Abstract: Microsponge drug delivery system offers a promising opportunities in multiple pharmaceutical implementations as it has distinctive characteristics such as enhanced product quality and elegance, expanded release, enhanced drug release profile, decreased discomfort, enhanced physical, chemical, and thermal stability, making it easy to develop novel product form. These are modern drug delivery systems capable of entrapping higher concentration of drugs due to networks or pores that interconnect. They can be prepared primarily by two techniques based on liquid suspension polymerization and solvent diffusion depending upon the physicochemical properties of the drug to be loaded. Microsponge delivery system was initially designed for the delivery of drugs topically or through the skin. Nowadays, Microsponges are often used for topical delivery carriers for anti-fungal, anti-inflammatory......
KEYWORDS: Topical drug delivery, Microsponges, release mechanisms, Nanosponges, suspension polymerization, Applications
[1]. Verma, RK, Garg, S. Drug delivery technologies and future directions. Pharmaceutical Technology 2001;25(2):1–14.
[2]. Jain, A, Gulbake, A, Jain, A, Shilpi, S, Hurkat, P, Jain, SK. Dual drug delivery using "smart" liposomes for triggered release of anticancer agents. Journal of Nanoparticle Research 2013;15(7):1–12.
[3]. Jain, A., Gulbake, A, Shilpi, S, Jain, A, Hurkat, P, Jain SK. A new horizon in modifications of chitosan: syntheses and applications. Critical Reviews™ in Therapeutic Drug Carrier Systems 2013;30(2):91–181.
[4]. Sharma, VK, Jain, A, Soni, V. Nano-aggregates: emerging delivery tools for tumor therapy. Critical Reviews™ in Therapeutic Drug Carrier Systems 2013;30(6):535–63.
[5]. Jain A, Jain, SK. Brain targeting using surface functionalized nanocarriers in human solid tumors. In: Singh, B, Jain, NK, Katare, OP. Drug Nanocarriers. Series Nanobiomedicine, Studium Press, Houston LLC, USA: Series Nanobiomedicine 2014;203–55.
[6]. Sastry, SV, Nyshadham, JR, Fix, JA. Recent technological advances in oral drug delivery-a review. Pharmaeutical Sciences Technology Today 2003;3(4):138–45..