Volume-8 ~ Issue-12 ~ December-2015

Abstract: Moringa oleifera is a tropical plant that grows rapidly with well established leaves and well documented nutritional, economic and medicinal benefits. The preliminary investigation of some phytochemicals as well as identification of organic functions has been achieved from the crude extract of the leaves by n-hexane using standard procedures. Phytochemical screening tested positive for saponins, phenols, glycosides, terpenoids and alkaloids as useful natural products that have been found potent for use as therapeutics. The infrared spectral data obtained revealed the following bonds: C-H, C=O, C-C, C=C, N-O and C=C-H that are diagnostic markers of aliphatic as well as aromatic compounds. However, because of the fingerprint region which has a pattern that is specific for every molecule, the presence of -OH function and N-O stretch, suggest that aromatic or aliphatic phenols or alcohols and nitrogen containing molecules are major components of the Moringa oleifera leaf that was studied.

Keywords: extraction, preliminary investigation, natural product, infrared spectral data, Moringa oleifera, n-hexane

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Abstract: A series of novel N'-arylidene-4-(2-(piperidin-1-yl)ethoxy)benzohydrazide derivatives (3a-3j) have been synthesized from condensation reaction between 4-(2-(Piperidin-1-yl)ethoxy)benzohydrazide 2 and various aldehyde. The structures of all these newly synthesized compounds were established on the basis of spectral studies (IR, NMR & MASS) and Element analysis. The anti-microbial activities of these compounds were tested in vitro by agar diffusion cup-plate method against two Gram-negative Escherichia coli, Pseudomonas aeruginosa and two Gram-positive Staphylococcus aureus, Bacillus substilis bacteria and fungi Candida albicans at 100 μg/ml concentration. All these compounds have displayed good or moderate activities against the test microorganisms and all these inactive against C. albicans.

Keywords: Antimicrobial activity, hydrazones, piperdine derivatives, Schiff bases.

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Abstract: Simple, accurate and precise UV- Visible spectrophotometric methods have been developed for the estimation of five drugs viz., Gemifloxacin mesylate(GEM),Moxifloxacin hydrochloride (MOX), Olmesartan medoxomil (OLM), Sumatriptan succinate(SUM), Trimetazidine dihydrochloride(TMZ). The method is based on the oxidation of drugs with acidic Potassium permanganate (excess), and subsequent estimation of unreacted Potassium permanganate (KMnO4) by using Saffranin – O (S-O) as an analytical reagent. The proposed methods were found to be successful for the estimation of these drugs in bulk and its pharmaceutical formulations. The results of analysis have been validated statistically for linearity, accuracy, precession, LOD, LOQ, robustness and ruggedness.

[1]. Ashok Kumar Bera, Amit Kumar De and Biswajit Pal. A Simple, Rapid and Validated Reverse Phase. High Performance Liquid Chromatographic Method for the Estimation of Gemifloxacin in Pharmaceutical Dosage Form. International Journal of PharmTech Research, (2014), 6(3),1011-1017. [2]. U. L. Narayan, B. Garnaik, S. K. Patro and S. Sahu. HPTLC Methods for Determination of Gemifloxacin Mesylate in Rabbit Plasma. British Journal of Pharmaceutical Research. (2014), 4 (14), 1707-1714. [3]. Narayan, U. L.; Garnaik, B. Patro, S. K.; Sahu,S. HPTLC methods for determination of gemifloxacin mesylate in rabbit plasma. British Journal of Pharmaceutical Research, 2014; 4(14): [4]. Abdallah, Nehad A. HPLC and densitometric TLC methods for simultaneous determination of gemifloxacin with some co-administered drugs in human plasma. Chromat Separation Techniq, (2010), 5(2), 9. [5]. A.R. Rote, S.P. Pingle. Reverse phase-HPLC and HPTLC methods for determination of gemifloxacin mesylate in human plasma. Journal of Chromatography B, (2009), 877(29), 3719–3723.

Abstract: Vanadium supported on unsulfated and sulfated Tungsten-Titanium-pillared claysare prepared andcharacterized then tested in the selective catalytic reduction of nitrogen oxide by ammonia. The structural, textural and acidic properties are largely influenced by either the presence or in the absence of sulfate. The catalytic activity in the selective catalytic reduction of NO by NH3indicates that vanadium supported on mixedtungsten- titanium pillared clay exhibit higher activity than that of a similar sample prepared in the presence of sulfate groups.
Keywords:Vanadium, Tungsten, Sulfate, Titanium, catalytic activity.

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Abstract: The present study is a modest attempt to develop a method of synthesis and examine the utility of starch based polymers in agro-medicinal fields. The enviromental impact of the pestilent synthetic plastic is profound; production may be cheap, however, disposal is difficult. Incineration of these non-biodegradable polymers leads to generation of toxic, hazardous fumes detrimental to human health and welfare. In addition to the dangers, petroleum resources are limited; so, generation of such non-biodegradable, synthetic polymers on an industrial scale cannot be sustained for a fesible, economically productive time period.

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Abstract: This paper is a review written on the defects of the Modern Periodic Table. It also shows the solution of the errors by introducing two specific Sections (A&B) in place of arrangements of four current blocks (s, p, d & f).
Keywords: The Modern Periodic Table, Electronic Arrangements of Elements, Distribution of Blocks (s, p, d& f), Logical Approach of Sections-A&B, CAS-System.

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[2] Adrian Dingle, The Periodic Table : Elements with Style, Kingfisher Publications (UK) & Macmillan (US) (2007).
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Abstract: In this study, synthesis of novel β-Lactam derivative comprising of 7-AVCA and NEPA-NCA [(R)- ethyl 2-(((S)-4-methyl-2,5-dioxo oxazolidin-3-yl)methyl)-4-phenylbutanoate] is disclosed. The synthesis of intended compound has been characterized and confirmed by 1H-NMR, 13C-NMR and Mass.
Key words: β-Lactam, NEPA-NCA, 7-AVCA

[1]. Shrivastava, Sarita; Ranjan, Amulya; Tripathi, Niraj Kumar; "Synthesis of novel β-Lactam derivative and it's application." IOSR
Journal of Applied Chemistry (IOSR-JAC) Volume 7, Issue 7 Ver. I. (July. 2014), PP 16-20.
[2]. Shrivastava, Sarita; Ranjan, Amulya; Tripathi, Niraj Kumar; "Synthesis of novel amino acid [(6R, 7R)-7-((S)-2-((S)-1-ethoxy-1-
oxo-4-phenylbutan-2-ylamino)propanamido)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4,2,0]oct-2-ene-2-carboxylicacid]"." IOSR
Journal of Applied Chemistry (IOSR-JAC) Volume 8, Issue 8 Ver. I. (Aug, 2015), PP 16-19.
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Abstract: In this communication, a simple, cost effective, high temperature gas sensor setup has been designed to measure the gas sensing response of metal oxide thin films. The setup is used to measure gas sensing response of metal oxide thin films at different temperatures ranging from room temperature to about 450 0C. Importance of prepared setup lies in its easy design, compact, reliability, easy way to inject probing gas into the chamber and to carryout temperature dependent gas sensing measurements. It is tested using tin oxide thin films deposited on glass substrate using chemical spray pyrolysis technique and H2S as the probing gas. It was found to be very sensitive even for a small amount of gas and the recorded gas response to electrical resistance change are quite reproducible. Hence here in it is proposed that the present setup is an innovative design to achieve low cost and high temperature gas sensing device.

Key words: Metal oxide, design and fabrication of gas sensor, tin oxide film, temperature dependent gas response..

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Abstract: The effects of precipitation pH values on the electrochemical properties of β-nickel hydroxide materials synthesized by co-precipitation method have been investigated. . The β-phase of the synthesized nickel hydroxide materials have been confirmed by x-ray diffraction studies. The structural characteristics such as crystallite size, degree of crystallinity, and capacitance of the electrode of the synthesized β-Ni(OH)2 are strongly dependent on the pH values of the co-precipitation reaction. The cyclic voltammetry (CV) studies clearly indicate the success of the pH factor by increasing the reversibility of the electrode reaction with a raise in the proton diffusion co-efficient within the nickel electrode. The Rct and capacitance of the electrodes have been fit to the equivalent circuit in the EIS spectrum.

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Abstract: A chemical speciation study on the interaction of adipic acid dihydrazide (AADH) with Mg(II) and Ca(II) (M) was carried out in aqueous medium at a temperature of 30.0 ±0.1°C and 0.1 mol.dm-3 ionic strength. The ditopic ligand, AADH possesses a number of potential donor atoms and is able to form both mono-nuclear and binuclear species in protonated, unprotonated and deprotonated forms. Best-fit chemical models representing the systems of different compositions were obtained using the Miniquad-75 computer program. Mononuclear species of the type MLH, ML, MLH-1, ML2H2, ML2H, ML2, ML2H-1 and binuclear M2L, M2LH-1 (L=AADH) were found to exist in solution. The species distribution diagrams were generated using HYSS program.
Key words: adipic acid dihydrazide, ditopic ligand, formation constant, speciation, Mg (II), Ca(II)

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