Abstract: The aim of the study is to develop a formulation of Atenolol for the nasal drug delivery system with consideration to parameters require for nasal administration, to get maximum utilization and efficacy of the drug also delivery of drug in case of emergency situation. The use of Atenolol in conventional dosage form possesses several disadvantages like the absorption in GI tract is low, hence low bioavailability, require large amount of dose and has to pass first pass metabolism. This encourages us to formulate the dosage form with Atenolol as a novel drug delivery whih will show maximum potential utilization of the Atenolol. The in vitro studies of microspheres were performed. The scattering electron microscopy (SEM), study was also performed. The SEM demonstrated spherical particle with rough surface. The mean partical force size increased with the increase in polymer concentration. The adhesive.......
Key-words: Microspheres, Atenolol, Eudragit RL 100, HPMC, Mucoadhesive
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