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| Paper Type | : | Research Paper |
| Title | : | Design and Evaluation of Regioselective Drug Delivery System By Using Dipyridamole Deug As Model |
| Country | : | India |
| Authors | : | Faheem Unnisa Begum || Maimona Farheen || Asfia Kauser || Ayesha Haseena || Sumaiya Sultana || Zehra Afreen || Zeenath Anjum |
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: | 10.9790/3008-1202020107  |
Abstract: In the present research work the gastro retentive floating matrix formulation of Dipyridamole by using various hydrophilic polymers. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Gas generating agent sodium bicarbonate concentration was optimized. Then the formulation was developed by using different concentrations of polymers of various natural polymers. The formulation blend was subjected to various preformulation studies..............
Keywords: Dipyridamole, Guar gum , Xanthum gum ,HPMC K15 M and Floating tablets.
[1]. Leon Lachman, Herbert A. Liberman, the Theory and Practice of Industrial Pharmacy: P.293-302.
[2]. Robinson Jr, Lee V.H.L, Controlled drug delivery: Fundamentals and Applications, 2nd edn. Marcel Dekker, New york: (1978) P.24-36.
[3]. Brahmankar D.M, Jaiswal S.B, Biopharmaceutics and Pharmacokinetics a treatise, 1st ed. Vallabh prakashan; New Delhi: (1995) P.64-70.
[4]. Chein Y.W, Novel Drug Delivery Systems, 2nd ed.: Marcel Dekker; New York: (1992) P.4-56.
[5]. Ansel, Pharmaceutical Dosage form and Drug Delivery System, Lipincott, 7th edition: P. 553.
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| Paper Type | : | Research Paper |
| Title | : | Drugs Regulation in Telangana State India: A Overview |
| Country | : | India |
| Authors | : | Kempaiah Suresh || Balamuralidhara V || T.M. Pramod Kumar |
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: | 10.9790/3008-1202020813 |
Abstract: Pharmacy is the health profession that links the health science with chemical science and it is charged with ensuring the safe and effective use of pharmaceutical drugs. Telangan has Drugs Control Department independent of the Health Department and the Heads of these Departments are reporting to the Government directly. The State of Telangana as some of the country's most dynamic entrepreneurs who are original and fast-paced in their thinking and focused in their drive for growth and profitability. Telangana is one of the most industrialised states in the country.............
Keywords: Pharmacy profession, Telangana, Education, Health, Drug.
[1]. Profile of Telanaga [Internet], Telangana [cited 2017 Jan 5] - Available from:Wikipedia https://en.wikipedia.org/wiki/Telangana
[2]. Drugs Control Administration, Telangana [Internet] [cited 2017 Jan 8] Available from: PDF]GOVERNMENT OF ANDHRA PRADESH DRUGS CONTROL ... - inogent inogent.com/images/GMP-Certificate-2011.pd
[3]. Drugs Control Administration, Government of Telangana [Internet] [cited 2017 Jan 8] Available from:www.dca.telangana.gov.in/
[4]. Telangana Pharameuctical Industry [Internet] [cited 2017 Jan 8] Available from:PHARMAHITEXwww.hitex.co.in/downloads/Industry%20Reports%20on%20Pharmaceutical%20Industry.pdf [5]. Information on Telangana pharmacy council [Internet] [cited 2017 Jan
[5] Available from:Official Website of Pharmacy Council appharmacycouncil.gov.in/site/bpharmreg [6]. Central Council - Pharmacy Council of India [Internet] [cited 2017 Jan 8] Available from:http://pci.nic.in/CouncilMembers/CentralCouncil.aspx.
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| Paper Type | : | Research Paper |
| Title | : | Characterization and Identification of Some Aerobic Spore-Forming Bacteria Isolated From Saline Habitat, West Coastal Region, Saudi Arabia |
| Country | : | Egypt |
| Authors | : | Naheda Alshammari || Fatma Fahmy || Sahira Lari || Magda Aly |
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: | 10.9790/3008-1202021419 |
Abstract: Ten isolates of aerobic endospore- forming moderately halophilic bacteria were isolated fromsaline habitat at the west coastal region near Jeddah. All isolates that were Gram positive, catalase positive andshowing different colony morphology and shapes were studied. They were mesophilic, neutralophilic, with temperature range 20-40°C and pH range 7-9. The isolates were separating into two distinct groups facultative anaerobic strictly aerobic.............
Keywords: Halobacillus, Bacillus, spore, mesophilic, physiological, morphological
[1]. Abd El-Rahman, H., Fritze, D., Sproser, C.and Claus, D. (2002). Two novel psychrotolerant species, Bacillus psychrotolerans sp. nov. and Bacillus psychrodurans sp. nov., which contain ornithine in their cell walls. Int. J. Syst. Evol. Microbiol., 52: 2127-2133.
[2]. Albuquerque, L., Tiago, I., Taborda, M., Nobre, M,F., Verı´ssimo, A. and Costa, M, S. (2008). Bacillus isabeliae sp. nov., a halophilic bacterium isolated from a sea salt evaporation pond, Int. J. Syst. Evol. Microbiol, 58: 226–230.
[3]. Ash, C., Priest, F.G. and Collins, M.D. (1993). Molecular identification of rRNA group 3 bacilli (Ash, Farrow, Wallbanks and Collins) using a PCR probe test. Proposal for the creation of a new genus Paenibacillus. Antonie Van Leeuwenhoek, 64:253-60.
[4]. Atrih, A., Bacher, G., Allmaier, G., Williamson, M. P. and Foster, S.J. (1999). Analysis of Peptidoglycan Structure from Vegetative Cells of Bacillus subtilis 168 and Role of PBP 5 in Peptidoglycan Maturation, J. Bacteriol., 181: 3956-3966.
[5]. Balca´zar, J, L., Pintado, J. and Planas, M. (2010). Bacillus galliciensis sp. nov., isolated from faeces of wild sea horses (Hippocampus guttulatus). Int. J. Syst. Evol. Microbiol. 60: 892–895..
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| Paper Type | : | Research Paper |
| Title | : | Pesticides Characters, Importance and Microbial Degradation |
| Country | : | Egypt |
| Authors | : | Magda M. Aly || Buthinah A. Al-aidaroos || Fahad A. Alfassi |
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: | 10.9790/3008-1202022028 |
Abstract: Agriculture in Saudi Arabia has been growing rapidly over the years and date palm (Phoenix dactylifera) is the most important agricultural crop.The red palm weevil, Rhynchophorus ferrugineus or Oliver, is considered one of the most economically important pest that attack date palm and many others crops, thus farmers usually use a variety of different types of chemicals called pesticide that are widely used for pest control worldwide, especially in the developing countries.............
Keywords: Diazinon, degradation, bacteria, pesticide, date palm, Rhynchophorus
[1]. Adawiyah, I. (2008). Isolation, characterization and identification of microorganism from soil contaminated with pesticide (Doctoral dissertation, University of Malaysia, Pahang.
[2]. Agarry, S.E., Olu-Arotiowa, O.A., Aremu, M.O. and Jimoda, L.A. (2013). Biodegradation of Dichlorovos (Organophosphate Pesticide) in soil by bacterial isolates. Biodegradation, 3(8): 11-16.
[3]. Amakiri, M.A. (1982). Microbial degradation of soil applied herbicides. Nig. J. Microbiol., 2: 17-21.
[4]. Baghel, P. S. and Pandey,B. (2013). Isolation of microorganism for mioremediation of monocrotophos pesticide. Int. J. Curr. Microbiol. App. Sci., 2(11): 202-205.
[5]. Bakry, N., El-Rashidy, A., Eldefrawi, A. and Eldefrawi, M. (2006). Direct actions of organophosphate anticholin esterases on nicotinic and muscarinic acetylcholinic receptors. J. Biochem. Toxicol., 3(4): 235-259..
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| Paper Type | : | Research Paper |
| Title | : | Postharvest Rot Diseases of Some Stone Fruits Collected From Jeddah City, Saudi Arabia |
| Country | : | Saudi Arabia. |
| Authors | : | Hawazen Hamid Khallaf || Lubna S. Nawar || Fatma H. Tawfiq |
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: | 10.9790/3008-1202022937 |
Abstract: The present investigation was designed to study intensively, the fungi associated with stone-fruits (apricots, cherries, peaches and plums) that causing rots for these kinds of fruits. Survey for the mycoflora of those fruits post-harvesting and during storage periods were carried out. The highest percentage of infection was recorded in fruits with street sellers and the smallest one was recorded in cold storage cars. Mycoflora of the apparently healthy fruits included Alternaria, Aspergillus, Diplodia, Fusarium, Monilinia............
Keywords: Aspergillus, Rot fungi, peach, chitosan, infection, Apricot Peach, Plum, Cherry
[1]. Abdullah, Q., Mahmoud, A., Al-harethi, A. (2016). Isolation and identification of fungal post-harvest rot of some fruits in Yemen. PSM Microbiol., 01(1): 36-44
[2]. Akinmusire, O.O. (2011). Fungal species associated with the spoilage of some edible fruits in Maiduguri Northern Eastern Nigeria. Advances in Environmental Biology, 5(1): 157-161.
[3]. Al-Hindi, R.R., Al-Najada, A.R., Mohamed, S.A., (2011). Isolation and identification of some fruit spoilage fungi: Screening of plant cell wall degrading enzymes. Afr. J. of Microbiol.
[4]. Snowdon, A.L., (1990). Color atlas of post-harvest diseases and disorders of fruits and vegetables, General Introduction and Fruits. CRC Press, Boca Raton FL. (1).302. Res., 5(4): 443-448.
[5]. Allen, S, E, Grimshaw, M.H, Parkinson, J.A. and Quarmby, C. (1974). Chemical Analysis of Ecological Materials. Blackwell's Scientific Publications, Oxford.
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| Paper Type | : | Research Paper |
| Title | : | Knowledge, Attitudes and Practices of Patients Regarding Chronic Wound Care and Point Prevalance of Chronic Wounds at Surgical and Medical Units in Teaching Hospital Karapitiya, Sri Lanka |
| Country | : | Sri Lanka |
| Authors | : | Priyadarshani R A C || Samarawickrama M B |
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: | 10.9790/3008-1202023846 |
Abstract: Management of chronic wounds remains a challenging clinical problem. The correct and efficient management of wounds by health professionals as well as the compliance of patients are essential for healing of these wounds. Objective: To identify the knowledge, attitudes and practices of patients regarding chronic wound care and to assess point prevalence of different types of chronic wounds in surgical and medical units in Teaching Hospital Karapitiya (THK), Sri Lanka. Methodology: This study was performed on patients who were admitted and treated for chronic wounds at surgical and medical units, in THK during a one month period from 1st April 2016 to 30th April 2016. Their knowledge on aetiology, treatments..............
Keywords: Chronic wounds, knowledge, attitude, practices.
[1]. Martin C robson, David L Steed, Michael G Franz Wound healing: biologic features and approaches to maximize healing trajectorie current problem in surgery February 2001vol. 38 issue 2, p A1, 72-140. at http://www.currprobsurg.com/article/S0011-3840(01)00036-3/pdf
[2]. Velnar T, Bailey T, Smrkolj V. (2009) the wound healing process: an overview of the cellular & molecular mechanisms. The Journal of International Medical Research. 37:1528-1542.
[3]. Ian D. Graham, Margaret B. Harrison,Mona Shafey, David Keast, Knowledge and attitudesregarding care of leg ulcers Survey of family physicians Canadian Family Physician, VOL 49: JULY. 2003 p 896-902
[4]. Nurhusien Nuru, Fisseha Zewdu, Senafikish Amsalu and Yohannes Mehretie Knowledge and practice of nurses towards prevention of pressure ulcer and associated factors in Gondar University Hospital, Northwest Ethiopia, BMC Nursing (2015) 14:34 [5]. Robert Nunan, Keith G. Harding, Paul Martin Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity Disease Models & Mechanisms 2014 7: 1205-1213; doi: 10.1242/dmm.016782 at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213725/.
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| Paper Type | : | Research Paper |
| Title | : | The antibacterial activity of the traditionally used Cymbopogon schoenanthus and Senna holosericea, collected from Alabwa region, Saudi Arabia |
| Country | : | Egypt |
| Authors | : | Magda M. Aly || Worood A. Al-youbi || Amal Y. Aldhebiani |
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: | 10.9790/3008-1202024852 |
Abstract: The biodiversity of medicinal plants have many economic importances and improve human health. Many biologically active compounds were isolated from plants that were traditionally used in folkloric medicine . These compounds can be either a new drug or a base for new drug. The antibacterial activity of the traditionally used Cymbopogon schoenanthus and Senna holosericea, collected from Alabwa region, Saudi Arabia was determined using agar well diffusion method. The plants were collected, identified and extracted using both different organic solvents (methanol, ethanol and acetone) and hot water. The tested bacteria were multidrug resistant, Escherichia coli, Micrococcus lutes, Klebsiella pneumonia, and Shigella sonnei..............
Keywords: Artemia salina, Cymbopogon schoenanthus, Senna holosericea, antibiotic, extract
[1]. Adoum OA, Akinniyi JA, Omar T (1997). The effect of geographical location on the antimicrobial activities and trace element concentrations in the root of Calotropis procera (Ait.) R. Br, Annals of Borno, 13(14): 199-207.
[2]. Adoum OA. (2009). Determination of toxicity levels of some savannah plants using brine shrimp test. Bst., 2 (1): 135–38.
[3]. Al Masoudi SB, Aly MM, Al-humidi NQ, Halwani M. (2013). Incidence and prevalence of Acinetobacter baumannii in King Fahd General Hospital, Saudi Arabia. Life Sci J.;10(4):1702-1710.
[4]. Aly MM and Bafeel S. (2008). Screening for antimicrobial activity of some medicinal plants in Saudi Arabia. World Conference on Medical and Aromatic Plants. WOCMAP IV Using Plants for the Benefit of People. 9-14 November; South Africa.
[5]. Aly MM and Bafeel S. (2010). Screening for antifungal activities of some medicinal plants used traditionally in Saudi Arabia. J. Appl. Anim. Res., 38:39-44..
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| Paper Type | : | Research Paper |
| Title | : | In Vitro Studies of Some Medicinal Plants Extracts for Antiviral Activity against Rotavirus |
| Country | : | Egypt |
| Authors | : | Zakia F. S. AL-Ballawi || Nezar A. Redhwan || Mohamed Ali |
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: | 10.9790/3008-1202025358 |
Abstract: Every year, Rotavirus infection is responsible for over 600,000 childhood deaths worldwide, occurring mainly in developing countries in addition to infections of elderly people in nursing homes and compromised patients. In this study, we investigated in vitro antiviral activity of aqueous extracts of some medicinal plants including, garlic bulbs (Allium Sativum), ginger rhizomes (Zingiber officinale), pomegranate peel (Punica granatum ) and Lemongrass leaves (Cymbopogon citratus) against rotavirus. The study was carried out using multiple approaches both at cellular level using cell live MA-104 such as the Plaque assay which used for determining the quantity..............
Keywords: Medicinal plants, Antiviral, Rotavirus, Cymbopogon citrates, Punica granatum, Zingiber officinale,
[1]. Ahmed MU, Urasawa S, Taniguchi K, Urasawa T, Kobayashi N, Wakasugi F, (1991). Analysis of human rotavirus strains prevailing in Bangladesh in relation to nationwide floods brought by the 1988 monsoon. J Clin Microbiol; 29:2273–9
[2]. Bern, C., Martines, J. de Zoysal, I and Glass. R. I. (1992). The magnitude of the global problem of diarrhoeal disease: a ten-year update. Bull. W. H. O. 70:705-714.
[3]. Andres, A., Donovan, S.M.; Kuhlenschmidt, T.B. and Kuhlenschmidt, M.S. (2007). Isoflavones at concentrations present in soy infant formula inhibit rotavirus infection in vitro. The Journal of Nutrition, 2068-2073.
[4]. Ankri, S. and Mirelman, D. (1999). Antimicrobial properties of allicin from garlic. Microbes and Infection, 2:125-129.
[5]. Bae, E. A.; Han, M. J.; Lee, M. and Kim, D. H. (2000). In vitro inhibitory effect of some flavonoids on rotavirus infectivity. Biological and Pharmaceutical Bulletin, 23:1122- 1124..
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| Paper Type | : | Research Paper |
| Title | : | Importance, Destruction and Recovery of Coral Reefs |
| Country | : | USA |
| Authors | : | Leonie Sophia van den Hoek || Emad K. Bayoumi |
|
: | 10.9790/3008-1202025963 |
Abstract: Coral reefs are an incredibly valuable ecosystem. [2] Coral reefs are being degraded worldwide by several reasons such as; human activities, increases in cyclone intensity, climate warming, bleaching and so on. The increasing frequency and severity of anthropogenic impacts throughout the global ocean have an impact on the coral reefs. This worldwide decline of coral reefs calls for an urgent reassessment of current management practices [1]. Coral reefs are important for our world for several reasons. Besides the fact that they are very beautiful and attract tourists, thus they function as a very important income, and they have other benefits for our marine environment and world such as symbioses and a source to finding medicine. In this review we point out the importance, destruction and the recovery of coral..............
Keywords: marine ecosystems, coral reefs, symbioses, biodiversity,
[1]. D. R. Bellwood, T. P. Hughes, C. Folke, M. Nyström. (2004), Confronting the coral reef crisis. Nature 429, 827-833. doi:10.1038/nature02691.
[2]. Cesar, H, and Burke, L. and Pet-Soede, L (2003) The Economics of Worldwide Coral Reef Degradation. Technical Report.
[3]. Nicholas H. Putnam1, Mansi Srivastava2, Uffe Hellsten1, Bill Dirks2, Jarrod Chapman1, Asaf Salamov1, Astrid Terry1, Harris Shapiro1, Erika Lindquist1, Vladimir V. Kapitonov3, Jerzy Jurka3, Grigory Genikhovich4, Igor V. Grigoriev1, Susan M. Lucas1, Robert E. Steele5, John R. Finnerty6, Ulrich Technau4, Mark Q. Martindale7, Daniel S. Rokhsar1,2, Science 06 Jul 2007: Vol. 317, Issue 5834, pp. 86-94, DOI: 10.1126/science.1139158
[4]. Barnes, R.D. 1987. Invertebrate Zoology; Fifth Edition. Fort Worth, TX: Harcourt Brace Jovanovich College Publishers. pp. 92-96, 127-134, 149-162.
[5]. (David W. Townsend, Oceanography and Marine Biology, 2012, ISBN 9780878936021).
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| Paper Type | : | Research Paper |
| Title | : | Combination of Ficus Carica Leaves Extract and Ubiquinone in a Chronic Model of Lithium Induce Reproductive Toxicity in Rats: Hindrance of Oxidative Stress and Apoptotic Marker of Sperm Cell Degradation |
| Country | : | Egypt. |
| Authors | : | Shimaa A. Haredy || Tamer S. Imam || Omar A. Ahmed-Farid |
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: | 10.9790/3008-1202026473 |
Abstract: Lithium carbonate (LC) is the most widely used as antipsychotic drug and can suppress reproductive performance via testicular toxicity and induction of oxidative stress. The aim of the study was to investigate biological activities of Ficus carica extract (FC) and ubiquinone (Coq10) against LC induced reproductive toxicity in male rats. For this purpose forty two Wistar albino rats were used in this study and allocated into seven groups 6 of each. 1st groups was served as normal control rats, received distill water (C). 2nd groups orally treated with 200 mg /kg body weight of Ficus carica extract (FE). 3rd groups orally administered with 20 mg /kg body weight of CoQ10 (CoQ10). 4th groups orally treated with 25 mg /kg body weight of Lithium carbonate (LC). 5th group simultaneously treated with 25 mg /kg body weight of Lithium carbonate and 200mg/kg b.w of FE (FC+ LC). .6th group simultaneously treated with 25 mg /kg body weight of Lithium carbonate and CoQ10 (20 mg/kg b.w) (LC+CoQ10).............
Keywords: Ficus carica, CoQ10, Lithium, semen quality, Caspase-3 and rats.
[1]. Abdel-Hady, E-S. K. and Abdel-Rahman, G. H. (2011). Protective effect of coenzyme q10 on cadmium-induced testicular damage in male rabbits,American-Eurasian Journal of Toxicological Sciences 3; 153–160.
[2]. Abdul-Rasheed, O. F. Farid, Y.Y. and Al-Nasiri, U. S. (2010). Coenzyme Q10 and oxidative stress markers in seminal plasma of Iraqi patients with male infertility. Saudi Med J. 31(5):501-6.
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[4]. Ahmed-Farid O. A, El-Sayed AI, Iraqi MM, Saad AM, Radwan AA. (2014). Comparative evaluation of different herbal formula and L-Carnitine on reproductive performance of male Moshtohor rabbits. 2nd International conference on biotechnology applications in agriculture (ICBAA), Benha University, Moshtohor and Hurghada. 8-12.
[5]. Algohary, A. M. Ahmad-Farid, O. A. Abd-Elrazek, A. M. and Al-Baradie, R. S. (2016). Neuroprotective effects of herbal cocktail on cerebrovascular dysfunction in rats with induced hyperhomocysteinaemia. Biomed Res Ther, 3(12): 1045-1061..
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| Paper Type | : | Research Paper |
| Title | : | Role of Diffusion Weighted MRI in Evaluation of Urinary Bladder Cancer in Iraqi Patient in Correlation with Histopathological Grade |
| Country | : | Iraq |
| Authors | : | Dr. Khaleel Ibraheem Mohson || Dr. Mohammed Bassil Ismail || Dr. Sura Tami Abduljabbar |
|
: | 10.9790/3008-1202027477 |
Abstract: Background: Bladder cancer is a common urologic cancer that has the highest recurrence rate of any malignancy. MRI (magnetic resonance imaging) is a vital complementary diagnostic device in the diagnosis, staging, and follow up of bladder cancer.
Objectives: The main purpose of this study was to explore the diagnostic effectiveness of pelvic MRI including ADC (apparent diffusion coefficient) and DWI (diffusion weighted imaging) in the assessment of bladder cancer grade and thus helping in patients' management.
Methods: A cross sectional study comprised forty preoperative patients complaining of hematuria referred to the urology consulting clinic in martyr Ghazi Al-Hariri hospital in Baghdad during the period from January 2015 to September 2016.............
Keywords: Diffusion weighted MRI, apparent diffusion Coefficient, urinary bladder cancer, histopathological grade.
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[2]. Roupret M, Zigeuner R, Palou J et al. European guidelines for the diagnosis and management of upper urinary tract urothelial cell carcinomas: 2011 update. Eur. Urol. 2011; 59: 584–94.
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| Paper Type | : | Research Paper |
| Title | : | Pine Bark Extract Protects Against Oxidative Stress Induced By Recurrent Hypoglycemia In Rats |
| Country | : | Egypt |
| Authors | : | Mamdouh Rashad Farag El-Sawi |
|
: | 10.9790/3008-1202027883 |
Abstract: The present work was designed to evaluate the role of pine bark extract (PBE) in protecting rats from oxidative stress produced by recurrent hypoglycemia. The animals were grouped as the following: control group, PBE-treated group (treated with 150 mg/ kg b wt; daily via oral gavage for 30 consecutive days); recurrent hypoglycemia group (injected with 1.14 units of insulin/ kg b wt; day after day subcutaneously, for 30 days) and recurrent hypoglycemia & PBE-treated group (the rats received PBE and insulin as in group 2 and group 3, respectively). Serum glucose and total proteins (TP) as well as liver and brain glycogen contents were significantly decreased when compared.............
Keywords: Oxidative stress; recurrent hypoglycemia; Pine bark extract; Insulin; Rats.
[1]. W. Dröge, Free radicals in the physiological control of cell function. Physiol. Rev., 82(1), 2002, 47-95. [2]. J. Patočkova, P. Marhol, E. Tumova, M. Krisiak, R. Rokyta, S. Stipek, J. Crkovska and M. Andel, Oxidative stress in the brain tissue of laboratory mice with acute post insulin hypoglycemia, Physiol Res., 52 (1), 2003, 131-135.
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[5]. X. Fioramonti, A. Deak, S. Deshpande, L. Carneiro, C. Zhou, N. Sayed, B. Orban, J. R. Berlin, L. Pénicaud, C. Leloup, A. Beuve and V. H. Routh, Hypothalamic S-nitrosylation contributes to the counter-regulatory response impairment following recurrent hypoglycemia. PLoS One, 8 (7), 2013, e68709.
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| Paper Type | : | Research Paper |
| Title | : | Synthesis and Evaluation of Some Novel N, N-Dialkylaminoalkoxy-2-Oxo-Indole-3-Ylidene Benzohydrazides as Anticonvulsant Agents |
| Country | : | India |
| Authors | : | Sravanthi Madhira || Kiranmai Mandava || Sarangapani Manda || Sai Prasanna R || Vijayalaxmi T |
|
: | 10.9790/3008-1202028493 |
Abstract: A series of N,N-dialkylaminoalkoxy-2-Oxo-indole-3-ylideneBenzohydrazides were synthesized by using the well designed synthetic route and the purity of the compounds were assessed by TLC, and characterized by FT-IR, NMR spectral data. The anti-convulsant activities of the synthesized compounds were evaluated against MES and PTZ induced seizure models in mice. All the test compounds were administered at doses of 50mg/kg body weight orally for MES method. The stimulus parameters in mice were 50mA in a pulse of 60Hz for 200ms. Intraperitonially for a PTZ............
Keywords: Anticonvulsant activity, Benzo hydrazides, Maximal electroshock, Pentylenetetrazole, 5-HT2c receptors, Molecular docking studies
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| Paper Type | : | Research Paper |
| Title | : | A New Dammarane Triterpenoid Compound Isolated From Ixora Finlaysoniana |
| Country | : | Egypt |
| Authors | : | Magda T. Ibrahim || Khaled Meselhy || Asmaa I. Ali || Amany A. Sleem |
|
: | 10.9790/3008-12020294105 |
Abstract: The air-dried leaves of Ixora finlaysoniana Wall. ex. Don ( family Rubiaceae) afforded a new dammarane triterpenoid named: 17β-dammara-1-one -20 ene-3β-3', 8'-dimethyloctanoate (1) together with two known saturated fatty acids capric (2) and palmitic (3) from the chloroform extract as well as three phenolic.............
Keywords: Ixora finlaysoniana, Rubiaceae, dammarane triterpenoid, kaempferol derivatives, isoflavones
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| Paper Type | : | Research Paper |
| Title | : | Modeling, Simulation, Docking Studies of Tyrosine Kinase Involved in Leukemia and Microwave Synthesis of Quinazoline Derivatives |
| Country | : | India |
| Authors | : | Raju Bathula || Satla Shobha Rani || K. Rama Devi |
|
: | 10.9790/3008-120202106116 |
Abstract: Acute Mylenoid Leukemia is a type of cancer which affects blood and bone marrow and is characterized by an abnormal proliferation of white blood cells. A number of genes are involved in regulating heamatopoiesis, and thereby affecting the susceptibility to Leukemia.One among them Tyrosine kinase which plays an important role in cell proliferation and differentiation. In this work three dimensional model of Tyrosine kinase was generated using 1Z3S as a template with the help of Modeller7v7. With the aid of the molecular mechanics and molecular dynamics methods, the final model is obtained and is further assessed by Procheck and Verify 3D graph programs.............
Keywords: Acute mylenoid Leukemia, Tyrosine Kinase, Modelling, Molecular Dynamics, Docking studies, stearic hindrance.
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