Abstract: Selenium, a chemical element which rarely occur in its elemental state or as pure compound in the earth's crust and also found in soils derived from seleniferous parent materials like sandstones, limestone, slate and coal series has been found to poses a wide variety of functions in the body which includes activity on the thyroid hormone metabolism, antioxidant defense system which involves the antioxidant enzymes such as glutathione peroxidase, thioredoxin reductase and iodothyronine deiodinases. Selenium has been shown to mop up the presence of reactive oxygen species known to cause damage to cellular lipids in the oxidation of low density lipoprotein. (LDL). The role of selenium in immune system is notable in Keshan disease, Kashin- Beck disease and Hashimoto's disease. Also on cancer and diabetes mellitus has it has been proven to significantly slow the progression of diabetes mellitus in some individuals......
Keywords: Diabetes mellitus, antioxidant defense system, reactive oxygen species, low density lipoprotein, Keshan disease.
[1]. Ahsan, U., Kamran, Z., Raza, I., Ahmad, S., Babar, W., Riaz, M. H., Iqbal, Z. (2014). Role of selenium in male reproduction - a review. Anim. Reprod. Sci. 140 (6):55–62.
[2]. Akbaraly, T. N., Arnaud, J., Rayman, M.P., Hininger-Favier, I., Roussel, A.M., Berr, C., Fontbonne, A. (2010). Plasma selenium and risk of dysglycemia in an elderly French population: results from the prospective Epidemiology of Vascular Ageing Study. Nutr. Metab. 43 (6):7-21.
[3]. Berry, M.J., Banu, L., Chen, Y.Y., Mandel, S.J., Kieffer, J.D., Harney, J.W., Larsen, P.R. (1991). Recognition of UGA as a selenocysteine codon in type I deiodinase requires sequences in the 3′ untranslated region. Nature. 91(353):273–276.
[4]. Bifano, A.L., Atassi, T., Ferrara, T., Driscoll, D.M. (2013). Identification of nucleotides and amino acids that mediate the interaction between ribosomal protein L30 and the SECIS element. BMC Mol. Biol. 13(14):67-80.
[5]. Burk, R.F., Hill, K. E. (2015). Regulation of Selenium Metabolism and Transport. Annu. Rev. Nutr. 15:(35)109–134..