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| Paper Type | : | Research Paper |
| Title | : | Findings of Gas chromatography - Mass Spectrometry (GCMA) Analysis of Eclipta Alba Plant Root |
| Country | : | India |
| Authors | : | Satheesh Naik K || Gurushanthaiah M || Kavimani M || Ramesh B || Rajesh B || Lokanadham S || Bhargav PRK |
 |
: | 10.9790/3008-1206020104  |
Abstract: Background: Eclipta alba L. Hassk. (Asteraceae), commonly known as Bhringaraja (Sanskrit), Maka (Marathi) and Bhangra (Hindi) has been reported to show protective effect on experimental liver damage in rats and mice. This study was designed to investigate the phytochemical compositions of methanol extract of Eclipta Alba root through GCMS analysis. Material and methods: 5 grams of plant material was extracted with 250 ml 99% methanol. For methonolic extract dried powder samples were extracted in a Soxhlet apparatus with methanol until becoming colourless. The extract was filtered and centrifuged at 1500 rpm for 20 minutes to remove any plant debris. Supernatants were stored at 22 °C c until assayed............
Keywords: Bhringraj (Eclipta Alba), GC-MS analysis, 2(3H)-Furanone, 5-acetyldihydro and D-Allose
[1]. B. Singh, A.K. Saxena, BK. Chandan, S.G. Agarwal, M.S. Bhatia, K.K. Anand, Hepatoprotective effect of ethanolic extract of Eclipta alba on experimental liver damage in rats and mice, Phytother Res, 7, 1993, 154-8.
[2]. R.N. Chopra, S.L. Nayar, I.C. Chopra, Glossary of Indian Medicinal Plants. New Delhi: Council of Scientific and Industrial Res, 1966, 104.
[3]. S. Karthikumar, K. Vigneswari, K.Jegatheesan, Screening of antibacterial and antioxidant activities of leaves of Eclipta prostrata (L). Scientific Res, 2, 2007, 10-104.
[4]. A.K. Saxena, B. Singh, K.K. Anand, Hepatoprotective effects of Eclipta alba on subcellular levels in rats. J. Ethnopharmacol, 40, 1993, 155–161.
[5]. S. Dixit, M. Achar, Bhringaraja (Eclipta alba Linn.) In the treatment of infective hepatitis. Curr. Med. Prac, 23, 1979, 237–242.
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| Paper Type | : | Research Paper |
| Title | : | Circulating Resistin Concentrations, Inflammatory Biomarkers and Insulin Resistance in Iraqi Patients with Chronic Kidney Failure |
| Country | : | Iraq |
| Authors | : | Ass.Prof Dr. Manal kamal Rasheed || Ass. Prof, Dr.Maysaa Jalal Majeed || Lecturer Dr. Wafa Mansor Merza || Dr. Mohammed kamal Rasheed || Prof Dr. Halla Ghazi Mahmoud |
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: | 10.9790/3008-1206020510 |
Abstract: Background: Resistin in humans is mainly produced by blood-derived leukocytes and mononuclear cells. Resistin antagonizes the effects of insulin on glucose metabolism in liver and skeletal muscle, interacts with and reinforces inflammatory pathways. Objective: Evaluation of the resistin level as inflammatory factor in patients with chronic renal failure. Patients and Methods: Study was conducted at the department of Biochemistry, College of Medicine / University of Baghdad and AL-Karama Hospital during the period from March 2016 to March 2017. This cross-sectional study was composed of 50 consecutive patients with CRF according to the National Kidney Foundation practice guidelines and 30 apparently healthy control subjects was matched............
Keywords: Chronic kidney disease, resistin, insulin resistance, Inflammation.
[1]. The American Journal of Kidney Diseases (AJKD), the official journal of the National Kidney May 2017Volume 69, Issue 5, p555-712, e21-e24
[2]. McTernan PG, Kusminski CM, Kumar S. Resistin. Curr Opin Lipidol. 2006;17:170 –175
[3]. Menzaghi C, Xu M, Salvemini L, De Bonis C, Palladino G, Huang T, et al. Circulating adiponectin and cardiovascular mortality in patients with type 2 diabetes mellitus: evidence of sexual dimorphism. Cardiovasc Diabetol. 2014;13: 130 "In press".
[4]. Lorena Ortega Moreno1, Lucia Salvemini1, Christine Mendonca2, Massimiliano Copetti3,et al: Serum Resistin and Glomerular Filtration Rate in Patients with Type 2 Diabetes: | DOI:10.1371/journal.pone.0119529 March 26, 2015
[5]. Kawamura R, Doi Y, Osawa H, Ninomiya T, Hata J, Yonemoto K, et al. Circulating resistin is increased with decreasing renal function in a general Japanese population: the Hisayama Study. Nephrol DialTransplant. 2010; 25: 3236–3240. doi: 10.1093/ndt/gfq155 PMID: 20339098
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| Paper Type | : | Research Paper |
| Title | : | Biosynthesis of silver nanoparticles using Streptomyces griseus PDS1 for anticancer activity |
| Country | : | India |
| Authors | : | M.Suba Sri || M.Mekala || K.Suganya || B.Nandhini |
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: | 10.9790/3008-1206021116 |
Abstract: Biological synthesis of nanoparticles provides advancement over chemical and physical methods. The use of micro-organisms to synthesize functional nanoparticle has been of great innovative interest. The research work focus on synthesis of silver nanoparticle using Streptomyces griseus PDS1. Both crude and filtered culture developed into nanoparticle. The reduction of silver ions was observed and monitored with the help of UV spectrum. Further an array of absorbance bands of silver nanoparticle was observed in FTIR. The size of the nanoparticle was observed under scanning electron microscope. The antimicrobial activity of produced nanoparticle was performed against the bacteria such as Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacillus subtilis, Escherichia coli and fungi Aspergillus niger. The development of cotton gauze with nanoparticle against Pseudomonas aeruginosa for anti cancer activity was recorded for biomedical application
Keywords: Silver nanoparticle, Streptomyces griseus, antimicrobial activity, anticancer activity.
[1]. Chitra,K and Annadurai G, "Bioengineered silver nano bowls using Trichoderma viride and its antibacterial activity against gram-positive and gram-negative bacteria", Journal Of Nanostructure in Chemistry- 3:9, 2013.
[2]. Dattu S. "Biologically Reduced Silver Nanoparticles from Streptomyces sp. VDP-5 and its Antibacterial Efficacy", International Journal of Pharmacy and Pharmaceutical Science Research, 4(2): 31-36,2014.
[3]. Duran N, Marcarto PD, De Souza GIH, Alves OL, Esposito E. "Antibacterial Effect of silver nanoparticles produced by Fungal process On Textile Fabrics And Their Effluent Treatment", Journal of Biomedical Nanotechnology, 3(1). 203-208, 2007.
[4]. Jeevan, Ramya, Edith Rena."Extracellular biosynthesis of Silver Nano particles by Culture Supernatant of Pseudomonas aeruginosa". Indian Journal of Biotechnology, 72-76, 2012.
[5]. Kalishwarlar, Deepak, Ramkumarpandian, Nellaiah&Sangiliyandi, Extraellular biosynthesis of Silver nanoparticles by the culture supernatant of Bacillus licheniformis",Mater lett, 4411-4413,2008.
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| Paper Type | : | Research Paper |
| Title | : | Current Trends in Performance of Forced Degradation Studies and Stability Indicating Studies of Drugs |
| Country | : | India |
| Authors | : | Panchumarthy Ravisankar || Vaka Swathi || Puttagunta Srinivasa Babu || Md. Shaheem Sulthana || SK. Gousepeer |
|
: | 10.9790/3008-1206021736 |
Abstract: The stability of a drug substance (or) drug product is a vital parameter which may affect purity, safety and potency and. Changes in drug stability can threat patient safety by formation of a toxic degradation product or products or deliver a lower dose than expected. Therefore it is necessary to know the purity profile and behaviour of a drug substance under different environmental conditions. Forced degradation testing studies are those undertaken to degrade the sample deliberately. These studies, which may be undertaken in the development phase normally on the drug substances, are used to evaluate the overall photosensitivity of the material for method development purposes and/or degradation pathway elucidation. The purpose of stability testing is to give evidence on how the quality of a drug substance or drug product varies with time under the influence of a variety of environmental factors such as temperature.............
Keywords: Drug product, Decomposition, Forced degradation, Stability indicating studies
[1] ICH guidelines, Q1A (R2): Stability Testing of New Drug Substances and Products (revision 2), November 2003.
[2] G. Ngwa, Forced degradation studies as an integral part of HPLC stability indicating method development, Drug Deliv. Technol., 10(5), 2010, 56-59.
[3] H. Brummer, How to approach a forced degradation study, Life Sci. Technol. Bull., 31, 2011, 1-4.
[4] S. Singh, M. Bakshi, Guidance on conduct of stress tests to determine inherent stability of drugs Pharm. Technol., 24,2000, 1-14.
[5] K.M. Alsante, A. Ando, R. Brown, et al. The role of degradant profiling in active pharmaceutical ingredients and drug products Adv. Drug Deliv. Rev., 59(1), 2007, 29-37.
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| Paper Type | : | Research Paper |
| Title | : | Microbial Pattern and Antibiotic Resistance in High Vaginal Swabs and Vaginal Swabs in Iraqi Women |
| Country | : | Iraq |
| Authors | : | Hind H. Shaker |
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: | 10.9790/3008-1206023740 |
Abstract: Background: Infections of the reproductive tract are a major problem of women's sexual health. They are commonly seen in women of reproductive age and usually present with vaginal discharge , which they include sexually transmitted infections (STI), bacterial vaginosis (BV), aerobic vaginitis and candidiasis. The microbial flora of vagina is a complicated environment, comprising of many microbiological species in variable proportions. The normal vaginal flora is usually well maintained by a complex balance of organisms. Bacterial vaginitis can occur in any age group but more commonly diagnosed in females of reproductive age group. Diagnosis and treatment can be misleading if based only on clinical symptoms and signs. Methods: This study was conducted to throw light on the prevalence of (100) samples of local pathogenic bacteria in high vaginal swabs and vaginal swabs in Iraqi women and their invitro antibiotic susceptibility pattern..............
Keywords: High Vaginal Swabs (HVS), vaginal swabs, Antibiotic sensitvity, Escherichia coli , Streptococcus spp, Staphylococcus aureus , Candida albicans, Klebsiella spp., Citrobacter spp, Proteus spp, Enterobacter spp.
[1] Blackwell AL, Thomas PD, Wareham K, Emery SJ(1993). Health gains from screening for infection of the lower genital tract in women attending for termination of pregnancy. Lancet; 342:206-10.
[2] Caillouette JC, Sharp CF, Zimmerman J, Roy S.( 1997) Vaginal pH as a marker for bacterial pathogens and menopausal status. Am J Obstet Gynecol; 176:1270-7.
[3] FFPRHC and BASHH Guidance.( 2006). The management of women of reproductive age attending non-genitourinary medicine settings complaining of vaginal discharge. J Fam Plan Reprod Health Care; 32(1):33-41.
[4] Mancuso AC, Ryan GL.( 2015) Normal Vulvovaginal Health in Adolescents. Journal of pediatric and adolescent gynecology. 28 (3): 132-5.
[5] Orish V.N , Ofori-AmoahJ. , François M. , Silverius B.K , Mensah E.K,(2016). Microbial and Antibiotic Sensitivity Pattern of High Vaginal Swab Culture Results in Sekondi-Takoradi Metropolis of the Western Region of Ghana: Retrospective Study. European Journal of Clinical and Biomedical Sciences. 2(5): 45-50.
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| Paper Type | : | Research Paper |
| Title | : | The Effectiveness of Thyme and Ferula Mixture İn Multi-drug Acinetobacter Baumannii species |
| Country | : | Turkey |
| Authors | : | Aylin Çalıca Utku || Mustafa Zengin || Hayriye Genç || Mustafa Arslan || Oğuz Karabay |
|
: | 10.9790/3008-1206024145 |
Abstract: In recent years, infections caused by Acinetobacter strains has been increasing in our country and around the world. Treatment of Acinetobacter infections are diffucult due to multi-drug resistant(MDR). Infections caused by resistant Acinetobacter strains lead to very high mortality. Therefore, alternative treatment methods are needed against MDR Acinetobacter strains and in recent years herbal treatment methods are promising. First, this study is intend to research the antibacterial effectiveness of a a mixture of Thymus longicaulis C. Presl. var. Subisophyllus(thyme) and Ferula elaeochytris(ferula) against MDR Acinetobacter baumannii(Ab). 20 MDRAb..........
Keywords: Acinetobacter baumannii, ferula, thyme.
[1] Osterburg A, Gardner J, Hyon SH, Neely A, Babcock G, Highly antibiotic-resistant Acinetobacter baumannii clinical isolates are killed by the green tea polyphenol (–)-epigallocatechin-3-gallate (EGCG), Clinical Microbiology and Infection, 15(4), April 2009, 341-346.
[2] Tripodi MF, Durante-Mangoni E, Fortunato R, Utili R, Zarrilli R, Comparative activities of colistin, rifampicin, imipenem, sulbactam/ampicillin alone or in combination against epidemic multidrug-resistant Acinetobacter baumannii isolates producing OXA-58 carbapenemases, Int J Antimicrob Agents, 30(6), 2007 Dec 537-540.
[3] Ahmad I, Aqil F, Owais M, Targeted screeningof bioactive plants extracts and phytocompounds against problematic groups of multidrug-resistant bacteria, Modern Phytomedicine: Turning Medicinal Plants into Drugs, 9,2006 Dec.
[4] Benli M, Yiğit N, Ülkemizde Yaygın Kullanımı Olan Kekik (Thymus vulgaris) Bitkisinin Antimikrobiyal Aktivitesi, Orlab On-Line Mikrobiyoloji Dergisi , 3(8), 2005, 1-8.
[5] Maraqakis LL, Perl TM, Acinetobacter baumannii: epidemiology, antimicrobial resistance, and treatment options, Clin infect dis., 46(8), 2008 Apr 15, 1254-63
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| Paper Type | : | Research Paper |
| Title | : | Efficacy And Tolerability Of Different Antihypertensive Drugs In Hypertension Alone And Type II Diabetes with Hypertension Patients: A Prospective Comparative Study |
| Country | : | India |
| Authors | : | Dr. S. Parveen || M.Sunil || T. S. Durga Prasad || Dr. M. Madhan Mohan Rao |
|
: | 10.9790/3008-1206024653 |
Abstract: Hypertension in diabetes is of the most widespread substantial cardiovascular risk factor of importance in clinical practice. A prospective comparative study was conducted in General Medicine (OP) Department at Rajiv Gandhi Institute of Medical Sciences (RIMS) Hospital, Kadapa in 83 patients Kadapa to study the efficacy and tolerability of different antihypertensive drugs in hypertensive alone and in type-2 diabetic with hypertension patients. Efficacy was assessed based upon the patient's reading of blood pressure and tolerability based on the patient's complaint on each follow up. By comparing the mean reduction in SBP and DBP with all class of antihypertensive drugs we observed that combination therapy showed high reduction in both SBP and DBP than monotherapy. Atenolol was more effective than Amlodipine. We noticed the underutilization of diuretics in monotherapy and in combination therapy. Although it was first line therapy for hypertension according to JNC-VI & VII report.
Keywords: Antihypertensive drugs, Diabetes Mellitus, Efficacy, Hypertension, Tolerability
[1]. Thiraj Dhanaraj, Amit Raval, Rajbharan Yadav, Anil Bhansali, and Pramil Tiwari Prescription Pattern of Antihypertensive Agents in T2DM Patients Visiting Tertiary Care Centre in North India International Journal of Hypertension Volume 2012.
[2]. J.David Curb, Effect of Diuretic-Based Antihypertensive Treatment on Cardiovascular Disease Risk in Older Diabetic Patients with Isolated Systolic Hypertension, UK Prospective Diabetes Study Group. Efficacy of Atenolol and Captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39.BMJ 1998; 317:713-20.
[3]. The Relationship between Hypertension and Diabetes available at: http://www.medscape.org/viewarticle/513876
[4]. Craig weber et al .Why Do Diabetes and Hypertension Commonly Occur Together February 26, 2008. Available at: http://highbloodpressure.about.com/od/highbloodpressure101/tp/hypertension-in-diabeteics.htm
[5]. AlanH.Gradmanstudyon"Strategies for combination therapy in Hypertension .Cur opin Nephrol hypertence 2012, 2152121(5):486491.
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| Paper Type | : | Research Paper |
| Title | : | Phytochemical Analysis, Cytotoxicity Activity And Acaricidal Activity Of Aqueous Crude Extract Of Phytolaccadodecandra Against Larvae Of Rhipicephalus appendiculatus |
| Country | : | Kenya. |
| Authors | : | Caroline J. Kosgei || Charles M. Mwendia || Josphat C. Matasyoh || Njeru S. Ngoci |
|
: | 10.9790/3008-1206025458 |
Abstract: Ticks are acari responsible for severe losses in the livestock industry. This study evaluated the larvicidalproperties of aqueous crude extract of Phytolaccadodecandra against larvae of Rhipicephalusappendiculatus. Contact toxicity was used in the bioassay and mortality data was obtained at 6, 12, 24 and 48 hrs. The data obtained during bioassay was then subjected to probit regression analysis to estimate concentration dependent mortality for LC50 and LC90 values in mg/ml.The LC50 and LC90were 17.3 (15.2-19.4) and 26.8 (23.3-34.4) mg/ml respectively. Phytochemical screening of aqueous extract revealed presence of saponins, steroids, flavonoids and terpenoids. The activity observed in this extract was attributed to the presence of saponins. The plant demonstrated........
Keywords: Phytochemicals, Cytotoxicity, Bioassay.
[1]. Allen-Gil, S., Aldea, M. (2003).Pokeweed (Phytolaccaamericana) as a Potential molluscicide for use in Aquaculture.
Biology Department, Ithaca College: New York, USA.
[2]. Armstrong, W. (2009) Pokeweed: aninteresting American vegetable. http://waynesword.palomar.edu/ Iecoph24.htm. Accessed
July 28, 2013
[3]. Bailey K. P. 1960 — Note on the rearing of Rhipicephalusappendiculatus and their infection with Theileriaparva for
experimental transmission. Bulletin of epizootic diseases of Africa, 8: 33-43
[4]. Delporte, V., Miranda, G and Asencio, O.(2009). Evaluación de la actividadanalgésicaaguda y crónica de
Phytolaccadioica.Tesis de Grado, Facultad de CienciasQuímicas y Farmacéuticas, Universidad de Chile.
[5]. Ding, L., Ding , W., Zhang, Y., Luo, J.(2013). Bioguided fractionation and isolation of esculentoside P from
Phytolaccaamericana L. Industrial Crops and Products, 44: 534–541.
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| Paper Type | : | Research Paper |
| Title | : | Ethnobotanical Survey Of Medicinal Plants In Ajanta Region (MS) India |
| Country | : | India. |
| Authors | : | Bankar M.V. || Bhosle N.P. |
|
: | 10.9790/3008-1206025964 |
Abstract: The study was conducted in Ajanta region in that Lenapur, Ajanta gaon, Savarkheda and Fardapur etc. in Aurangabad District (M.S.). Ajanta forests are situated between latitude 20º 31" North and between 75o,44" east. In ethnobotanical study the selected plants are wild and endemic viz. Caralluma adscendensn(Roxb), Madhuca longifolia (J.Konig), Terminalia arjuna (Roxb.), Euphorbia tirucalli (L.), Tridax aprocumbens (L.) Bombax ceiba (L.), Terminalia ballirica (Roxb), Terminalia chebula (Retz), Trichosanthes tricuspidata(L.), Tinospora cardifolia (Thunb). etc. We met tribal, old peoples, Hakims and Vaidu for collection of ethnobotanical data. On the basis of data we concluded that these locally available medicinal plants having great importance in there different ailments.
Keywords: Ethnobotanical, Endemic plants, Carruluma adscedens, Madhuca indica, Terminalia arjuna, Tribal
[1]. Anonymous (1992). The Wealth of India (1992). The Dictionary of Indian Raw Materials and Industrial Products. Raw Material, revised ed. Publication and Information directorate, CSIR, New Delhi. 5: 84- 94.
[2]. Asolkar LV, Kakkar KK, Chakra OJ (1992). Second supplement to glossary of Indian medicinal plants with active principles. Part I (A-K). Publication and Information Division, CSIR, New Delhi, India, pp. 205-206.
[3]. Chopra R.N., D. Chopra and B. S. Verma (1969) Supplement to Glossary of Indian medicinal plants. Publication and information Directorate CSIR New Delhi.
[4]. Gogte VM (2000). Ayurvedic Pharmacology and Therapeutic Uses of Medicinal Plants (Dravyagunavigyan), First ed. Bharatiya Vidya Bhavan (SPARC), Mumbai Publications. pp. 421-422.
[5]. Jain S.K. (1987), A manual of Ethnobotany, Scientific publisher, Jodhpur.
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| Paper Type | : | Research Paper |
| Title | : | Chemical Scheme of Water-Splitting Process during Photosynthesis by the Way of Experimental Analysis |
| Country | : | India |
| Authors | : | Umasankar Dolai |
|
: | 10.9790/3008-1206026567 |
Abstract: Different water oxidation schemes during photosynthesis are developed from different view-point by analysis of different experimental data. In this paper, an approach will be done to create a symmetrical opinion among all of the opinions of water oxidation by perfect analysis of experimental data. However it is an important guide-line to explain the chemical changes in S-state mechanism during water oxidation process.
Keywords: S-state Mechanism, Bonding Chemistry, Photochemical Effect, Oxide Reaction.
[1]. Groot, M. L., N. P. Pawlowicz, L. J. G. W. van Wilderen, J. Breton, I. H. M. van Stokkum, and R. van Grondelle. 2006. Initial electron donor and acceptor in isolated photosystem II reaction centers identified with femtosecond mid-IR spectroscopy. Proc. Natl. Acad. Sci. USA. 102:13087-13092.
[2]. Kok,B., B. Forbush, M. McGloin. 1970. Cooperation of charges in photosynthetic O2 evolution-I. A linear four step mechanism. Photochem. Photobiol. 11(6):457-75. Doi:10.1111/j.1751-1097.1970.tb06017.x.PMID 5456273.
[3]. Renger, G. 2012. Mechanism of light induced water splitting in photosystem II of oxygen evolving photosynthetic organisms. Biochimica et Biophysica Acta 1817(2012) 1164-1176.
[4]. Jablonsky, J., D. Lazar. 2008. Evidence for intermediate S-states as initial phase in the process of oxygen-evolving complex oxidation. Biophys. J. 94(7):2725-36. Doi:10.1529/biophysj.107.122861.PMC 2267143. PMID 18178650.
[5]. Joliot, P. 2003. Period-four oscillations of the flash-induced oxygen formation in photosynthesis. Photosyn. Res. 76(1-3):65-72. Doi:10.1023/A:1024946610564. PMID 16228566.
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| Paper Type | : | Research Paper |
| Title | : | Bio-Assay Guided Fractionation and Isolation of α-Glucosidase Inhibitory Constituents from Dillenia indica L. Fruit Extracts |
| Country | : | India |
| Authors | : | Saiprasanna Rasamalla || Dr Kiranmai Mandava || Dr Pal BC || Sravanthi Madhira || Uma Rajeswari B || Dr Narendra Sharath Chandra JN |
|
: | 10.9790/3008-1206026874 |
Abstract: The plant Dillenia indica Linn. is used for the treatment of diabetes by the rural community of Dhemaji district of Assam, by the Khamptis "Chauya" traditional healers and Arunachal Himalaya, northeast, India. The plant is also reported to possess anti-diabetic and hypolipidemic activities in animal models. Based on the traditional uses and reported scientific contribution the plant was selected in the present investigation to study its α-glucosidase targeted action. The objective of the present study was to investigate the α-glucosidase inhibitory assay guided fractionation and isolation of phytoconstituents from D.Indicia fruit extracts. In the present investigation the methanolic fruit extract was prepared............
Keywords: α- Glucosidase inhibition, Compound 6, Dillenia indica, Docking studies, Masilinic acid.
[1] Narkhede MB. Investigation of in vitro 𝛼-amylase and 𝛼glucosidase inhibitory activity of polyherbal extract. Int J Pharmaceu Res Develop. 2011; 3(8): 97–103.
[2] Holman RR, Cull CA, Turner RC. A randomized double-blind trial of acarbose in type 2 diabetes shows improved glycemic control over 3 years. Diabetes Care. 1999; 22: 960–4.
[3] Kim KY, Nam KA, Kurihara H, Kim SM. Potent α-glucosidase inhibitors purified from the red algae Grateloupia elliptica. Phytochem. 2008; 69: 2820–5.
[4] Lee SS, Lin HC, Chen CK. Acylated flavonol monorhamnosides, α-glucosidase inhibitors, from Machilusphilippinensis. Phytochem. 2008; 69(12): 2347-53.
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| Paper Type | : | Research Paper |
| Title | : | Oral Lichen Planus- A Review |
| Country | : | India |
| Authors | : | Dr. Ayesha Sameera || Dr. Sridhar Reddy Erugula || Dr.Mohammed Aziz Ur Rahman || Dr.Mohammed Umar Farooq || Dr.Deepika Veldurthi || Dr.Shahid Imran6, Dr.Jesu Das Govada || Dr.Juvaeria Fatima Heena |
|
: | 10.9790/3008-1206027580 |
Abstract: Lichen planus is a disease involving skin and mucosal membranes of various parts of the body. The exact etiology of oral lichen planus (OLP) still remains partially understood. According to the literature, pathogenesis of OLP is due to cell-mediated immunopathological response to antigenic alterations of keratinocytes in the skin and mucosa.The World Health Organization (WHO) has defined OLP as a potentially precancerous disorder, representing a generalized state associated with a significantly increased risk of cancer. OLP affects 0.5% to 2.2% of the population and is more frequent in women than men, from 2:1 to 3:1, respectively. The common age at presentation is 30 to 60 years, predominantly involves middle-aged women and younger-aged men.OLP is relatively not so common among the pediatric population, and it usually appears along with cutaneous Lichen Planus (LP). Only 17% of the affected patients recover totally from OLP, however remission seen in 39% of the OLP lesions.
Keywords: Oral Lichen Planus, Wickham's Striae, Autoimmume Disorder, T- Lymphocytes.
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