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Abstract: Nanoparticles have received much attention in present scenario due to their application in cancer therapy. Based on clinical efficacy, TiO2 has a very wealthy data related to cytotoxicity. The present study involves novel synthesis of nanocrystalline powders of virgin and also the ones doped with Pt, Pd and bimetallic Pt/Pd. The synthesized nanocrystalline TiO2 were characterized by UV, IR, XRD, SEM, and DLS. The Characterization results demonstrated that doping decreases the band gap or introduces intra-band gap states leading to photosensitizer (PS) systems that exhibit enhanced efficiency under visible light. The prospects of using newly synteised nanocrystalline powders..........
Key words: Nanoparticle TiO2, doped with Pt,Pd , both Pt/Pd ,EAC, SGD, ILS
[1]. Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin. 2015; 65: 87-108.
[2]. G. Zhao and B. L. Rodriguez, "Molecular targeting of liposomal nanoparticles to tumor microenvironment," International Journal of Nanomedicine 8, 61 (2013).
[3]. Y. Wang, F. Yang, H. X. Zhang, X. Y. Zi, X. H. Pan, F. Chen, W. D. Luo, J. X. Li, H. Y. Zhu, and Y. P. Hu, "Cuprous oxide nanoparticles inhibit the growth and metastasis of melanoma by targeting mitochondria," Cell Death & Disease4(8), e783 (2013).
[4]. Lanthanides: Applications in Cancer Diagnosis and TherapyRuijie D. Teo†, John Termini*,‡, and Harry B. Gray*,†
[5]. S. Ganta , H. Devalapally , A. Shahiwala , M. Amiji , J. Control. Release 2008 ,126 , 187 ..
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Abstract: Parkia biglobosa (Mimosaceae) is a plant commomly used in african traditional medicine to treat several diseases among which hypertension and heart disorders. The present work, carried out with the total aqueous extract of the trun bark of Parkia biglobosa (AEPB) on the mechanical activity of isolated rat heart proposes to deepen studies on mechanisms of action underlying its effects in Cardiac level. Spontaneous Contractile Activity of the isolated rat heart has been recorded. The aqueous extract of Parkia biglobosa (AEPB), at concentrations between 10..........
Key words: Isolated rat heart, Parkia biglobosa, Atropine, Adrenaline, Atenolol, Cardiodepression
[1]. Ake Assi L.and Ginko S., Plantes utilisées dans la médecine traditionnelle en Afrique de l'Ouest (Editions Roche, Switerland,
1991).
[2]. Adjanohoun E. J., Ahyi M. R. A., Ake Assi L., Akpagana K., Chibon P., Hadhi EL., Eyme J., Garbam., Gassita J.N., Gbeassor M.,
Goudote E., Ginko S., Hodouto K.K., Houngnon P., Keita A., Keoula Y., Kluga-Ocloo W. P., Lo L., Siamevi K. M., Taffame K.K.,
Médecine traditionnelle et pharmacopée. Contribution aux études ethnobotaniques et floristiques au Togo ( Rapport ACCT, Paris –
France, 1987).
[3]. Kerharo J. and Bouquet A., Plantes médicinales et toxiques de la Côte d'Ivoire – Haute – Volta (Editions. Vigot Frères, Paris,
1950).
[4]. Kerharo J. and Adam J. G. (1974). La Pharmacopée Sénégalaise traditionnelle. Plantes médicinales et toxiques (Editions Vigot
Frères, 1974).
[5]. Kouadio F., Kanko C., Juge M., Grimaud N., Jeazn A., N'guessan Y. T., Petit J.Y., Analgesic and antiinflamatory activities of
extract from Parkia biglobosa used in traditional medicine in Ivory coast, Phytotherapie research, 14 (8), 2000, 635 – 637. ..
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Abstract: Aim: The primary objective of the study was to evaluate the possible effects of ethanolic, chloroform extracts and isolated constituents of Justicia beddomei leaves (JB) on against Ehrlich's ascites carcinoma (EAC) induced cancer on male Swiss albino mice. Tumors were induced by Ehrlich's ascites carcinoma (EAC) at dose of 200 mg/kg (p.o). Materials and Methods: The EAC was maintained in the ascetic form by the sequential passages in Swiss mice, by means of every 10 days i.p transplantation of 2x106 tumour cells. All the groups except the control were inoculated with 2x106 tumor cells. For tumour..........
Key words: Justicia beddomei, EAC, SGD, ILS,Bioactivity-guided
[1]. Mehta K, Gandhi V, Pathak S, Aggarwal BB, Grover RK. Multi-targeted approach to cancer treatment: an international translational cancer research symposium. Anticancer Res. 2014; 34:6791-6795.
[2]. Manju K, Jat RK, Anju G. A review on medicinal plants used as a source of anticancer agents. Int J Pharm Technol. 2012;2(2):177-183.
[3]. Saxe, TG (1987), "Toxicity of Medicinal Herbal Preparations, Am Fam Physician, 35,135-42.
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[5]. Moffat J G, Rudolph J, Bailey D. Phenotypic screening in cancer drug discovery-past, present and future. Nat Rev Drug Discov. 2014; 13, 588-602. http://dx.doi.org/10.1038/nrd4366..
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Abstract: Le sarcome granulocytique (SG) est une localisation extramédullaire peu fréquente de la leucémie aigue myéloïde (LAM). Ses modes de révélation sont variés et peuvent être cause d'erreur diagnostique. A travers cette observation nous soulignons l'intérêt de l'anatomopathologie et de l'immunohistochimie dans le diagnostic de cette pathologie rare.
[1]. Dusenbery KE, Howells WB, Arthur DC, et al. Extramedullary leukemia in children with newly diagnosed acute myeloid leukemia: a report from the Children's Cancer Group. J Paediatr Hematol Oncol 2003;25:760–8.
[2]. Byrd JC, Edenfield WJ, Shields DJ, et al. Extramedullary myeloid cell tumors in acute nonlymphocytic leukaemia: a clinical review.
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[3]. Reinhardt D, Pekrun A, Lakomek M, et al. Primary myelosarcomas are associated with a high rate of relapse: report on 34 children from the acute myeloid leukaemia-Berlin-Frankfurt- Mu¨nster studies. Br J Haematol 2000;110:863–6.
[4]. Paydas S, Zorludemir S, Ergin M. Granulocytic sarcoma: 32 cases and review of the literature. Leuk Lymphoma 2006;47:2527–41.
[5]. Chung EM, Smirniotopoulos JG, Specht CS, et al. From the archives of the AFIP. Pediatric orbit tumors and tumorlike lesions non osseous lesions of the extraocular orbit Radiographics 2007;27:1777–99...
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Abstract: A simple and effective synthesis of pyrazoles and cyanopyridines derivatives from Chalcone according to Claisen-Schmidt condensation. Chalcone, (2E)-N-(4-((2,6-bis(4-methoxyphenyl)-3-methylpiperidin-4-ylidene)amino)phenyl)-3-(p-tolyl) acrylamide (5) have been prepared. Further this chalcone with hydrazine hydrate gives pyrazoles (6) and on reaction with malononitrile gives cyanopyridines (7). The structure of the newly synthesized compounds have also been screened for their antioxidant activities and it was characterized by IR, 1 H NMR and 13C NMR spectral data.
Key words: Chalcones, Claisen-Schmidt condensation, pyrazoles, cyanopyridines, antioxidant activity.
[1]. Katrizky A R, Pozharskii A F. Handbook of Heterocyclic Chemistry. J. Chem.Pharm, (2010); 2(3): 127-132.
[2]. Sweety, Kumar S, Nepali K, Sapra S, Suri. O P, Dhar K L, Sarma G S, Saxena A K. Indian Journal of Pharmaceutical Sciences, (2010);72(6): 801-806.
[3]. Rao G K, Kothal R B, Pai P N S. J.Chem.Pharm, (2010); 2(3): 368-3.
[4]. Vinita Sharma, Nitin Chitranshi, Ajay kumar Agarwal. International Journal of Medicinal Chemistry, Volume 2014,(2014):P 3.
[5]. Ahmed M R, Sastry V G, Bano N, Ravichandra S, Raghavendra M. Rasayan J.Chem, (2011); 4(2): 289-294..
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Abstract: The seeds of Nigella sativa (NS), have been widely used in herbal medicines worldwide. It has been shown to possess prophylactic effects against oxidative stress. However, there is a paucity of information regarding the protective role of NS against oxidative stress, in the absence of toxic agents. The aim of the study was to elucidate the anti-oxidative stress pharmacodynamics of NS. Eighteen, 12-week-old Sprague-Dawley rats, weighing about 300 ± 25 gm were divided equally into six groups. Four of the groups were supplemented with NS at 100 mg/kg b.w/day orally (P.O.) and labeled as, 1st, 3rd, 5th and 6th day groups. The PCx (positive control) group was given distilled water orally, and the NCx (negative control) group rats were provided with food and water ad libitum. Blood samples were collected........
Key words: Antioxidant, GSH-Px, Nigella sativa, pharmacodynamic and prophylactic
[1] Ahmad, A., Husain, A., Mujeeb, M., Khan, S. A., Najmi, A. K., Siddique, N. A., & Damanhouri, Zoheir, O. (2013). A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pacific Journal of Tropical Biomedicine, 3(5), 337–352.
[2] Al-Bukhari, M. I., & Sahi, A. B. (1976). The collection of authentic sayings of Prophet Mohammad (peace be upon him), division 71 on medicine. Hilal Yayinlari, Ankara, Turkey.
[3] Al-Ghamdi, M. S. (2003). Protective effect of Nigella sativa seeds against carbon tetrachloride-induced liver damage. The American Journal of Chinese Medicine, 31(5), 721–728.
[4] Al-okaily, B. N., Mohammed, R. S., Al-Mzain, K. A., & Khudair, K. K. (2012). Effect of flavonoids extracted from Black Cumin (Nigella sativa) and vitamin E in ameliorating hepatic damage induced by sodium nitrate in adult male rats. In Proceeding of the Eleventh Veterinary Scientific Conference (Vol. 172, p. 181).
[5] Alkharfy, K. M., Ahmad, A., Khan, R. M. A., & Al-Shagha, W. M. (2015). Pharmacokinetic plasma behaviors of intravenous and oral bioavailability of thymoquinone in a rabbit model. European Journal of Drug Metabolism and Pharmacokinetics, 40(3), 319–323..
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Abstract: The purpose of this study was to estimate the acute toxicity of oil effluent on Cirrhinus mrigala and to evaluate the lethal levels. The 120 hrs median lethal concentration of oil effluent were found to be 20ppt for Cirrhinus mrigala. Further experiments were proceeded with sub lethal concentration of (1/10th conc. of LC50) oil effluent which were evaluated from the LC50 value. After treatment the fishes were reared in ideal condition, then sacrificed dissected at different predetermined interval during the accumulation period, (i.e.) 1st day to 20th day, during the depuration period from 1st day to 15th day for Cirrhinus mrigala in oil effluent treatment for assay studies. The enzyme activity.........
Key words: Oil effluent; Cirrhinus mrigala; SGOT; SGPT
[1]. Ambrose T, Vincent S and Cyril L. (1994). Susceptibility of the freshwater fish Gambusia affinis (Baird and Girard), Sarotherodon mossambicus (Peters) and Cirrhinus mrigala (Ham) to Zinc toxicity. Indian Journal of Environment and Toxicology, 4, 29-31.
[2]. Antonella, V and Landriscina C. (1999). Changes in liver enzyme activity in the teleost Sparus aurata in responses to cadmium intoxication. Ecotoxicology and Environmental Safety, 43, 111-116.
[3]. Bhatnagar, MC and Tyagi M. (1995). Pyrethroid induced alternations in transaminases in liver and muscle of Clarias batrachus (Linn). Proceedings of the Academy of Environmental Biology, 4(2), 251-253.
[4]. De AK. (1996). Environmental Chemistry, 3rd edition, New Age International Pvt. Ltd. New Delhi.
[5]. De la Torre FR, Salibian A and Ferrari L. (2000). Biomarkers assessment in juvenile Cyprinus carpio exposed to waterborne cadmium. Environmental Pollution, 109, 277-282..
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Abstract: A simple, rapid, sensitive, specific, precise and accurate Ultra-Fast liquid chromatography (UFLC) method was developed for simultaneous determination of Irbesartan and Hydrochlorothiazide in Pharmaceutical formulations. The chromatographic separation was conducted on Shimadzu (Prominence LC 20 UFLC XR) connected with photodiode array (PDA) detector; using ACE column, C18/CN (100 x 4.6 mm, 5 μm) as stationary phase. Isocratic mobile phase consisted of Methanol and 0.1% Phosphoric acid 85% in the ratio of (55:45 v/v); at flow rate of.........
Key words: UFLC, Irbesartan, Hydrochlorothiazide, Mixed column, Method validation
[1]. E.J. Lewis, L.G. Hunsicker, W.R. Clarke, T. Berl, M.A. Pohl, J.B. Lewis, E. Ritz, R.C. Atkins, R. Rohde, I. Raz, Collaborative Study Group, Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med., 2001, 12:851-860.
[2]. S. Rossi, editor. Australian Medicines Handbook 2006, Adelaide: Australian Medicines Handbook, 2006.
[3]. B.M. Massie, P.E. Carson, J.J. McMurray, M. Komajda, R. McKelvie, M.R. Zile, S. Anderson, M. Donovan, E. Iverson, C. Staiger, A. Ptaszynska, Irbesartan in patients with heart failure and preserved ejection fraction. N. Engl. J. Med., 2008, 23:2456-2467.
[4]. Hydrochlorothiazide, The American Society of Health-System Pharmacists, 2017.
[5]. J.M. Wright, V.M. Musini, R. Gill, First-line drugs for hypertension. Cochrane database of systematic reviews., 2018, 4:CD001841.
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Abstract: A simple, rapid and accurate Ultra-fast liquid chromatography (UFLC) method was developed for simultaneous determination for cefepime, cefotaxime and ceftriaxone in pharmaceutical formulation. The chromatographic separation was conducted on UFLC Shimadzu connected with PDA detector; using column Phenomenex, Prodigy, ODS3, 5 μm, (250 x 4.6 mm) with a mobile phase was isocratic consisted of Acetonitrile and 0.025M KH2PO4 pH 3.0 in the ratio of 15:85 (by volume) and was delivered to the system at a flow rate of 1.5 ml/min. An injection.......
Key words: UFLC, Cefepime, Cefotaxime, Ceftriaxone, PDA detector; Method Validation
[1]. Al-Attas A, Nasr JJ, El-Enany N and Belal F, A green capillary zone electrophoresis method for the simultaneous determination of piperacillin, tazobactam and cefepime in pharmaceutical formulations and human plasma, Biomed Chromatogr., 2015, (12):1811-1818.
[2]. Ghafur A, Sensitivity pattern of Gram negative bacteria to the new β-lactam/ β-lactamase inhibitor combination: Cefepime/tazobactam, J. Microbio. & Infect. Diseas., 2012, (1):5-8.
[3]. Hurum D., De Borba B., and Rohrer J., Assaying the concentration of cefepime by HPLC with UV detection, LC GC North America, 2009, (2):48.
[4]. I.N. Valassis, M.Parissi-Poulou, and P. Macheras, Quantitative determination of cefepime in plasma and vitreous fluid by high performance liquid chromatography, J. Chromatogr. B, 1999, (2):249-255.
[5]. N. Cherti, J.-M. Kinowski, J. Y. Lefrant, and F. Bressolle, High-performance liquid chromatographic determination of cefepime in human plasma and in urine and dialysis fluid using a column-switching technique, J. Chromatogr. B, 2001, (2):377-386...
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Abstract: The main aim of the present investigation is to evaluate the medicinal plants used for various diseases in Dharmapuri district. Based on the abundance of plant diversity, we have selected the Dharmapuri district. Totally we have visited 7 villages around the district and evaluate the medicinal plants through direct interview with traditional medicinal practitioners. In this study we have screened 104 medicinal plants belong to 41 families used for 42 disease, also we have recorded the medicine preparation particularly the plant parts used for the treatment in this present investigation we have evaluated more number of medicinal plants are available among the total plant bio diversity also Dharmapuri district found to be the comparatively best medicinal plants source for making healthy society.
Key words: Ethnoveterinary medicine, evolution, Livestock production.
[1]. Agarwal, A. (1995) Indigenous and scientific knowledge: Some critical comments. Indig. Knowl.Dev.Monit., 3: 3-35.
[2]. Alagesaboopathi, C. (2015) MLedicinal plants used in the treatment of Livestock diseases in Salem District, Tamil Nadu , India. World Jounal of Pharmaceutical Research, 2015; 4 (4): 829-836.
[3]. Balakrishnana, V., et al, (2009). Ethno veterinary studies Amoung Farmers in Dindigual District, Tamil Nadu, India: Global J. Pharmacol., 3(1): 15-23.
[4]. Bipul saikia&Borthakur,S.K.,(2010).Use of medicinal plants in animal health care .Indian Journal Traditional Knowledge.Vol.9(1);49-51.
[5]. Chinsembu,K.C Mbangu (2014)An Ethnobotanical study of medicinal plants used to treat livestock diseases in onayena and katima mubilo nambia vol 94,101-107...
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Abstract: Plants produce thousands of specialized metabolites, many of which have medicinal uses. Over the next few years, the study of medicinal plants as antimicrobial agents should be focused on ascertaining specific information about the plant's antimicrobial activity. In the present investigation the phytochemical, antimicrobial and DPPH radial scavenging activities were screened by using two plants namely Opilia amentaceaea and Anogeissus latifolia. Different solvent extracts were used in the phytochemical analysis to elucidate the tannins, Saponins, Flavonoids, Catachins and Sugars from these plants. Significantly Anthroquinones are present only in Anogeissus latifolia. Both of these plants inhibit the growth of Escherichia coli ATCC 25922, Salmonella entericatyphimurium........
Key words: Anogeissus latifolia ,Opilia amentaceae, phytochemical, antimicrobial and DPPH
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[2]. Dejong, J. (1991). Traditional medicine in Sub- Saharan Africa: Its importance and potential Policy options, Policy, Research and external Affairs, World Bank Publication.
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[5]. Kokwaro JO (2009). Medicinal plants of East Africa, 3rdEd.University of Nairobi press
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Abstract: Phytochemical screening study well showed the presence of alkaloids, steroids, protein, saponins and flavonoids. Murraya koenigii leaves have potent antioxidant. Murraya koenigii leaves possess anticancer activity against MCF- 7 cell lines, like wise Murraya koenigii leaves possess antibacterial agent against Pseudomonas aeruginosa, Bacillus subtilis and Escherichia coli. Docking studies were performed for the four proteins with four marker compounds. The interaction of protein and ligands for the docked ligands with least binding energy was calculated. Mahanimbicine has least binding energy with HER2 protein. Further research has to be conducted for components present in the methanolic extract of Murraya koenigii which may act as active principles. In future the components present on Murraya koenigii may act as a drug, for the above mentioned cell line.
[1]. Arouma, O.I., (2002). Methodological considerations for characterizing potential antioxidant actions of bioactive components in plants foods. Mutation Res., 523-524: 9-20.
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[4]. Elangovan S, Hsieh T-C, Wu JM (2008). Growth Inhibition of Human MDA-MB-231 Breast Cancer Cells by δ-Tocotrienol Is Associated with Loss of Cyclin. D1/CDK4 Expression and Accompanying Changes in the State of Phosphorylation of the Retinoblastoma Tumor Suppressor Gene Product. Anticancer Res. 28: 2641-2648.
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Abstract: The objective of this work is to study the physico-chemical and nutritional composition of 3 diets formulated on the basis of lower-cost, available local products and that of a commercial food, intended for the feeding of poultry on Ivory Coast. As a first step, the 3 food diets (A1, A2 and A3) were formulated. In front of these 3 foods formulated, there was a food of commerce at which served as a control food. Room these foods (formulated and witnessed) have been analyzed on the physico-chemical and nutritional levels. The results revealed that the formulated foods are real sources of protein, carbohydrates and various other nutrients are not the concentrations are similar.......
Key words: Flour, seed, néré, pulp, fish, snail, corn, food, formulated, trade, physico-chemical, nutritional
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