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| Paper Type | : | Research Paper |
| Title | : | Design, Synthesis And Biological Evaluation of New Benzotriazepine Derivatives As Cytotoxic Agents |
| Country | : | Egypt |
| Authors | : | Lamia W. Mohamed |
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: | 10.9790/3008-1305020106  |
Abstract: New benzotriazepine derivatives were synthesized and evaluated for their cytotoxic activity against human breast cancer cell line MCF-7, The new derivatives were found to inhibit cancer growth at three different concentrations with derivative 2-((4-(dimethylamino) benzylidene) amino)-3H- benzo[e] [1,2,4] triazepin-5(4H)-one (IIIo) as the most potent with IC50 value 49,9 μg/ml compared to doxurubucin 3.83 μg/ml.
[1]. K. Ita, Percutaneous penetration of anticancer agents: Past, present and future, Biomed. Pharmacother. 84 (2016) 1428–1439.
[2]. V. Janganati, J. Ponder, S. Thakkar, C.T. Jordan, P.A. Crooks, Succinamide derivatives of melampomagnolide B and their anti-cancer activities, Bioorganic Med. Chem. 25 (2017) 3694–3705.
[3]. E. Kaemmerer, T.E. Rodriguez Garzon, A.M. Lock, C.J. Lovitt, V.M. Avery, Innovative in vitro models for breast cancer drug discovery, Drug Discov. Today Dis. Model. 21 (2016) 11–16.
[4]. Y. Tang, Y. Wang, M.F. Kiani, B. Wang, Classification, Treatment Strategy, and Associated Drug Resistance in Breast Cancer, Clinical Breast Cancer, 16 ( 2016) 335-343.
[5]. S.I. Cunha, M. Bocci, J. Lövrot, N. Eleftheriou, P. Roswall, E. Cordero, L. Lindström, M. Bartoschek, B.K. Haller, R.S. Pearsall, A.W. Mulivor, R. Kumar, C. Larsson, J. Bergh, K. Pietras, Endothelial ALK1 is a therapeutic target to block metastatic dissemination of breast cancer, Cancer Res. 75 (2015) 2445–2456.
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| Paper Type | : | Research Paper |
| Title | : | Detection of Treponema pallidum among Couples Planning To Marry In Baqubah City, Iraq |
| Country | : | Iraq |
| Authors | : | Areej Atiyah Hussein || Anfal Shakir Motib |
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: | 10.9790/3008-1305020710 |
Abstract: Syphilis is one of the most important disease transmit sexually by Treponema pallidum. It can also be transmitted by blood transfusion or vertically. Screening blood widely used and necessary to prevent several blood borne microbial infection among general population especially in blood donations, before surgery and before marry. Objectives: To determine the infection rate of Treponema pallidum among couples planning to marry in Baqubah city. Patients and methods: A cross-sectional study of 15135 couples planning to marry with age 20-70 years, attending to Baqubah Teaching Hospital- Blood bunk, Iraq, during the period from first of January 2017 till end of December 2017. All subjects.......
Keywords: Treponema pallidum, married, syphilis, Iraq.
[1]. Syphilis. CDC. 4 June 2015. Archived from the original on 21 February 2016. Retrieved 3 February 2016.
[2]. Newman L, Rowley J, Vander HS, Wijesooriya NS, Unemo M, Low N, Stevens G, Gottlieb S, Kiarie J and Temmerman M. Global Estimates of the Prevalence and Incidence of Four Curable Sexually Transmitted Infections in 2012 Based on Systematic Review and Global Reporting. Plos One. 2015; 10 (12): e0143304.
[3]. Syphilis - CDC Fact Sheet (Detailed). CDC. 2 November 2015. Archived from the original on 6 February 2016. Retrieved 3 February 2016.
[4]. Syphilis and Men Who Have Sex With Men (MSM) - CDC Fact Sheet. Centers for Disease Control and Prevention (CDC). 16 September 2010. Archived from the original on 24 October 2014. Retrieved 18 October 2014.
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| Paper Type | : | Research Paper |
| Title | : | Effect of Lycopene on Pharmacokinetic and Pharmacodynamics of Gliclazide in Diabetic Animal Models |
| Country | : | |
| Authors | : | Umachandar.Lagisetty || Dr.Habibuddin Mohammed || Dr.Sivakumar Ramaiah |
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: | 10.9790/3008-1305021119 |
Abstract: Background: Diabetes mellitus is one of the metabolic disorders associated with high blood sugar levels. Utilization of natural drugs among patients under diabetes mellitus pharmacotherapy is across the board. Objective: To examine the pk-pd(pharmacodynamic-pharmacokinetic) interactions of lycopene and gliclazide in animal models and to understand the safety & effectiveness. Methods: Single and multiple dose interaction studies were carried out in normal rats, diabetes induced rats and rabbits to evaluate the effect of lycopene on the gliclazide activity. Blood samples from the study animals were used for the estimation insulin and glucose levels by using radioimmunoassay method and chemistry analyzer (automated) respectively. Homeostasis model assessment used for determination...........
Keywords: Lycopene; Gliclazide; Diabetes mellitus; Pharmacokinetics; Pharmacodynamics
[1]. Anna Gumieniczek, Hanna Hopkala ,Zbigniew Wójtowicz and Justyna Nikolajuk. Changes in antioxidant status of heart muscle tissue in experimental diabetes in rabbits. ActaBiochimicaPolonica 2002; 49(2):529-35.
[2]. AnuragK, Richa S, Dethi, ChopraK. Lycopene attenuates diabetes associated cognitive decline in rats. Life sci 2008; 83: 128-34.
[3]. Ashcroft F.M., and Rorsman P. KATP channels and islet hormone secretion: new insights and controversies. Nat. Rev. Endocrinol 2013; 9:660–9.
[4]. Brien RC, Luo M, Balaza N. In vitro and in vivo antioxidant properties of gliclazide. J Diabetes Complications 2000; 14(4):201–6.
[5]. Chang CL, Lin Y, Bartolome AP, Chen YC, Chiu SC, Yang WC. Herbal therapies for type 2 diabetes mellitus: chemistry, biology, and potential application of selected plants and compounds. Evid Based Complement Alternat Med 2013; Article ID 378657 33 pages..
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| Paper Type | : | Research Paper |
| Title | : | Antibiotic Bead Pouches In Open Fractures: Elution of Antibiotics From Pmma Bead Pouches In Open Fractures |
| Country | : | India |
| Authors | : | Dr S Amarnath M.S (Ortho) || K Bindu Madhuri || L Tejaswi || A Chetanya Brahma || Dr Shaik Faizan Ali Pharm.D |
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: | 10.9790/3008-1305022030 |
Abstract: The increasing incidence of open fractures has led to higher infection rates leading to higher incidence of non-union and morbidity. Antibiotic impregnated PMMA (polymethyl methacrlyte) bone cement, (in the form of bead pouch) is used to deliver higher concentrations of local antibiotics to prevent bone infection in open fractures. This study demonstrates the effectiveness of combination antibiotic impregnated bone cement in infected open fractures. This study shows that local antibiotic elution through antibiotic impregnated bone cement is more potent and helps in controlling the infection. Combination antibiotics added to bone cement are more effective against a wide spectrum of bacteria than single antibiotic (gentamicin as provided by manufacturer).
Keywords: Antibiotic bead pouch, Open fractures, gentamicin, PMMA (polymethyl methacrlyte) bone cement.
[1]. Seligson, David, Mehta, Sanjiv, Voos et al. The use of antibiotic-impregnated polymethylmethacrylate beads to prevent the evolution of localised infection. Journal of orthopaedic trauma. December 1992.
[2]. Buchholz HW, Engelbrecht H. Depot effects of various antibiotics mixed with palacos resins. Clin Orthop 1993, 295: 63-76.
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[5]. Peter A .W.Ostermann. David Seligson, Stephen L.Henry. Local Antibiotic therapy for severe open fractures.
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| Paper Type | : | Research Paper |
| Title | : | Relationship Between Body Mass Index, And Type 2 Diabetes Mellitus Among Adult Nigerians In Makurdi, Nigeria |
| Country | : | Nigeria |
| Authors | : | Dr. Emmanuel Eru || Dr. Barnabas Eke || Christian Onahinon || Dr. Julie Ibu || Dr. Nndunno Akwaras || Dr. Augustine Adugba || Prof. John Ibu |
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: | 10.9790/3008-1305023137 |
Abstract: Obesity and diabetes are major public health problems in developing countries in the 21st century. The fundamental cause is imbalance between energy intake on one hand and energy expenditure on the other hand which is attributable to westernized lifestyle and decreased physical activity. This study was designed to assess the relationship between body mass index and fasting blood glucose of adult Nigerians in Makurdi metropolis, North Central Nigeria. . A total of five thousand one hundred and twenty participants (3326 males (65%) and 1794 females (35%) were randomly recruited for this study. The following measurements were taken -weight, height, and fasting blood sugar. Results showed mean values to be as follows, weight (68.8±0.2 kg), height (1.61±0.002 m2), BMI (26.42±0.08kg/m2) and FBG (6.7±0.03) for male participants compared to female with weight 70.1±0.3kg) height (1.62±0.002m2), BMI(26.9±0.1kg/m2),FBG(6.7±0.4mmol/L)Fasting blood sugar showed no significant differences...........
Keywords: Body mass index, obesity, diabetes Mellitus
[1]. CDC causes of obesity US centers for Disease control, 2001found at http/ww cdc gov,htm, accessed on 10th Sept Biritwum
[2]. R, Gyapong J, Mensah G: The epidemiology of obesity in Ghana, Ghana Med .200539[3]:82-85.ember 2010
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[5]. 5.Asfaw A –The effects of obesity on doctors diagnosed chronic diseases in Africa, empirical result from Senegal and south African,J.public : health policy 2006, 27 6[.3] :250-264
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| Paper Type | : | Research Paper |
| Title | : | Crisis of Antibiotic Resistance -A Definite Ban on Healthcare |
| Country | : | India |
| Authors | : | Sriram S || Christy |
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: | 10.9790/3008-1305023841 |
Abstract: Anti-microbial resistance patterns can vary regionally and even among different hospitals within the same community. Infections are the most common reasons for patients to seek medical advice and for antibiotics to be prescribed. Inappropriate or indiscriminate use of antibiotics can increase the cost of care by increasing drug cost, increasing toxicity, increasing resistance, and increasing laboratory costs. Prophylactic antibiotic use in some hospitals remains a problem. Antibiotics are prescribed unnecessarily and empirically for complaints where no antibiotic is required or where culture and sensitivity results could be safely awaited. The key action by the clinician should be the provision of a specimen for accurate identification of the offending pathogen by means of culture and sensitivity method..........
Keywords: Antibiotic resistance,sensitivity pattern,rational prescribing.
[1]. Tarai B, Das P, Kumar D. RecurrenT Challenges for Clinicians: Emergence of Methicillin‑resistant Staphylococcus aureus, Vancomycin Resistance, and Current Treatment Options. Journal of Laboratory Physicians .Jul-Dec 2013 ;Vol-5; Issue-2.
[2]. Adhikari R, Pant N, Neupane S, Neupane M, Bhattarai R, Chaudhary R et al. Detection of Methicillin Resistant Staphylococcus aureus and Determination of Minimum Inhibitory Concentration of Vancomycin for Staphylococcus aureus Isolated from Pus/Wound Swab Samples of the Patients Attending a Tertiary Care Hospital in Kathmandu, Nepal. Canadian Journal of Infectious Diseases and Medical Microbiology. Volume 2017, Article ID 2191532, 6 pages.https://doi.org/10.1155/2017/2191532
[3]. Lee C, Cho I, Jeong B. Strategies to Minimize Antibiotic Resistance 2013 Int. J. Environ. Res. Public Health 10, 4274-4305.
[4]. Kaleem F, Usman J, Khalid A, Hassan A, Omair M. Comparison of in vitro efficacy of linezolid and vancomycin by determining their minimum inhibitory concentrations against Methicillin Resistant Staphylococcus aureus (MRSA). J Pak Med Assoc 2011;61:356.
[5]. Arias C, M.D., Ph.D., Murray B, M.D. Antibiotic-Resistant Bugs in the 21st Century —A Clinical Super-Challenge. The New England Journal of Medicine 2009;360;5.
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| Paper Type | : | Research Paper |
| Title | : | Urodex Injection (Urethral Bulking Agent) Outcomes In Treatment of Stress Incontinence, Interventional Study |
| Country | : | Iraq |
| Authors | : | Dr. Jihad Anad Khalef || Dr. Jamal Kh. Ibraheem || Dr. Luai Farhan Zghair |
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: | 10.9790/3008-1305024245 |
Abstract: The stress incontinence is caused by internisic sphincter deficiency, or weakness of pelvic floor muscle, which is divided into three stamey grades according to severity, urodex is used to mild to moderate grades. The study is started in February 2017 to July 2018; this study was done on 15 patients in private outpatient clinic, 12 of them presented with GSI and other three patients presented with mixed incontinence. for those patient whom complaining from mixed incontinence were treated with an anticholinergic medication (used to oxybutynin tab 5mg 1x2), the diagnosis is confirmed with cystometry, the other of patients with urodex injection which are containing 1cc in four site (12,3,6,9)............
Keywords: Stress Incontinence, Urodex, Urethal Bulking Agent.............
[1]. Langford CF, Elmissiry MM, Ghoniem GM. Do women have realistic expectations of treatment for stress urinary incontinence? Neurourol Urodyn. 2008; 27: 480-484…………………………... \
[2]. Mc Guire EJ. Pathophysiology of stress urinary incontinence. Rev Urol.2004; 6 Suppl 5: S11-17. N. F. Davis, F. Kheradmand, and T. Creagh, "Injectable biomaterials for the treatment of stress urinary incontinence: their potential and pitfalls as urethral bulking agents," International Urogynecology Journal, vol. 24, no. 6, pp. 913–919, 2013……………………………………... M. Bioˇci´c, J. Todori´c, D. Budimir et al., "Endoscopic treatment of vesicoureteral reflux in children with subureteral dextranomer/ hyaluronic acid injection: a single-centre, 7-year experience," Canadian Journal of Surgery, vol. 55, no. 5, pp. 301–306, 2012…………………….
[3]. O. Aydogdu, C. Ozcan, B. Burgu, M. Mermerkeya, and T. Soygur, "Does the diameter of dextranomer microspheres affect the success in endoscopic treatment of vesicoureteral reflux?" Urology, vol. 80, no. 3, pp. 703–706, 2012……………………………………………………….
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| Paper Type | : | Research Paper |
| Title | : | Detection of The Optimum Conditions For The Amplification of Some Regions In The Multidrug Resistance Gene In Acute Myeloid Leukemia Patients In Iraq |
| Country | : | Iraq |
| Authors | : | Oras N.Hamad || Amran Sib || Bilal K. Sulaiman || Batool Ali Shihab || Ahmed Qasim Abd Al-Hasan |
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: | 10.9790/3008-1305024649 |
Abstract: A molecular study on MDR1 gene by a specific PCR is carried out for the patients of acute myelogenous leukemia before and after chemotherapy to study the possible alteration in MDR1 gene and its correlation with development of multidrug resistance for acute myelogenous leukemia patients from Iraq. Samples were collected from 57 patients who were admitted to the Hematology Department of Baghdad Teaching Hospital and were diagnosed as acute myelogenous leukemia patients from 2017 to 2018 The studied Patients are classified in to two groups; the first includes 19 patients in the stage of early diagnosis and the second group involved 23 patients in the stage of after taking the treatment in addition to a control group that include 15 healthy people...........
Keywords: MDR-1, AML, PCR
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| Paper Type | : | Research Paper |
| Title | : | Distribution of Vibrio Cholera in Iraq during 2017 |
| Country | : | Iraq |
| Authors | : | Areej Atiyah Hussein || Anfal Shakir Motib || Israa Salim Musa |
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: | 10.9790/3008-1305025861 |
Abstract: Background: Cholera is one of the most important waterborne disease which cause only by O1 and O139/Vibrio cholera strains, highly morbidity and mortality among general population. Objective: To determine the infection rate of Vibrio cholera in Iraq during 2017. Materials and Methods: All data presented in this paper was collected from Communicable Disease Control Center - Bacteriology Unit in Baghdad, during the period from January 2017 till December 2017 then analyzed by use the statistical analysis system program for 2012. Results: The majority 109(63.75%) was in Baghdad-Alrisafa, followed by Babylon 34 (19.88%) and Wassit 24(14.04%) respectively, while lower frequency were recorded in 3(1.75%) Diwaniya and 1 (0.58%) Najaf, also there were no infections.........
Keywords: Vibrio cholera, surveillance, waterborne pathogens, Iraqi province
[1]. O'Reilly CE, Jaron P, Ochieng B, Nyaguara A, Tate JE, Parsons MB, et al. Risk Factors for Death among Children Less than 5 Years Old Hospitalized with Diarrhea in Rural Western Kenya, 2005-2007: A Cohort Study. 2012 PLoS Med, 9(7): e1001256.
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| Paper Type | : | Research Paper |
| Title | : | Physiological Determination (Manavaca Solution) of Alluminium Toxicity Tolerance In Selected Wheat Lines (Triticum Aestivum |
| Country | : | Kenya |
| Authors | : | Richard Kiprob |
|
: | 10.9790/3008-1305027080 |
Abstract: This study was conducted to determine the aluminium tolerance of fifteen strains of wheat. Aluminium (Al) toxicity is one of the major limiting factors for wheat production on acid soils. It inhibits root cell division and elongation, thus reducing water and nutrient uptake, consequently resulting in poor plant growth and yield. The studies involved field work where wheat was grown in three locations (Chepkolel, Moiben and Kaptagat) arranged in RCBD. Tiller numbers, spikelets number, main tiller height, main head length, seed yield and 1000 kernel weight measured. Physiological test was then carried out using Magnavaca (nutrient) solution in the laboratory to determine length of root growth. Where sufficient number of wheat seeds was set to germinate on trays between germination papers moistened.........
Keywords: Growth,Mollecular,phytotoxicity,Tillering,Screening
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| Paper Type | : | Research Paper |
| Title | : | Diversity of Commercially Important Marine Crabs In Nagapattinam Coastal Area, Tamilnadu, India |
| Country | : | India |
| Authors | : | U. Sathiya || V. Valarmathi |
|
: | 10.9790/3008-1305028186 |
Abstract: The crustaceans are commercially important valuable sea food contributing directly to support the mankind. The data was collected for decapod crabs from the Akkaraipettai landing centre of Nagapattinam . Nearly 12 varieties of commercially important species were identified during the study period from January 2017 to December 2017 in Nagapattinam coastal area. The collected data were subjected to study the Species diversity (Shannon diversity index), Richness (Margalef Richness Index ) and Evenness (Pielou's Evenness index) to assess the diversity of crab species. The calculated index values showed that the highest Shannon's diversity value observed was -0.1173 (March........
Keywords: Crab, Diversity, Richness, Evenness, Season, Index values
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