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| Paper Type | : | Research Paper |
| Title | : | Anti-Obesity Potential of Heritiera Fomes Leaves Methanolic Extract in a Preclinical Model |
| Country | : | India |
| Authors | : | M.Salim Mirza || Sayed Ayaz Ali || Indrajeet Sanghvi |
 |
: | 10.9790/3008-1204010105  |
Abstract: Objective: This study was undertaken to evaluate the anti-obesity potential of the methanolic extract of leaves of Heritiera fomes. (MEHF) in high fat cafeteria diet (HFCD) fed obese rats.
Methods: Wistar strain of albino rats were divided into six groups comprising of six rats each. Group I served as normal control fed with normal pellet chow, group II served as disease control fed with high fat cafeteria diet, group III, IV and V animals, received MEHF at a dose level of 100, 200 and 400mg/kg b.w along with HFCD for 40 days, while, group VI served as standard drug control, which received Orlistat at a dosage of 50mg/kg b.w along with HFCD.............
Keywords: High Fat Cafeteria diet, Obesity, Heritiera fomes, Orlistat.
[1]. Vinay Kumar, Uma Bhandari, Chakra Dar Tripathi, Geetika Khanna. Evaluation of antiobesity and cardioprotective effect of Gymnema sylvestre extract in murine model. Indian J Pharmacol 2012; 44(5): 607-613.
[2]. Mokdad A, Ford E, Bowman B, Dietz W, Vinicor F, Bales V, Marks J. Prevalence of obesity, diabetes, and obesity related health risk factors. JAMA 2003; 289: 76–79.
[3]. Cragg GM, Newman DJ. Natural Product Drug Discovery in the Next Millennium. Pharm Biol 2001; 39(1): 8-17.
[4]. Ali, K. Nahar, M. Sintaha et al., "An evaluation of antihyperglycemic and antinociceptive effectsof methanol extract of Heritiera fomes Buch- Ham. (Sterculiaceae) barks in Swiss albino mice," Advances in Natural and Applied Sciences, vol. 5, no. 2, pp. 116–121, 2011.
[5]. M. A. Hossain, S. Panthi, M. Asadujjaman, S. R. Khan, F. Ferdous, and S. K. Sadhu, "Phytochemical and pharmacological assessment of the ethanol leaves extract of Heritiera fomes Buch. Ham. (Family- Sterculiaceae)," Journal of Porphyrins and Phthalocyanines, vol. 2, pp. 95–101, 2013.
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| Paper Type | : | Research Paper |
| Title | : | Evolution of Reovirus in Cancer Therapy |
| Country | : | India |
| Authors | : | Bindhu Jayaprakash || Sivapriya Veeraiyan || Silambarasan Gunaseelan || Yasodha Purushothaman |
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: | 10.9790/3008-1204010614 |
Abstract: The overactive Ras signaling can ultimately lead to cancer. The 3 Ras genes in humans (HRas, KRas, and NRas) are the most common oncogenes in human cancer.Mutations that permanently activate Ras are found in 20% to 25% of all human tumors and up to 90% in certain types of cancer (e.g., pancreatic cancer). For this reason, Ras inhibitors are being studied as a treatment for cancer and other diseases with Ras overexpression. Reovirus was noted to be a potential cancer therapeutic when studies suggested it reproduces well in certain cancer cell lines..............
Keywords: Reovirus, monotherapy, anticancer
[1] Goodsell DS (1999). "The molecular perspective: the ras oncogene". Oncologist. 4 (3): 263–4. PMID 10394594.
[2] Jump up^ Downward J (January 2003). "Targeting RAS signalling pathways in cancer therapy". Nat. Rev. Cancer. 3 (1): 11–22. PMID 12509763. doi:10.1038/nrc969.
[3] 24 Lal R, Harris D, Postel-Vinay S, de Bono J (October 2009). "Reovirus: Rationale and clinical trial update". Curr. Opin. Mol. Ther. 11 (5): 532–9. PMID 19806501.
[4] Coffey MC, Strong JE, Forsyth PA, Lee PW. Reovirus therapy of tumors with activated Ras pathway. Science. 1998;282(5392):1332–1334. [PubMed]
[5] Schirrmacher V, Fournier P. Newcastle disease virus: a promising vector for viral therapy, immune therapy, and gene therapy of cancer. Methods Mol Biol. 2009;542:565–605. [PubMed].
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| Paper Type | : | Research Paper |
| Title | : | Male Aphrodisic Screening of Plants Mucuna Prurita, Mesua Ferrea, Punica Granatum on Rats |
| Country | : | India |
| Authors | : | Sonu Sharma || Dr. Ashish K. Sharma |
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: | 10.9790/3008-1204011527 |
Abstract: India has a rich culture of medicinal herbs and spices, including Ayurvedic, Unani, Siddha and other traditional medicines but only very few have been studied chemically and pharmacologically for their potential medicinal value. According to the World Health Organization, most populations still rely on traditional medicines for their psychological and physical health requirements. Herbal medicines are in great demand in both developed and developing countries as a source of primary health care owing to their attributes having wide biological.............
Keywords: Pruritus, Haemorrids, Ulcers, Depsia, Impotency, Leucorrhoea, Haemoptysis, Cephalalgia, Fever , Cardiac Debility.
[1] Ghosh K and Bhattacharya T K. "Preliminary study on the anti implantation activity of compound from the extracts of seeds of thespesiapopulnea. India Journal of Pharmacology. 2004; 36 : 288-291
[2] Thakare V N, Kothavade P S, Dhote V V, Deshpande A D. Antifertility Activity of Ethanolic Extract of Allium cepaLinn in Rats. International Journal of PharmTech Research. 2009;1 : 73-78
[3] Singh Shiv Pal. Fertility Control of Female through SesbaniSesbian Seeds. The Journal of Research and Education in Indian Medicine. 1990; 9 (4): 27- 32.
[4] ShahuAlakh N. Phyto-pharmacological review of mesuaferrealinn. International Journal OfPhytopharmacology. 2014; 5(1): 6-14.
[5] Ramya R, Sivasakthi R, Senthilkumar C, Anudeepa J, Santhi N, Venkata Narayanan N: Preliminary phyto chemical and anti fertility Studies on Dodonea viscose Linn.Asian Journal Res Pharm Sci, 2011; 1 : 77-79
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| Paper Type | : | Research Paper |
| Title | : | Prevalence of Antibiotic Resistance in Clinical Strains of E. Coli and Their Control |
| Country | : | India |
| Authors | : | Sujatha.J || Anusuya.P |
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: | 10.9790/3008-1204012833 |
Abstract: The present study was to evaluate the isolates of antibiotic resistant E. coli in clinical samples and their control. A total of 50 E. coli strains were isolated from samples such as ENT, Pus and UTI. 5 different antibiotics were tested. 20% of the strains showed resistance to single antibiotic (AMP, AMX), whereas rest of the strains to 2-5 antibiotics (i.e.) AMP-AMX (6%); AMP-AMX-CXM (16%), AMP-AMX-CN (20%), AMP-AMX-CN-CPD (20%), and AMP-AMX-CXM-CN-CPN (18%). MAR index for the isolates was found to be from 0.4-1.0..............
Keywords: E.coli, Haemolytic, β-lactam, Antibiotic resistance
[1] Agwu, O.A and O. Oluwagunke, 2014. Pattern of multiple antibiotics resistance among surface water Escherichia coli. Adv. Life Sci., 4(5): 213-219.
[2] Balagué, C. and E.García-Véscovi, 2001. Cultivation of multiple antibiotic resistances in uropathogenic Escherichia coli strains by aryloxoalcanoic acid compounds. Antimicrob. Agents Chemother, 45: 1815-1822.
[3] Beutin, L., M. A. Montenegro, I. Ørskov, F. Ørskov, J. Prada, S. Zimmermann and R. Stephan, 1989. Close association of verotoxin (shiga-like toxin) production with enterohemolysin production in strains of Escherichia coli. J. Clin. Microbial, 27: 2559–2564.
[4] Bonnet, R., 2004. Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes. Antimicrob. Agents Chemother, 48: 1–14.
[5] Boon, P. I., and M. Cattanach. 1999. Antibiotic resistance of native and faecal bacteria isolated from rivers, reservoirs and sewage treatment facilities in Victoria, south-eastern Australia. Lett. Appl. Microbiol., 28:164-168..
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| Paper Type | : | Research Paper |
| Title | : | Protease Production from Immobilized Bacillus Subtilis and Its Application |
| Country | : | India |
| Authors | : | Dr.K. Jagathy |
|
: | 10.9790/3008-1204013437 |
Abstract: Biofilm is a complex aggregation of microorganisms growing on a solid substrate. Biofilms are characterized by structural heterogeneity, genetic diversity, complex community interactions, and an extracellular matrix of polymeric substances. Hence adherent cells are frequently embedded within a self-produced matrix of extracellular polymeric substance (EPS). Biofilms have been found to be involved in a wide variety of microbial infections in the body, by one estimate 80% of all infections. Biofilms have been implicated in urinary tract infections, catheter infections.............
Keywords: Bacillus subtilis, Biofilm, Biuret method, Protease.
[1] Adinarayana, K. Jyothi, B and Ellaiah, P. 2005. Production of Alkaline Protease with Immobilized Cells of Bacillus subtilis. AAPS PharmSciTech; 6: (3) 48-52.
[2] Champion Lee I-Ming Chu and Tsu-Shun Li. 2002. The protease enzyme production and immobilization. Enzyme and Microbial Technology 14: 9, 755-76.
[3] Chapman, J. W and Piggot, P. J. 1987. Analysis of the inhibition of sporulation of Bacillus subtilis caused by increasingthe number of copies of the spoOF gene. J. Gen. Microbiol. 133:2079-2088.
[4] Eric, D. van Hullebusch,. Marcel, H. Zandvoort and Piet, N.L. 2003. Lens Metal immobilisation by biofilms: Reviews in Environmental Science and Biotechnology. 2: 9-33.
[5] Fukui, S and Tanaka, A. 1982. Immobilized microbial cells. Ann. Rev. Microbiol., , 36: 145-172
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| Paper Type | : | Research Paper |
| Title | : | Isolation and Partial Characterisation of Bacteriocin Produced By Lactobacillus Fermentum |
| Country | : | India |
| Authors | : | K. Vanmathi Selvi || R.Kanthamani |
|
: | 10.9790/3008-1204013844 |
Abstract: The present study was confined to the velar estuary in Cuddalore District, Tamil Nadu.Water samples were collected to isolate the bacteria. The collected samples were plated (MRS agar), incubated and the Bacterial colonies were identified. Effect of different ecological parameters such as pH (6-11), temperature (30-60ºC), salinity (0.5-3%), substrates (carbon &nitrogen source) on the growth of bacteria was also determined. Maximum bacterial growth was observed in pH 9,.............
Keywords: Growth characteristics - Effect of physical and chemical parameters, SDS-PAGE, Lactobacillus fermentum (Bacteriocin)
[1] Abee, T., L.Krockel and C.Hill, 1995. Bacteriocins:modes of action and potentials in food preservation and control of food poisoning. Int. J. Food Microbiol., 28:169-185.
[2] Andersen, E.L., D.B. Diep, I.F. Nes, V.G.H. Eijsink, J. Nissen-Meyer, 1998. Antagonestic activity of Lactobacillus plantarum CII: two new two-peptide bacteriocins, plantaricins EF and JK, and the induction factor plantaricin A. Appl. Environ. Microbiol., 64:2269-2272.
[3] Corsetti, A, M. Gobbetti, E. Samcchi, 1996. Antibacterial activity of sourdogh Lactic acid bacteria: isolation of a bacteriocin like inhibitory substance from Lactobacillus sanfrancico C57. Food Microbiol., 13:447-456.
[4] Diep, D.B. and I.F. Ner, 2002. Ribosomally synthesized antibacterial peptides in gram positive bacteria. Curr. Drug Targ., 3:107-122.
[5] Ennahar, S., D. Aoude-werner, O. Sorokine, A. Van Dorsselaer, F. Bringel, J.C. Hubest, and C. Hasselman, 1996. Production of pediocin ACH by Lactobacillus plantarum WHE 92 isolated from cheese. Appl. . Envion. Microbiol., 62:4381-4387.
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| Paper Type | : | Research Paper |
| Title | : | Pharmacognostical and Phytochemical Evaluation of Leaves of Mimusops elengi L. |
| Country | : | India |
| Authors | : | Vineeta Singh || V.N. Pandey || Kalawati Shukla |
|
: | 10.9790/3008-1204014549 |
Abstract: Herbal drug attaining wide acceptance day by day because they are safe, very effective and less costly. The utilization of plant as a medicine is mentioned in Ayurveda, Siddha, Unani medicines etc. but the therapeutic properties of most of them have not be proven scientifically. Therefore, Pharmacognostic and Phytochemical evaluation of Mimusops elengi L. is carried out to know the complete information of crude drug. Mimusops elengi L. (Sapotaceae) is an important medicinal plant because each and every part is used in treatment of various ailments..............
Keywords: Herbal drugs, Physiochemical, Pharmacological, Sapotaceae..
[1] Fransworth NR., AkereleOlayiwola, Bingel AS, Soejarto DD, Guo Z. Medicinal plant in therapy. Bulletin of the WHO, 1985; 63(6): 965-981.
[2] Chopra RN., Nayar SL., Chopra IC.Glossary of Indian Medicinal plants. CSIR, New Delhi, 1956; 169.
[3] Chopra RN, Nayar SL, Chopra IC, Handa KL, Kapoor LD. Indigenous drug of India. UN Dhur and Sons. Ltd. Calcutta, 1958; 514.
[4] Dymock W, Warden CJ, Hooper D. Pharmacographia indica, vol I, Thacker, spink and co, Calcutta, 1891.
[5] Nadkarni, AK. Dr. K.M. Nadkarni's India MateriaMedica 3rdedn. Popular Book Depot Bombay, 1954; 800-802..
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| Paper Type | : | Research Paper |
| Title | : | Evaluation of Wound Healing Activity of Aerial Parts of Ocimum Basilicum Linn and Bark of Ficus Benghalensis Linn and Their Polyherbal Formulation in Wound Healing Models |
| Country | : | India |
| Authors | : | Gaurav Dubey || Satkar Prasad || Sailesh Kumar Ghatuary || Anil Sarathe || Kalpana Prajapati || Reena Sheride |
|
: | 10.9790/3008-1204015056 |
Abstract: A wound is break in the skin. Wound are usually caused by cuts or scalps, symptoms at wound or injury include swelling, stiffness, tenderness, discoloration skin tightness, itching and scar formation, two types of tissue injury:. Wound healing is a complex dynamic process. The main objective of this investigation is to evaluate wound healing activity of aerial part of Ocimum basilicum Linn and bark of Ficus benghalensis Linn and their polyherbal formulation in wound healing models..............
Keywords: Epithelisation, Excision, Incision, Tensile strength, Wound.
[1] Baddui, Prakesh ,Nagori et al.,Role of medicinal plants inwound healing , Research Journal of medicinal plants,2011,5(4):392-40.
[2] F Strodtbeck , Physiology of wound healing, new borninfant nurse,2001 Rev.I, page 43-45.
[3] P.Martin , Wound healing – Aiming for perfect skinregeneration, science,1991 vol. 276.No: 5309, pp 75-81.
[4] P Chitra, G.B Sajithalal and G Chandrakasan, Influence Aloe Vera, on collagen turnover in healing of dermal wounds inrates, Indian journal of Exp. Biol, 1998,36: 896-901.
[5] Chitra shenoy, M.B Patil, Ravikumar, Preliminaryphytochemical investigation and wound healing activity ofAllium.Cepalin (Liliaceae). International journal of pharmacy andpharmaceutical sciences; vol.2, issue 2, July – Sep...
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| Paper Type | : | Research Paper |
| Title | : | A Study of Caffeine Level Changes, Fat and Water in Arabica Coffee Due to the Attack of Coffee Borer Pests (Hyphothenemus Hampei). |
| Country | : | Indonesia |
| Authors | : | Olyfia Rosalina || Muhammad Sayuthi || Rita Hayati |
|
: | 10.9790/3008-1204015761 |
Abstract: Coffee borer beetles (Hyphothenemus hampei) generally bore the coffee fruit which its endosperm has already hardened, and thenthere is a disability at coffee bean causing a damage of chemical quality, while the flavor of coffee is influenced by combination of chemical compound components contained in the coffee bean. This study aims to see the changes in levels of caffeine, fat and water in coffee due to the attack of coffee borer beetle (H. hampei). The levels test of caffeine, fat and coffee water were carried out in the laboratory of Baristan Aceh and the farm laboratory of agriculture faculty of Syiah Kuala University..........
Keywords: caffeine level, fat level, water level, Hyphothenemus Hampei..
[1] Aryanu, F. A., Ida, A. R. A. A., I Wayan, S. (2010). Analisis Kandungan Kafein Pada Kopi Di Desa Sesaot Narmada Menggunakan Spektrofotometri Uv-Vis. Jurnal Kimia 10 (1), Januari 2016: 110-114
[2] Brooker, D. B., F. W. Bakker-arkema and C. W. Hall, 1974. Drying Cereal Grains. The AVI publishing Company, Inc. Wesport. Ciptadi, W. dan Nasution, M.Z. 1985. Pengolahan Kopi. Fakultas Teknologi
[3] Coffefag.(2001).Frequently Asked Questions about Caffeine, www.Coffefag.com, Diakses 26 Maret 2013
[4] Farmakologi,U.I. (2002). Farmakologi dan Terapi, 4th ed, Gaya Baru , Jakarta
[5] Gandul. (2010). Sejarah Kopi. http://sekilap.blog.com/ 2010/ 01/05/sejarah-kopi/diunduh 22 juli 2010. Posted by ajhiin Jan 05, 2010.
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| Paper Type | : | Research Paper |
| Title | : | Evolution of Reovirus in Cancer Therapy |
| Country | : | India |
| Authors | : | Bindhu Jayaprakash || Sivapriya Veeraiyan || Silambarasan Gunaseelan || Yasodha Purushothaman |
|
: | 10.9790/3008-1204016270 |
Abstract: The overactive Ras signaling can ultimately lead to cancer. The 3 Ras genes in humans (HRas, KRas, and NRas) are the most common oncogenes in human cancer.Mutations that permanently activate Ras are found in 20% to 25% of all human tumors and up to 90% in certain types of cancer (e.g., pancreatic cancer). For this reason, Ras inhibitors are being studied as a treatment for cancer and other diseases with Ras overexpression. Reovirus was noted to be a potential cancer therapeutic when studies suggested it reproduces well in certain cancer cell lines...............
Keywords: Reovirus, monotherapy, anticancer.
[1] Goodsell DS (1999). "The molecular perspective: the ras oncogene". Oncologist. 4 (3): 263–4. PMID 10394594.
[2] Jump up^ Downward J (January 2003). "Targeting RAS signalling pathways in cancer therapy". Nat. Rev. Cancer. 3 (1): 11–22. PMID 12509763. doi:10.1038/nrc969.
[3] 24 Lal R, Harris D, Postel-Vinay S, de Bono J (October 2009). "Reovirus: Rationale and clinical trial update". Curr. Opin. Mol. Ther. 11 (5): 532–9. PMID 19806501.
[4] Coffey MC, Strong JE, Forsyth PA, Lee PW. Reovirus therapy of tumors with activated Ras pathway. Science. 1998;282(5392):1332–1334. [PubMed]
[5] Schirrmacher V, Fournier P. Newcastle disease virus: a promising vector for viral therapy, immune therapy, and gene therapy of cancer. Methods Mol Biol. 2009;542:565–605. [PubMed].
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| Paper Type | : | Research Paper |
| Title | : | Study And Assessment Of Drug-Drug Interactions In Hospitalised Patients In Quaternary Care Hospital |
| Country | : | India |
| Authors | : | Bhavana Chowdary M || Chaitra.T || D Sai Muktha Sushma || Johncy Nathasha || R Srinivasan |
|
: | 10.9790/3008-1204017175 |
Abstract: Drug-Drug Interactions (DDI) in patients receiving multi-drug therapy are of wide spread. Such interactions are one of the important cause of adverse drug reactions (ADRs) and may lead to increased risk of mortality and morbidity. Hence, health cost will increase. This study estimates to find out the potential DDIs among the hospitalized patients. The final results of the study concluded with a major preponderance towards ATORVASTATIN and ASPIRIN In which the interaction of ATORVASTATIN and PANTOPRAZOLE can lead..............
Keywords: drug-drug interaction, adverse drug reaction, patient medical record..
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