Abstract: Cypermethrin is a type II synthetic pyrethroid prescribed for bed nets for neonates, infants and adults.This study aimed at evaluating its reproductive toxicity and therapeutic effect of co-administration of Lycopene on male rats. Histopathological evaluation of the testes revealed approximately 40% loss of germ cells including interstitial cells of Leydig and Sertoli cells. Luminal diameter increased with complete loss of spermatozoa indicating the inhibition of maturation and differentiation of secondary spermatocytes into mature spermatozoa. The seminiferous epithelium became sparsely populated due to mitotic inhibition. Animals co-administered Lycopene recovered as observed bythe regenerationof all spermatogenic elements. it is concluded that processed Solanum lycopersicum and its pure extract exhibited a therapeutic effect on Cypermethrin –induced reproductive toxicity. It is also worthy of note that fresh fruits of Solanum lycopersicum possess some form of lycopene but require further processing to make it bioavailable to mammals lacking Cellulase
Keywords: Antioxidant,cypermethrin, lycopene, reproductive stress, spermatogenesis
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