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| Paper Type | : | Research Paper |
| Title | : | Evaluation of Serum Vitamin B12 and Ferritin Levels in H. Pylori- Associated Gastritis |
| Country | : | Sudan |
| Authors | : | Awad-Elkareem Abass || Khalid O. Mohamed || Alaa A. Yosif || Fatima A. Mohamed || zobaida Mohamed || Marwa Elfadil |
Abstract: H. Pylori infection is a major gastric infection worldwide and has been associated with many haematinics deficiencies. The aim of the study was to find out an association between H. Pylori associated gastritis, vitamin B12 and iron deficiencies. A prospective case control study was conducted on 60 confirmed H. Pylori associated gastritis' patients and 60 non- H. Pylori infected controls. The detection of H. Pylori was confirmed by endoscopy and either rapid urease test or urea breath test for each patient. A venous blood sample was collected; complete blood count, serum ferritin and vitamin B12 measurement were performed for all cases and controls. Among the total 60 H .Pylori associated gastritis there were 32(53.3%) males and 28(46.7%) were females, their ages ranged between 17-80 years.
[1]. Tan HJ, Goh KL. Extra gastrointestinal manifestations of Helicobacter pylori infection: facts or myth? A critical review. J Dig Dis, 2012, 13, 342-349.
[2]. Kuipers EJ, B MJ. Acid peptic disease: Epidemiology and Pathobiology. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Elsevier, 2007, 1009-1013.
[3]. Cave DR. Transmission and epidemiology of Helicobacter pylori. Am J Med, 1996, 100(suppl 5A), 12-18.
[4]. Graham DY, Malaty HM, Evans DG, Evans DS, Klein PD, Adam E. Epidemiology of Helicobacter pylori in an asymptomatic population in the United States. Gastroenterology, 1991, 100, 1495-1501.
[5]. Megraud F. Epidemiology of Helicobacter pylori. Gastroenterol Clin North Am, 1993, 22:73-86.
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| Paper Type | : | Research Paper |
| Title | : | Natural Occurrence of Diverse Fungal Species and their Toxins in Dried Fruits of Emblica officinalis, Terminalia chebula and T. bellerica- Constituents of Triphala, an Important Ayurvedic Preparation of India |
| Country | : | India |
| Authors | : | Seema Sharma || Geeta Sumbali || Vishal Sharma |
Abstract: This investigation was designed to throw light on the microbial status of some herbal materials used in 'triphala preparation'. Dried fruit samples of Phyllanthus emblica (Amla), Terminalia belerica (Baheda) and Terminalia chebula (Harada) were collected from random market sources of Jammu & Kashmir state (India). Mycological analysis was carried out for the detection and enumeration of fungi using standard media. Fungal contamination was detected from all the samples. Nearly half of the spoilage fungi belonged to Aspergillus, Penicillium and their perfect states. Four measures of diversity were considered viz., species richness (S), Shannon-Wiener's diversity index (H'), Simpson Dominance index (Cd) and Berger Parker's Dominance index (d') to study the diversity of recovered fungi.
[1]. Tandon, V. Kapoor, B. Gupta, B.M. (2004). Herbal research in India: A trend analysis using I J P as marker (1995-August 2003). Indian Journal of Pharmacology. 36: 99-100.
[2]. Dubey, N. K. Kumar, R. and Tripathi, P. (2004). Global promotion of herbal medicine : India's opportunity. Current Science. 86: 37-41.
[3]. Pandey, M.M. Rastogi, S. Rawat, K.S. (2008). Indian herbal drug for general healthcare: An overview. The internet Journal of Alternative Medicine 6(1).
[4]. Wealth of India. 1952. Raw Materials, 10: 168-170.
[5]. Wealth of India. 1976. Raw Materials, 11: 164-167, 171-177.
[6]. Juss, S.S. (1997). Triphala D: The wonder drug. Indian Medicine Gazette. 13: 194-196.
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| Paper Type | : | Research Paper |
| Title | : | Effect of Drug Abuse Among Youth and Its Impact on Learning |
| Country | : | Nigeria |
| Authors | : | H A Ibrahim || S Mahmud || A Abubakar || A Harazimi C || S Abdulkadir |
Abstract:Drug abuse is a global phenomena found in most countries of the world among youth. Although it covers various age range group, its mostly common in youth between 18 – 35 years of age. A total of 100 structured questionnaires were distributed to the respondents, followed by face to face interview to establish a relationship between what is in the questionnaire and responses from the interview. It has been found out that youth of the age range 18 – 25 years were more in number in terms of drug misuse. Unemployment and low level of education also play a role in drug abuse.
[1]. Global Burden of Disease Study (2013). Mortality and Causes of Death, Collaborators (17 December 2014). "Global, regional, and
national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the
Global Burden of Disease Study 2013.". Lancet. doi:10.1016/S0140-6736(14)61682-2. PMID 25530442
[2]. Mosby's Medical, Nursing & Allied Health Dictionary (2002). Drug abuse definition, Sixth Edition p. 552. Nursing diagnoses, p.
2109.
[3]. Nutt, D.; King, L. A.; Saulsbury, W.; Blakemore, C. (2007). "Development of a rational scale to assess the harm of drugs of
potential misuse". The Lancet 369 (9566): 1047–1053.
[4]. Jaffe, J.H. (1975). Drug addiction and drug abuse. In L.S. Goodman & A. Gilman (Eds.) The pharmacological basis of therapeutics
(5th ed.). New York: MacMillan. pp. 284–324.
[5]. Barrett SP, Meisner JR, Stewart SH (2008). "What constitutes prescription drug misuse? Problems and pitfalls of current
conceptualizations". Curr Drug Abuse Rev 1 (3): 255–62.
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| Paper Type | : | Research Paper |
| Title | : | Ethnobotanical Study of Medicinal Plants In Barkin Ladi Local Government Area, Plateau State, Nigeria |
| Country | : | Nigeria |
| Authors | : | Dawang D Noel, Mashat M Victor || Nyam D Brenda || Pam P Gabriela || Tongwring D Peace |
Abstract:It is no longer news that medicinal plants have become integral part of health care delivery system. The Ethnobotanical survey of medicinal plants was carried out in one out of six Local Government Areas spread across the northern senatorial zone in Plateau State, Nigeria. This research was aimed to document the information on the indigenous plants in this locality. The people here are mostly farmers. The information on the plants was gotten through verbal interview from the farmers and traditional healers. Medicinal plants reported to be effective in treatment and management of human diseases was collected using herbarium process. Some of the plants identified were Aloe vera,Tamarindus indica, coffee, avocado, betty, Moringa oleifera, Eucalyptus, Psidium guajava, Hibiscus, Amaranth, Elephant ear, Bitter leaf etc.
[1]. Sofowora EA. Medicinal Plants and Traditional Medicine in Africa. 2 edn, England, John and Wiley and Sons Ltd.,1993; 55-62.
[2]. Duraipandiyan V, Ayyanar M, Ignacinmuthu S. Antimicrobialactivity of some ethnomedicinal plants used by Paliyar tribe
fromTamil Nadu, India. BMC Complementary Altern. Med.,2006; 6: 35-51.
[3]. SawadogoW.R, M. Schumacher, M. Teiten, M. Dicato, and M. Diederich. "Traditional West African pharmacopeia, plants and
derived compounds for cancer therapy," Biochemical Pharmacology, 2012; vol. 84, pp. 1225–1240.
[4]. Mahomoodally M.F. Traditional Medicines in Africa: An Appraisal of Ten Potent African Medicinal Plants 2001, Evidence-
Based Complementary and Alternative Medicine ,2013;Volume 2013 (2013), Article ID 617459, 14
pages.http://dx.doi.org/10.1155/2013/61745
[5]. Gurib-Fakim,A "Medicinal plants: traditions of yesterday and drugs of tomorrow," Molecular Aspects of Medicine, 2006; vol. 27,
no. 1, pp. 1–93.
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| Paper Type | : | Research Paper |
| Title | : | Prevalence of Hepatitis B & C Virus in Population of Rawalpindi, Pakistan |
| Country | : | Pakistan |
| Authors | : | Nazar ul Islam Hajra Haneef || Muhammad Adil |
Abstract:The viruses of Hepatitis B and C (HBV & HCV) usually cause chronic infection which may develop the Cirrhosis and Hepatocellular carcinoma (HCC). Moreover, carriers of chronic hepatitis become the source of transmission of the disease throughout their lives. The current study is designed to evaluate occurrence of HBV & HCV infection in community of Rawalpindi. Each patient was tested out by screening their serum samples for the incidence of both HBV & HCV. The achievements of present study were analyzed statistically to uncover occurrence of HBV & HCV in patients.
Keywords: Hepatitis, cirrhosis, hepatocellular carcinoma.
[1]. 1. Aspinall, E, J. Hawkins, G. Fraser, A. Hutchinson, S, J. and Goldberg, D. Hepatitis B prevention, diagnosis, treatment and care: a review Oxford Journal of Medicine and Health 61( 8) 531-540 (2011).
[2]. 2.Wolfram, H, G. Review Medical Virology of Hepatitis B: how it began and where we are now. Virology Journal: 10:239 doi:10.1186/1743-422X-10-239 (2013).
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| Paper Type | : | Research Paper |
| Title | : | A Study on the Correlation between Infection with Helicobacter Pylori and Hepatic Encephalopathy in Patients with Chronic Liver Disease |
| Country | : | India |
| Authors | : | Nag Arindam || Mandal ch Bidhan || Hembram Anjan || Debnath Partho || Hembram Mrinal |
Abstract:Background: Hepatic encephalopathy is a complex neuropsychiatric syndrome occurring in patients with severe hepatic insufficiency. A multitude of factors and pathogenic processes appear to be operative, with the accumulation of toxic products in the brain, originating from the gut, not metabolized by the diseased liver, being the most important factor. Objectives: To find out whether there is any correlation between the gastric ammonia concentration and Helicobacter pylori infection of the stomach. To find out whether there is any correlation between the gastric ammonia and blood ammonia concentration and occurrence of hepatic encephalopathy in Helicobacter pylori infected subjects.
[1]. Gitlin N, Lewis DC, Hinkley L. The diagnosis and prevalence of subclinical hepatic encephalopathy in apparently healthy, ambulant, non-shunted patients with cirrhosis. Journal of Hepatology 1986; 3: 75-82.
[2]. Gitlin N. Hepatic Encephalopathy. In : Zakim D, Boyer TD. eds: Hepatology : A Textbook of Liver Disease 3"Ed. Vol. 1. Philadelphia.W.B. Saunders,: 1996; 605-617.
[3]. Riordan SM, Williams R. Treatment of hepatic encephalopathy. New England Journal of Medicine 1997; 337: 473-479.
[4]. Deutz NEP, Dejong CHC, Soeters PB. Ammonia and glutamine metabolism during liver insufficiency: the muscle-gut-liver axis. Italian Journal of Gastroenterology 1993; 25:79-86.
[5]. Dasani BM, Sigal SH, Lieber CS. Analysis of risk factors for chronic hepatic encephalopathy: the role of Helicobacter pylori infection, American Journal of Gastroenterology, 1998 May; 93(5): 726-731.
[6]. Gubbins GP, Moritz TE, Marsano LS, et al. Helicobacter pylori is a risk factor for hepatic encephalopathy in acute alcoholic hepatitis: the ammonia hypothesis revisited. American Journal of Gastroenterology 1993; 11: 1906-1910.
[7]. Dasani BM, Sigal SH, Lieber CS. The role of Helicobacter pylori in the pathogenesis and treatment of chronic hepatic encephalopathy. Hepatology 1995; 22: A161.
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| Paper Type | : | Research Paper |
| Title | : | Comparison Study between Two Types of Formulation Taking a Newly Formulated Effervescent Ciprofloxacin |
| Country | : | Saudi Arabia |
| Authors | : | Ahmed M. A.Masaad || Majed Al robaian |
Abstract:This research is a formulation of the drug as an effervescent tablet by two methods (direct compression and wet granulation). The bitter taste was masked by saccharine as sweeting agent furthermore the effervescent effect of citric acid, tartaric acid and sodium bicarbonate lead to improve the taste of the drug. Also the Guar was used as binder agent lead to hide the taste (1) (2). The vanillin which was used as flavoring agent also enhances the palatability (3) (4). The formulated tablets were passed all the fundamental testes in the monograph, and also microbiological sensitivity test was done against (Escherichia coli, Salmonella typhi, Salmonellapara typhi and Staphylococcus aureus ) and then the results were compared to select the suitable one. Also compression was done between two formula of wet granulation method (the binder increase concentration and die cavity when was change).
[1]. Blasé, C.M. Shah, M.N. Taste Masked Pharmacuetical Suspensions for Pharmaceutical Actives. Eur. Pat. Appl. EP0556057, August 18, 1993.
[2]. Skraanga, A.T.P. Tully, R.E. Oral liquid Antidepressant Solution. U.S. Patent 6,050,301, March 31, 2000.
[3]. Hussain, M.M, Barcelon, S.A. Flavor enhancing and medicinal test masking agent. U.S. Pat. No. 4,983,394 to Warner- Lambert Co, 1991.
[4]. Pather, S.I. Khankari, R.K. Eichaman, J.D. Robinson, J.R. Hontz, J. Sublingual Buccl Effervescent. U.S. Patent 20,020,110,578: August 15, 2002.
[5]. Nichols, W. K. (2000) Oral Solid Dosage Form. In: Remington: The Science and Practice of Pharmacy. 20th ed. Alfonso, R.G. Philadelphia College of Pharmacy and Science. Pp. 858-93.
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| Paper Type | : | Research Paper |
| Title | : | Electrophrotic Analysis of C - reactive protein with Body Mass Index |
| Country | : | India |
| Authors | : | Nirmala Natarajan || B.Elaveini |
Abstract:The study was conducted at Harman Institute by Harman Institute of Science Education and Research, Thanjavur – 5. 64 obese and 61 non obese with Body Mass Index (BMI) 18.5 – 24.9 kg/m2, 25 – 29.9 kg/m2, 30 – 34.9 kg/m2 and 35 – 39.9 kg/m2 were selected. A parameter such as CRP was assessed with obese and non – obese subjects. The figure exhibits a relation of CRP with BMI. CRP levels with BMI ranges, suggesting a source of inflammation are more common among obese subjects than in non obese subjects. Key words: Obesity, Body Mass Index, Gender, C – Reactive Protein.
[1]. Aronson, D., Bartha, P., Zindr, O., Kerner, A., Markiewicz, W., Avizohar, O., Brook, G.J, and Levy, Y. (2004). Obesity is the major determinant of elevated C-reactive protein in subjects with the metabolic syndrome. International journal of obesity, 28: 674 – 679.
[2]. Bourne, L.T., Lambert, E.V, and Steyn, K. (2002). Where does the black population of South Africa stand on the nutrition transition? Public Health Nutr; 5: 157-162.
[3]. Festa, A., D'Agostino,R., Howard, G., Mykkanen, L., Tracy, R.P, and Haffner, S.M. (2000). Chronic subclinical inflammations as part of the insulin resistance syndrome: the insulin resistance atherosclerosis study (IRAS). Circulation: 102:, 42 – 47.
http://earthing Canada.ca/chronic – inflammation – and –heart –disease/ chronic inflammation and heart disease.
[4]. Kyle, R. A. (1999). Sequence of testing for monoclonal gammopathies. Arch Pathol Lab Med;123:114-8.
[5]. Martin, C. A, and Dorf, M.E. (1991). Differential regulation of interleukin-6, macrophage inflammatory protein-, and JE/MCP-1 cytokine expression in macrophage cell lines. Cell. Immunol; 135: 245- 258.
[6]. Miao, C.Y, and Z.Y. Li. (2012). The role of perivascular adipose tissue in vascular smooth muscle cell growth. British Journal of Pharmacology. 165(3): 643 – 658.
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| Paper Type | : | Research Paper |
| Title | : | "Evaluation Of Anti-Convulsant Activity Of Aqueous Extract Of Argyreia Nervosa Against Induce By Mes And Ptz Methods In Mice" |
| Country | : | India |
| Authors | : | Lagu surendra babu || M. satti babu || CH. Suresh || K. phani kumar |
Abstract:The present investigation was aimed to study an anticonvulsant activity of aqueous extract of Argyreia nervosa (family: convolvulaceae) in mice. Valuated the anti convulsant activity followed by two animal models: Maximal electroshock seizures induced seizure model and Pentylenetetrazole induced seizure model. Estimation was done by measuring decrease in the duration of HLTE induced by MES, when compared with the control group. AEAN at dose of 250 & 500 mg/kg p.o. showed reduction in HLTE and no mortality was found against MES induced convulsion. Phenytoin (25 mg/kg i.p.) significantly reduced the duration of MES-induced HLTE (***p<0.001) and completely prevented the various phases of convulsion induced by MES.
[1]. Bromfield EB, Cavazos JE, and Sirven JI. CHAPTER I-Basic Mechanisms Underlying Seizures and Epilepsy. 2006, Page No. 12.
[2]. World Health Organisation-Media Center-Fact Sheets.
[3]. Vyawahare NS, Bodhankar SL. Anticonvulsant activity of Argyreia speciosa in mice. Indian J Pharm Sci. 2009;71:131–4.
[4]. Galani VJ, Patel BG. Central nervous system activity of Argyreia speciosa roots in mice. Res J Pharm Tech. 2009;2:331–4.
[5]. Kamal J, Sunil T, Narender T. Antipyretic Activity Of Whole Aerial Part From Argyreia Nervosa. Int J Pharm Pharm Sci, 2012; 4(4): 76-77.
[6]. Bhosle V. Anticonvulsant and antioxidant activity of aqueous leaves extract of Desmodium triflorum in mice against pentylenetetrazole and maximal electroshock induced convulsion. Rev. bras. farmacogn. 2013; 23(4): 692-698.
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| Paper Type | : | Research Paper |
| Title | : | Epidemology of Trypanosomiasis in Derived Savannah of Nigeria |
| Country | : | Nigeria |
| Authors | : | A. Abubakar || H. M Sabo || S. Abdulkadir || S. N. Halliru || R. B. Umar || D.A. Abdulkadir |
Abstract:Bovine (cattle) trypanosomosis, an important protozoan disease caused by the genus Trypanosoma is transmitted through bites by different species of Glossina and mechanically by a number of biting flies such as Tabanus and Stomoxys sp. Bovine trypanosomosis and its vectors (Glossina species) occur in vast areas of the sub-Saharan Africa with devastating impact on livestock productivity posing a serious threat to the lives and livelihood of entire communities and constitutes the greatest single constraint to livestock and crop production thereby directly contributing to hunger, poverty, protein malnutrition and suffering of entire communities in Africa Parasitological evaluation of bovine trypanosomosis to assess its impact in 113 cattle from Ogunola, Olodo, and Imeko in derived savanna areas of Ogun State were carried out. Blood samples were collected aseptically and screened using standard trypanosome detection methods in addition to packed cell volume (PCV) determination.
[1]. Akinwumi, J.A. and Ikpi, J.E. (1985) Trypanotolerant cattle production in Southern Nigeria. Report submitted to the International Livestock Centre for Africa, Humid Zone Programme, Ibadan, Nigeria.
[2]. Di Domenico, C.M. (1989) Counting the cost: A study of dairy consumption, marketing and production in southern Nigeria. Consultancy Report to ILCA, Humid Zone Programme, Ibadan, Nigeria.
[3]. Ikede, B.O., Reynolds, L., Ogunsanmi, A.O., Fawumi, M.K., Ekwuruke, J.O. and Taiwo, V.O. (1987) The epizootiology of bovine trypanosomiasis in the derived savannah zone of Nigeria—a preliminary report. Paper presented at the 19th meeting of the ISTRC, Lome, Togo, March 30 to April 3.
[4]. ILCA (International Livestock Centre for Africa) (1987) ILCA Annual Report 1986. ILCA, Addis Ababa, Ethiopia.
[5]. Mohammed, T.A. (1990) A study of periurban cattle pastoralism in the derived savanna of Oyo State, Southwest Nigeria. ILCA Humid Zone Programme, Ibadan, Nigeria.
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| Paper Type | : | Research Paper |
| Title | : | Antimicrobial Susceptibility Test of Aqueous Extract of Parkia biglobosa Stem Bark on Methicillin Resistant Staphylococcus aureus (MRSA) |
| Country | : | Nigeria |
| Authors | : | Solomon Jauro || Mohammed Yusuf Zanna || Fatima Adamu Lawan || Istifanus James Waziri || Isa Adamu Gulani || Mustapha Bala Abubakar |
Abstract: The study into the phytochemical constituents and the in-vitro antibacterial effects of the crude aqueous extract of Parkia biglobosa was evaluated against twelve (12) Methicillin-resistant Staphylococcus aureus (MRSA) using agar plate disc diffusion technique at varying concentration of 100, 200, 400 and 600mg/ml with vancomycin 10μg standard drug as control. Preliminary phytochemical screening test of the aqueous extract revealed the presence of the following secondary metabolites; saponins, terpenoids, garlic tannins, reducing sugar, alkaloids, and flavonoids. The susceptibility of MRSA was tested against MRSA isolates from Human and Sheep.
[1]. Chamber, H.F. (2001). The Changing epidemiology of Staphylococcus aureus. Emerging Infectious Diseases. 7: 178-182
[2]. Ayliffe GA (1997). The progressive intercontinental spread of methicillin-resistant Staphylococcus aureus. Clin Infect Dis 1: S74-
S79.
[3]. Finch, R. G. (1998). Antibiotic resistance. J. Antimicrob. Chemother. 42(2): 125-128.
[4]. Centre for Disease Control and Prevention (CDC) (2008) Staphylococcus aureus resistant to vancomycin. JAMA 288: 825.
[5]. Ness T (2010) Multi-resistant bacteria in ophthalmology. Ophthalmologe 107: 318-322.
[6]. De Albuquerque UP (2006) Re-examining hypotheses concerning the use and knowledge of medicinal plants: a study in the
Caatinga vegetation of NE Brazil. J Ethnobiol Ethnomed 2: 30.
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| Paper Type | : | Research Paper |
| Title | : | A Green Approach For The Simultaneous Estimation Of Gatifloxacin And Flurbiprofen by a Very Sensitive Spectrofluorimetric Method |
| Country | : | India |
| Authors | : | Ceema Mathew || Nikitha Mala || Ajitha Makula || Sathesh Babu Puvvadi |
Abstract:Gatifloxacin (GAT), an antibiotic and Flurbiprofen (FLU), a Non-steroidal anti-inflammatory drug are co-formulated as an ophthalmic solution for the reduction of post operative ocular inflammation & ocular infections. Quality control of the ophthalmic solution of GAT and FLU is very essential and hence this work aims at the development of an economic and ecofriendly method for simultaneous estimation of GAT and FLU in an ophthalmic solution. Spectrofluorimetric method is selected due to the known fact of its inherent sensitivity. 10mM SLS was used as the solvent and micellar solubilisation resulted in an enhanced fluorescence for GAT and FLU.
[1]. Indian Pharmacopoeia. Government of India, Ghaziabad: The Indian Pharmacopoeia Commission; 2007.Vol.2. p.540.
[2]. British Pharmacopoeia. London, the stationary office, 2003; vol-I, p.104-05.
[3]. Indian Pharmacopoeia. Vol.2. Government of India, Ghaziabad: The Indian Pharmacopoeia Commission; 2010.p.1378.
[4]. British Pharmacopoeia 2008. Vol.1. London: Stationery office; 2007. Flurbiprofen; p.953.
[5]. The United state Pharmacopoeia. USP 34-NF 29. Rockville, MD: US Pharmacopoeial convention Inc.; 2010; 31(4):1069.
[6]. A.V. Mali, R.P. Dhavale, V.L. Mohite, A.R. Mahindrakar, Y.V. Pore and B.S. Kuchekar, Spectrophotometric estimation of
gatifloxacin in tablets, Indian Journal of Pharmaceutical Sciences, 68 (3), 2006, 386-387.
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| Paper Type | : | Research Paper |
| Title | : | Profil De L'hémogramme Chez Les Diabétiques De Type 2 À Lubumbashi En République Démocratique Du Congo. Hemogram Profile in Type 2 Diabetics in Lubumbashi in the Democratic Republic Of Congo. |
| Country | : | Belgique |
| Authors | : | Arsène Kabamba Tshikongo || Richie Kipenge Kyandabike || Hervé Musola Cansa || Yves Kisunka Bwalya || Zet Kalala Lukumwena || Albert Otshudi Longanga |
Abstract:Contexte :Malgré la prévalence de l'anémie liée au diabète et la connaissance de ses conséquences, très peu de recherches ont été menées sur les mécanismes physiopathologiques et moléculaires sous jacents de l'anémie chez les patients diabétiques. En conséquence, la corrélation entre l'anémie où autre perturbations hématologiques chez les patients diabétiques restent encore moins connues. Objectif : Cette étude avait pour objectif de déterminer le profil de l'hémogramme des diabétiques de type 2 à Lubumbashi. Méthodes : Il était question d'une étude descriptive transversale menée de Mai à Juillet 2015 à Lubumbashi (République Démocratique du Congo).
[1]. Ghosh D., Bhattacharya B., Mukherjee B., Manna B., Sinha M., Chowdhury J., Chowdhury S. Role of chromium supplementation in Indians with type 2 diabetes mellitus. J Nutr Biochem. 2002 Nov; 13(11):690-697.
[2]. Pretorius E., Bester J., Vermeulen N., Alummoottil S., Soma P., Buys A.V., Kell D.B. Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin: implications for diagnostics. Cardiovasc Diabetol. 2015 Mar;14(8):30.
[3]. Kundu D., Mandal T., Nandi M., Osta M., Bandyopadhyay U., Ray D. Oxidative stress in diabetic patients with retinopathy. Ann Afr Med. 2014 Jan-Mar; 13(1):41-6.
[4]. Bandeira Sde M., Guedes Gda S., da Fonseca L.J., Pires A.S., Gelain D.P., Moreira J.C., Rabelo L.A., Vasconcelos S.M., Goulart M.O. Characterization of blood oxidative stress in type 2 diabetes mellitus patients: increase in lipid peroxidation and SOD activity. Oxid Med Cell Longev. 2012; 2012(25):819310.
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| Paper Type | : | Research Paper |
| Title | : | In Vitro Antibacterial Activity of Spinacia Oleracea and Melilotus Indicus Used In Pakistani Folk Medicines against Some Specific Bacterial Strains |
| Country | : | Pakistan |
| Authors | : | Fahad Akhtar || Madiha Bashir || Warda Baig || Fareeha Zahoor || Nodia Shujaat || Ehsan Humayun || Bad-e-Saba Jamshaid || Azam Hayat || Malik Mujaddad ur Rehman || Muhammad Ayub Jadoon || Attiya Abdulmalik || Zakir Ullah || Sundas Gul || Muhammad Arshad Mallick || Qazi Inam ul Haq |
Abstract:The medicinal plants Melilotus indicus and Spinacia oleracea were collected from herb dealer in
order to check antibacterial activity in opposition to different Gram-positive and Gram-negative bacterial
strains.Such medically important bacterial strains including pseudomonas aeroginosa, Bacillus subtilis,
Microccocus luteus and Escherichia coli. Well diffusion method was used to check antibacterial activity of these
plants. Spanacia oleracea showed better antibacterial activity against these bacterial strains but Melilotus
indicus did not illustrate any results. The collected ethonomedicinal plants are used in folk medicines in
treatment of osteoporosis, high blood pressure, cancer, and kidney and liver complaints.
K e y w o r d s: Melilotus indicus, Spinacia oleracea, Pseudomonas aeroginosa, Bacillus subtilis, Micrococcus
luteus
[1]. European Food Safety Authority (EFSA), Scientific Opinion on the substantiation of health claims related to lutein and maintenance
of normal vision, (ID 1603, 1604, further assessment) pursuant to Article 13(1) of Regulation (EC) No 1924/2006.10(6), 2012,
s2716.
[2]. Cragg G M and Newman, Biodiversity: A containing source of novel drug leads, Pure Appl. Chem. 77(1), 2005,
Doi: 10.1002/0471141755.ph0911s46.
[3]. Chevallier A, the Encyclopedia of Medicinal Plants Dorling Kindersley, London, 1996, ISBN 9- 780751-303148.
[4]. Boeheme, Signature of all things: James Clarke and co: Cambridge Cimolai. MRSA and the environment: implications for
comprehensive control measures. European journal of clinical microbiology & infectious diseases: official publications of the
European Society of Clinical Microbiology. vol 27,1982, Pp. 481-93.
[5]. Samuelsson, Gunnar, Bohlin and Lars, Drugs of natural origin, a text book of pharmacognosy, 5th Swedish pharmaceutical press,
Stockholm, 2004, (ISBN10: 1439838577 / ISBN13: 9781439838570).
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| Paper Type | : | Research Paper |
| Title | : | Formulation and Characterization of Meloxicam Loaded Microspheres Intended for the Treatment of Rheumatoid Arthritis |
| Country | : | India |
| Authors | : | Kalla Madhavi || Dr S.Shobha Rani || Jubeda || Dr D.Sudheer Kumar |
Abstract:The present work was to prepare and evaluate colon specific meloxicam loaded microspheres for the treatment of rheumatoid arthritis. Sodium alginate microspheres were prepared by using emulsification method using different ratios of sodium alginate (1:1, 1:2, 1:3 and 1:4). Prepared microspheres were coated with eudragit S100. The microspheres were characterized for different physical parameters such as particle size, particle size distribution, shape, percent entrapment efficiency, FTIR studies, in vitro drug release studies and stability studies. The SEM studies of coated microspheres showed smooth spherical surface and size ranged from 584-890nm. The release studies of coated microspheres were performed and showed good release retardation in 0.1N HCl (2hr), pH 4.5 (2hr) and had a controlled released in pH 7.4 (up to 24hr).
Keywords: Emulsification method, Eudragit microspheres, Meloxicam microspheres, NSAID microspheres, Sodium alginate microspheres.
[1] Rana Mazumder, Verma Siddharath, and Gujral Sunny, Formulation, evaluation and characterization of meloxicam loaded micro emulsion for the treatment of Rheumatoid Arthritis, World journal of pharmaceutical Research, 3(3), 2014, 4305 – 4335. [2] K.H. Ramteke, V.B. Jadhav, and S.N. Dhole, Microspheres: as carriers used for novel drug delivery system, IOSR Journal of pharmacy, 2(4), 2012, 44-48.
[3] P. Yvonne, and R. Thoma, Controlling drug delivery, In pharmaceutics: Drug delivery and targeting, 2, 2012, 8-13.
[4] Vikrant Deshmukh, Shubhangi Warad, Rahul Solunke, Shital Walunj, Shivaprasad Palve, and Ganesh Jagdale, Microspheres: As new drug delivery system, World Journal of pharmacy and pharmaceutical sciences, 2(6), 2013, 4504-4519.
[5] Harsh Bansal, Simar Preet Kaur, and Atul Kumar Gupta, Microspheres: Method of preparation and applications: A comparative study, International journal of pharmaceutical sciences, 10(1), 2011, 69-78.
[6] Behin Sundara Raj, Shanthi, Rajesh Sreedharan Nair, and Vidya, Formulation and evaluation of coated microspheres for colon targeting, Journal of applied pharmaceutical science, 3(8 suppl 1), 2013, S 68 – S 74.
[7] M.L. Soni, M. Kumar, and K.P. Namdeo, Sodium alginate microspheres for extending drug release and in vitro evaluation, International journal of drug delivery, (2), 2010, 64-68.