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| Paper Type | : | Research Paper |
| Title | : | Identification of lead compounds against human hepatitis B viral capsid protein in three medicinal plants through in silico method |
| Country | : | India |
| Authors | : | Subin Mathew M S || Sreekumar S || Biju C K |
Abstract: Hepatitis B viral infection is a serious health problem in all over the world and its treatment is expensive with limited success (30-40%.) The current treatment system may induce serious side effects. It is well acknowledged that plant-derived drug molecules are safe and cost effective. In traditional medicine, several plants have been used as hepatoprotective but its efficacy and mode of molecular mechanism of drug action are seldom investigated.......
Keywords: AutoDock, Allamanda cathartica, Docking, Hepatitis B, Phytochemicals, Solanum indicum, Vigna mungo,
[1]. WHO report, July 2015 http://www.who.int/mediacentre/factsheets/fs204/en/
[2]. L. Stuyver, Sija De Gendt, C. V. Geyt, F. Zoulim, M. F., Raymond, F. Schinazi, and R. Rossau, A new genotype of hepatitis B virus: Complete genome and phylogenetic relatedness, Journal of General Virology, 81, 2000, 67-74.
[3]. T. J. Liang, Hepatitis B: The virus and disease, Hepatology, 49(5),2009, S13-S21.
[4]. M. Arooj, M. Sattar, M. Safdar, S. Kalsoom, and S Shahzad, In silico molecular docking and design of anti-hepatitis B drugs, IOSR Journal of Pharmacy and Biological Sciences, 3(6), 2012, 41-55.
[5]. V. Prabhadevi, S. S. Sathish, M. Johnson, B. Venkatramani, and N Janakiraman, Phytochemical studies on Allamanda cathartica L. using GC-MS, Asian Pacific Journal of Tropical Biomedicine, 1, 2012, S550-S554.
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| Paper Type | : | Research Paper |
| Title | : | Mineral Responses of P. Vulgaris L. To Telfairia Mosaic Virus Infection |
| Country | : | Nigeria |
| Authors | : | Mofunanya, A. A. J. |
Abstract: Mineral responses of P. vulgaris to Telfairia mosaic virus (TeMV) infection were investigated. Saponins, alkaloids, tannins and reducing sugars showed significant (P< 0.05) reductions in response to TeMV infection with percentage reductions of 89.3%, 54.5%, 46.3% and 18.3% respectively. Protein showed insignificant increase of 4.3% in inoculated samples.......
Keywords: Mineral responses, Phaseolus vulgaris, Telfairia mosaic virus infection.
[1]. Ecocrop 2013. Ecocrop database. FAO, Rome Italy.
[2]. S. Smoliak, R. L. Dittterline, J. D. Scheetz, L. K. Holzworth, J. R. Sims, J. R. Wiesner, D. E. Baldridge, G. L. Jibke, Common bean. Montana State University, Animal and Range Sciences Extension Service, Forage Extension Program. (Zozeman: USA,1990).
[3]. T. Sandra, J. Trupti, B. Kimberly, B. Campbell, X. U. Scheffler. Dong, C. Bret, T. N. Henry, and T. Gary General ton of Phaseolus vulgaris ESTS and investigation of their regulation upon uromyces appendiculatus infection. BCM Plant Biology. 9, 2009, 46.
[4]. C. S. Wortmann, Phaseolus vulgaris L. (Common bean). in Brink, M and Belay, G. (Ed.) Record from prota4U.prota (Plant resources of tropical Africa/ ressources vegetales de I'Afrique tropicale), (Wageningen, Netherlands, 2006).
[5]. Ecoport, 2013. Ecoport database. Ecoport. FAO, Rome Italy.
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| Paper Type | : | Research Paper |
| Title | : | Coenzyme Q10 - A Review of Its Promise |
| Country | : | India |
| Authors | : | S. Arshiya Banu || S. Asadulla || M. Venkata Subbaiah |
Abstract: Coenzyme Q10 (CoQ10) is a powerful antioxidant found in the membranes of many organelles. Experimental studies in animal models suggest that CoQ10 may protect against neuronal damage that is caused by ischemia, atherosclerosis and toxic injury. It buffers the potential adverse consequences of free radicals produced during oxidative phosphorylation in the inner mitochondrial membrane........
Keywords: Coenzyme Q10, antioxidant, statins, cardiovascular diseases, neurodegenerative disorders, diabetes, cancer.
[1]. Ernster, L; Dallner, G (1995). "Biochemical, physiological and medical aspects of ubiquinone function". Biochimica et Biophysica Acta 1271 (1): 195–204. doi:10.1016/0925-4439(95)00028-3. PMID 7599208.
[2]. Dutton, PL; Ohnishi, T; Darrouzet, E; Leonard, MA; Sharp, RE; Cibney, BR; Daldal, F; Moser, CC (2000). "4 Coenzyme Q oxidation reduction reactions in mitochondrial electron transport". In Kagan, VE; Quinn, PJ. Coenzyme Q: Molecular mechanisms in health and disease. Boca Raton: CRC Press. pp. 65–82.
[3]. Okamoto, T; Matsuya, T; Fukunaga, Y; Kishi, T; Yamagami, T (1989). "Human serum ubiquinol-10 levels and relationship to serum lipids". International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 59 (3): 288–92. PMID 2599795.
[4]. Aberg, F; Appelkvist, EL; Dallner, G; Ernster, L (1992). "Distribution and redox state of ubiquinones in rat and human tissues". Archives of Biochemistry and Biophysics 295 (2): 230–4. doi:10.1016/0003-9861(92)90511-T. PMID 1586151.
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| Paper Type | : | Research Paper |
| Title | : | Comparative Acute Toxicity Studies of Selected Indigenous Herbal Plants in Swiss Albino Mice |
| Country | : | India |
| Authors | : | Ram Garg || Rahul Kumar || Deepak Nathiya || Omprakash Goshain || Vinita Trivedi || Ashish Kumar Sharma || Krishna Murti |
Abstract: Objective: Toxicology may be defined as the study of harmful / poisonous effects of drugs and other chemicals with emphasis on detection, prevention and treatment of poisonings. The present study was aimed to determine LD50 and to establish the safety margin ofdifferent solvent extracts of selected herbal plants sources namelySaussurea lappa (Root), Ficus bengallensis (Root ), Flacourtria romantchi (stem bark and Root), andOroxyllum indicum (Root ) by acute toxicity study in Swiss albino mice as per OECD guideline 425........
Keywords: Acute toxicity(LD50), Root extract of Saussurea lappa(RESL), Root extract of Ficus bengallensis (REFB), Stem bark and root extract of Flacourtria romantchi(SBAREFR), root extract of Oroxyllum indicum (REOI), OECD guideline 425.
[1] Khadke S.S.,Pachauri D.R.,, and Swapnil D. Mahajan S.D., An Acute Oral Toxicity Study of Gnidiaglauca(Fresen.) Gilg. in Albino Rats as per OECDGuideline 425, International Journal of PharmTech Research, 2(3) (2011) 787-791.
[2] K.D.Tripathi, Essentials of Medical Pharmacology. (Jaypee Brothers Medical Publishers (P) Ltd; 2008).
[3] Humber J.M., The role of complementary and alternative medicine: Accomodating pluralism. J Am Med Assoc , 288 (2002) 1655-1656.
[4] Newman D.J., Cragg G.M., and Snader K.M., Natural Products as Sources of New Drugs. J Nat Prod 66(2003) 1022-1103.
[5] Sastri B.N.,The Wealth of India: Raw Materials, New Delhi, CSIR, 1(1985) 248-249.
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| Paper Type | : | Research Paper |
| Title | : | Growth Performance, Genital Organ Dimensions, Viscera Organ Weights and Haematology of Male Rabbits Fed Graded Levels Of Gmelina Arborea Leaf Meal |
| Country | : | Nigeria |
| Authors | : | T.Ahemen || D.T. Shaahu || N.N. Kwaghve |
Abstract: The study was undertaken to determine the effect of feeding varying levels of Gmelina arborea leaf meal on growth performance, genital tract dimensions visceral organ weights and haematology of male rabbits. A total of 32 rabbits of mixed breeds, aged between 8 and 12 weeks, weighing between 1100 and 1250g were randomly allocated to four dietary treatments in a trial that lasted for sixteen (16) weeks. The four diets were designated T1, T2, T3 and T4 with Gmelina arborea leaf meal inclusion of 0%, 5%, 10% and 15% respectively........
Keywords: Gmelina arborea, Growth performance, rabbits, organ weights, haematology
[1] Ani, A. O. (2006). Effect of toasted Bambara groundnut (Voandzeia subterranean.L) Waste on heamatology, carcass and organ characteristics of growing rabbits.Proc.of NSAP,12-15th March. BayeroUniversity Kano, P. M. B 3011 Kano, Nigeria.
[2] Herbert,U.,Ozoje,M.O. and Adejumo,D.O.(2005). Effect of Leucaeus and Gliricidia leaf meals on the seminal characteristics, testis weights and seminiferious tubules. Majgaonkar, S. V.,Patil, S.S. and Toro, V.A (1987) chemical composition and nutritive value of Gmelina arboreatree leaves. Indian J. Anim.Sci.57. 1235-1236
[3] Gangadharan, V. (2012).Materials behind the method the new Indian Express, page 2. TAC (2009). Makuridi weather elements records. Nigerian Air Force Tactical Air Commond, MakurdiMetereologicalStation,Makurdi, Nigeria.
[4] Ahemen, T., Bitto, I.I., Oluremi, O.I.A and Anugwa, F.O.I. (2015).Genital tract morphpmetry and haematology of male rabbits fed hraded levels of cassava leaf meal. Nig. J. Anim. Prod. 41(1): 50-59.
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| Paper Type | : | Research Paper |
| Title | : | Effect of Extraction Solvent on the Phenolic Content, Flavonoid Content and Antioxidant Capacity Of Clove Bud |
| Country | : | Nigeria |
| Authors | : | Banji Adaramola and Adebayo Onigbinde |
Abstract: In this research, the effect of extraction solvent on the phenolic content, Flavonoid content and antioxidant capacity of clove bud (Syzygium aromaticum) was investigated. The extraction of clove bud was carried out with water, methanol (80%) and acetone (80%). The Flavonoid and phenolic contents of the extracts were evaluated by standard Aluminum chloride and Folin-Ciocalteu methods respectively while their antioxidant capacity was assayed by determining their total reducing power as well as their free radical.......
Keywords: Antioxidants, Flavonoids, Percentage yield, Phenolics, Syzygium aromaticum
[1] Y. M. Dongmei, W. M. Qiushuang, K. B. Leqin, B. J. Jianmei, and Y. Tiejin, Antioxidant activities of various extracts of lotus (Nelumbo nuficera Gaertn) rhizome, Asia Pacific Journal of Clinical Nutritions, 16, 2007, 158–163.
[2] Clove. http://www.newworldencyclopedia.org/entry/Clove
[3] S. P. Ambasta, The useful plants of India. New Delhi: Publications and Information Directorate, CSIR, 1986.
[4] Boulos, L. Medicinal plants of North Africa (Algonac, Michigan: Reference Publications Inc., 1983 286 p)
[5] B. Rashi, K. Ajai, and P. Sadhna, Phytochemical Constituent of Syzygium aromaticum L. International Journal of Current Research, 3(7), 2011, 215-217.
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| Paper Type | : | Research Paper |
| Title | : | Bacteriocin Production by Newly Isolated Lactobacillus Strain |
| Country | : | Egypt |
| Authors | : | Ahmed Abdelrazak || Mahmoud M.Elaasser || Manal Elshal || Haroun SA |
Abstract: An Egyptian local Lactobacillus strain was isolated from Cabbage and was identified to be more closely related to thetypestrains LactobacilluspentosusD79211and LactobacillusarizonensisAJ965482via 16S rRNA gene sequencing and analysis. The isolated strain was found to be a gram positive, rods and react negatively with catalase test. A Central Composite Design [CCD] algorithm was applied to determine.......
Keywords: Bacteriocin,Central Composite Design, Lactobacillus spp, MRS agar, 16s rRNA,
[1] Walstra, P., Dairy technology: principles of milk properties and processes. 2013: CRC Press.
[2] Singh, G. and R.R. Sharma, Dominating species of Lactobacilli and Leuconostocs present among the lactic acid bacteria of milk of different cattles.Asian Journal of Experimental Sciences,23(1), 2009, 173-179.
[3] Bush, L.M., De Almeida,K.N., Marfin,G.,& Perez, M.T.Probiotic-Associated Bifidobacterium Septic Prosthetic Joint Arthritis.Infectious Diseases in Clinical Practice,22(4), 2014, e39-e41.
[4] Coeuret, V., Dubemet,S.,Bemardeau,M.,Gueguen, M.,& Vermoux,J.P.Isolation, characterisation and identification of lactobacilli focusing mainly on cheeses and other dairy products.Le lait,83(4), 2003, 269-306.
[5] Jay, J.M., Modern food microbiology. 1978: D. Van Nostrand Co.
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| Paper Type | : | Research Paper |
| Title | : | Evaluation of Nutritional andAntioxidative properties of Rosa kordesii Petal Extracts |
| Country | : | Bangladesh |
| Authors | : | BelalMH || YesminMR || Islam MD || Mamun MA || Hasan N || Rahman MA || Islam A || Tasnin MN || Ara T || Rabbi MAR || Rahman MS || Khan MMH || Rahman M || Karim MR || Islam MA |
Abstract: Plant extracts have been reported to have contributed to the increase of nutritional values which are important to the human health.Investigations were carried out toevaluate the phytochemicals content and antioxidant activity of Rosa kordesii petal extracts in different solvents. Methanol, water and n-hexane were used as solvent.Under an observational analytic studyrevealed the presences of alkaloids, flavonoids, phenols, carbohydrate, resins,saponins, steroids, tannins, anthracenosides and coumerins as phytochemicals in the extracts........
Keywords: Rose, Petal, Phytochemical, Phenolic, Flavonoid, Antioxidant Activity.
[1] Lee JJ, Lee CW, Cho YH, Park SM, Lee BC, Hyeong BP. Tinged autumnal leaves of maple and cherry trees as potential antioxidant
sources. In Antiaging: Physiology to formulation 1st edition. Illinois, USA, Allured Publishing Corporation; 2006:11.
[2] Soni H, Sahu N, Sihghai AK, Malik J. Radical Scavenging Activities and Natural Indicator Activity of Aqueous and Ethanolic
Extract of Rosa Damascena, International Journal of Pharmacy and Pharmaceutical Sciences 2012,Vol 4, Suppl 5.
[3] Tamsyn SAT, Pauline H, Declan PN. Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants.BMC Complementary and Alternative Medicine2009; 9:27, doi:10.1186/1472-6882-9-27.
[4] Alang G, KaurR, Singh A, Budhlakoti P, Singh A. Free radical scavenging activity of methanolic root extract of the plant Crotolariaburhialinn. Pharmacologyonline 2010; 1: 78-85.
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| Paper Type | : | Research Paper |
| Title | : | Hypoglycemic activity and Phyto-chemical screening on Coccinia grandis leaf and fruit |
| Country | : | India |
| Authors | : | J.V.C. Sharma || P.Swapna || B.Shiva Prasad || A.Ashok || J.L.K Soundarya || G. Mounika || B.Parshuram |
Abstract: Many plant drugs are studied for effecting in the treatment of Diabetes mellitus. In the present study methanolic extract of herb of Coccinia grandis leaf and fruit was evaluated for hypoglycemic effect in Alloxan induced diabetic rats using oral glucose tolerance test. A comparison was made between the actions of methanolic extract Coccinia grandis leaf and fruit and known antidiabetic drug Glibenclamide (5 mg/kg, p.o)........
Keywords: Alloxan induced Diabetes, Coccinia grandis, Hypoglycemic activity, Oral glucose tolerance test.
[1]. Tapsell LC, Hemphill I, Cobiac L, et al. (August 2006). "Health benefits of herbs and spices: the past, the present, the future". Med J Aust. 2006 Aug 21; 185(4 Suppl):14-24.
[2]. Lai PK, Roy J (June 2004). "Antimicrobial and chemopreventive properties of herbs and spices". Curr. Med. Chem. 2004 Jun; 11(11):1451-60.
[3]. Syed Z, Krishna B, Kandukuri V, Singara C. Antimicrobial activityof the fruit extracts of Coccinia indica. Afr J Biotechnol 2009; 8(24):7073-7076.
[4]. Shyam KB, Gnanasekaran D, Jaishree V, Channabasavaraj KP. Hepatoprotective activity of Coccinia indica leaves extract. Int J Pharm Biomed Res 2010; 1(4): 154-156.
[5]. Vadivu R, Krithika A, Biplab C, Dedeepya P, Shoeb N, Lakshmi KS. Evaluation of hepatoprotective activity of the fruits ofCoccinia grandis Linn. Int J Health Res 2008; 1(3): 163-168.
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| Paper Type | : | Research Paper |
| Title | : | Pollens İn The Atmosphere Of Bartın,Turkey And Relationships With Meteorological Parameters |
| Country | : | Turkey |
| Authors | : | Sevil Pehlivan || Hanife İris |
Abstract: An aeropalynolojical study was performed in Bartın in 2003 and it is aimed to help physicians with the diagnosis and treatment of airbone pollen grains causing allergic diseases. Samples which came from Yalı and Balamba in Bartın have been analyzed in two different stations by using Durham-gravimetric method's application. The plant taxa of the pollen grains in Bartın atmosphere has been determined and after their identifications are being morphologically made, their microphotographs are taken.......
Keywords: Pollen, Meteorology, Bartın- Turkey, Pollen-calendar, Durham-gravimetric method
[1] Pehlivan S (1995)" Türkiye‟ nin Allerjen Polenleri Atlası‟, Ünal Ofset, Ankara Aytuğ B (1973) İstanbul Yöresinin Polinizasyon Takvimi. İ.Ü.Or.Fak.Dergi 23(1),1-33.
[2] Özkaragöz K and Karaosmanoğlu K (1967) Allergenic polen and mold spore survey in the Ankara area. Acta Allerpol.22, 399-407.
[3] İnceoğlu Ö, Pınar NM,Şakıyan N and Sorkun K (1994) Airborne pollen concentration in Ankara, Turkey, 1990-1993. Grana 33, 158-161.
[4] Kizilpinar I, Civelek E, Tuncer A, Doğan C, Karabulut E, Sahiner U M, Yavuz T S, Saçkesen C (2010) Pollen counts and their relationship to meteorological factors in Ankara, Turkey during 2005-2008. Int J Biometeorol 55: 623-631
[5] Yurdukoru S (1979) Samsun İli Havasındaki Allerjenik Polenler. Ank. Tıp Bülteni 1.37- 44
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| Paper Type | : | Research Paper |
| Title | : | Phytochemical and Antifungal Activity of Nigeria Jatropha Multifudia Latex |
| Country | : | Nigeria |
| Authors | : | Olagunju, Esther Olajumoke || Oladipupo, Oluremi Adikat || Abejoye, Abidemi Oluyinka || Pharm. Badejo, Precious Olohigbe || Ajala, Lawrence Olusegun || Badejo Johannes Adedokun |
Abstract: Jatropha multifudia is an ornamental plant which is employed to cure various infections in traditional medicine. The phytochemical analysis of the latex in mg/100g revealed the presence of secondary metabolites with phenols having the greatest quantity of 14.32 ± 0.18, followed by tannins 8.16 ± 0.18, oxalates 6.03 ± 0.12 and phytates having least of 0.21 ± 0.10. Latex of this plant was analysed and screened against......
Keywords: Jatropha multifundia, latex, phytochemicals, antifungal, Trichoderm rubrum Seleretion rolfisii.
[1] Ezigbo, V.O., Odinma, S.C., Duruaku, I.J. and Onyema, C.T.(2013). Preliminary Phytochemical Screening and Antibacterial Activity on Stem Bark Extractsof Ceiba Pentandra. IOSR-JAC. 6(1): 42-43.
[2] Tyler, V.E.(1994). Herbs of choice: The Therapeutic Use of Phytomedicinals. Bingham NY:Haworth Press Inc.
[3] Evans, W.C. (2002). Trease and Evans Pharmacognosy, 15th ed., Churchill Livingstone Harcourt publishers Limited, London: 221- 336.
[4] Anyasor, G.N., Aina, D.A., Olushola, M. and Aniyikaye, A.F. (2011). Phytochemical constituent, Proximate Analysis, antioxidant, antibacterial and wound healing properties of leaf extracts of Chromolaena Odorata. Ann. Bio. Res. 2(2):441-451.
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| Paper Type | : | Research Paper |
| Title | : | Role Of Panchatikta Ksheerghrita Basti,Panchatikta Ghrita Guggul Vati And Janubasti In The Management Of Sandhigata Vata W.S. R. To Osteoarthritis |
| Country | : | India |
| Authors | : | Vd.Ujwala Rodge || Vd. V.E. Gogate || Vd. Sharmili Suryavanshi |
Abstract: Ageing is a process of physical, psychological and social change in multi dimensional aspects. Geriatric health care is very important because in India 3.8% of the population are older than 65 years of age. Sandhigata Vata i.e.Osteoarthritis is also known as degenerative joint disease. Majority of geriatric population suffer from Sandhigata Vata .Modern medicines have limitations in treating Osteoarthritis and have many adverse effects with its prolonged use. Now is the era of TKR (Total Knee joint Replacement) Surgery , But due to some underlying systemic illness.......
Keywords: Vatavyadhi ,Sandhigata Vata, Panchatikta Kshirghrita Basti , Panchatikta Ghrita Guggul , Janubasti
[1] Dr. Bramhananda Tripathi, Charaksamhita, 2009-edition,Chaukhamba Surbharati Publication, Varanasi [Ch.Chi.28/56 page no 948]
[2] http://en.kipedia.org/wiki/osteoarthritis
[3] www.ncbi.nlm.nih.gov>PMC3215322.
[4] Aacharya Vidyadhar Shukla,Prof. Ravidatta Tripathi ,Charaksamhita , 2007- edition,Chaukhamba Publishing House, New Delhi, [ch.su. 28/25 page no. 431]
[5] Aacharya Vidyadhar Shukla,Prof. Ravidatta Tripathi ,Charaksamhita , 2007- edition,Chaukhamba Publishing House, New Delhi, [Ch.Vi. 6/16 page no. 600]
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| Paper Type | : | Research Paper |
| Title | : | Effect of Solvents Extraction on the Yield and Physicochemical Properties of Dehulled Hunteria Umbellata Seed Oil |
| Country | : | Nigeria |
| Authors | : | P.O. Badejo || E.O. Olagunju || S.O. Afolabi || O.S. Olatunbosun || F. Olawoyin || R. Olayiwola || A.R. Olowe || J. A. Badejo |
Abstract: In this study, the characterization and physicochemical properties of dehulled Hunteria umbellate (DHUS) were critically examined to ascertain the functional groups and components of the extracted oils. Oils were extracted from DHUS using; methanol, aqueous and ethyl acetate in soxhlet extractor. The low acid and peroxide values (5.61-23.00mgKOH/g) and (4.00-7.20Meq/kg) respectively confirm the presence of antioxidants, flavonoids and free fatty acid.......
Keywords: Dehulled hunteria umbellate seed (DHUS), Hunteria umbellate (HU), Soxhlet extraction, Saponification value, Iodine value, Acid value
[1]. A.O. Longe, and Momoh. Effects Of Methanolic Seed Extract Of Hunteria Umbellata (Abere) On Blood Glucose Level, Hematological And Lipid Profile Parameters In Alloxan- Induced Diabetes In Male Ratspinnacle Medicine & Medical Sciences, Vol1 (2), 2014.
[2]. AOAC. Association of Official Analytical Chemists. 17th edn. Official Methods of Analysis. Washington, DC., 1997.
[3]. AOAC. Official Methods of Analysis. Association of Official Agricultural Chemists, 2nd edn. Washington D.C., 1975, pp 832.
[4]. M.O. Aremu, O. Olaofe, and E.T. Akintayo. Chemical composition and physicochemical characteristics of two varieties of bambara groundnut (Vigna subterrenea) flours. J. Applied Sciences, 6(9), 2006a, pp. 1900 – 1903.
[5]. V.O.E. Akpambang, I.A. Amoo, and A.A. Izuagie. Comparative Compositional Analysis on Two Varieties of Melon (Colocynthis citrullus and Cucumeropsis edulis) and a variety of almond (Prunus amygdalus). Research Journal of Agriculture and Biological Sciences, 4(6), 2008, pp. 639 – 642.
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| Paper Type | : | Research Paper |
| Title | : | Gastroretentive Floating and Mucoadhesive Drug Delivery Systems- Insights and Current Applications |
| Country | : | Nigeria |
| Authors | : | Anita Ayre || Neha Dand || K. G. Lalitha |
Abstract: Gastro retentive drug delivery system (GRDDS) is one of the novel approaches in the area of oral sustained release dosage forms. Drugs that are easily absorbed from gastrointestinal tract (GIT) and have short half-lives are eliminated quickly from the systemic circulation require frequent dosing to achieve suitable therapeutic activity. To avoid this limitation, the development of oral sustained release GRDDS is an attempt to release the drug slowly into the GIT and maintain an effective drug concentration in the systemic circulation for a long time.......
Keywords: Bioadhesive, floating drug delivery, gastroretentive, mucoadhesive, polymeric nanoparticles
[1]. Makwana, K. Sameja, H. Parekh and Y. Pandya, Advancements in controlled release gastroretentive drug delibery system- A review, Journal of Drug Delivery & Therapeutics, 2(3), 1998, 12-21.
[2]. P. G. Welling and M. R. Dobrinska, Dosing considerations and bioavailability assessment of controlled drug delivery systems, in J. K. Robinson and V. Lee, Controlled drug delivery : Fundamentals and Applications, 2 (New York: Marcel Dekker Inc., 1978) 254-289. [3]. A. K. Nayak, R. Maji and B. Das, Gastroretentive drug delivery systems: a review, Asian J Pharm Clin Res., 3(1), 2010, 2-10.
[4]. S. Desai and S. Bolton, A Floating Controlled Release Drug Delivery System: In vitro–In vivo Evaluation, Pharma. Res., 10(9), 1993, 1321-325.
[5]. V. Pawar, S. Kansal, G. Garg, R. Awasthi, D. Singodia and G. Kulkarni, Gastroretentive dosage forms: A review with special emphasis on floating drug delivery systems, Drug Deliv, 18(2), 2011, 97-110.