Abstract: Background: To treat cancer, micronutrients obtained from certain fruits appear to offer an alternative to the frequently toxic chemotherapy methods. We therefore focused on Lycopene and Apigenin, the main components in pink guava Psidiumguajava L, and Resveratrol, a reference biomolecule with recognized anti-oxydant, neuroprotective and anticancer properties. Our aim was to assess and compare their antiproliferative action on LNCaP cells (prostate cancer) and UACC257 cells (melanoma). Materials and Methods: Micronutrients were studied separately first and then in combination, using MTT assays. Confocal microscopy using anti-PCNA and anti-5-α-reductase primary antibodies enabled to evaluate the antitumoral pathway of Lycopen alone or in combination with Apigenin or Resveratrol, on prostate cancer cell......
Keywords: Lycopene, Apigenin, Resveratrol, Prostate cancer, Psidiumguajava L, Melanoma
[1] F. Priam, O. Marcelin, R. Marcus, A. Wijkhuisen, and E. J. Smith-Ravin, "Evaluation of Anti-Cancer Effects of Lycopene extracted from Pink Guava Psidium guajava L. and its Combination with Apigenin or Resveratrol‟, In Review, preprint, Jul. 2021. doi: 10.21203/rs.3.rs-626677/v1.
[2] A. J. Miller and M. C. Mihm, "Melanoma‟, N Engl J Med, vol. 355, no. 1, pp. 51–65, Jul. 2006, doi: 10.1056/NEJMra052166.
[3] L. Multigner et al., "Chlordecone Exposure and Risk of Prostate Cancer‟, JCO, vol. 28, no. 21, pp. 3457–3462, Jul. 2010, doi: 10.1200/JCO.2009.27.2153.
[4] Luc Multigner et al., "Pollution par le chlordécone aux Antilles Quel impact sur la santé de la population ?‟, Environnement, Risques & Santé, vol. 6, no. 6, pp. 405–407, Nov. 2007, doi: 10.1684/ers.2007.0121.
[5] A. Eichholz, R. Ferraldeschi, G. Attard, and J. S. de Bono, "Putting the brakes on continued androgen receptor signaling in castration-resistant prostate cancer‟, Molecular and Cellular Endocrinology, vol. 360, no. 1–2, pp. 68–75, Sep. 2012, doi: 10.1016/j.mce.2011.09.038.