Volume-7 ~ Issue-8 ~ August-2014

Abstract: Charge Transfer Complexes of Amino Pyridine derivatives as donor with the organic π- Acceptors, maleic anhydride,-nitroso--naphthol ,p-chloroaniline ,picric acid ,anthraquinone and p-bromoaniline in polar solvent have been determined . The study was performed in three different polar solvents namely N,N-dimethylformamide (DMF), acetonitrile (ACN) and dimethylsulfoxide (DMSO). The stoichiometric ratios of these complexes were found to vary from (1: 1) to (1: 1.5) (acceptor – donor) depending on the system solvent used and the (ασM) values has been examined . The distribution profiles of the various pyridine derivatives species and organic -acceptors formed, are obtained.

Keywords: Charge transfer, molecular complexes, amino pyridine, organic -acceptors , polar solvents,.

[1]. Ishaat , M. K., Afaq, A. (2010). Synthesis, spectrophotometric, structural and thermal studies of the charge transfer complex of p-phenylenediamine, as an electron donor with π acceptor 3,5-dinitrobenzoic acid. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 76, 3–4, 287-428 .
[2]. Xiong ,Y. , Weiwei , T . , Jingbo , Z . , Yuan , L . , Xurui , X . , Xiaowen , Z . , Xueping , Li . and Babasaheb , R. (2008).Synthesis of pyridine derivatives and their influence as additives on the photocurrent of dye-sensitized solar cells . Journal of Applied Electrochemistry , 39(1):147-154.
[3]. Singh, D.P., Malik, V., Kumar, K., Sharma, C. and Aneja, K.R. (2010).Macrocyclic metal complexes derived from 2,6-diaminopyridine and isatin with their antibacterial and spectroscopic studies. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , 76, 1. 45-49.
[4]. Davis , K. M. and Farmer, M. F.(1967). Charge-transfer complexes. Part II. Complex formation between halogenomethanes and aromatic amines . Journal of Chemical Society B, 28-32 . [5]. Hasse,O.(1970). Nobel Lecture, Structural Aspects of Interatomic Charge Transfer Bonding, 9. [6]. Matsubara,H., and Obara,Y. (1978) . OPINION ON2,6-DiaminopyridineCOLIPA n°, A136. Nippon Nogeikagaku Kaishi 52 (3), 123-127.

Abstract: An important property of micelles in pharmacy is their ability to increase the solubility of sparingly soluble drugs in water thus increasing their bioavailability, minimize drug degradation and loss to prevent harmful side effects. The proposed work mainly involves the "Physicochemical studies in this micellar solution of surfactant – sodium dodecyl sulphate in aqueous medium. This work is mainly useful in determining the availability of SDS as drug carrier for some poorly soluble drugs in water.

Keywords: CMC, Micelle, Surfactant, SDS

[1]. M.Vlachy, M.Dreshler and T.M.Vesbarvatz,Role of surfactant head group on counterion specificity in micelles to vesicle transition through salt addition,J.colloid interface Sci.319,542,2008.
[2]. Y.Moroi, Micelle: theoretical and applied aspect, Plenum press, Newyork, 1992.
[3]. S.P.Moulik,Micelles: self-organized surfactant assemblies current Sci.,71,5,1996.
[4]. D.P.Tieleman,VanderSpoel,H.J.C.Berendsen,Molecular dynamics simulations of dodecyl phosphocholine micelle at three different aggregate sizes: Micellar structure and chain relaxation,J.Phys.Chem.B104,6380-6388,2000.
[5]. M.A.Etman,R.O.Salama,M.A.ShamsedeenandA.Elkamel.Solubilisationofetodolacfor parenteral administration. Indian j. Pharm. Sci.63, 459-467, 2001.

Abstract: A simple and sensitive colorimetric gold nanoparticle probe for detection of melamine in infant formula was developed by the reduction of Au(III) salt with sodium citrate. This method is rather simple that does not involve any surface modification of the nanoparticles or multistep sample treatment. This technique is based on the fact that the optical properties of gold nanoparticles depend on distance between particles. Gold nanoparticles are aggregated in a neutral media in the presence of melamine; this causes an easily measurable change in the absorption spectrum of the particles, which can be monitored with the naked eye or UV-vis spectrophotometer. Here, the color of gold nanoparticles changed from wine red to blue in the presence of melamine and no color change was observed before melamine was introduced into the milk sample. The observed color change is the result of the coupling of the surface plasmon resonance (SPR) between particles in close proximity. This method is also sensitive and a limit of detection of 0.90 ppm of melamine was obtained with the UV-vis spectrophotometer in aqueous solution and 0.46 ppm of melamine was detected visually with the naked eye in a solution of infant formula.

Keywords: Gold nanoparticles (AuNPs), infant formula, melamine, pH stability, Surface plasmon resonance (SPR), TEM, UV-vis

[1]. H. Guan, J. Yu, and D. Chi, Label-free colorimetric sensing of melamine based on chitosan-atabilized gold nanoparticles probes, Food Control, 32, 2013, 35.41.
[2]. Q. Zhou, N. Liu, Z. Qie, Y. Wang, B. Ning, and Z.Gao, Development of gold nanoparticles-based rapid detection kit for melamine in milk products, Journal of Agricultural and Food Chemistry, 59, 2011, 12006-12011.
[3]. Y. Liu, E. E. D. Todd, Q. Zhang, J. R. Shi, and X. J. Liu, Recent developments in the detection of melamine, Journal of Zhejiang University-Science B (Biomedicine & biotechnology (, 13(7), 2012, 525-532.
[4]. M. S. Fligenzi, E. R. Tor, R. H. Poppenga, L. A. Aston, and B. Puschner, Simultaneous determination and confirmation of melamine and cyanuric acid in animal feed by zwitterionic hydrophilic interaction chromatography and tandem mass spectrometry, Rapid Communications in Mass Spectrometry, 21, 2007, 4027-4032.
[5]. W. C. Andersen, S. B. Turnipseed, C. M. Karbiwnyk, S. B. Clark, M. R. Madson, and C. M. Gieseker, Determination and confirmation of melamine residues in catfish, trout, tilapia, salmon and shrimp by liquid chromatography with tandem mass spectrometry, Journal of Agricultural Food and Chemsistry, 56, 2008, 4340-4347.

Abstract: Helminthes infestation is a major constraint to livestock production. Increasing anthelmintic resistance and the impact of conventional anthelmintics on the environment has led to increased interest on new novel plant-based compounds. In this study, the in vivo activity of a herbal extract mixture containing Entada leptostachya and Prosopis juliflora was determined using faecal egg count (FEC) reduction tests on sheep. There were no signs of toxicity in all the groups throughout the study period apart from reduced feed intake in the initiation stage of the experiment. The herbal formula exhibited a time-dependent but not dose-dependent in- vivo anthelmintic activity. The 500mg/kg b.w.dose produced the maximum faecal egg reduction of 84% while 4500mg/kg b.w.dose gave the least reduction of -59% on day 19 post-treatment (PT). The results of the FEC reduction tests indicated that the herbal formulation tested passed the threshold FEC reduction of 80%. All the groups had an increase in their mean live body weights (LBWs) by day 19 PT except the untreated group. However, none of the increase was significant (P>0.05). All the animals recorded pre- and post-treatment packed cell volume (PCV) values that were within the permissible range of between 24-45% for experimental sheep. All the groups recorded improved PCV values except the doses at 1500mg/kg b.w. and 4500mg/kg b.w. In conclusion, the herbal mixture was, therefore, safe and sufficiently active and has potential as a novel anthelmintic drug for the treatment of gastro-intestinal nematodes in ruminants.

Key words: Gastro-intestinal nematode, anthelmintic, faecal egg count, Prosopis juliflora

[1]. Adama, K., Amadou, T., Man, N., Hamidou, T.H. and Gaston, B.A.M. (2012). Anthelmintic activity of Daniellia oliveri (Rolfe) Hucht. and Dalz (Caesalpiniaceae) in sheep in Burkina Faso, Journal of Research in Antimicrobials: 1(1): 049-055.
[2]. Ademola, I.O., Ajayi, A., and Okotie, S.V. (2008). Larvicidal effects of Aframomum danieli seed extracts against gastrointestinal nematode of sheep: in vitro studies, African Ethnomedicines Network: 5(3): 173-179.
[3]. Ademola, I.O. and Eloff, J.N. (2010). In vitro anthelmintic activity of Combretum molle (R. Br. ex G. Don) (Combretaceae) against Haemonchus contortus ova and larvae, Veterinary Parasitology: 169(1-2): 198-203.
[4]. Agaie, B.M. and Onyeyili, P.A. (2007). Anthelmintic activity of the crude aqueous leaf extracts of Anogeissusleiocarpusin sheep, African Journal of Biotechnology: 6: 1511-1515.
[5]. Barry, T. N., McNeill, D. M. and McNabb, W. C. (2001). Plant secondary compounds; their impact on nutritive value and upon animal production, pp. 445–452. Proc. XIX Int. Grass. Conf., Sao Paulo, Brazil

Abstract: Water is an extraordinary abnormal liquid and omnipresent compound from very outset of civilization in all scriptures and testaments .In ancient India the importance of pure water was too much and for that reason the king of all Gods Indra was made the authority of protection and judicious distribution of rain water on the earth which is the purest form of water from natural resources .We have focussed our studies on purity of drinking water in the state of Bihar which is larger in area and thickly populated 1102 person per sq.Km. Depletion of water table in most of the district of the state are going to be trapped in arsenic, iron and fluoride contamination. The state has an average 50 rainy days. It is divided into two parts by holy river Ganga, Koshi is another perinial river of north Bihar originating from Himalayan basin in Nepal. This piece of study was to carried out the characterization of drinking water coming from different resources including underground water collected from different parts of state from popularly used up resources by local population. For each sample their TDS, TSS, PH, EC, DO, COD, concentration of Mg(II),Ca(II),nitrate, sulphate, were determined and compared with BIS and MCI desirable limit

Keywords: sacred, riverbasin. toyam, vein, basin. Termite, nano, perinial, fetor

[1]. Patil V.T and Patil P.R. E.J.Chem.7(1), 111-116(2007)
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[3]. Ranjana A. Journal of chemical, environmental and pharmaceutical research,1(2),111-113(2010).
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[6]. Kautilya Arthsastra

Abstract: The aim of this investigation is to carry out the synthesis of bisazo dye 2, 2[benzene-1, 3-diyl di (E) diazene 2, 1-diyl] bis (4-nitroaniline).The synthesis was conducted through the diazotization and coupling of m-phenylene diamine with 4-nitroanline leading to the production of azo metal (II) complex of Cobalt. Characterization of the ligand and the metal complex was carried out using various 34hysic-chemical techniques. The metal chelates have a metal to ligand ratio of 1:1. The synthesized azo metal (II) complex dye had a potential application for high density optical recording media due to their good absorption spectra and high thermal stability.

Key Words: Azo dye, Ligand, Metal Complex, UV-Visible Spectroscopy

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[2]. E. N. Abrahart, Dyes and Their Intermediates. New York: Chemical Publishing 1977, pp 1-2

[3]. H. Keharia, H. Patel, and D. Madamwar Decolourisation Screening of Synthetic Dyes by Anaerobic Methanogenic Sludge Using Batch Decolourisation Assay. World J. Microbial Biotechnol, 20, 2004, 365-370.

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Abstract: Context based learning approaches have been presented in this article as a way to enhance student‟s interest in, as well as time economic learning outcomes from chemical education. In this article state of s-p hybridization of hetero atoms in heterocyclic compounds is empirically calculate from the number of bonds and delocalized lone pair of electrons associated with it. The article explores the results and gives implications for context-based teaching, learning and assessment.
Keywords: General public, High School, Under Graduate, Graduate student, Chemical Education Research, Organic Chemistry, Hybridization, Heterocyclic Compounds and Chemical Bonding

[1]. Das Arijit, 'Simple Thinking Makes Chemistry Metabolic And Interesting- A Review Article‟, IOSR-JAC, 2014, 6(4), 08-15,
doi:10.9790/5736-0640815,e-ISSN: 2278-5736.
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Article." World Journal of Chemical Education, vol. 2014, 2(3), 29-38. doi: 10.12691/wjce-2-3-1.
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Abstract: Solvent free and simple one-pot synthesis for three-component protocol has been used for efficient synthesis of new mannich products (HB7-B12) in excellent yields from heterocyclic aldehyde, phenol as uv absorbing material and various amide derivatives with using Ethyl ammonium nitrate (reusable ionic liquid) as catalyst under 80 0C temperature. All synthesized compounds were characterized by 1H-NMR, 13C NMR spectra and screened for their in vitro antibacterial activity by using the agar dilution technique. Specially two compounds shows very good microbial activity as Shown by standard drugs, HB9 and HB10 compounds showed potential activity especially against E. Coli MTCC 443 (MIC =45-50 μg/mL) P. Aeruginosa MTCC 1688 (MIC =45-50 μg/mL) and S. Aureus MTCC 96 (MIC=45–50 μg/mL). All compounds HB7-12 shows very good activity but HB9 and HB10 compound shows excellent antifungal activity between 75-100 μg/mL which is most active rather than Greseofulvin. Antituberculosis activity of HB9 and HB10 compounds shows good activity 1 μg/mL using L. J. medium conventional Method.

Keywords: Solvent-free, One-pot synthesis, Reusable ionic liquid, Uv absorbing materials, Mannich products.

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Abstract: A series of some coumarin derivative have been synthesized by the interaction of 4-hydroxy coumarin with substituted benzaldehyde. The identities of these synthesized compounds have been established on the basis of chemical transformation and IR, 1H NMR and Mass spectral studies. In the present study synthesized compounds were studied for their in-vitro anti inflammatory activity by using HRBC membrane stabilization method, all compounds studied shows satisfactory results

Keywords: Coumarin, Anti-inflammatory, etc

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