iosr-JPBS   Volume-13 ~ Issue-4 ~ July-August 2018

Abstract: This original research article aims a comprehensive study on the prevalence of different types of cancer in Bangladesh. In addition, the study investigated the usage of different types of chemotherapeutic drugs to treat various types of cancer. The study also categorized the patients based on the cancer stages when they were treated with chemotherapeutic drugs. An observational and retrospective study was conducted on 100 cancer patients attending National Institute of Cancer Research and Hospital and Ahsania Mission Cancer Hospital from July 2017 to November 2017. Patients were differentiated based on the cancer stage and 32 types of cancer were found of 7 different systems of the body. The study categorized the patients based on the cancer stages, 32 types of cancer were found of seven different systems of the body. Most of the patients receiving treatment from the National Institute...........

Keywords: Chemotherapeutic Drugs Frequency, Cancer Stage, Systems of the Body, Breast Cancer, Cisplatin

Abstract:Spherical Ag NPs particles with smooth surface were obtained in the presence of Cassia auriculata leaves extract. The formation of dimensional structure of spherical took place with the addition of leaves extract and as the amount of 1Molar solution is increased in the reaction system the formation of spherical particles decreased gradually. Again, the prepared Ag NPs was successfully and its value was nearly 61 nm. When the Cassia auriculata leaves extract, it is used as reducing agent of Ag NPs from silver nitrate spherical particles, it was observed that the morphology of Ag NPs have studied by using scanning electron microscopy and Transmission electron microscopy after calcinations at 350 °C. The anticancer activities of Cassia auriculata was studied for MCF7 cell line and was reported.

Key Words: Cassia auriculata, Ag NPs, MCF7 Cell line and Reflux method

Abstract: Background: Both infertility and subfertility are defined as the inability to conceive after a certain period of time (the length of which vary), so often the two terms overlap.Cytokines are important in health and disease, specifically in host responses to infection, immune responses, inflammation, trauma, sepsis, cancer, and reproduction,these have been shown to act both in an autocrine and paracrine manner to regulate preimplantation embryo development and migration which is necessary for placental development.When local injury-induced in endometrial tissue this enhance an inflammatory reaction which is useful for favors implantation of embryo. Natural killer cells, macrophages, and dendritic cells are recruited to the injured site and increased quantities of cytokines, growth factors, and chemokines Objectives:To assess the cytokine levels (IL6 & TNF-a) both in Serum & Endometrial secretions of infertile patients after induced Endometrial scratching.........

Keywords: endometrial scratching, Interleukin 6, Tumor necrosis factor, endometrial secretions, cytokines

Abstract:The species of Cyathea delgadii Sternb. presents potential interaction with the flora and fauna, especially with the anuran fauna. Thus, the research aimed to verify the relationship between anuran amphibians and C. delgadii fern in two fragments in the brazilian Cerrado. The method used was active collection. eight species of anuran amphibians belonging to three families were recorded. Hylidae was the most representative, with six species, followed by Bufonidae and Leptodactylidae, which presented only one species each. Due to the lack of specific terms on species of anurans associated with arborescent ferns, especially with C. delgadii, the terms "samambaicolous" and "samambaigenous" were created, to guide future research that aims to know the ecology of anurans associated with ferns. For the anurans that use the ferns to shelter or for foraging activities, they will be called "samambaicolous" species, while the anuran species that use the ferns for breeding purposes will be called "samambaigenous".

Keywords: Samambaicolous, Samambaigenous, Anuran fauna, Ferns.

Abstract: Smoking is pathological addiction and biggest health risk contributing to morbidity and mortality. India accounts 12 % of the global smokers with the highest number of cigarette smokers recorded in J&K. Our primary objective was to find out the level of dependence in tri-cities of Telangana using FTND scale and to create awareness as a clinical pharmacist. Of the data collected among 524 tobacco users, the mean age was 40 years and more than 65% people are moderate to severely addicted to tobacco and tobacco products. Smoking kills upto 50 % of tobacco users causing CAD with mortality rate of 30 – 40 % and 90 – 95 % of lung cancer, 12% of our study population have health related problems showing low QoL. Poor awareness, Work stress, Peer pressure were found to be the major factors for addiction. It was observed that these factors for addiction are modifiable with proper counselling and awareness. Government policies, NGOs and health care professionals in particular Clinical Pharmacist can make a significant contribution in smokers life and can have positive impact in their life..

Keywords:smoking, FTND, factors, addiction, awareness, QOL

Abstract: Introduction: Renal or ureteric calculi are a common incidental finding on abdominal imaging. In most cases no definite cause is identified and the natural cumulative recurrence rate is reported to be 14% at 1 year, 35% at 5 years and 52% at 10 years. Many factors, including race, diet, occupation and water hardness have been implicated in stone formation. In most cases a definite cause is not identified but certain predisposing factors are recognized. Non enhanced helical computed tomography (CT) has become the primary imaging modality for evaluating acute flank pain and suspected renal stone disease. Ultrasound has an important role in the diagnosis and management of urinary tract stones but it has its limitations. The safety and ease of the ultrasound examination are........

Key words: ultrasound (us), non- enhanced CT(CT), stone size, renal pelvis, calculi,indinavir .

Abstract: Background: The development of in-vivo anti-malarial and anti-typhoid drug has become an essential tool in research to study different drug effects, especially assessing their pharmacological effects on parasites and bacteria. Study drug effects on Plasmodium and Salmonella, specific stages at which drug activity and suppression are most effective, improves the development of new drugs and vaccines production against Malaria and Typhoid. Methodology: A simple random sampling technique utilizing modified Peter's 4-day suppressive in-vivo culture method was used on Albino Mice, to evaluate drug effects and assess their pharmacological effects. Anti-malarial drugs were tested........

Key words: Drug Effect, Malaria, Typhoid, Vaccine Production .

Abstract: The aim of the research iscloning the human tropomyosin and produce the recombinant protein from them .Tropomyosin 4, tropomyosin 3 iso 2, tropomyosin 4 iso 2 and PJC20 plasmid vector were used. Competent cells were prepared by rapid and highly efficient method in order to transform the DNA for cloning. The prepared insert DNA from pcr product and plasmid vector DNA were digested with restriction enzymes such as BamHI or XhoI and NdeI .followed by ligation step was carried out to produce the recombinant DNA. SDS-PAGE used to examine the expression of protein in the cell. The recombinant tropomyosin proteins were expected to characterize by using SDS-PAGE and western blotting technique and ELISA technique to check the reactivity of three different human tropomyosin isoforms with three different monoclonal antibodies. The simple method to produce the recombinant protein was described here.These proteins are useful in therapeutic replacement therapies and treatment of life threatening markers..

Key words: tropomyosin, recombinant, isoforms, pcr, DNA .

Abstract: Ocular coloboma is a rare eye malformation due to faulty closure of the embryonic fissure, which normally occurs in the sixth and seventh weeks of fetal development. Coloboma may involve various parts of the eye, including the iris, lens, ciliary body, choroid, retina, and optic nerve. Classic defects include the absence of the inferior quadrant of the iris, choroid, and retina [1,2]. Associated ophthalmologic manifestations can include cataract, microcornea, nystagmus, optic atrophy, and retinal detachment [3]. We report here a case of iris and chorioretinal coloboma with bilateral congenital cataract..........

Abstract: Four samples were taken from patients with burns and wounds, MacConky agar was prepared for isolation and identification the samples , after inoculated and incubated at 37C for 24 hr. the results were pale colonies because Pseudomonas aerugenosa is lactose non-fermenter .The isolated bacteria was cultured on congo red agar to tested its ability for biofilm formation after incubated at 37c for 24 hr. its give positive result by forming black colonies with adhesion . The detergents were used to study their ability to inhibit biofilm formation are zahi al-wazer , qasir brayt , emlaq and lifebuoy by diluted them and add 1 ml to congo red agar after that inoculated with bacteria and incubation at 37c for 24 hr. the results were indicated that all detergents were inhibited the biofilm formation by forming red to black colonies with loss adhesion but Zahi-al-wazer is more effects and lifebuoy is little effect on it.

Key words: Pseudomonas aeruginosa, biofilm, congo red, detergents .

Abstract: In the present study modified released formulation of Rabeprazole sodium was formulated to study the gastric and duodenal ulcer activity in rats. Ulcers were produced by ethanol induced ulcers in rats. The animals were randomly divided into 4 groups with 6 animals in each group. In group 1 animals were of the control group and they received only water and in group 2 animals received ethanol (70%) at the dose of 10ml/kg body weight, the animals of group 3 received Rabeprazole Sodium at the dose of 20mg/kg body weight and the group 4 animals received the aqueous solution of enteric coated alginate bead of Rabeprazole sodium + ethanol at the dose of 20mg/kg body weight. The antiulcer activity was correlated for reduction in ulcer levels. The parameters like ulcer index, histopathological Evaluation........

Key words: Rabeprazole sodium, alginate beads, ethanol induced ulcers, antiulcer activity, antioxidant parameters