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| Paper Type | : | Research Paper |
| Title | : | Study of Bacterial Isolates and their Susceptibility Pattern in Chronic Suppurative Otitis Media |
| Country | : | Iraq |
| Authors | : | Zina Bakir Al-Hilli |
Abstract: Chronic Suppurative Otitis Media (CSOM) is one of the common ear diseases which can cause many complications if not treated properly . This study was done to determine isolates causing CSOM and their antibiotic susceptibility pattern. The study was carried out from November 2014 to April 2015. Ear swabs were collected & cultured from one hundred and twenty patients with CSOM attending the ENT Out Patient Clinic in Al- Hillah Teaching hospital. The specimens were cultured The isolated organisms were identified by standard microbiological methods.
[1]. Bhargava, K.B.; Bhargava, S.K.; and Shah, T.M. (2005). A Short Textbook of E.N.T. Diseases. Usha publications, India.7, 110.
[2]. Maharjan, M.; Bhandari, S.; Singh, I.; and Mishra, S. C. (2006). Prevalence of otitis media in school-going children in eastern
Nepal. Kathmandu Univ. Med. J.16:479-82.
[3]. Berman, S. (1997). Classification and criteria of Otitis Media. Clin. Microbiol. Infect. (Suppl). 3: 1-4.
[4]. Acuin, J.( 2004). Global burden of disease due to Chronic Suppurative Otitis Media: Disease, deafness, deaths and DALYs
Chronic Suppurative Otitis Media-Burden of Illness and Management Options.
[5]. Mirza, I. A.; Ali, L.; Ali, L. and Arshad, M. (2008). Microbiology of chronic suppurative otitis media - experience at Bahawalpur.
Pak. Armed Forces Med. J. 58:372-6.
[6]. Kena, M. (1988). Etiology and pathogenesis of chronic supporative otitis media. Arch. Otolaryngol. Head and Neck Surg. 97 (2)
(Suppl. 137): 16-17.
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| Paper Type | : | Research Paper |
| Title | : | The Central and Peripheral effects of the methanol extract of Fadogia cienkowskii schweinf. var cienkowskii Leaves |
| Country | : | Nigeria |
| Authors | : | Ode O.J. || Omeje J.N. || Nuhu U. || Oladele G.M. || Madubuike S.A. |
Abstract: The methanol extract of Fadogia cienkowskii schweinf. var cienkowski leaves was investigated for central and peripherally mediated nervous effects. Oral acute toxicity studies, the effect on phenobarbitone-induced sleeping time, local anaesthetic effects, analgesic activity using acetic acid-induced writhing response, and muscle relaxant effects with hind limb grip reflex and inclined board tests were carried out on the methanol extract following standard models. The extract was tolerated by the oral route up to the highest test dose of 4000 mg/kg; hence, there was no mortality or overt clinical manifestations in mice within 48 h duration of the investigation.
[1]. J.M. Kong, N.K. Goh, L.S. Chia, and T.F. Chia, Recent advances in traditional plant drugs and orchids, Acta Pharmacology Science, 24, 2008,7-21.
[2]. H.P. Rang, M.M. Dale, J.M. Ritter, and P.K. Moore, Pharmacology (London: Churchil Livingstone, 2003) 503-514.
[3]. J.B. Calixto, A. Beirith, J. Ferreira, A.R.S. Santos, V.C. Filho, and R.A.Yunes, Naturally occurring antinociceptive substances from plants, Phytother. Res., 14, 2000, 401-118.
[4]. J.D. Griffiths, N.V. Le, S. Grant, A. Bjorksten, P. Hebbard, and C.Royse, Symptomatic local anaesthetic toxicity and plasma ropivacaine concentrations after tranversus abdominis plane block for caesarean section, British Journal of Anaesthesia, 110, 2012, 996-1000.
[5]. G.B. Marino-Betlolo, Traditional medicine and health practice. J. Ethnopharmacol, 2, 1980, 5-7.
[6]. P.S.A. Emeline, C. A. Aristide, and S. Brice, Magnoliophyta, Biosphere Reserve of Pendjari, Atakora Province, Benin. Checklist, 8, 2012, 642-661.
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| Paper Type | : | Research Paper |
| Title | : | Effect of Indian Spices to Manage the Diabetes and Associated Metabolic Disorder |
| Country | : | India |
| Authors | : | Dinesh K. Garg || Pranav Pandya |
Abstract: India is a country, where we have more than four crores of insulin dependent diabetics and this number is growing regularly. The situation is more or less same in other developing/non developing neighboring countries and across the globe. This disease is a non-curable and the management is the only remedy using variety of systemic chemicals as drugs/insulin. The resistance to the drugs/insulin is also a challenge to strengthen the management for a longer period.
[1]. Ling Chew Yik.,Wan Chan Elaine, Tan Pei Ling, Linn Yau Yan, Stanlas Johnson, Kheng Goh Joo. Assessment of phytochemical content, poly phenolic composition, antioxidant and anti-bacterial activities of leguminosae medicinal plant in penninsular Malaysia, BMC complement Altern. Med. 11, 2011,12.
[2]. S M Karandikar, V A Pandit & S D Kulkarni, Pharmaco-epidermiological study of use of herbal medicine in elderly Pune, Bharati vidyapeeth Bull. 1 , 1997,9.
[3]. A K Gupta, N Tondon,"Review on the Indian medicinal plant" Indian Council of Medicinal Research, New Delhi. 2004,312
[4]. A Subramaniam. The problems and prospects of plant drug research in India: Pharmacological evaluation of ecotypes in herbal drug development. Indian J Pharmacol, 33, 2001,145.
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| Paper Type | : | Research Paper |
| Title | : | A Comparative study of the Antimicrobial activities of five varieties of essential oils from the seeds of Artocarpus |
| Country | : | India |
| Authors | : | Sirisha Nagala || Gangaraju Rapaka || Raghava Rao Tamanam |
Abstract: Hexane and methanolic oil extracts from five varieties of Artocarpus seeds were studied to explore its suitability for ethno medical uses. Crude hexane and methanolic oils were found to shown good to moderate activity against bacteria, in particular Gram +ve (Bacillus cereus, Bacillus subtilis and Staphylococcus aureus) and Gram-ve (Eschirichia coli and Pseudomonas aeruginosa) and fungal stains, more specifically Aspergillus niger, Aspergillus flavans, Candida albicans and Saccharomyces cerevisiae. Maximum activity was observed on bacterial strains compared with fungal strains.
[1]. Adebayo-TayoBC.,Ajibesin KK 2008. Antimicrobial activities of Coulaedulis. Res J Med Plant., 2:86-91.
[2]. Adebolu TT and Oladimeji SA 2005. Antimicrobial activity of leaf extracts of Ocimumgratissimum on selected diarrhea causing bacteria in Southwestern Nigeria. Afr J Biotechnol., 4: 682-684.
[3]. Anwar F., HussainAI.,Sherazi STH and Bhanger MI 2009. Changes in composition and antioxidant and antimicrobial activities of essential oil of fennel (Foeniculumvulgare Mill.) fruit at different stages of maturity. J Herbs Spices Med Plants., 15: 1-16.
[4]. Bayliss M 1936. Effect of the chemical constitution of soaps upon their germicidal properties. J Bacteriol., 31:489-504.
[5]. Bergsson G., Arnfinnsson J., Karlsson SM., et al 1998. In vitro inactivation of Chlamydia trachomatis by fatty acids and monoglycerides. Antimicrob Agents Chemother., 42:2290-2294.
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| Paper Type | : | Research Paper |
| Title | : | Biochemical Study on Endothelial Nitric Oxide Gene Polymorphism in Fatty Liver Patients |
| Country | : | Egypt |
| Authors | : | Rizk Ahmed El-Baz || Alaa Wafa || Nasser Mohammed Hosny || Sameh Refaat El-Saka |
Abstract: Endothelial nitric oxide synthase (eNOS) gene polymorphism association with non-alcoholic fatty liver disease (NAFLD). Objective: to check for association of polymorphism of eNOS gene with susceptibility and severity of NAFLD in cases from Egypt. Subjects: This work included 100 cases with NAFLD from Internal,liver unit and 100 healthy individuals. The mean age of cases was 45.45 ± 15.29 (range: 18 – 80 years).
[1]. Adams LA, Lymp J, St Sauver J, et al. (2005). The natural history of nonalcoholic fatty liver disease: a population based cohort study. Gastroenterology;129:113–21.
[2]. Alkharfy KM, Al-Daghri NM, Al-Attas OS, Alokail MS, Mohammed AK, Vinodson B, Clerici M, Kazmi U, Hussain T, Draz HM (2012): Variants of endothelial nitric oxide synthase gene are associated with components of metabolic syndrome in an Arab population.Endocr J; 59(3):253-63.
[3]. Angulo P. (2002).Nonalcoholic fatty liver disease. N Engl J Med; 346:1221–31.
[4]. Barshop N. J., Sirlin C. B., Schwimmer J. B., et al., ( 2008). Review article epidemiology, pathogenesis and potential treatments of paediatric non-alcoholic fatty liver disease," Alimentary Pharmacology and Therapeutics, vol. 28, no. 1, pp.13–24.
[5]. Begriche, K.; Igoudjil, A.; Pessayre, D.; Fromenty, B(2014). Mitochondrial dysfunction in NASH: Causes, consequences and possible means to prevent it. Mitochondrion, 6, 1–28. Int. J. Mol. Sci., 15 8734
[6]. Bjorkegren J., Beigneux A., Bergo M. O., Maher J. J., and Young S. G.,(2002). "Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury," Journal of Biological Chemistry, vol.277, no. 7, pp. 5476–5483.
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| Paper Type | : | Research Paper |
| Title | : | Distribution, Threats and Conservation Strategies of Anurans at Central Aravalli foothills of Ajmer, Rajasthan India. |
| Country | : | India |
| Authors | : | Dr Rashmi Sharma |
Abstract:Ajmer is located in the center of Rajasthan (INDIA) between 25 0 38 " and 26 0 58 " north Latitude and 73 0 54 " and 75 0 22" east longitude covering a geographical area of about 8481sq km surrounded all sides by Aravalli hills.
Amphibians, particularly anurans, are of immense ecological and economical importance.Amphibian species diversity is highest in Tropics. But now these are declining at fast rate. The initial release of Global Amphibian Assessment (GAA) in 2004 reported amphibian species had been analyzed in order to assess their conservation status and distribution.
[1]. Amphibian CAMP Handbook (2001). Declining Amphibian populations a task force South Asia, Zoo Outreach Organization,Peelamedu, Coimbatore,Tamil Nadu.
[2]. Bishop C., D., Bradford, G. Casper, S. Droege, G. Fellers, P. Geissler, D. M. Green, R. Heyer, M. Lanoo, D. Larson, D. Johnson, R. Mc Diamond, J. Sauer, B. Shaffer, H. Whiteman &H. Wilbur (1994) A proposed north American Amphibian monitoring program. Proceedings from the 1994 North American Monitering program Conference, 1-13.
[3]. Boulenger, G.A. (1890). Thefauna of British India including Ceylon and Burma,Reptiles and Batrachia. Taylor and Francsis, London, XVIII+541PP.
[4]. Chanda, S.K. (2002). Handbook Indian Amphibians. Zoological Survey of India, Calcutta, Viii+335pp.
[5]. Daniel, J.C.(2002). The book of Indian Reptiles and Amphibians. Bombay Natural History Society & Oxford University Press, Mumbai, VIII238pp.
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| Paper Type | : | Research Paper |
| Title | : | Study of medication appropriateness during hospital stay and revisits in medicine department of tertiary care hospital |
| Country | : | India |
| Authors | : | Vineeta Dhyani || Pankaj Mohan Dhyani || Geetanjali Salimath || Charu Pundir |
Abstract: The primary objective was to identify the medication reconciliations among elderly, based on Lund integrated medicines management (LIMM), during their admission and discharge from hospitals. The secondary objective was to study the impact of LIMM based patients within 6 months of their hospital discharge and revisits. It was a prospective surveillance study in which 120 patients aged ≥65 years or old intervention patients, received LIMM model.
[1]. L.M. Hellström, Å. Bondesson, P. Höglund, T. Eriksson, Errors in medication history at hospital admission: prevalence and predicting factors. BioMed Central; 12(1), 2012.
[2]. R. Elliott, Geriatric pharmacy practice, in G. Parthasarathi, K.N. Hansen, M.C. Nahata (Ed.), A Text Book of Clinical Pharmacy Practice, (Chennai: Orient Longman Private Limited; 2004) 190-218.
[3]. F. Napolitano, M.T. Izzo, G. Di. Giuseppe, I.F. Angelillo, Frequency of Inappropriate Medication Prescription in Hospitalized Elderly Patients in Italy, PloS ONE; 8(12), 2013, 8-14.
[4]. J. Bremner, A. Frost, C. Haub, M. Mather, K. Ringheim, E. Zuehlke, Old age dependency. Popul Bull; 65, 2010, 6-8.
[5]. G.K. Ingle, A. Nath, Geriatric health in India: Concerns and solutions, Indian Journal of Community Medicine; 33, 2008, 214-218.
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| Paper Type | : | Research Paper |
| Title | : | Anti-aging potential of a cream containing herbal oils and honey: Formulation and in vivo evaluation of effectiveness using non- invasive biophysical techniques |
| Country | : | Turkey |
| Authors | : | Ebru Altuntaş || Gülgün Yener |
Abstract: A topical oil in water type (o/w) emulsion containing pomegranate seed oil, grape seed oil, sesame oil and flower honey was developed in this study. In order to determine stability, the selected formulations were kept at room temperature (25±2°C) and accelerated conditions (40±2°C ve %75 relative humidity). Physicochemical and microbiological stability of the formulations were evaluated. In order to determine anti-aging efficacy and safety of the selected formulation, various skin parameters such as moisture level, pH value, sebum content, roughness, mean size of skin pores and elasticity of the application area of 12 healthy female volunteers, 25-65 years old were assessed by non-invasive biophysical techniques. In addition to this, the panelists answered a preformed questionnaire to assess the performance of the product.
[1] H. Assaf, M.A. Adly, M.R. Hussein, Aging and intrinsic aging: pathogenesis and manifestations, in M.A. Farage, K.W. Miller, H.I. Maibach, (Ed.), Textbook of aging skin, (Berlin: Springer, 2010) 129-138.
[2] F.C. Lau, M. Bagchi, S. Zafra-Stone, D. Bagchi, The benefits of antioxidant-rich fruits on skin health, in A. Tabor, R. Blair, (Ed.), Nutritional cosmetics, (Oxford: Elsevier, 2009) 217-232.
[3] N. Wilson, Market evolution of topical anti-aging treatments, in N. Dayan, (Ed.), Skin aging handbook: an integrated approach to biochemistry and product development, (NY: William Andrew 2008) 16-31.
[4] G. Yener, J. Hadgraft, W.J. Pugh, Penetration of two sunscreens in various formulations through a synthetic membrane as compared to human skin in vitro, Acta Pharmaceutica Turcica, 40(1), 1998, 27-32.
[5] M.A. Zaid, F. Afaq, D.N. Syed, H. Mukhtar, Botanical antioxidants for protection against damage from sunlight, in A. Tabor, R. Blair, (Ed.), Nutritional cosmetics, (Oxford: Elsevier 2009) 162-177.
[6] J. Shi, J. Yu, J.E. Pohorly, Y. Kakuda, Polyphenolics in grape seeds-biochemistry and functionality, Journal of Medicinal Food, 6(4), 2003, 291-299.
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| Paper Type | : | Research Paper |
| Title | : | Genotyping and subgenotyping of Trichophyton rubrum isolated from dermatophytosis in Iraqi patients using RFLP-PCR |
| Country | : | Iraq |
| Authors | : | Sara k. Kadhim || Adnan H. Al-Hamadani || Jawad k. Al-Janabi |
Abstract: Aim: To identify the genotypes and subgenotypes of Trichophyton rubrum isolates based on the molecular techniques. Methods: Eight isolates of T. rubrum were isolated and identified phenotypically and genotypically using cultural, physiological and molecular tests; respectively, based on conventional and RFLP-PCR. Results: Its noticed that only 8/24 (33.33%) isolates were classify as T. rubrum with amplicon size equal 601bp. RFLP-PCR showed the presence of two genotypes (I,II) belong to T. rubrum. The profile of RFLP-PCR showed that 6/8 (75%) of isolates represent the genotype I which contained subgenotypes (Ia-Id) while the other genotype symbolized as genotype II that contained the subgenotypes (IIa-IId).
[1]. Behzadi, P. and Behzadi, E. (2012). Modern fungal Biology. 1st ed. Tehran: Persian Science & Research Publisher.
[2]. Behzadi, P.; Behzadi, E. and Ranjbar, R. (2014). Dermatophyte fungi: infections, diagnosis and treatment. SMU medical journal., 1: 50-62.
[3]. Borman, A.M.; Linton, C.J.; Miles, S.J. and Johnson, E.M .(2008). Molecular identification of pathogenic fungi. J. Antimicrob. Chemother.; 61: S1,i7-i12, dio: 10.1093/jac/dkm425.
[4]. Burns, T.; Breathnach, S.; Cox, N. and Griffiths, C. (2010).Rook's Textbook of Dermatology., 8th ed. Blacwell publishing 22:1814-1829.
[5]. Chen, J.; Yi, Jinling; Liu, Li, et al. (2010). Substrate adaptation of Trichophyton rubrum. Microbial Pathogenesis, 48 (2): 57-61.
[6]. Collee, J.G.; Fraser, A.G.; Marmion, B.P. and Simmons, A. (1996). Practical Medical Microbiology. 14th edition , vol. 1. Churchill Livingstone.
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| Paper Type | : | Research Paper |
| Title | : | Case study on Holistic Diabetic Care using Diet, Yoga, Resisted Exercises using Physioball and Walking. |
| Country | : | India |
| Authors | : | Dr.S.S.Subramanian |
Abstract: Obesity and poor Glycaemic control among Type II diabetes Mellitus coexists. This case study where subject's obesity and glycaemic control improves substantially. Methods: Diet along with Specific resisted exercises using Physioball yoga and regular waling. Results: Unique features recorded are a reduction of HBA1C from 8% to 6%, with 6 months of treatment, physiotherapy in 65 sessions of thrice weekly duration. Conclusion: The outcomes of this study with larger sample size, including control subjects, various age groups are essential to further substantiate the evidence. Keywords HbA1C: Glycoselated haemoglobin, Physioball: An Air inflatable ball of various sizes from 550m to 750m, Cadence: Number of steps per minute.
[1]. WHO: Obesity and Overweight Fact Sheet NO: 311 March 2013. Available from: http//www.who/int/mediacenre/fact sheets.
[2]. Lipton .L, using yoga to treat disease: an evidence based review. JAAPA.2008:21:34-6, 38, 41.
[3]. Anandacoomarasamy A, Leibman S, Smith G, Caterson I, Giuffre B, Fransen M etal Weight lose in people has structure modifying effects on medial not an lateral Knee articular cartilage Ann Rhaum dis 2012:71:26-32.
[4]. Subramanian 2014, Stability Ball on Glycaemic Control in Type 2 Diabetes Mellitus International Organization of Scientific Research Journal of Applied Chemistry July to Aug. 2012 Volume 1 Issue 3 Page.No.10 – 13
[5]. Subramanian 2012, Stability Ball exercises in Type 2 diabetic patients Journal of Research in Biology June 2012 JRB/2012/ Volume 2/No.4 P. No: 403-409
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| Paper Type | : | Research Paper |
| Title | : | Case Study Report on a Parkinson's Disease Patient with Inversion Therapy Using Physioball and Inversion Based Yoga Postures. |
| Country | : | India |
| Authors | : | Dr.S.S.Subramanian |
Abstract: As Age Advances Neurological ailments, depression, difficulty in movements, obesity with lowered cognitive functioning are known and well recorded. This single case study where a obese patient with difficulty in walking, low confidence level, difficulty in speech and hand tremors under goes Inversion Therapy using Physioball along with Inversion based yoga postures. He has improved significantly with improved confidence, confident in walking less tremor and reduction in obesity which is highly significant and an innovative means of treating patients with movement disorders.
Key words: Physioball: An air inflated ball Inversion Therapy: upside down postures used for Therapeutic Purpose.
[1]. F. Chandra, on head stands Yoga postures of their physiological and psychological effects.
[2]. Journal of Canadian chiropractic association on Inversion Therapy.
[3]. WWW. Sungray.org. benefits of Inversion techniques.
[4]. Gord Kerr, Demand Media, 2015 on Inversion Table risks and benefits.
[5]. David coulter, Anatorist, University of Mirnesota. US 1992, Yoga. Anatomy of Hatha Yoga: A Manual for Students, Teachers, and Practitioners Paperback – January 1, 2010.
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| Paper Type | : | Research Paper |
| Title | : | Synthesis, Characterization and Antiinflammatory activity of Cinnolines (pyrazole) derivatives |
| Country | : | India |
| Authors | : | Mishra Pankaj || Saxena Vikas || Keshri Minu || Saxena Abhishek |
Abstract:In the substituted Cinnoline Pyrazole series, the compounds which are halogen mainly Chloro,
Bromo and Fluoro Substituted were showed potent antibacterial, anti-inflammatory and anti-fungal activity
than other compounds. Especially Chloro Substituted Compounds Showed more potent anti-inflammatory
activity among all the substituted cinnoline pyrazole compounds.
Keywords: cinnoline, pyrazole, anti-inflammatory activity.
[1]. Armarego, W.L.F. (1977) Stereo chemistry of Heterocyclic compounds. 2nd edn. A Wiley – Interscience publication. p.p 238-240.
[2]. Amer, A.M. Atti, I.AG. Mobayad, M.E. and Asker, S. (2000) On the chemistry of cinnoline III : condensation reactions of (4 - amino cinnolin – 3- yl) – Phenyl – methanone and 4- amino - 3- cinnoline – carbonitrile. Polish J. Chem. 74, 681 – 686.
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[6]. Bhusari, K.P. Khedekhar, P.B. Umathe, S.N. Bahekar, R.H. Ramrao, R.A. (2000) Synthesis and antibacterial activity of some substituted 2-(4-amino phenyl sulphonamido) Benzothiazoles. Indian J. Chem. 9, 213-216.
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| Paper Type | : | Research Paper |
| Title | : | Phytochemical Evaluation and Pharmacological Screening of Ethanolic Leaf Extracts of Erythroxylum Monogynum and Pupalia Lappacea for Hepatoprotective, Nephroprotective, Antihyperlipidemic and Antihyperglycemic Activity in Alloxan- Induced Diabetic Albino Wistar Rats. |
| Country | : | India |
| Authors | : | Mehnoor Farheen || Chakrapani Ramesh |
Abstract: Type 1diabetes is associated with damage to the liver, kidney and pancreas of patients. The damage varies in proportion and susceptibility among diabetic patients of type 1 class. This study assessed the hypoglycaemic, hepatoprotective, antihyperlipidemic and nephroprotective activities of whole methanolic leaf extract of erythroxylum monogynum and pupalia lappacea in alloxan-induced diabetic albino Wistar rats. Extraction of the ethanol extract of erythroxylum monogynum and pupalia lappacea was performed by maceration. Thirty six rats were divided into six groups. Group I consists of normal rats that were given only normal saline solution and served as a control group.
[1]. "About diabetes". World Health Organisation. Retrieved 4 April 2014.
[2]. Kitabchi, AE; Umpierrez, GE; Miles, JM; Fisher, JN (Jun 2009). "Hyperglycemic crises in adult patients with diabetes." Diabetes Care 32 (7): 1335-43. Doi: 10.2337/dc09-9032. PMC 2699725. PMID 19564476.
[3]. Shi, Yuankai; Hu, Frank B. " The global implications of diabetes and cancer". The lancet 383 (9933): 1947-8. Doi: 10.1016/S0140-6736 (14)60886-2. PMID 24910221.
[4]. Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, et al. (Dec 15, 2012). " Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systemic analysis for the Global Burden of Disease Study 2010.". lancet 380 (9859): 2163-96. Doi:10.1016/s0140-6736(12)61729-2.PMID 23245607.
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| Paper Type | : | Research Paper |
| Title | : | Correlation between Anti-infliximab and Anti-CCP Antibodies Development in Patients with Rheumatoid Arthritis Treated with Infliximab in Baghdad Teaching Hospital |
| Country | : | Iraq |
| Authors | : | Mohammed A. Al-Karkhi || Aida Rashid AL-Derzi || Sarmad M. H. Mohammed Zeiny || Nizar A.Jassim || Batool M.Mahdi || Muhammed M.Al-A |
Abstract: Background: Many of patients with rheumatoid arthritis was currently successfully treated with infliximab(anti-tumor necrosis factor);however, about 30% of the patients do not responded to infliximab.one of postulated hypotheses of not responding is the fast clearance of infliximab due to development of infliximab-anti-infliximab complexes. Objective: to study the correlation between anti CCP and anti-infliximab antibodies in patients with rheumatoid arthritis treated with infliximab. Patients and Methods: fifty Iraqi RA patients(36 females and 14 males) compared with 50 control( 25 healthy control and 25 case control (patients with RA on other treatment) ) were enrolled in this study from begging of March 2014 till end of September 2014.All patients were diagnosed by full history, complete clinical examination and laboratory test............
Key words: anti-infliximab, anti-CCP (anti-cyclic-citrullinated peptide) antibodies, Rheumatoid arthritis.
[1]. Scott, D.L., Wolfe, F. & Huizinga, T.W. Rheumatoid arthritis. Lancet 376, 1094–1108 (2010).
[2]. Helmick CG, Felson DT, Lawrence RC, et al; National ArthritisData Workgroup. Estimates of the prevalence of arthritis andother rheumatic conditions in the United States. Part I. ArthritisRheum. 2008;58(1):15-25.
[3]. Englund, M., Jöud, A., Geborek, P., Felson, D.T., Jacobsson, L.T. & Petersson,I.F. Prevalence and incidence of rheumatoid art hritis in southern Sweden 2008 and their relation to prescribed biologics. Rheumatology (Oxford) 2010, 49, 1563 –1569.
[4]. Al-Rawi ZS, Al-Azawi AJ, Al-Ajili FM, et al. Rheumatoid arthritis in population samples in Iraq. Ann Rhem Dis 1978; 37(1):73-5.
[5]. Smolen JS, Landewe R, Breedveld FC, et al. EULAR recommendations for themanagement of rheumatoid arthritis with synthetic and biologicaldisease-modifying antirheumatic drugs. Ann Rheum Dis 2010; 69:964–75.