Series-3 (July-August 2019)July-August 2019 Issue Statistics
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| Paper Type | : | Research Paper |
| Title | : | Micro architecture of the Testes following administration of Coconut Oil (Cocos nucifera L.) on Adult |
| Country | : | Nigeria |
| Authors | : | Albino Wistar Rats |
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: | 10.9790/3008-1404030109  |
Abstract: This study was aimed at determining the effect of different dosages of coconut oil on the histology of the testis. The rats in the control group were administered with distilled water while those in the low, moderate and high dose groups were administered with coconut oil extract of 0.5, 1.1 and 2.2ml/kg body weight respectively once daily for fourteen days. On day 14 of the experiment, the rats were sacrificed. The testes of rats from various groups were carefully dissected out and weighed. There was no significant decrease (p<0.05) in mean testicular weight of the treated rats.........
Key Words: Cocos nucifera, testis, histology, spermatogenesis
[1]. Ahmed, M., Al-Daghri, N., Alokail, S., and Hussain, T. (2013). Potential Changes in Rat Spermatogenesis and Sperm Parameters after Inhalation of Boswellia papyrifera and Boswellia carterii Incense. Int. J. Environ. Res. Public Health 2013, 10, 830-844; doi:10.3390
[2]. Ali, M. (2007). The effect of alcoholic extract of coconut (Cocos nucifera L.) fruits on some reproductive aspects of male albino mice. Ph.D Thesis. Department of Physiology. University of Basrah.
[3]. Arunima, S. & Rajamohan, T. (2013). Effect of virgin coconut oil enriched diet on the antioxidant status and paraoxonase 1 activity in ameliorating the oxidative stress in rats - a comparative study. Food Func.,. 4, 9:1402-9.
[4]. Benninghoff, A. (1993). Testis, epididymis and spermatogenesis: History. Retrieved from http://www.urology-textbook.com/testis-histology.html
[5]. Bruce, C. N. (2004). The Coconut Oil Miracle. Harper & Row Avery, USA
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| Paper Type | : | Research Paper |
| Title | : | Carcinome sarcomatoïde du pancréas: à propos d'une nouvelle observation Sarcomatoïd carcinoma of the pancreas: A case report |
| Country | : | Maroc |
| Authors | : | Salwa Belhabib || Amine Azami || Adil Boudhas || Mohamed Oukabli || Abderrahmane Al Bouzidi |
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: | 10.9790/3008-1404031013 |
Abstract: Le carcinome sarcomatoïde du pancréas est une tumeur maligne rare, caractérisée par la coexistence d'une composante sarcomatoïde prédominante associée à un contingent adénocarcinomateux bien différencié. Nous rapportons l'observation d'une patiente âgée de 44 ans, hospitalisée pour des épigastralgies transfixiantes évoluant depuis un mois, avec conservation de l'état général. L'échographie et la tomodensitométrie abdominale concluaient à une masse pancréatique solide de de la queue envahissant le hile splénique. Le geste opératoire avait consisté en une spléno-pancréatéctomie caudale et l'examen anatomopathologique de la pièce révélait un carcinome sarcomatoïde du pancréas. Une chimiothérapie adjuvante été instauré. La patiente est décédée après 6 mois.
Key words: Carcinome sarcomatoïde – pancréas - différentiation épithéliale
[1]. Kloppel G, Solcia E, Longnecker DS, Capella C, Sobin H.World Health Organization Typing of Tumours of the Exocrine Pancréas. 2nd Ed. Berlin: Springer-Verlag; 1996.p. 17-8.
[2]. Pan ZG, Wang B (2007). Anaplastic carcinoma of the pancreas associated with a mucinous cystic adenocarcinoma. A case report and review of the literature. JOP 8 Suppl 6:775–8
[3]. Strobel O, Hartwig W, Bergmann F, et al (2011). Anaplastic pancreatic cancer: Presentation, surgical management, and outcome. Surgery 149:Suppl 2:200–8.
[4]. Higashi M, Takao S, Sato. Sarcomatoide carcinoma of the pancréas : A case report with immunohistochemical study. Pathology Iternational 1999 ;49 :453-456.
[5]. Hoorens A, Prenzel K, Lemoine NR, Kloppel G. Undifferentiated carcinoma of the pancreas: analysis of intermediate filament profile and Ki-ras mutations provides evidence of a ductal origin. J Pathol 1998 ; 185(1) :53-60.
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| Paper Type | : | Research Paper |
| Title | : | Analysis of frequency of alterations in EGFR exon 18-21 in Glioblastoma multiforme and its prognostic significance – A single centre experience from India |
| Country | : | India |
| Authors | : | Wesley Mannirathil Jose || Vinayak Munirathnam || Narendranath V || Arun Philip || Bindhu MR || Pavithran Keechilat |
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: | 10.9790/3008-1404031419 |
Abstract: Background: Glioblastoma multiforme (GBM) is a disease with poorest outcome among all central nervous system malignancies. Alteration in epidermal growth factor receptors (EGFR) is reported in GBM and may be a prognostic and predictive marker of overall disease outcome. Objective: We aimed to analyze the frequency of alteration of EGFR exon 18-21 in patients with GBM and their outcomes after standard treatment. Methods: Since there are no study from southern part of India this was conceived as a pilot, retrospective study in a single tertiary cancer center in South India. Results: Forty patients with GBM who had......
Key words: Glioblastoma Multiforme, Epidermal growth factor receptor, Alteration, Mutation.
[1]. Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol 2016; 131: 803.
[2]. Ostrom Q T, Gittleman H, Truitt G, Boscia A, Kruchko C, Barnholtz-Sloan JS. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2011–2015. Neuro-Oncology2018; 20 (suppl 4): iv1–iv86. [available at https://doi.org/10.1093/neuonc/noy131]
[3]. Jalali R, Datta. Prospective analysis of incidence of central nervous tumors presenting in a tertiary cancer hospital from India. J Neurooncol. 2008; 87: 111–4.
[4]. Jain A, Sharma MC, Suri V, Kale SS, Mahapatra A K, Tatke M, Chacko G, Pathak A, Santosh V, Nair P, Husain N, Sarkar C. Spectrum of pediatric brain tumors in India: A multi-institutional study. Neurol India 2011;59:208-11.
[5]. Quinn T. Ostrom, Luc Bauchet, Faith G. Davis, Isabelle Deltour, James L. Fisher, Chelsea Eastman Langer et al. The epidemiology of glioma in adults: a "state of the science" review. Neuro-Oncology 2014; 16(7): 896–913.
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| Paper Type | : | Research Paper |
| Title | : | Synthesis of New Derivatives of 1-(4-(5-(3,4-substituted phenyl)-4H-1,2,4-triazol-3-yl)phenyl)-2-methyl-1H-indoles and their antibacterial & antifungal activity |
| Country | : | India |
| Authors | : | B. Bhagyalaxmi || Dr. Raghunandan Nerella || Dr. Shyam Panga || Dr. Naveen Kumar Podila |
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: | 10.9790/3008-1404032026 |
Abstract: Ten new derivatives of 1-(4-(5-(3,4-substitutedphenyl)-4H-1,2,4-triazol-3-yl)phenyl)-2-methyl-1H-indoles(3a-j) have been synthesized, and most of the derivatives were promisingly active towards antibacterial and antifungal strains as compared with Ampicillin and fluconazole as positive controls due to the presence of triazole and is indole heterocyclic ring systems. All the new derivatives were prepared from 3,4-substituted phenylamidine hydrochlorides (1a-j) salts were reacted with 4-Iodobenzonitrile in presence of cuprous chloride and cesium carbonate in DMSO yields 3-(3,4-substituted phenyl)-5-(4-iodophenyl)-4H-1,2,4-triazoles ( 2a-j). Finally, 2-methylindole reacts with 3-(3,4-substituted phenyl)-5-(4-iodophenyl)-4H-1,2,4-triazoles(2a-j) to form 1-(4-(5-(3,4-substitutedphenyl)-4H-1,2,4-triazol-3-yl)phenyl)-2-methyl-1H-indole(3a-j). The structures of newly synthesized derivatives were confirmed by IR, 1H NMR,13CNMR, MS spectral data and elemental analysis.
Key words: 4-Iodobenzonitrile; Substituted phenyl triazole derivatives; 2-methyl indole; antibacterial activity; antifungal activity.
[1]. Kaplancikli Z A, Turan-Zitouni G, Ozdemir A & Revail G (2008), Eur J Med Chem, 43,155.
[2]. Mishra R, Kumar R, Kumar S, Majeed J, Rashid M & Sharma S (2010), J Chil Chem Soc, 55, 359.
[3]. Muhi-Eldeen Z, Nadir M, Aljobory N R, Husseen F & Stohs S(1991), Eur J Med Chem, 26, , 237.
[4]. Upmanyu N, Kumar S, Kharya M D, Shah K & Mishra P(2011), Acta Pol Pharm, 68, 213.
[5]. Zahajska L, Klimesova V, Koci J, Waisser K & Kaustova J(2004), Arch Pharm (Weinheim), 337, 549
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| Paper Type | : | Research Paper |
| Title | : | Promoting therapeutic outcomes in the management of Diabetes with Lycopene and VitaminE |
| Country | : | Nigeria |
| Authors | : | Joseph C Ndefo || Austine E Ighorodje || Santus C Arisukwu |
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: | 10.9790/3008-1404032733 |
Abstract: An association exists between diabetes and liver injury. Liver pathology among diabetics is similar to that of alcoholic liver disease and cirrhosis. Elevated serum activity of aspartate (AST), and alanine aminotransferase (ALT) are frequently found in diabetics; both in human and experimental diabetes. This liver toxicity is partly caused by free radicals. The aim of this study is to evaluate the benefits of antioxidants Lycopene and Vitamin E in the management of diabetes. The experimental Albino rats used were divided into nine groups. The first and the second groups were controls; eight out of the nine groups were made diabetic with alloxan. The rats were treated accordingly with three concentrations of lycopene and vitamin E for four weeks. The increased level of glucose and liver markers were significantly reduced by the administration of Lycopene and Vitamin E especially with increasing doses.Lycopene and Vitamin E will be useful to promote therapeutic outcome in the management of diabetic patents..
Key words: Diabetes mellitus,Hepatocarcinoma, Lycopene, Vitamin E
[1]. K D Tripathi ,Essentials of medical pharmacology. 5thed.New Delhi: Jaypee brother's medical publishers(p) Ltd;1996, 245-253.
[2]. M Inoue, M Iwasaki, T Otani, S Sasazuki, M Noda, and S Tsugane. Diabetes mellitus and the risk of cancer: results from a large-scale population-based cohort study in Japan,Arch Intern Med,166 ,2006, 1871-1877
[3]. M S Lai,M S Hsieh,Y H Chiu, T H Chen. Type 2 diabetes and hepatocellular carcinoma: A cohort study in high prevalence area of hepatitis virus infection. Hepatology, 44(6), 2006,1408-1410.
[4]. Yimin Yin, ZicongZheng, Zhuoqin Jiang,Effects of lycopene on metabolism of glycolipid in type 2 diabetic rats.Biomedicine and Pharmacotherapy,109, 2019, 2070-2077.
[5]. A B Jain,A V Jain,Vitamin E, its beneficial role in Diabetes mellitus(DM) and its complications.Journal of clinical and Diagnostic Research,6(10), 2012, 1624-1628.
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| Paper Type | : | Research Paper |
| Title | : | Phytochemical and Therapeutic Potential of Physalis species: a Review |
| Country | : | India |
| Authors | : | Pooja Shah || Dr. Kundan Singh Bora |
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: | 10.9790/3008-1404033451 |
Abstract: The present review article disclosed the importance of specific species of genus Physalis Linn which are spreaded in all over the world and this considerable research details on different species is noteworthy for worldwide future researchers. In this article morphological, therapeutic activities phytochemicals and ethnobotanical data have been considerable records for important species of the genus Physalis L. In this extensive exploration on morphologic and phytochemical particulars for important medicinal species of Physalis, the aim of this article is to provide detailed, faithful and comprehensive information of precise species of the genus Physalis L. like; P. peruviana L., P. angulata L., P. pubescens L., P. minima L., P. longifolia Nutt., P. ixocarpa......
Key words: Physalis species, Morphology, Phytochemicals, Therapeutic activities, Ethno-botany.
[1]. Ahmad Javed, Farooqui H. A., Ahmad Sageer. 2008. Trianthema portulacastrum L., an herbal drug for the cure of edema. Journal of herbs, species and medicinal plants. Vol. 7(2). Page no. 65-70.
[2]. Ahmad wasim, Zeenat Fahmeede, Ahmad Minahaj, Ansari Naseen. 2017. Medicinal plants as Potent Diuretic: A Review. Researchgate. Page No. 2-5.
[3]. Alramadhan Elham Alramadham, Hanna S. mirna, Hanna S. mena, Goldstein A. todd, Avila M. Samantha and Weeks S. Benjamin. 2012. Dietary and botanical anxiolytics. Mad.scimonit. Page No. 43.
[4]. Andrabi Shamim Adil Syed, Goyal Chanchal. 2018. Hypertension: The silent killer. Indian council of medical research. Page No.1
[5]. Anjani Kumari and Kumar Harsh. 2018. Morphological features for characterization of local populations of Physalis minima L. (Ban Tipariya) in Bihar. International journal of agriculture sciences. Vol. 10. ISSN: 0975-3710. Page no. 5047- 5051.
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| Paper Type | : | Research Paper |
| Title | : | Review on Compositions, Formation, and Genetic Control of Bacterial Biofilm |
| Country | : | Iraq |
| Authors | : | Salih Abdul Mahdi Khadim |
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: | 10.9790/3008-1404035259 |
Abstract: Biofilm is an innate defensive way through which bacterial cells are linked together to be associated with the biotic and abiotic surfaces within a self-produced matrix of extracellular polymeric substance. A biofilm is consisted of attached microbial cells sessile within a matrix of extracellular polymeric secretions (EPS). EPS has been composed of ; proteins arranged from 1-2% including enzymes, DNA and RNA less than 1%, while the polysaccharides was 1-2% and the main remaining component is, water up to 97% which is responsible for the flow of nutrients inside biofilm matrix. which surround and protect bacterial cells. The EPSmatrix is typically composed......
Key words: Bacteria, Biofilm, Composition, Genetic control.
[1]. Hall-Stoodley L, et al. Bacterial biofilms: from the natural environment to infectious diseases. Nat Rev Microbiol. 2004; 2:95-108.
[2]. Costerton J, et al. Bacterial biofilms: a common cause of persistent infections. Sci. 1999; 284: 1318-1322.
[3]. Dobell, C. . Antony van Leeuwenhoek and his "Little Animals." Dover Publications, (ed) 1960. New York.
[4]. Henrici A. Studies of freshwater bacteria. 1. A direct microscopic technique. J Bacteriol 1933;25:277–86.
[5]. ZoBell CE, Allen E. The significance of marine bacteria in the fouling of submerged surfaces. J Bacterial. 1935;29:239–51.
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| Paper Type | : | Research Paper |
| Title | : | Physicochemical Study of Gomutra and Formulation of Gomutra ARK |
| Country | : | India |
| Authors | : | Chavan Ajinkya || Gurav Yogesh || Gharge Varsha || Patil Reshma || Birajdar Avinash |
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: | 10.9790/3008-1404036064 |
Abstract: Gomutra is important part of Indian tradition. It is not only holy but also has various important medicinal uses. Classical treatises in Ayurvedic. Charka, Sushrutaand Vagbhata Samhita has described Ashtamutra (eight types of urine) along with their properties, indication and formulations. Cow urine is one of them. In this modern era, the diseases related to life style like cancer, autoimmune diseases, diabetes, AIDS etc. are increasing day by day. Irrational use of antibiotics is also responsible for increase in antibiotic resistant infectious diseases. Gomutra (Cow urine) is scientifically proven to act as an immunomodulator along with its bacteriostatic action. Various actions and researches on cow urine are summarized in this article. However, more studies experimental as well as clinical can throw better light on it.
Key words: Cow urine, antimicrobial activity, gomutra ark.
[1]. Valiathan M. S. Hyderabad, India, Orient Longman Private Ltd, 2007, The Legacy Of Susruta, Page no. 158
[2]. Dhama K, Chauvhan R. S., Singhal Lokesh. Anti-Cancer Activity Of Cow Urine: Current Status and Future Directions, International Journal Of Cow Science, 1(2):1-25 2005
[3]. Jain NK, Gupta VB, Garg Rajesh, Silwat N. Efficacy of cow urine therapy on various cancer patients, 2010, Vol-1, Issue-4, Page no. 29-35.
[4]. Dhama K, Chakraborty S, Mahima, YakoobWani M 2013. Novel and emerging therapies safeguarding health of human and their companion animals : A Review. Pak. J. Bio. Sci. 16(3): 101-113 .
[5]. Gosavi D. D. Sachadev D. Salwe K, 2011 Immunomodulator and Antioxident effect of Gomutra Arka in Rats‟ MGIMS, September 2011, Vol 16, No (ii), 37-41.
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| Paper Type | : | Research Paper |
| Title | : | Assessment of satisfaction with community pharmacy services using SERVQUAL; Implications for quality of service |
| Country | : | Nigeria |
| Authors | : | Paul Otor Onah || SiyakaAbdulLateef || Ahmed Abdulmalik |
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: | 10.9790/3008-1404036571 |
Abstract: Introduction: In recent years there have been increased roles for pharmacist in healthcare services. Pharmacists in addition to traditional dispensing and medication supply functions are expected to participate in multidisciplinary patient care services. Pharmacy services now lay emphasis on appropriateness of drug selection, cost effectiveness, safety, public health, prevention of adverse events and drug information to mention but a few. Ineffective pharmacy services are reported to increase incidence of dosage errors, adverse drug reactions and irrational drug use. Satisfaction with services is increasingly being recognized as a quality indicator in healthcare services. There is need to ensure that expectations of patients and service performance is given due consideration in service delivery operations. Objectives: To identify common pharmacy services, assess level of satisfaction and identify dimensions associated with high level of satisfaction...........
Key words: Community pharmacy, Satisfaction, Expectations, Perception, SERVQUAL
[1]. Kleimann K, Harvey AK. 1994. Do we really care? Am J Hosp Pharmacy 51(6): 2011 – 2015
[2]. Helpler CD, Strand LM 1990. Opportunities and responsibilities in pharmaceutical care. Am J Hosp Pharmacy 47(3): 533 – 543
[3]. Mannese CK, Derkx FH, de Rider MA, t Veld MAJ, van de Cammen TJ 2000. Contribution of adverse drug reactions to hospital admissions of older patient. Age Ageing 29: 35 – 39
[4]. Ernest FR, Grizzle AJ 2001. Drug related deaths updating the cost of illness model. J AM Pharm Assoc 41(2): 192 – 199
[5]. Ebbesen J, Buajordet J, Erriksssen J, Brors O, Hilberg T, Svaar H, Sandvik L 2001. Drug related deaths in a department of internal medicine. Arch Intern Med. 161(19): 2317 – 2323
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| Paper Type | : | Research Paper |
| Title | : | Nasal Carriage of Staphylococcus aureus in People Living with Human Imunodefficiency Virus (HIV) And Tuberculosis Patients In Lagos, Nigeria |
| Country | : | Nigeria |
| Authors | : | O. A Babatunde || O. O. Akinnola || A. David || E. A. Omonigbehin |
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: | 10.9790/3008-1404037277 |
Abstract: Staphylococcus aureus is one of the leading human pathogens responsible for a wide range of infections in susceptible host. Nasal carriage has been identified as the major risk factor causing varying degrees of infections in immunosuppressed individuals. This studyevaluatedthe prevalence of nasal carriage of S. aureusin individuals with HIV, TB and HIV/TB co infection, antibiotic susceptibility pattern of the S. aureus isolates and the presence of mec A and virulence gene were also evaluated. This study was conducted at the DOT and HIV clinics of the Nigeria Institute of Medical Research (NIMR) between November 2018 and April 2019. A total of 250 nasal swab samples were collected from the anterior nares of the participants. The result showeda prevalence rate of 18.8% nasal carriage...........
[1]. Ansari SS, Nepal HP, Gautam RR, et al. Threat of drug resistantStaphylococcus aureus to health in Nepal. BMC Infectious Diseases. 2014;14:157.
[2]. Ayepola OO, Taiwo SO, Anifowose A. et al. Nasal Carriage of Staphylococcus aureus and Associated Risk Factors among Nigerian University. 2018; Acta ScientificMicrobiology, 1 (2): 06-08.
[3]. Abiye JP, Alo M, Nwokah EG. et al. Nasal Carriage of MRSA in People living with HIV/AIDS undertaking Antiretroviral Therapy in a Tertiary Hospital in Port Harcourt. International. Journal of innovative Health Research. 2018;6(1): 12-23.
[4]. Kotpal R, Krishma P, Preena B. et al. Incidence and Risk Factors of Nasal Carriage of Staphylococcus aureus in HIV Infected Individuals in Comparison to HIV Uninfected Individuals.: A Case-control Study. Journal of International Association of AIDSCare. 2014; 15(2):141-147.
[5]. Kluytmans J, Belkum A, Verbrusch H. Nasal Carriage of Staphylococcus aureus: Epidemiology, Underlying Mechanisms, and Associated Risks. Clinical Microbiology Reviews, American Society for Microbiology. 1997; 505-520.
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| Paper Type | : | Research Paper |
| Title | : | Biochemical and Molecular Characterization of Bacteria Associated With Cnidoscolus aconitifolius (Mill.) I. M. Johnston |
| Country | : | Nigeria |
| Authors | : | Iyanyi, N. G. || Ataga, A. E. || Nwachukwu, E. O. |
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: | 10.9790/3008-1404037885 |
Abstract: Cnidoscolus aconitifolius (Mill.) I. M. Johnston is an economic plant with various medicinal and food values. Little is known about the bacterial organisms associated with this plant. The use of molecular techniques in determining the bacterial composition of biological samples has proved be a more reliable method than the traditional cultural method which is based only on morphological and biochemical characteristics of isolates; in which case, misinterpretation or wrong identification of organisms may occur. In this study, the bacterial organisms associated with Cnidoscolus aconitifolius were isolated and identified using traditional cultural method, biochemical tests.........
Keywords: Cnidoscolus aconitifolius, bacterial organism, polymerase chain reaction, sequencing
[1]. Aneja, K. R. (2003). Experiments in Microbiology, Plant Pathology and Biotechnology, Fourth Edition, New Age International (P) Ltd., Publishers, New Delhi, 320 pp.
[2]. Beiki, F., Busquets, A., Gomila, M.,Rahimian, H., Lalucat, J. and García-Valdés, E. (2016). New Pseudomonas spp. are Pathogenic to Citrus. PLoS ONE, 11(2) doi: 10.1371/journal.pone.0148796
[3]. Collins, C. H., Lyne, P. M. and Grange, J. M. (2004). Microbiological Methods (8th edn), Butterworth, London. 456pp.
[4]. Dawn, B. (2006). Chaya. ECHO Technical Notes. 16pp.
[5]. Donkoh A, Kese A. G. and Atuahene, C. C. (1990). Chemical Composition of Chaya Leaf Meal (Cnidoscolus aconitifolius) and Availability of its Amino Acids to Chicks. Animal Feed Science and Technology, 30 (1-2): 155-162..