Abstract: The human malaria parasite Plasmodium falciparum possess an increasing threat to human health in the tropical regions of the world, and the validation and assessment of possible drug targets is required for the development of new antimalarials. The erythrocytic stages of the parasite responsible for the pathology of the disease in humans, are under enhanced oxidative stress and are particularly vulnerable to exogenous challenges by reactive oxygen species. The disruption of the antioxidant or redox systems of the parasite is a feasible way to interfere with their development during erythrocytic schizogony; targeting these antioxidant or redox system of the parasite is the major property.......
Key word: Plasmodium falciparum thioredoxin reductase; malaria; antimalarial; screening for mechanism of action; Malaria Box
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