Abstract: The endocannabinoid system, specially the cannabinoid receptor-1 (CNR-1) is associated with depression and antidepressant treatment. Some polymorphisms of CNR1 gene of the cannabinoid receptor-1 are associated with depression and clinical response to antidepressants.
This study investigated the effect of the polymorphisms 4895A/G and 1359 G/A of the CNR1 gene on the etiology of depression, and on response to treatment withEscitalopram.
CNR1 polymorphisms 4895A/G and 1359 G/A of cases and controls were determined by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism technique. Diagnosis of cases was determined by Diagnostic and Statistical Manual of Mental Disorders-5th edition, and then they were treated with Escitalopram for six weeks. Drug response was determined by Hamilton Rating Scale of Depression.
The association between both polymorphisms.....
Key words: Major Depressive Disorder; Endocannabinoid system; CNR1 gene; 4895A/G; 1359 G/A; rs806368; rs1049353; Escitalopram; Egyptian population
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