Series-1 (July-August 2019)July-August 2019 Issue Statistics
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| Paper Type | : | Research Paper |
| Title | : | Antioxidant Activity Of Two Different Extracts From Doum(Hyphaenethebaica) Fruits |
| Country | : | Iraq |
| Authors | : | Lamiaa A. Gharb || Laith Z.Fadhel |
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: | 10.9790/3008-1404010104  |
Abstract: In the present study we have investigated antioxidant activity ofdoum(Hyphaenethebaica) fruit by using soxhlet apparatus for 9 hours to each of ethanol and ethyl acetate solvents. The antioxidant activity was done by using(DPPH) 2, 2 - diphenyl, 1- picrylhydrazyland ( FRAP) ferric reducing antioxidant power assays.(BHT)butylatedhydroxytoluene was used as control. The results show that the scavenging effects of both extracts from our plant on DPPH radicals increased by increasing theconcentration. Ethyl acetate extract of the H. thebaica showed strong DPPH scavenging activity at concentrations (400, 600, 800 μg/ml)more than ethanolic extract and BHT which were 70.20, 88.70 and 95.80% respectively. Ethyl acetate extract showed highest FRAP scavenging activity at concentration...........
[1]. Shariff ZU. Modern Herbal Therapy for Common Ailments. Nature Pharmacy Series Vol.1, SpectrumBooks Ltd., Ibadan, Nigeria in Association with Safari Books. . 2001. pp. 9-84.
[2]. EldahshanO., Ayoub N., Singab A., Al-Azizi M. Potential superoxide anion radical scavenging activity of doum palm(Hyphaenthebaica L.) Leaves Extract. Rec. Nat. Prod.2008. 2, 83–93.
[3]. Eldahshan O., Ayoub N., Singab A., Al-Azizi M. Potential antioxidant phenolic metabolites from doum palm leaves. Afr. J. Pharm. Pharmacol.2009. 3, 158–164.
[4]. Hsu B., Coupar I.M., Ng K. Antioxidant activity of hot water extract from the fruit of the doum palm, Hyphaenethebaica. Food Chem.2006. 98, 317–328.
[5]. Langley-Evans S.C. Antioxidant potential of green and black tea determined using the ferric reducing power (FRAP) assay. Int. J. Food Sci. Nutr.2000. 51, 181–188.
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| Paper Type | : | Research Paper |
| Title | : | Effects of In-utero Exposure to Varied Doses of Carbamazepine on Fetal Growth and Development in Albino Rats (Rattusnorvegicus) |
| Country | : | Kenya |
| Authors | : | Mwangi A. Wairimu || Kweri J. Kariuki || Kanyoni J. Mwangi || Thuo Reuben |
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: | 10.9790/3008-1404010518 |
Abstract: Prenatal exposure to carbamazepine has been shown to interfere with the normal morphogenesis and differention of the various fetal organs when applied in management of various maternal conditions like bipolar disorders, trigeminal neuralgia, andseizures associated with epilepsy among others.Such perturbations on normal development of the fetal organs in-utero can help in explainingthe cause of some of the structural, behavioral and functional mental disorders observed in adulthood whose cause is yet to be established. Such disorders of embryological origin are currently a major contributor to the disability-adjusted life years (DALY) in adulthood.Though, the existing literature has linked the prenatal exposure to alteration in various growth and development parameters......
[1]. Elshama SS, Eldin H, Osman H, El-kenawy AE. Teratogenic effect of Carbamazepine use during pregnancy in the mice Teratogenic effect of Carbamazepine use during pregnancy in the mice. 2015;(January).
[2]. El-gaafarawi I, Abouel-magd M. Teratogenic Effect of Carbamazepine Administration in Pregnant Rats. 2015;59:244-257. doi:10.12816/0012182.
[3]. Gerenutti M, Oliveira CC De, Conceição A, et al. Reproductive performance and embriotoxicity of rats exposed to carbamazepine. 2008;44.
[4]. Lander CM, Neurology A. Antiepileptic drugs in pregnancy and lactation. 1800:70-72.
[5]. Bromley RL, Baker GA. Fetal antiepileptic drug exposure and cognitive outcomes. Seizure Eur J Epilepsy. 2017;44:225-231. doi:10.1016/j.seizure.2016.10.006.
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| Paper Type | : | Research Paper |
| Title | : | Safety and Toxicological Evaluation of Siddha Anti HIV Medicine Deva Choornam |
| Country | : | India |
| Authors | : | Thangadurai. K || Vinayak. S || Subha.V || BR. Senthilkumar || Gayathri Natarajan || K.P. Kannan || N.J. Muthukumar |
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: | 10.9790/3008-1404011925 |
Abstract: Deva choornam (DC) is a renowned Siddha herbal formulation, which is clinically acclaimedacclaimed for its efficacy in treating Acquired Immuno Deficiency Syndrome (AIDS) patients. The formulation was assessed for its safety and toxicological profile using Animal model. Our study aims to validate the safety profile of the test drug DC using Albino wistar rat model. Acute and chronic toxicity studies were carried out as per the WHO guidelines. Oral Acute toxicity study was done at the limit dose level of 2000 mg/kg body weight of the animal. For.........
Key words: Siddha medicine, Anti HIV Formulation, Deva Choornam, Toxicity studies
[1]. Thangadurai K, Suresh K, Niranjana N, ThirunavukkarasuDharmalingam, Banumathi V. A review on siddha herbal formulation deva chooranam for improving the QOL in Acquired Immuno Deficiency Syndrome (AIDS).World Journal of Pharmaceutical Research.2017; 6(5): 319-332.
[2]. Thangadurai K, Rengasundari R., Vinayak S, Gayatri R, Suresh K and Banumathi V.In vitro free radical scavenging assay (DPPH (2, 2- diphenyl 1-2 picrylhydrazyl method) of Siddha HIV herbal formulation Deva Choornam.World Journal of Pharmaceutical Research.2018; 7(15): 770-775.
[3]. K.S.Murugesa mudhaliyar.Gunapadam-mooligai vaguppu.Directorate of Indian Medicine and Homoeopathy. 2008; 2nd ed.
[4]. Samraj K, Thillaivanan S, Padmanathan S, Kanagavalli K, Parthiban P. Acute and Sub-Acute Toxicity Study on Siddha Drug MagizhamPattaiChooranam in Rodents. International Journal of Pharmacognosy. 1:9.
[5]. Murugan R, Vembu T, Kumarswamy M. Toxicological Study of a Siddha Sastric Formulation ArumugaChendhuram in Rat Model. Journal of Applied Pharmaceutical Science. 2016;081–7..
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| Paper Type | : | Research Paper |
| Title | : | Effects of Prenatally Exposed Phenytoin Varying Doses on Fetal Growth of Albino Rats |
| Country | : | Kenya |
| Authors | : | Caroline C. Sigei || Kweri J Kariuki || Thuo Reuben || Kafaya G. Kibe |
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: | 10.9790/3008-1404012631 |
Abstract: Phenytoin is an antiepileptic drug with no sedative effects widely used in treatment of convulsive disorders. However, its use in pregnancy has been associated with various fetal malformations and impairment of fetal growth.Many factors have been attributed to these effects including phenytoin capacity to cause hypoxia in embryonic tissue, interference with maternal folate metabolism, maternal hemodynamic alterations, its inhibition on potassium channels among others,these consequently affect various developing fetus structures and organs that be associated with currently common postnatally problems of unknown cause such as growth retardation, congenital rickets ,congenital.........
[1]. Charan J, Kantharia ND. How to calculate sample size in animal studies ? 2013;4(4):129–32.
[2]. Ratas C De, Etapas D. Study of Wistar Rats Heart at Different Stages in the Evolutionary Cycle. 2014;32(2):614–7.
[3]. Garibay P, Angel M, Marti A, Manuel NEZ, Sofi A. Chronological and Morphological Study of Heart Development in the Rat Chronological and Morphological Study of Heart Development in the Rat. 2012;(October 2017).
[4]. Heart T. 129. 19.5 Development of the Heart.
[5]. Kelly RG, Buckingham ME, Moorman AF. Heart Fields and Cardiac Morphogenesis. 2011;(i)..
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| Paper Type | : | Research Paper |
| Title | : | Effect of Olibanum Essential Oil on Bacterial Plasmid |
| Country | : | Iraq |
| Authors | : | Lamiaa A. Gharb |
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: | 10.9790/3008-1404013234 |
Abstract: Essential oils are concentrated natural extracts derived from plants, which were proved to be good sources of bioactive compounds with antimicrobial properties. Olibanum essential oil has become increasingly popular in skin care. The current study exhibited the effect of this essential oil on curing resistant plasmid of Staphylococcus aureus isolated from burned skin. The oil was extracted by using Clevenger apparatus.Alkaline lysismethod was done to determine the antiplasmid activity. Loss of plasmid band was confirmed by agarose gel electrophoresis. The curing efficiency of olibanum essential oil was found to be 100% in all concentrations (0.5%, 1%, 3% ) as compared with control. In conclusion, the essential oil of Boswellia resin may be considered as a natural source for antimicrobial and antiplasmid agents and could be used for application in pharmaceutical industries.
[1]. Hassan R. 2012.Medical plant important and use ' Pharmaceuticaanalytica acta.3:10
[2]. Lemenih.M and Teketay.D.2003. Frankincense and myrrh resources of Ethiopia distribution ,production ,opportunities for dry land development and research need .SINET :ETHIOP.J.SCI.;26(1):63-27.
[3]. RameshkumarK.B.2014.Frankincense.https://www.researchgate.net/publication/299436058
[4]. Maloney, G.A. 1997. Gold, frankincense, and myrrh: An introduction to EasternChristian spirituality . New York: C rossroads Pub. Co
[5]. Suhail MM, Wu W, Cao A, Mondalek FG, Fung KM, Shih PT, Fang YT, Woolley C, Young G, Lin HK.2011.Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cell BMC Complement Altern Med. 15;11:129..
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| Paper Type | : | Research Paper |
| Title | : | Pharmacognostical Standardization of Roots of Acacia Nilotica Linn |
| Country | : | India |
| Authors | : | F. Johnsy Mary || M.SenthilKumar || G.Delhibabu || V.Karthikeyan || S.Muthu Meenal || R.Priyadharshini || S.Shanmugam |
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: | 10.9790/3008-1404013537 |
Abstract: Acacia Nilotica LINN (mimosaceae) commonly known as karuvalem is used in traditional system of medicine for healing various disease. It is used in the treatment of antioxidant, anticancer, the leaves are used as antibacterial.In the present investigation an attempt has been made for the pharmacognostical standardization of A.nilotica roots which includes macroscopy, microscopy as well WHO recommended physico-chemical parameters. The root extracts were subjected preliminary phytochemical screening. The result of this standardization may be helpful for identification, authentification & quality control of drug..
Key words:Acaica nilotica roots, Pharmacognostical Standardization
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| Paper Type | : | Research Paper |
| Title | : | The Maternal pregnancy outcomes following prenatal exposure to varied doses of alcohol in albino rats (rattusnorvegicus) |
| Country | : | Kenya |
| Authors | : | Teresiah W. Musa || Kweri J. Kariuki || P.J. Kasyoki || A.N.Malik |
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: | 10.9790/3008-1404013843 |
Abstract: Background- Problems related to ethanol (alcohol) ranks among the global public health concerns andIn-utero exposure to alcohol directly or indirectly perturb maternal organ functions like liver and placental among others. This perturbation has been shown to occurs through different mechanisms including alteration of maternalprotein, carbohydrate and lipid metabolism, as well as placental blood vessel vasoconstriction which in turn may interferes with fetal blood supply and oxygenation hence placing the fetus at risk of weight deficit, congenital defects among others.ThoughMany factors likethe genetic inheritance of mutant genes, nutritional status and many other factors have been shown toinfluence the range and severity of the maternal alcohol outcomes, data on whether the observed maternal alcohol outcomes are dose and time dependent are not well elucidated hence forming the basis of this study............
[1]. Nakhoul MR, Seif KE, Haddad N, Haddad GE. Fetal Alcohol Exposure : The Common Toll Alcoholism & Drug Dependence. 2017;5(1):1–7.
[2]. Manzo-avalos S, Saavedra-molina A. Cellular and Mitochondrial Effects of Alcohol Consumption. 2010;4281–304.
[3]. Rehm J, Ph D, Gmel G, Ph D, Sempos CT, Ph D, et al. Alcohol-Related Morbidity and Mortality. :39–51.
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[5]. Ornoy A, Ergaz Z. Alcohol Abuse in Pregnant Women : Effects on the Fetus and Newborn , Mode of Action and Maternal Treatment. 2010;364–79..
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| Paper Type | : | Research Paper |
| Title | : | Histological and Morphometric Effects of Liv 52 on Acetaminophen Induced Liver Toxicity in Adult Albino Rats |
| Country | : | Kenya |
| Authors | : | Rono .k walter || Kweri j Kariuki || Kibe G. Kafanya || Thuo Rueben || Kanyoni j.Mwangi |
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: | 10.9790/3008-1404014451 |
Abstract: Paracetamol a commonly used analgesic has been associated with liver toxicity and resultant alteration of its histomorphology with eventual liver malfunctions. This hepatotoxicity has been shown to be as a result of prolonged use or overdoses of paracetamol. On the other hand LIV52 also known as livercare, a herbal formulation has been shown to have restorative effects on the liver induced hepatotoxicity. However there is paucity of data on its restorative histo-morphological effects on the acute induced liver hepatotoxicity or its chronic usage. In addition, Data on the restorative effects of LIV52 on the liver induced hepatotoxicity when used in varied doses is also lacking. This study aimed at determining the histo- morphological and morphometric restorative effects of varied doses of LIV52 following the liver hepatotoxicity induced with paracetamol. The research was..........
Key words: hepatotoxicity, liver volume and morphological changes
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[2]. Bjõrnsson E. Hepatotoxicity by Drugs: The Most Common Implicated Agents. Vol 17.; 2016. doi:10.3390/ijms17020224.
[3]. Kaplowitz N. Drug-Induced Liver Injury. 2011;90033(Suppl 2):44-48.
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[5]. Chen M, Suzuki A, Borlak J, Andrade RJ, Lucena MI. Review Drug-induced liver injury : Interactions between drug properties and host factors. J Hepatol. 2015;63(2):503-514. doi:10.1016/j.jhep.2015.04.016...
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| Paper Type | : | Research Paper |
| Title | : | A Brief Study on Motor Neuron Disease; and its Treatment Includes Drug Delivery System; Future Aspects on Neurological Science |
| Country | : | India |
| Authors | : | Mohammad Gayoor Khan || Umama Yezdani || Shivam Choudghal || Sana Rahman || Mayur Sadar || Ayush Kumar |
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: | 10.9790/3008-1404015256 |
Abstract: Motor neuron disease is vary hazards disease in recent time, MND (Motor Neuron Disease) basically it shows clinical presentation to ALS (Amyotrophic lateral sclerosis) considered is most neurodegenerative disease. In MND basically loss of nerves in the spine and brain is not working so it is Refferd to neurodegeneration. It is recorded as in last past year we have seen lots of changes related to patient care treatment improving and drug safety but also rapid scientific advances is there, so that rational therapies based on key pathogenic mechanisms now seem plausible. ALS have both properties in heterogeneous. it occurs 1 year to delay from first symptoms...........
Key Words: Neurodegenerative disease, RNA, Amyotrophic lateral sclerosis, neurological sciences
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| Paper Type | : | Research Paper |
| Title | : | Optimization of Chitosan Nanoparticles for Direct Nose-To Brain Sumatriptan Deposition |
| Country | : | Egypt |
| Authors | : | Hend Mohamed Abdel-Bar |
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: | 10.9790/3008-1404015765 |
Abstract: The aim of this study was to optimize different chitosan nanoparticles to improve sumatriptan brain uptake. Different chitosan nanoparticles (CS NPs) were prepared by cross linking CS with tripolyphosphate (TPP). The NPs were statistically optimized by Box-Behnken design using Design Expert® software (Version 9.0.6.2, Stat-Ease Inc. Minneapolis, MN, USA). The influence of CS and TPP concentrations as well as stirring speed on particle size and entrapment efficiency (EE%) were evaluated. The optimized formulae were evaluated concerning zeta potential, TEM and in vitro release. Plasma pharmacokinetics and brain deposition were also investigated following intranasal............
Keywords:Brain uptake, Chitosan, Intranasal, Nanoparticles, Sumatriptan
[1]. Huang D, Ren L, Qiu C-S, Liu P, Peterson J, Yanagawa Y, Caoa Y-Q. Characterization of a mouse model of headache. Pain. 157(8), 2016, 1744–1760.
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[3]. Hansraj GP, Singh SK, Kumar P. Sumatriptan succinate loaded chitosan solid lipid nanoparticles for enhanced anti-migraine potential. Int J BiolMacromol. 81, 2015, 467-76.
[4]. Chen Y, Liu L. Modern methods for delivery of drugs across the blood-brain barrier. Adv Drug Deliv Rev. 64(7), 2012, 640-65.
[5]. Pridgen E. M., Alexis F, Farokhzad O.C. Polymeric nanoparticle drug delivery technologies for oral delivery applications. Expert Opin Drug Deliv. 12, 2015, 1459-1473..
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| Paper Type | : | Research Paper |
| Title | : | Bacteriological Quality of Boreholes And Wells in Bokkos, Plateau State Nigeria |
| Country | : | Nigeria |
| Authors | : | Philomena, Dan Ayika || Margaret M. A Danladi || Istifanus M.F || Yenkat George |
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: | 10.9790/3008-1404016671 |
Abstract: Access to safe drinking water is scarce in most developing countries. As a result most communities depend on underground water sources such as well and boreholes. The aim of this research was to analyze the bacteriological quality of water used in Ndar and Butura communities in Bokkos, Plateau State. Thirty water samples from 15 wells and 15 boreholes were analyzed using standard water evaluation techniques. The physicochemical analysis of the water samples reveals that most of the water samples were colourless, odourless and tasteless, contain no particle with a pH range of 6.5 to 8.4. This is within the acceptable standard limit of 6.5 -8.5for drinking water. The most probable number (MPN)/ 100ml of both the wells and boreholes ranged from 12 -24/100ml.........
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[3]. Anyanwu, C. U., & Okoli, E. N. (2012). Evaluation of the bacteriological and physicochemical quality of water supplies in Nsukka, Southeast, Nigeria. African Journal of Biotechnology, 11(48), 10868-10873.
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[5]. Azizullah, A., Khattak, M. N. K., Richter, P., & Häder, D. P. (2011). Water pollution in Pakistan and its impact on public health—a review. Environment international, 37(2), 479-497.
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| Paper Type | : | Research Paper |
| Title | : | Stenose Du Duodenum De Cause Inhabituelle : Hyperplasie Pseudo-Tumorale Des Glandes De Brunner |
| Country | : | Maroc |
| Authors | : | Salwa Belhabib || Mohamed Tbouda || Malika Amarir || Amine Azami || Adil Boudhas || Hassan Ennouali || Mohamed Oukabli |
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: | 10.9790/3008-1404017274 |
Abstract: Brunner's gland hyperplasia is a benign lesions of duodenum. Most of case are revealed by obstructive signs. They are usually small less than 1cm in diameter. When Brunner's gland hyperplasia does not have common dimensions, it may also mimic a malignancy and it can lead to over treatment. We report the case of 60-years old man with a large Brunner's gland hyperplasia mimicking a malignancy which lead to excessive treatment by a partial gastrectomy.
Keywords: Brunner's gland, hyperplasia, over treatment
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| Paper Type | : | Research Paper |
| Title | : | Managing Burns and Related Complications in Emergency |
| Country | : | |
| Authors | : | Asra Shaik || Vallala Akhila || Dr. Nikhil Kumar Vanjari |
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: | 10.9790/3008-1404017580 |
Abstract: A burn is a thermal injury caused by biological, chemical, electrical and physical agents with local and systemic repercussions. They have a greater incidence in economically and culturally marginalized countries. Knowing the kind of burn is vital for effective management. Following a burn, there's a huge production of free radicals that is harmful and involved in inflammation, systemic inflammatory response syndrome, immunosuppression...........
Keywords:Burns, severity assessment, fluid resuscitation, excision, skin grafting, nutrition
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| Paper Type | : | Research Paper |
| Title | : | Garlic (Allium Sativum): Pharmaceutical Uses |
| Country | : | India |
| Authors | : | DR. SAVITA CHAHAR |
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: | 10.9790/3008-1404018182 |
Abstract: Garlic (Allium sativum ) is one of the most researched and bestselling herbal product in the market. For centuries it was used as a traditional remedy for health related disorders. Also, it is widely used as a food ingredients, spice and aphrodisiac. The garlic plant's bulb is most commonly used part of the plant. Garlic bulbs are normally divided in to numerous fleshy sections called cloves. These cloves are consumption (raw or cooked) or for medicinal purpose. They have a characteristic pungent, spicy flavor that mellows considerably with cooking. The distinctive aroma is mainly..........
Keywords:Allium sativum, Cloves, Bulb, Bulbils, Scallion, Green garlic
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