Abstract: The usage of Tetracycline's, a broad spectrum group of antibiotics in pregnancy has for years been associated with debate about its teratogenic effects on the fetal bones. Present studies show that not all tetracycline's are bone teratogenic. Notably, minocycline and doxycycline augment bone synthesis at low doses. In addition, doxycycline has been shown not to be teratogenic. The study utilized 30 Albino rat dams weighing between 200-250g and were grouped into a control group(n=3) and experimental group (n=27) rats which were further grouped into 3 different trimesters i.e. trimester 1, 2 and 3 groups each having 9 rats. The 9 rats were further subdivided into 3 different dosing categories as Low (155mg/kg/day), Medium(232mg/kg/day) and High dose (310mg/kg/day) tetracycline groups. Confirmation of pregnancy marked the 1st day of pregnancy upon which treatment was began for rats......
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