Series-1 (May-June 2019)May-June 2019 Issue Statistics
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| Paper Type | : | Research Paper |
| Title | : | Toxicological Effect of Ficus musuco Leaf Extract onLiver andKidney Functions Variables of Male Rats |
| Country | : | Nigeria |
| Authors | : | Atasi || Chikanma Onyeoguzoni || Ibegbulem Edna Ogechi || Brown Holy |
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: | 10.9790/3008-1403010107  |
Abstract: Ficus mucuso is a plants whose various parts are employed traditionally in the treatment of different ailments. The decoction of the leaves is commonly used in the management of fever and anemia. The plant is consumed both as medicines and as vegetables with the trust that they are natural and safe without any side effects. Natural does not signify absence of adverse effects. Some plants are said to produce adverse effects that may not be immediate while others may be toxic but no investigation to prove and therefore not documented. The aim of this study........
Key words: Ficus mucuso, toxicity, kidney, liver, plant-extract.
[1] Chukwuma, E.C., Mike, O.S. & Roseline, T.F. (2015). Traditional Medicine and the Future of Medicinal Plants in Nigeria.Journal of Medicinal Plant Studies, 3(4).23-39.
[2] Petrovska, B.B. (2012). Historic review of medicinal plants usage.Pharmacognosy Review, 6(11),1-5.
[3] Khan, K.Y., Khan, M.A., Ahmad, M., Mazani, P., Hussain, I., Fazat, H., Ali, B. &Khan, Z.I. (2011).Ethno-Medicinal Species of Genus FicusL.Used to Treat Diabetes in Pakistan. Applied Journal of Pharmaceutical Sciences, 1(6),209-211.
[4] Alhadi, E.A., Khalid, H.S., Alhassan, M.S., Kabashi,A.S. & Moor, M.O. (2005). Antimicrobial and Phytochemical Screening of Cardia africana in Sudan. World Journal of Pharmaceutical Research, 4(3), 257-267
[5] YazdaniD., TanY.H.,Zainal AbidinM.A.AndJaganathI.B (2011). A review on bioactive compounds isolated from plants against plant pathogenic fungi. Journal of Medicinal Plants Research, 5(30), 6584-6589.
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| Paper Type | : | Research Paper |
| Title | : | Ethanoic Extract of Citrullus Lanatus Seeds Modulates Lipid Variables of Diabetes Induced Rats |
| Country | : | Nigeria |
| Authors | : | Brown Holy || Alozie || Innocent Chinonyerem || Ben-Chioma || AdlineErima |
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: | 10.9790/3008-1403010813 |
Abstract: Approaches to the management of diabetes mellitus is multifaceted. The role of some phytonutrients in the reduction of blood glucose levels is being recognized. Present study investigated the effect of ethanolic extract of Citrullus lanatus seeds on biochemical variables and some haematological indices. Seventy-seven (77) male wistar rats divided into eleven (11) groups of seven (7) rats each were used in this study. Diabetes mellitus was induced in the test animals in groups V – XI by streptozotocin (40mg/kg) after 2 weeks feeding on a High-fat diet (HFD). Group I was normal control rats. Groups II, III and IV were non-diabetic control rats given the vehicles 1% ethanol, corn...........
Keywords: Streptozotocin, diabetes, Citrullus lanatus, lipids, high- fat- diet
[1] Crook, M. A. (2012). Clinical biochemistry and metabolic medicine (8th ed., pp. 176-199). London, England:Hodder& Stoughton.
[2] Muhammad, Y., Saidu, A. Y., Muazu, S., Wali, U., Yaldu, M. H., Abubakar, N. &Bako, H. (2015). Effects of watermelon seed extracts on fasting lipid profile in streptozotocin induced diabetic albino rats. International Journal of Research and Innovations, 3(4), 81-84.
[3] Deshmukh, C. D. & Jain, A. (2015). Antidiabetic and antihyperlipidaemic effects of ethanoicextract of Citrulluslanatus seeds in rats. International Journal of Pharmacy and Pharmaceutical Sciences, 7(10), 232-236.
[4] Omigie, I. O. &Agoreyo, F. O. (2014). Effects of watermelon (Citrulluslanatus) seed on blood glucose and electrolyte parameters in diabetic wistar rats.Journal of Applied Sciences and Environmental Management, 18(2), 231-233 Muhammad et al,2015;
[5] Barbosa-da-Silva, S. Sarmento, I. B., Bargut, T. L. C., Souza-Mello, V. Aguila, M. B. & Mandarim-de-Lacerda, C. A. (2014). Animal models of nutritional induction of type 2 diabetes mellitus. International Journal of Morphology, 3(1), 279–293
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| Paper Type | : | Research Paper |
| Title | : | Assessing the Level of Community Pharmacists' Knowledge about Medicine Inventory Management in Delta State, Nigeria |
| Country | : | Nigeria |
| Authors | : | Austine E Ighorodje || Niyi J Ola-Olorun |
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: | 10.9790/3008-1403011420 |
Abstract: Purpose: To assess the level of community pharmacists' knowledge about medicine inventory management in Delta State. Methods: A cross-sectional descriptive survey of 125 community pharmacists selected using simple random sampling method. Primary data were collected with the aid of a pretested semi-structured questionnaire. Sample size was determined using Taro Yamane's formula for finite population. The questionnaire was designed using simple statements on Likert-type scale with five alternative responses having weighting scores of 0-4. Data collected were analysed using descriptive and inferential statistics at 5% level of significance. Results:The response rate was 96.2% and reliability of the questionnaire was 0.97. Respondents were mostly superintendents (63.2%), computer (63.2%) usage in their premises with 84.8% being used for inventory management purpose. "Record about inventory........
Keywords: Community pharmacy, Inventory management, Stockout
[1] S. Maharaj, M. D'Souza, R. Doodh, N. Kissoon, C. Mohammed, and K.S. Sooklal, Inventory Management Practices in Pharmacies across Trinidad and Tobago. International Journal of Universal Pharmacy and life Sciences, 2(3), 2012, 243-253.
[2] C. C. Orga,Production Management: A Qualitative Approach, (Enugu, Nigeria. Veamarks Publishers,2006.
[3] G. Santhi, and K. Karthikeyan, Recent review on Pharmaceuticals inventory Models. International Journal of Pharm.Tech.Research, 9(5), 2016, 435-443.
[4] M. O. Afolabi, and Oyebisi T. O. Pharmacists' Perceptions of Barriers to Automation in Selected Hospital Pharmacies in Nigeria",Journal of Pharmacy Practice 20(1), 2007, 64- 71.
[5] R. Adepu, andB.G.Nagavi, Attitude and behaviours of practicing community pharmacists towards patient counselling. Indian Journal of pharmaceutical sciences 71(3), 2009, 285-289..
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| Paper Type | : | Research Paper |
| Title | : | Computational studies of plant derived natural compounds with HMG-CoA enzyme through in silico analysis |
| Country | : | India |
| Authors | : | M. Sellappan || M. Rajasekara Pandian || A. Krishnamoorthi || S. Senthilnathan |
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: | 10.9790/3008-1403012125 |
Abstract: Plant products have always been well thought-out for many important metabolic disorders due to its abundant medicinal properties. This study was aimed to identify potent compounds with anti-dyslipidemic property from selected plants and analyse them for their efficiency in binding with HMG-CoA reductive. The 3D structure of HMG-CoA protein was retrieved from protein data bank (PDB ID:3CCZ). Totally four plant derived compounds were selected for docking studies such as 6-gingerol, guajavarin, hesperetin and phloretin. Based on the present study, the maximum docking energy was observed at -100.092kcal/mol with guajavarin and the protein binding sites were identified.........
Keywords: HMG-CoA, Docking, Guajavarin, Phytocompounds.
[1] Bentzon, J.F., Otsuka, F., Virmani, R., Falk, E. Mechanisms of plaque formation and rupture. Cir. Res. (2014); 114: 1852–1866.
[2] Carbonell T, Freire E. Binding thermodynamics of statins to HMG-CoA reductase. Biochemistry. (2005); 44: 11741–8.
[3] Chen ZY, Jiao R, Ma KY.Cholesterol lowering nutraceuticals and functional food.S. J. Agric. Food Chem, (2008); 56: 8761–8773.
[4] Dehghan, M., Mente, A., Teo, K.K., Peggy Gao, P., Sleight, P., Dagenais, G., Avezum, A., Probstfield, J.L., Dans, T., Yusuf, S. Relationship between healthy diet and risk of cardiovascular disease among patients on drug therapies for secondary prevention. A prospective cohort study of 31546 high-risk individuals from 40 countries. Circulation (2012); 126: 2705–2712.
[5] Istvan, E.S., Deisenhofer, J. Structural mechanism for statin inhibition of HMG CoA reductase. Science ( 2001); 292: 1160–1164.
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| Paper Type | : | Research Paper |
| Title | : | Autotoxicity and Yield Decline in Sugarcane under Monocropping in Pune District, Maharashtra, India |
| Country | : | India |
| Authors | : | Dr. HASE C. P. |
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: | 10.9790/3008-1403012632 |
Abstract: Sugarcane is an industrial cash crop in India. Maharashtra is a leading state in sugar production. Monocropping is the most common practice in almost all the sugar producing countries of the world, including India. India is the largest producer of sugarcane as it is profitable crop. Present work deals the study of drastic reduction in cane and sugarcane yield during monocropping is attributed because of allelopathic potential of sugarcane trash (dried leaves), decomposing of trash, releasing many allelochemicals, exudation of phytotoxic chemicals from old roots of ratoon cane, soil sickness, alteration in enzyme activities and autotoxicity.
[1]. AL-Khatib, A. A. and Abd-Elaah, G. A. Allelopathic potential of Zilla spinosa on growth of associated flowering plants and some rhizosphere fungi. Biol. Planta. 1999; 41: 461-468.
[2]. Al-Wakeel, S. A. M., Gabr, M. A., Hamid, A.A. and Abu-el Soud, W.M. Allelopathic effect of Acacia nilotica leaf residue on Pisum sativum L. Allelopathy J. 2007; 19: 411-422.
[3]. Baziramakenga, R., Simard, R. R. and Leroux, G. D. Effects of benzoic and cinnamic acids on growth, mineral composition and chlorophyll content of soybean. J. Chem. Ecol. 1994; 20: 2821–2833.
[4]. Bhakat, R. K., Bhattacharya, A., Maiti, P. P., Das, R. K. and Kanp, U. K. (2006) Effect of Eupatorium odoratum L. on Mimosa pudica L. Allelopathy J. 2006;17: 113-116.
[5]. Bhakat, R. K., Kanp, U. K., Das, R. K. and Bhattacharya, A. Evaluation of allelopathic action of Parthenium hysterophorus using differently aged horse gram seeds. In: Stress Biology (Eds. U. Chakraborty and B. Chakraborty). 2005: 175-180...
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| Paper Type | : | Research Paper |
| Title | : | Efficacy of Silodosin in comparison with Tamsulosin in the medical expulsive therapy for ureteral calculi |
| Country | : | Iraq |
| Authors | : | Dr. Ali MahmoodShakir || Dr.MustafaAbdulrazzaqAl.rikaby || Dr. Mohammad Taha Kareem Al-Tameemi || Dr. Ali Mudhermizhir || Dr. Mohammed Bassil Ismail || Dr.RaghibJassamHameedAlshimmre |
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: | 10.9790/3008-1403013339 |
Abstract: Objectives: To compare the efficacy of silodosin (8mg) versus tamsulosin (0.4mg), both in terms of the stone expulsion rate and the time to stone expulsion. Settings and Design: A prospective and randomized controlled study was conducted in the department of Urology, Surgical Sub-Specialties Hospital, Medical City Complex in Baghdad. Patients and Methods: Starting from October 2013, till September 2014; a total of 96 patients (M=56; F=40) who were between age group of 18–50 years, who had unilateral, non–impacted, uncomplicated middle or lower ureteral stones which were ≤ 1cm, were enrolled in a prospective study and they were randomized into two groups. Group 1 received tamsulosin (0.4mg), and group 2 received silodosin (8 mg) for a maximum period of 4 weeks. The patients were followed up weekly or biweekly with imaging studies............
Keyword: Ureteric stone, silodosin, tamsulosin, medical expulsive therapy.
[1]. Shah J, Whitfield HN. Urolithiasis through the ages. BJU International 2002; 89(8): 801–810.
[2]. Resim S, Ekerbicer H, Ciftci A. Effect of tamsulosin on the number and intensity of ureteral colic in patients with lower ureteral calculus. Int. J Urol. 2005; 12: 615–20.
[3]. Phillips E, Kieley S, Johnson EB, et al. Emergency room management of ureteral calculi: current practices. J Endourol 2009 Jun; 23(6):1021-4.
[4]. Seitz C, Liatsikos E, Porpiglia F, et al. Medical Therapy to Facilitate the Passage of Stones: What Is the Evidence? EurUrol 2009 Sep; 56(3):455-71.
[5]. Porpiglia F, Ghignone G, Fiori C, Fontana D, Scarpa RM. Nifedipine versus tamsulosin for the management of lower ureteral stones. J Urol. 2004; 172:568-71
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| Paper Type | : | Research Paper |
| Title | : | Ground Level Observations of Microfailarial Fever Cases On The Basis Of Age and Sex Wise Incidents In Narasannapeta Urban Population, Narasannapeta Mandal, Srikakulam, Andrapradesh, India |
| Country | : | India |
| Authors | : | Pooja Bharadwaj Gumadapu || Prof. B.V. Sandeep |
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: | 10.9790/3008-1403014043 |
Abstract: Lymphatic filariasis is a mosquito-borne parasitic disease and an important cause of chronic morbidity in tropical countries detailed observations of lymphatic filariasis was conducted in Narasannapeta urban village of Srikaulam district in Andhrapradesh. Out of the 1660 persons examined, 8.1% were found asymptomatic but microfilaraemic. Morbidity pattern due to filarial infection showed an increase with advancement of age and significantly high in males as compared to female .Acute and chronic filarial disease was observed as 0.3% and 7% respectively. Microfilaria was found in 8.1% of acute and 9.3% of chronic filarial cases.............
Keywords: Lymphatic filariasis, Microfilariamia, Morbidity, chronic, mosquiogenic, Narasannapeta
[1]. Anne C, Haddix AC and Kestler A. Lymphatic filariasis- economic aspects of the disease and programme for its elimination. Tran Ryl Soc Trop Med Hyg 2000; 94(6):592-593.
[2]. Das PK, Sirvidya A, Vanamail P et a l . Wu c h e r e r i a b an c r o f t i microfilaraemia in children in relation to parental infection status. Trans Ryl Soc Trop Med Hyg 1997; 91(6):677-679.
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| Paper Type | : | Research Paper |
| Title | : | In Process Validation of Nevilast-30 |
| Country | : | India |
| Authors | : | Thejovathi B || Kondal Reddy J || Kondla Usha |
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: | 10.9790/3008-1403014469 |
Abstract: Process validation and optimize the manufacturing process and established key process parameters involved in the manufacturing of NEVILSAT – 30 Tablets. The objective of present study was to develop a stable and robust manufacturing process for NEVILAST – 30 Tablets. The process parameters will yield product which meets predetermined quality attributes .The prospective process validation was performed on three consecutive batches. The future scope of the work is to enable the process on commercial production of tablet meeting its predetermined specification and quality attributes after these validation batches. Concurrent process validation is carried out for the NEVILAST 30............
Key Words: Nevirapine, Lamivudine, Stavudine, Croscarmellose Sodium (Primellose), Croscarmellose Sodium (Primellose), 3batches, Bowl & Lots.
[1]. Aiken, J., "Panel criticizes FDA inspections of imported drugs".
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[3]. J. Hekster, Y.A., Burger, D.M., "High-performance liquid chromatography of HIV protease inhibitors in human biological matrices. Journal of Chromatography B, 2001, 764: 363–384.
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[5]. Antiretroviral drug content in products from developing countries.HIV/AIDs: 38.
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| Paper Type | : | Research Paper |
| Title | : | In Vitro Inhibitory Effects of Different Formula of Essential Oils against Bacterial Pathogens Associated withBurn and Wound Infections |
| Country | : | Egypt |
| Authors | : | Magda M. Aly || Mayson Al-Sowayigh || Seham Abounasef || Reda Amasha |
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: | 10.9790/3008-1403017078 |
Abstract: Essential oils (EOs) from plants represent an alternative approach in combating antibiotic-resistant bacteria. The objective of this study was to investigate in vitro antibacterial activity of five essential oils, Eucalyptus globules (eucalyptus), Eugenia caryophyllata (clove), Nigella sativa (Black seed), Zingiber officinale (ginger), and Cocos nucifera (coconut) individually and in combination with Eucalyptus globules oil against four pathogenic bacteria that invade burns and wounds. Two Gram-positive bacteria Staphylococcus aureus (S. aureus) and Methicillin-resistant Staphylococcus aureus (MRSA) and two Gram-negative bacteria Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa) were used as test organisms. The antimicrobial activity was determined using agar- well diffusion method. Eucalyptus and Eugenia oils showed the greatest antimicrobial activities against all tested pathogenic bacteria. In addition, the combination of Eucalyptus oil with other tested.........
Key Words: Eucalyptus globules, Eugenia, essential oils, Staphylococcus aureus, Escherichia coli, MRSA, Pseudomonas aeruginosa, Artemia salina
[1]. Kon, K. and M. Rai, Antibacterial activity of Thymus vulgaris essential oil alone and in combination with other essential oils. 2012.
[2]. Yazdi, F.T., B.A. Behbahani, and A. Mortazavi, Investigating the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the Lavandula stoechas L. and Rosmarinus officinalis L. extracts on pathogen bacterias "in vitro". Journal of Paramedical Sciences (JPS) Spring, 2014. 5(2): p. 2008-4978.
[3]. Sugumar, S., A. Mukherjee, and N. Chandrasekaran, Eucalyptus oil nanoemulsion-impregnated chitosan film: antibacterial effects against a clinical pathogen, Staphylococcus aureus, in vitro. Int J Nanomedicine, 2015. 10 Suppl 1: p. 67-75.
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[5]. Hendry, E., et al., Antimicrobial efficacy of eucalyptus oil and 1, 8-cineole alone and in combination with chlorhexidine digluconate against microorganisms grown in planktonic and biofilm cultures. Journal of Antimicrobial Chemotherapy, 2009. 64(6): p. 1219-1225..
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| Paper Type | : | Research Paper |
| Title | : | Epiphytic Bacteria Associated with the Green Algal Halimeda Opuntia as a Source of Antibacterial Agent |
| Country | : | Egypt |
| Authors | : | Sawsan H. Basondwah || Doaa K. Baker || Ebtihaj Jambi || Mohammad Abuzaid || Magda Aly |
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: | 10.9790/3008-1403017985 |
Abstract: Marine bacteria have great potential in developing pharmaceutical industry because they are able to produce many bioactive secondary metabolites. This study aimed to isolate, identify and evaluate the antibacterial activity of some bacteria associated with Halimeda opuntia, isolated from Red Sea, Jeddah. Four epiphytic bacteria were identified by morphological and biochemicals characters as well as 16S rRNA gene sequencing. Bacterial strains were found to belong to two major families, Bacillaceae and Vibrionaceae. The identified bacterial isolates were of genera Bacillus (two isolates), Vibrio (one isolate) ans Lysinibacillus (one isolate). Primary screening results using well diffusion technique shown75% of epibiotic bacteria exhibited antibacterial activity. Among them, Bacillus niacini extract showed significant antibacterial activity against all the tested Gram-negative E.coli, K. pneumonia..........
Key Words: Red Sea, Halimeda opuntia, Epiphytic bacteria, Antibacterial activity, MIC, Ethyl acetate extract
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