Jallali I, Zaouali Y, Missaoui I, Smeoui A, Abdelly C, Ksouri R. Variability of antioxidant and antibacterial effects of essential oils and acetonic extracts of two edible halophytes: Crithmum maritimum L. and Inula crithmoïdes L. Food Chemistry. 2014;145:1031-1038
[2]. Jallali I, waffo Téguo P, Smaoui A, Mérillon J, Abdelly C, Ksouriet R. Bio-guided fractionation and characterization of powerful antioxidant compounds from the halophyte Inula crithmoїdes. Arabian Journal of Chemistry. 2020;13:2680-2688
[3]. Hao H Z, Liang L, Liu H, Yan Y, Zhang Y. Exploring the Extraction Methods of Phenolic Compounds in Daylily (Hemerocallis citrina Baroni) and Its Antioxidant Activity. Molecules. 2022;27: 2964-2977
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Abstract: Trace elements play an important role in human metabolism. The aim of this work was to determine iron (Fe), copper (Cu), cadmium (Cd), lead (Pb) and arsenic (As) concentrations in healthy livers by the atomic absorption spectrometry technique and set normal reference ranges for the region. Analytical methods were duly validated by evaluating figures of merit. This topic is important because there are a few research works about trace element contents in the liver of live human beings, so no data were found in the literature in similar papers. Analyses of 25 liver tissue samples were carried out (12 male and 13 female subjects, between 18 and 85 years old). Sample number and size were important critical issues, since the possibility of obtaining samples from healthy living subjects was limited........

Keywords: human liver; biopsies; trace elements; atomic spectrometry.

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