Volume-18 ~ Issue-3 ~ March 2025

Abstract: Background: Fadogia pobeguinii is a suffrutex used by Chad population for treat some ailments including hypertension. Objective: Assess the diuretic potential of this plant's extracts and determine the classes of compounds it closes. Materials and Methods: Female rats were randomly divided into three groups of six. In phase one, rats in the control group received a 0.9% NaCl aqueous solution at 25 ml/kg, while the test groups received 50 mg/kg, 100 mg/kg or 200 mg/kg of aqueous or ethanolic extract of root material. In the subsequent phase, a 2% solution of Tween-80 in a saline solution at 25 ml/kg was administered to the controls, while the test groups received the DCM fraction (1.81 mg/kg), AcOEt fraction (1.51 mg/kg), MeOH fraction (20.10 mg/kg) and BuOH fraction (0.60 mg/kg) of aqueous extract.....

Keywords: Fadogia pobeguinii, hypertension, sodium potassium ratio, HPLC, phytochemical.

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