Series-2 (March-April 2019)March-April 2019 Issue Statistics
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| Paper Type | : | Research Paper |
| Title | : | Role of Excipient's HLB Values in Microemulsion System |
| Country | : | India |
| Authors | : | Arushi Pant || Kanupriya Jha || Manisha Singh |
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: | 10.9790/3008-1402020106  |
Abstract: The hydrophilic-lipophilic balance (HLB) system provides distinctive feature in deciding the role of surfactants and co surfactants combinations (Smix), oil content and ratio of aqueous phase in a microemulsion system. Also, it has definitive role in the formulation of different types of microemulsion systems including O/W, W/O and bicontinuous microemulsions asit offers a strategic approach to determine on the choice and selection of suitable emulsifiers.The present study is based on the evaluation of hydrophilic-lipophilic balance (HLB) system in fabrication of various types of microemulsions. Microemulsions can be made through two different methods i.e. Phase titration method wheremicroemulsion can.........
Key words: Surfactants; Co surfactants; interfacial tension; aqueous phase; amphiphillic.
[1]. A. D. Gadhave and J. T. Waghmare, "A Short Review on Microemulsion And Its Application in Extraction of Vegetable Oil," IJRET Int. J. Res. Eng. Technol., vol. 3, no. 9, pp. 147–158, 2014.
[2]. I. Micro-emulsion, "Synthesis of Nanoparticles: Microemulsion Method," pp. 98–117, 2010.
[3]. C. O. Agubata, I. T. Nzekwe, N. C. Obitte, C. E. Ugwu, A. A. Attama, and G. C. Onunkwo, "Effect of oil, surfactant and co-surfactant concentrations on the phase behaviour, physicochemical properties and drug release from self-emulsifying drug delivery systems," J. Drug Discov. Dev. Deliv., vol. 1, no. 1, pp. 1–7, 2014.
[4]. R. Martel, P. J. Gelinas, J. E. Desnoyers, and A. Masson, "Phase diagrams to optimize surfactant solutions for oil and DNAPL recovery in aquifers," Groundwater, vol. 31, no. 5. pp. 789–800, 1993.
[5]. H. K. Syed and K. K. Peh, "Identification of phases of various oil, surfactant/co-surfactants and water system by ternary phase diagram," Acta Pol. Pharm. - Drug Res., vol. 71, no. 2, pp. 301–309, 2014
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| Paper Type | : | Research Paper |
| Title | : | A Brief Review on Gestational Diabetes Mellitus |
| Country | : | India |
| Authors | : | P. Kishore || P. Shirisha || P.Mounika || D. Sudheerkumar |
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: | 10.9790/3008-1402020711 |
Abstract: Gestational Diabetes Mellitus(GDM) or impaired glucose tolerance is the most common complication of pregnancy. It is first diagnosed during pregnancy, affects ~14 % of pregnant women (135,000 women) per year in the US. It has many harmful implications for the woman, and foetus. The understanding of risk factors, pathophysiological factors and biomarkers helps in identifying the women at risk of developing GDM.Initial management includes blood glucose monitoring, Medical Nutritional Therapy (MNT) and exercise. Even if the glucose levels remain above target levels, then pharmacological therapy with insulin and metformin has to be started. This review mainlyfocuses on the epidemiology,etiopathogenesis,risk factors,clinical manifestations,screening, diagnostic criteria, treatment as well as role of pharmacist inthe management of GDM.
Keywords: Gestational Diabetes Mellitus, Medical Nutritional Therapy, Hypertension (HTN).
[1]. Robert E. Ratner, Costas A, Christophi, Boyd E, Metzger, Dana Dabelea, Peter h, Bennett,Prevention of Diabetes in Women with a history of Gestational Diabetes: Effects of Metformin and Lifestyle Interventions.J ClinEndocrinolMetab December 2008; 93(12) :4774-4779
[2]. Eman M.Alfadhli,Gestational diabetes mellitus.Saudi Med J 2015; 36(4):399-406
[3]. AbdelHameed Mirghani Dirar,John Doupis,Gestational diabetes from A to Z,World J Diabetes 2017;8(12):489-506
[4]. catherinekim, katherinem.newton, roberth.knopp,GestationalDiabetes and the Incidence of Type 2 Diabetes, diabetes care 2002; 25:1862-1868
[5]. Deirde K.Tobias,Katherine Bowers,CulinZhang,Frank B.Hu,Physical Activity Before and During Pregnancy and Risk of Gestational Diabetes Mellitus.diabetes care 2011; 34:223-229
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| Paper Type | : | Research Paper |
| Title | : | Antimicrobial activity of Streblus asper (Moraceae) against bacteria causing dental caries |
| Country | : | India |
| Authors | : | Pratima Kumar || Aman Kumar || Shantwana Rani || Baidyanath Kumar |
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: | 10.9790/3008-1402021219 |
Abstract: Streblus asper Lour (Family: Moraceae) is a small tree which is indigenous to tropical countries. The plant is a rich source of cardiac glycosides which are pharmacologically very important because of its antimicrobial, antifilarial, anticancer, anti-allergic and insecticidal activities. S. aspera is most useful in oral hygiene because its leaf extract is active against Streptococcus mutans and some other bacteria causing dental caries. In the present investigation the antibacterial activity of four solvent extracts of leaves of S. asper was assayed against bacteria causing dental caries. The results revealed that the four solvent extract fractions were not equally antimicrobial against Gram positive and Garam negative bacteria. The solvent fractions are found to be more inhibitory to Gram negative bacteria in comparison to Gram positive bacteria. Among four solvent fractions Dichloromethane (DCM) and ethyl acetate (EAE) did not cause any growth inhibition to Streptococcus mutans and.........
Keywords: Streblus asper, dental caries, Streptococcus mutans, Streptococcus salivarus, Actinomyces odontolyticus, Bifidobacterium dentium, Escherichia coli, Enterobacter aerogens..
[1]. Glasby JS. Dictionary of Plants containing Secondary Metabolites. London: Taylor and Francis; 1991. p. 307.
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[3]. Kirtikar KR, Basu BD. Indian Medicinal Plants. Vol. 3. Allahabad: Lalit Mohan Basu Publications; 1933. p. 2291.
[4]. Bhakuni DS, Dhar ML, Dhar MM, Dhawan BN, Mehrotra BN. Screening of Indian plants for biological activity. Indian J Exp Biol. 1969;7:250–62.
[5]. Hooker JD. Flora of British India. Vol. 5. London: L. Reeve and Co.; 1886. p. 489.
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| Paper Type | : | Research Paper |
| Title | : | Assessment of Parents Perceptionconcerning children's Antibiotic Use by PAPA Scale |
| Country | : | Libya |
| Authors | : | Huda Kutrani || Haloom Abdel Salam Elhashmi || Hend Mohamed Adam || Antisar Ali Abdlwanis Atiyah |
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: | 10.9790/3008-1402022026 |
Abstract: Antibiotics overuse and misuse are major health issues worldwide. These misuse and overusecausethe development of bacterial resistance, increasing the burden of health issues, and rising the costs of health services. However, the PAPA scalecan assist in discovering factors influencing antibiotic use and parental practice in terms of administering antibiotics to their children. This study aims to assess parents' knowledge, behaviors, adherence, information seeking, and antibiotic resistanceawareness using the PAPA scale. A descriptive cross-sectional study was conducted involving 283 parents from July 2018 to January 2019.A self-administered questionnaire was distributed toparents who attended the out-patient pediatricsclinics at Benghazi Medical Center and the Children..........
Keywords: PAPA scales, antibiotic resistance, parent perceptions, antibiotic usage for children..
[1]. Teck KC, Ghazi HF, Bin Ahmad MI, Abdul-Samad NB, Ee Yu KL, Ismail NF, Bin Esa MA. Knowledge, Attitude, and Practice of Parents Regarding Antibiotic Usage in Treating Children's Upper Respiratory Tract Infection at Primary Health Clinic in Kuala Lumpur, Malaysia: Pilot Study. Health Services Research and Managerial Epidemiology. 2016; 3:1-8. DOI: 10.1177/2333392816643720.
[2]. Centers for Disease Control and Prevention. Untreatable: today's drug-resistant health threats. Available from: http://www.cdc.gov/media/dpk/2013/dpk-untreatable.html . Updated 2014. [Accessed 14 Mach 2018
[3]. Alumran A. Assessment of antibiotic use in children by their parents in Saudi Arabia. PhD thesis, Institute of Health and Biomedical Innovation, School of Public Health, Queensland University of Technology; 2014.
[4]. Awadh AM, Raja AK, Mahdi AI, Khalid AA. Assessment of Knowledge, Attitude and Practice Regarding Antibiotics Misuse among the Public in Saudi Arabia. The Egyptian Journal of Hospital Medicine. 2017; 69(5): 2405-2411. DOI: 10.12816/0041684
[5]. Agarwal S, Yewale VN, Dharmapalan D. Antibiotics Use and Misuse in Children: A Knowledge, Attitude and Practice Survey of Parents in India. Journal of Clinical and Diagnostic Research. 2015; 9(11): SC21-SC24. DOI: 10.7860/JCDR/2015 /14933.6819.
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| Paper Type | : | Research Paper |
| Title | : | Haemotological Indices Of Oryctolagus cuniculus (New- Zealand Rabbit) Experimentally Infected With Trypanosoma brucei brucei Treated With Diminazene Diaceturate (Sequzene ) In Maiduguri, Bornu State, Nigeria |
| Country | : | Nigeria |
| Authors | : | Inuwa, A. || Mbaya, A. W || Kokori, A.M. || David, A.B |
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: | 10.9790/3008-1402022733 |
Abstract: This study was conducted to determine the haematological indices of experimentally inoculated Oryctolagus cuniculus (New-Zealand Rabbit) with Trypanosoma brucei brucei at a concentration of 1.5 x 106 then treated with Diminazine diaceturate (Sequzene) for twenty one (21) days. A total of thirty rabbits of both sexes were divided into six groups (A-F) of five (5) animals each. Group A were infected with T. brucei brucei only but untreated, while group B were uninfected , untreated control. Group C was infected with T. brucei brucei and treated with Sequzene at 3.5 mg/kg, while group D was infected and treated with the drug at 7.0 mg/kg body weight. Group E were........
Keywords: Haematological, Oryctolagus cuniculus (New-Zealand Rabbit), Trypanosoma brucei brucei, Diminazene diaceturate (Sequzene), Anaemia.
[1]. ILRAD (1996). Guide for the care and use of laboratory animals. Institute for laboratory animal research, the National academic press, pp. 114-115.
[2]. Ikede, B.O and lasos, G. I. (1972). Pathology of experience disease in sheep produced by Trypanosome brucei. Journal of veterinary pathology, 9: 278-289.
[3]. Anosa, V. O. and Kaneko, J. J. (1983). Pathogenesis of Trypanosomabrucei infection in deer and mice (cp. Manuculatus). Light electron microscopic studies on erythrolytes pathological changes and phagocytosis. Annual journal of veterinary research, 44: 645-651.
[4]. Mbaya, A.W.,Kumshe, H.A. and Nwosu, C.O. (2012a). The Mechanisms of ofAnaemia in Trypanosomosis. In: Anaemia, (D .S. Silverberg .Ed )., In Tech. Publishers, Crotia , PP.270-282
[5]. Clarkson , M. J. (1968). Blood and plasma volumes in sheep infected with Trypanosomavivax. Journal of comparative pathology, 78: 189-193..
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| Paper Type | : | Research Paper |
| Title | : | Effect of Eudragit on Glimepiride Matrix Tablets |
| Country | : | India |
| Authors | : | Deepika B || U. Srikar Reddy || P. Shireesha || A. Pallavi || R. Mounika || K. Sunitha || M. Ramya Rasi || Naga Raju Kandukoori || K. Sujatha |
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: | 10.9790/3008-1402023438 |
Abstract: Sustained Release Matrix Tablets of Glimeiride were prepared by using Different Rate controlling polymers like Eudragit RL and RS using different drug polymer ratios. Developed total six formulations by using Direct Compression method . The prepared sustained release matrix tablets were evaluated for different evaluation tests like weight variation, Hardness, thickness, friability, Content Uniformity and Invitro release studies. Out of all the six formulations F4 containing eudragit RL showed 100 % drug release within 10 hours with sustained release. So, Eudragit RL was selected as best formulation based on the invitroevaluation tests.
Keywords: Matrix tablets, sustained release dosage forms, Glimepiride, Eudragit RL
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[5]. Loyd V. Allen. Jr, Nicholas G.Popvich, Howard C.Ansel. Ansel‟s Pharmaceutical dosage forms and drug delivery system, 1994; 8(2): 260-263..
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| Paper Type | : | Research Paper |
| Title | : | A Comparative Study of Misoprostol and Dinoprostone Gel for Induction of Labor at a Tertiary Care Teaching Hospital |
| Country | : | India |
| Authors | : | S. Sreedhar || K. Venugopal || K. Sasikala || G. Anjali || K. Ravali || K. Divya || Divya Koduru |
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: | 10.9790/3008-1402023948 |
Abstract: Objective: The present study was conducted to compare induction of labor by using Misoprostol and Dinoprostone gel in a tertiary care hospital. Materials and Methods: A prospective cross-sectional study was conducted in tertiary care hospital, Kadapa, A.P., and India for six months and utilized 80 women's with single live fetus, cephalic presentation, reactive fetal heart rate, gestational age > 36weeks. for the study. They were randomized and prescribed with 0.25 mcg of misoprostol tablet and 0.5 mg of dinoprostone tablet and combination of both drugs. To assess the efficacy of drug, the induction – initiation interval, induction to delivery interval, mode of delivery were recorded. The maternal and fetal outcome were measured with bishops scoring system, Apgar scoring system and maternal and fetal side effects...........
Keywords: LMP- Last menstrual period, EDD- Expected date of delivery, IOL- Induction of labor.
[1]. Swaran Gupta, Jyothi Hak, Dinesh Kumar (2015),Comparative study of misoprostol Vs Dinoprostone Gel for Induction of labour,Vol.17 No . 3
[2]. Joan Crane, Robert Gagnon, Diane Sawchuck, Vyta Senikas (2013), Induction of labour, No. 296, Vol. 35(9).
[3]. Surg Cdr Sushil kumar , Surg Cmde RT Awasthi, Surg Lt Cdr A Kapur , Surg Lt Cdr S Srinivas ,Dr Hetal Parikh ,Dr Shobha Sarkar (2001), Induction of labour with misoprostol-a prostaglandin E1analoug Vol 57,No 2,pg no:107-109.
[4]. S. Kulshreshitha ,P. Sharma, G. Mohan, Sunitha singh and Saroj Singh ,Comparative study of misoprostol vs dinoprostone for induction of labour, Indian J Physiol Pharmacol 2007 ;51(1) :55-61.
[5]. Stephanie Pierce, Ronan Bakker, A. Myers, Rodney K. Edwards(2018), clinical insights for cervical ripening and labour induction using prostaglandins, e307-e314..
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| Paper Type | : | Research Paper |
| Title | : | Pathogenic Microorganisms Isolated From Indoor Air of Banks And Hospital in Ile-Ife. |
| Country | : | Nigeria |
| Authors | : | Adekunle O.C || Aina A.A || Ojedele R.O |
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: | 10.9790/3008-1402024956 |
Abstract: Air contains large number of microorganisms including bacteria, fungi and their estimation is important as an index of cleanliness for any particular environment. It becomes imperative to undertake a study of the microbiological assessment of indoor air of our environment. Places where people visit often were selected: hospital and banks. The study sites were General outpatient department of Obafemi Awolowo University Teaching Hospital, First bank, and Guaranty trust bank in Ile-Ife. Different culture media were employed to collect samples and the indoor air samples were assessed using settled plate method for the enumeration of microorganisms. The samples were collected in the morning after cleaning and also after the influx of people. Isolates were..........
Keywords: pathogenic bacteria, fungal isolates, hospital, banks
[1]. Vilčeková S., Apostoloski I.Z., Mečiarova L., Burdová E.K., Kiselák J.. Investigation of Indoor Air Quality in Houses of Macedonia. Int. J. Environ. Res. Public Health. (2017)14:37 doi: 10.3390/ijerph14010037.
[2]. U.S. Environmental Protection Agency. Fundamentals of Indoor air quality in building. EPA/402/K-03/006. 2018 Washington, DC.
[3]. Alessandra Cincinelli and Tania Martellini. Indoor Air Quality and Health. Int. J Environ Res Public Health. 2017 ; 14(11): 1286.
[4]. Chen Y., Sung F., Chen M., Mao I. Indoor Air Quality in the Metro System in North Taiwan. Int. J. Environ. Res. Public Health. 13:1200 doi: (2016)10.3390/ijerph13121200.
[5]. Awosika, S.A. Olajunbu, F.A. Amusa N.A. Microbiological assessment of indoor air of a teaching hospital in Nigeria AS.Pac. J.Trop.bio. (2012) 16:465-468..
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| Paper Type | : | Research Paper |
| Title | : | Free Radicals as Mediators of oxidative Damage and Disease |
| Country | : | Nigeria |
| Authors | : | Abiodun Olusoji Owoade || Adewale Adetutu || Olubukola Sinbad Olorunnisola |
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: | 10.9790/3008-1402025764 |
Abstract: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) areknown to play a dual role in biological systems, since they can be either harmful or beneficial to living systems.The cumulative production of ROS/RNS through either endogenous or exogenousinsults is termed oxidative stress. Oxidative stress determines structure modifications and function modulation in nucleic acids,lipidsand proteins which has been found to be present in various disease cells when compared with normal cells. This reviewexamines the evidence for involvement of the oxidative stress in disease process. Attention is focused on endogenous and exogenous sources of free radicals generation, the metal (iron,copper.........
Keywords: Reactive oxygen species, free radicals, oxidative stress, fenton chemistry, DNA damage
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[5]. Beard, J. (2003) Iron deficiency alters brain development and functioning. Journal of Nutrition 133: 1468S- 1472S..
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| Paper Type | : | Research Paper |
| Title | : | Mesures et déterminants de la qualité de vie chez les patients atteints de maladies inflammatoires chroniques de l'intestin |
| Country | : | Maroc |
| Authors | : | S.Miry || I.Akoch || A.Lamine || M.Lahlali || H.Abid || N.Lahmidani || D.BenajahM.ElAbkari || A.Ibrahimi || M. El Yousfi |
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: | 10.9790/3008-1402026571 |
Abstract: Les MICI peuvent occasionner une altération majeure de la qualité de vie (QDV) avec une discordance importante entre le vécu de ces maladies et les indices d'activité clinico-biologique et endoscopique disponibles. Nous cherchons à travers cette étude à mesurer la qualité de vie à l'ordre d'une échelle générique : Le SF-12 en arabe dialectal. Et à en identifier les déterminants chez les patients marocains atteints de MICI. Nous nous posons aussi la question sur le retentissement de la sévérité des symptômes sur la qualité de vie et les facteurs associés à la sévérité des symptômes chez cette population. La qualité de vie des malades marocains ayant une maladie inflammatoire.........
Keywords: quality of life ; Inflammatoryboweldisease ; SF-12 score
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| Paper Type | : | Research Paper |
| Title | : | Development and Validation of Forced Degradation Studies of Rasagiline Mesylate Using RP-HPLC and Characterization of Degradants by LC-MS/MS |
| Country | : | India |
| Authors | : | Dr. K. Bhavyasri || Dr. D.Rambabu |
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: | 10.9790/3008-1402027277 |
Abstract: Aim of the present work was to develop simple, shorter and effective HPLC method with UV detection (210nm) and subsequent validation for forced degradation studies of Rasagiline mesylate using RP-HPLC and characterization of degradants by LC-MS/MS. The method uses isocratic the mobile phase mixture of Buffer and acetonitrile taken in the ratio in the ratio of 45:55(v/v) on Hypersil BDS, C18, 250 x 4.6 mm, 5 m column. The RSD for five injections was observed to 0.7 percentage and linearity range of 25 –150 percentage of label claim established with 0.999 correlation. The observed result shows that the method was rapid, precise, accurate and simple. The method was validated as per ICH guidelines.
Keywords: Rasagiline mesylate , Method development, LC-MS, Hypersil BDS.
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| Paper Type | : | Research Paper |
| Title | : | Evaluation of the Effect of Ethanolic Extract of Annonamuricata Leaf on the Testes and Prostate Gland of Male Albino Rats |
| Country | : | Nigeria |
| Authors | : | Elizabeth O. Nweke || Frank C. Akpuaka |
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: | 10.9790/3008-1402027883 |
Abstract: Thisstudyinvestigated the effect of ethanolic extract of Annonamuricata leaf on the testes and prostate gland. Twenty four male albino rats weighing between 150-180 g were used in this study. The animals were divided as follows: Group A was treated with 2 ml/kg body weight of distilled water, Group B was treated with 100 mg/kg body weight of the extract of A. muricata, Group B was treated with 200 mg/kg body weight of the extract of A. muricataand Group C was treated with 300 mg/kg body weight of the extract of A. muricata. The treatments were given orally and.......
Keywords: Annonamuricata; Testes;Prostate gland; Albino rats; Sperm count; Sperm motility
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| Paper Type | : | Research Paper |
| Title | : | Ulcère rectal de Dieulafoy. A propos d'un cas. Dieulafoy's rectal ulcer. Case report |
| Country | : | Maroc |
| Authors | : | S.Miry || N.Lahmidani || A.Lamine || M.Lahlali || H.Abid || M.Elyousfi || M. El Abkari || A. Ibrahimi || D.Benajah |
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: | 10.9790/3008-1402028486 |
Abstract: A propos d'un cas d'ulcère de Dieulafoy du rectum révélé par une hémorragie digestive basse grave. Il s'agit d'une localisation rare d'une affection elle-même rare, liée à l'existence d'une artériole anormalement volumineuse dans la couche sous muqueuse de la paroi digestive. La patiente a été traitée avec succès par voie endoscopique. Mots clés : ulcère de Dieulafoy/ hémorragie digestive/ traitement endoscopique Abstract: Case report of Dieulafoy'sulcer of the rectum revealed bye a severe digestive bleeding. It's a rare localization of a rarediseasewhichisparticular by the presence of an abnormalvessel in the sub-mucosa layer of the digestive wall. The patient wassuccessfullytreated withendoscopic clips
Keywords: Dieulafoy'sulcer / digestive bleeding / endoscopictreatment
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