Abstract: Abstract
Substituted pyran derivatives were identified as potential drug targets for the treatment of cancer. Herein we report the synthesis, molecular docking studies, cytotoxic activity, and ADME properties of twelve substituted pyran-linked triazole derivatives. The anticancer evaluation against HCT-116 ( Carcinoma cancer Cell line), and PC-3 (Prostate cancer Cell line) was carried out by MTT assay. The IC50 values of compounds (4a-l)displayed good to moderate anti-cancer activities. All the compounds of the series exhibited promising activity with IC50 values in the micro molar range 19.27 ±1.96 to 5.42 ±1.20 for the HCT-116 cell line and 21.46 ±1.25 to 8.78 ±1.21 for PC-3 cell line in comparison with Doxorubicin. Molecular docking studies revealed that all the newly synthesized......
Keywords: 1,2,3-triazole, Pyran ,Cytotoxicity, molecular docking studies and ADME Properties
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