Volume-7 ~ Issue-4 ~ April-2014

Abstract: The electrochemical oxidation of Organic pollutant has been studied at solid micro electrodes over a wide pH range. Phenyl hydrazine exhibited a single anodic diffusion controlled and irreversible peak during cyclic voltammetric studies . Voltammograms were recorded prior to electrolysis at different pH, scan rates and concentrations. The redox behaviour of the compounds was studied to have the optimum experimental conditions for their degradation and to find out the decrease in toxicity in the breakdown products of the degradation. The purpose of the present study is to address the issue by investigating the performance of electrochemical treatment for the removal of toxicity.

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Abstract: The rate at which reaction proceeds and how yield does it provide, has always been a question of key importance in the field of research, carried out at both academic and industrial level. With the advent of microwave irradiation technology, it has now become possible to address this difficulty owing to its property to interact directly with molecules of reacting mixture without altering their molecular structure and thus providing a forward thrust to this whole time consuming process. The presented work compares the synthesis of derivatives of 4-aminoantipyrine with microwave irradiation and conventional method. It also addresses and attempts to find out the possession of anti-oxidant activity of the derivatives. The analysis of the synthesized derivatives was carried out using analytical techniques such as HPLC, FTIR.
Keywords: 4-Aminoantipyrine, Microwave irradiation, Anti-oxidant Activity etc.

[1]. J. Panda, V. Jagannath Patro, B. Mohan Sahoo and J. Mishra, Green Chemistry Approach for Efficient Synthesis of Schiff Bases of Isatin Derivatives and Evaluation of Their Antibacterial Activities, Journal of Nanoparticles, 2, 2013, 1-5.
[2]. CO Kappe, Angew Chem Int Edn: 43, 2004,6256
[3]. S. Ravichandran, E.Karthikeyan, Microwave Synthesis - A Potential Tool for Green Chemistry, International Journal of ChemTech Research, 3(1), 2011, 466-470.
[4]. N. Raman, S. Thalamuthu, J. Dhaveethuraja, M. A. Neelakandan and S. Banerjee, DNA cleavage and antimicrobial activity studies on transition metal (ii) complexes of 4-aminoantipyrine derivative, Journal of the Chilean Chemical Society, 53(1), 2008,27.
[5]. A. Jitareanu and G. Tataringa, A-M. Zbancioc, M. Balan, U. Stanescu Synthesis, Cinnamic acid Derivatives and 4-Aminoantipyrine Amides – Synthesis and Evaluation of Biological Properties, 3(3), 2013, 9-13.

Abstract: The advantages of Microwave irradiation technology in the field of organic chemistry have been long known as it facilitates accelerated reaction rates, higher yields with relatively less power consumption than classical techniques. The presented study compares aspects like reaction time and percentage yield of various 2-amino-1, 3, 4-thiadiazole derivatives when synthesized by both, conventional as well by microwave irradiation along with their characterization using techniques such as FTIR and HPLC. They have a very promising role in the field of medicinal chemistry owing to their anti-cancer and anti-fungal properties The study also aims to evaluate biological activity of the compounds a simple and inexpensive technique making use of 2,2-Diphenyl-1-picrylhydrazyl(DPPH) to establish their worth as potential anti-oxidants . Thus this combination of faster synthesis and cost effectiveness can significantly reduce the cost of production of various pharmaceutical products containing thiadiazole and/or its derivatives which are known to be clinically potent.
Keywords: 2-amino-1, 3, 4-thiadiazole, Microwave irradiation, anti-oxidant activity, DPPH.

[1]. M. Surati, S. Jauhari, K. R. Desai, A brief review: Microwave assisted organic reaction, Archives of Applied Science Research, , 4 (1), 2012, 645-661,
[2]. CO Kappe, Angew Chem Int Edn: 43, 2004,6256.
[3]. C. R. Strauss, D. W. Rooney, Accounting for clean, fast and high yielding reactions under microwave conditions, Green Chem. 12, 2010, 1340-1344
[4]. C. Redlich, W. S. Beckett, J. Sparer; K. W .Barwick, C. A. Riely, H. Miller, S. L. Sigal, S. L. Shalat, Liver disease associated with occupational exposure to the solvent dimethylformamide, Annals of Internal Medicine ,108 (5), 1988, 680–686
[5]. W. Rzeskia, , J. Matysiakb, M. Kandefer-Szerszeńa, Anticancer, neuroprotective activities and computational studies of 2-amino-1,3,4-thiadiazole based compound, Bioorganic & Medicinal Chemistry, Volume 15, Issue 9, 2007, 3201–3207

Abstract: A rapid, efficient, clean and environmentally benign exclusive synthesis of Schiff bases as new ligands and their complexes with Cu(II) have been developed using condensation of salicylaldehyde and amoxicillin (L1), cephalexin (L2), sulphamethoxazole (L3) and trimethoprim (L4) efficiently in analcoholic suspension medium using alkali catalyst with excellent yields under microwaves irradiation. This method provides several advantages such as environmental friendliness, simple work-up procedure, short reaction times, non-hazardous and excellent yield of products.The results are compared with conventional methods for their yield and reaction time.

[1]. V. Polshettiwar, Aqueous Microwave Assisted Chemistry: Synthesis and Catalysis, 2010, Royal Society of Chemistry, ISBN 978-1-84973-038-9, Cambridge, UK.
[2]. P. Ali; P.Ramakanth; J.S. Meshram, J. Coord. Chem., 2010, 63(2), 323-329.
[3]. B.L. Hayes, Recent Advances in Microwave-Assisted Synthesis, Aldrich Chimica Acta, 2004, 37(2), 66-76.
[4]. N. E. Leadbeater, Microwave Heating as a Tool for Sustainable Chemistry, 2010, CRC Press, ISBN 978-1-4398-1270-9, Boca Raton, USA.
[5]. B. L. Hayes, Microwave Synthesis: Chemistry at the Speed of Light, 2002, CEM, ISBN 0-9722229-0-1, USA.

Abstract: Mixed ligand complexes of Co(II) ion with some heterocyclic nitrogen donors and 1,1-dicyanoethylene-2,2-dithiolate of the compositions, Co(N-N)2(i-MNT), Co(N-N)(i-MNT).2H2O and Co(N-N)(i-MNT)L2 [N-N = 1,10-phenanthroline, 2,2'-bipyridine ; i-MNT 2- = 1,1-dicyano- ethylene -2,2-dithiolate ; L = pyridine(py), -picoline (-pic), -picoline (-pic) or -picoline (-pic) have been isolated and characterized on the basis of analytical data, molar conductance, magnetic susceptibility, electronic and infrared spectral studies.

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Abstract: An efficient one-pot reductive acetylation of aromatic nitro compounds is developed without isolating the intermediate amine. The nitro compound is efficiently reduced by sodium borohydride and catalytic amount of Pd-C in MeOH-water media in presence / absence of alkali, and the amine thus generated is acetylated by acetic anhydride in situ in excellent yields through easy work-up. The technique unveils a new route for direct conversion of synthetically accessible nitro compounds to acetamido functionality and is reproducible in large scale. The method has been successfully extended in case of nitrosophenols as well. Mechanistic rationale of this methodology is also significant.

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Abstract: The kinetics of oxidative decolorization of fast red e (FRE) by chloramine-B and bromamine-B in HClO4 medium has been investigated spectrophotometrically (λmax = 508 nm) at 298 K. Kinetic runs were performed under pseudo first-order conditions of [oxidant]o >> [FRE]o. Under identical experimental conditions, reactions with both the oxidants follow identical kinetics with a first-order dependence on each [oxidant]o and [FRE] and a fractional-order dependence on [HClO4].

[1]. Zollinger, H., Colour chemistry: Synthesis, properties and applications of organic dyes and pigments, New York, VCH, 1981.
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Abstract: The effect of microwave heating on the Fatty Acid Profiles (FAPs) of three Nigerian Vegetable oils (soya, groundnut and palm oils) was studied. Samples of the oils namely were separately heated for thirty minutes in a microwave oven. FAP of each oil was analyzed before and after microwave heating using gas chromatograph. Comparative study of the FAPs of the three oils before and after microwave heating showed that the microwave heating had a very marginal impact on the compositions of their fatty acids.

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Abstract: The adsorption of ethanolic root extract of Portulaca oleracea as corrosion inhibitor for the corrosion of mild steel in H2SO4 medium at the temperature range of 305K to 315 K was studied using weight loss method and characterized using the common adsorption isotherms. The inhibition efficiency, IE%, was found to increase with both increase in the inhibitor concentration and rise in temperature. The increase in IE% with rise in temperature is suggestive of chemisorption.

[1]. E. I. Ating, S. A. Umoren, I .I .Udousoro, E. E. Ebenso, and A P Udoh, Green Chemical Letter and Review,3. 2010, 61–68.
[2]. L. A. Nnanna, B. N. Onwuagba, I. M. Mejeha, and K. B. Okeoma, Inhibition effects of some plant extracts on the acid corrosion of aluminium alloy, African Journal Pure and Applied Chemistry, 4, 2010, 011-016
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Abstract: In Rajasthan state printing and dyeing units represent an important economic sector.bagru in Jaipur district has got many printing and dyeing industry, in this industry Natural and vegetable dyes are mainly used for printing but some enterprises make use of synthetic dyes and mordants.

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