iosr-JPBS   Volume-13 ~ Issue-2 ~ March-April 2018

Abstract: Burden of Diabetes is increasing globally. In India it is affecting about 40 million people. High prevalence is attributed to a combination of genetic factors and environmental factors due to urbanization and industrialization. Untreated Diabetes can lead to many complications including foot complications. Prevalence of Diabetic foot ulcers is 3.6% in the clinical population. In about 3 – 5 % of cases ulcers lead to amputation resulting in lifelong disability and dependency. This study was done to emphasize the importance of education in care of feet among the diabetic patients. A sensitized patient will have less chances of developing foot complications. This study aimed to assess the effectiveness of structured teaching programme on foot care among people diagnosed with diabetes. The study was conducted in March 2017- April 2017. 30 people diagnosed with diabetes were included in this study. Mean score difference was seen between the pre and post intervention (t-10.20, p<0.001) knowledge status. Significant difference was seen in areas of foot inspection( 47.34%) and use of foot ware(39.17%). The study concluded that structured teaching programme improved the overall knowledge of the people diagnosed with diabetes

Keywords: Diabetes, diabetic foot care, education, knowledge, prevention

Abstract: Phospholipase A2 Enzymesare Basically Of Three Types i.e The Cytosolic PLA2, Secretory Phospholipase A2And Lipoprotein Associated PLA2. There Is Growing Interest In Developing Novel And Potent PLA2Inhibitors For Various Therapeutic Purposes E.G Alzheimer's Disease, Allergic Conditons, Arthritis And Cancer, Cardiovascular Disorders And To Counter The Envenomation By Bee, Spider And Snake Bites. One Of The Excellent Example Is Darapladib Which Is An Effective And Potent Inhibitor Of The Lipoprotein Associated PLA2and Is Used For Clinical Conditions. On The Other Hand Computational Studies Conducted On The Numerous Snake Species Having Endogenous Phospholipase A2Inhibitors, Can Be Exploited For Therapeutic Purposes..............

Keywords: Phospholipase A2, Inhibitors, Endogenous, Crotoxin, Lipoprotein, Molecular, Therapeutic

Abstract: Aerobiological investigations were carried out over cotton field at Kandhar for two seasons from 7th July to 23rd Dec. 2009 and 10th July to 27th Dec. 2010. A total of 49 and 46 fungal spores were recorded in respected year, out of which Ramularia areola G. F. Atk., (6.82% &9.29%) , cercospora sp. ( 1.01% & 1.70%), Helminthosporium sp. (5.29% & 2.45%), Alternaria sp. (15.19% &16.26%) were found to be pathogenic to the cotton crop. These pathogenic fungi were taken in to a separate count to study corelation of fungal concentration with meteorological parameters and disease incidence. Incidence of pathogenic fungi recorded maximum in the month of August and September in both crop seasons. The percentage contribution of pathogenic fungi was 28.31 % & 29.70% to the total airspora during Ist and IInd crop seasons respectively. Meteorological parameter was maintained throughout the period of investigation.

Keywords: Gossypium sp., Pathogenic fungi weather parameters

Abstract:The Chemiluminescence Immunoassays(CLIA) And Enzyme Linked Immunosorbentassays (ELISA) Per Se Are Widely Used Diagnostic Tools For Detection Of Specific Antigens And / Or Antibodies Present In The Sample Of Interest.The ELISA Is A Most Common And Straightforward Technique, Which Involves A Number Of Variables, Such As Reagent / Sample Addition, Microtiter Plate Washing,Incubation Temperature And Time Etc., Hence If The Test Is Not Performed Correctly It Can Affect Subsequent Steps And Finally The End Results Also. Whereas, Now A Days CLIA Is Quick, Simple, Human Error Free As It Performs Complete Automatic Sample Processing, Testingandprovides Clear Interpretation Of The Test Results...........

Keywords: Immunodiagnostic Kit, Chemiluminescence Immunoassay, Enzyme Linked Immunosorbentassay, Human Immunodeficiency Virus, Hepatitis B Virus Surface Antigen, Hepatitis C Virus

Abstract:Comparative Study On The Antibacterial Activities Of Bee Products (Propolis, Pollen, Bee Wax And Honey) Was Studied To Determine The Antibacterial Efficacy Of These Products Against Pathogenic Gram- Positive Bacteria. (B. Subtilis, S. Aureus, S. Faecalis) And Gram Negative Bacteria (P. Multocida, S Typhi, And E.Coli). Ditch Diffusion Method, Minimum Inhibitory Concentration (Mic) And Minimum Bactericidal Concentration (Mbc) Were Employed To Evaluate The Antibacterial Activities Of These Products. The Result Obtained Were Analyzed Using One Way Analysis Of Variance (Anova). Among The Bee Products, Pollen Was Discovered To Be More Active Against............

Abstract: A validated method was developed for determination of sodium metal content in pantoprazole sodium by using atomic absorption spectrophotometer (AAS). The method was developed on atomic absorption spectrophotometer with 0.2nm slit width with sodium hallow cathode lamp. The read time was set at 5.0 second with 589.0 nm wavelength. The system performance was evaluated by performing the system suitability parameters. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.012 ppm and 0.036 ppm, respectively. The percentages of recovery for low, medium and high spiked concentration levels of sodium metal in pantoprazole sodium were found to be 98.26%, 99.59% and 93.28%, respectively. With the developed method the sodium metal content in pantoprazole sodium bulk sample was found to be 5.72 % which compliance the United States Pharmacopoeia standard.

Keywords: Pantoprazole Sodium, Sodium metal, AAS, Validation.

Abstract: Background:Nutritional rickets (NR)or vitamin D deficiency rickets remain prevalent in developing regions of the world and rank among the 5 most common diseases in children. In Bangladesh, it is the second most common micronutrient deficiency. Despite scope of abundant sun exposure, increasing number rickets incite the mind to search for the risk factors associated with it. Therefore, to evaluate the risk factor for nutritional rickets among 0-5 years children in Bangladesh was the objective of the study. Materials and Methods:This observational study was conducted in Dhaka Sishu (child) Hospital for 2-year period following formal ethical clearance. Total 120 children were include into the study. Of all, 60 children of NR were consideredas cases and another 60 age and sex matched children were taken as control. NR diagnosis was based on clinical, radiologic and biochemical parameters...........

Keywords: Nutritional rickets, Risk factor of nutritional rickets,, vitamin D deficiency management, 0-5 years of age.

Abstract: The Increasing Resistance Of Microorganism To Antibiotics In The Last Decades, Drove Microbiologists, Botanists, And Natural-Products Chemists To Search For Phytochemicals That Could Be Used For Treatment Of Infectious Diseases. Essential Oils, Which Are Derived From Plants, Such As Thujone, Have Been Recognized To Display Many Biological Activities Many Of Which Needed More Exploration. This Study Was Designed To Test The Ability Of Alpha Thujone To Inhibit The Growth And Biofilm Formation Of Clinical Bacterial Isolates. The Agar Dilution Method Used To Detect The Antibacterial.........

Keywords: Essential Oils, Alpha Thujone, Antibacterial Agents, Bacterial Biofilms, Inhibition Of Biofilm Formation

Abstract: Introduction :Les Kératopathies Associées Aux Dysgénésies Du Segment Antérieur Sont Variables Sur Le Plan Physiopathologique, Clinique Et Le Pronostic Dépend De L'étendue De L'atteinte, De L 'Existence D'un Glaucome, D'atteinte De La Surface Oculaire Et De La Précocité De La Prise En Charge. Matériel Et Méthodes : Le But De Ce Travail Est D'illustrer Les Principales Entités Cliniques Associant Une Kératopathie A Travers Des Cas De Dysgénésie Du Segment Antérieur En Excluant Les Kératopathies Congénitales Isolées. Résultats :14 Patients Ont Eté Suivis Entre 2014 Et 2017.La Kératopathie A Eté Observée Au Cours D'une Aniridie Dans 9 Cas, Elle S'intégrait Dans Le Cadre D'un Syndrome D'axenfeld Rieger Dans 1 Cas, 3 Patients Présentaient Une Anomalie De Peters.............

Keywords: Anterior Segment Dysgenesis, Congenital Eye Disorders, Glaucoma, Keratopathy, Visual Impairment.

Abstract: Diabetes shows damage of cells and organs due to improper sugar metabolism. It leads to oxidative damage which cause microvascular and macrovascular complications. It becomes requirement of drug development that act against hyperglycemia and oxidative damage, so the plants containing various bioactive compounds and minerals with less side effects were analyzed for drug development. Among various plants, the commonly used spices black pepper corn (Piper nigrum) is extensively used for various medicinal purposes traditionally. The compounds extracted from P. nigrum are used in many creams to treat various diseases at present selected for analysis. The leaf of Piper nigrum collected from karumandhuri and extracted with ethanol is used for further studies which showed antidiabetic and antioxidant activity in in vitro assay

Keywords: Antioxidant activity, antidiabetic activity, Ethanol, Piper nigrum.

Abstract: Increasing of measles infection cases in last few years is an important issue, which must be dealing with to assess the reasons. Immunizing lab animals with measles vaccine to is a better way understanding of vaccine-induced immune responses against measles vaccine. The current study is done investigated the phagocytosis index and the titer of specific antibody in response to measles vaccine measured by HI test in rabbits who received the vaccination to estimate the immune status after vaccination. Our study revealed that the rabbits subjected to the vaccine demonstrated an increase of 4-fold antibody concentration and increase in phagocytosis index (55.2, 59.8, 53.7, 51.5, 41.7)% after 14 days from immunization with the antigen comparing to the control. These results showed that the live attenuated measles vaccine is efficient. The aim is to evaluate the immune status after vaccination with measles............

Keywords: Measles, virus, immune, response, antigen