iosr-JDMS   Volume-16 ~ Issue-11 ~ November-2017

Abstract: Fever is one of the commonest symptoms presented by patients to a healthcare provider. However, most of these fever cases are poorly described which affects the outcomes. Hence it is essential to understand clinico-social profile of fever cases and their management. Objectives: The objectives were to study the socio-demographic characteristics, classification of fever, pattern of antibiotic uses and distribution of risk factors among children attending pediatric OPD with fever. Methodology: It is an institution based cross-sectional, observational study, conducted in Pediatric Out Patient Department of Medical College Hospital, Kolkata during February 2016 to January 2017. All the patients with chief complaint of fever constituted the study population. A 10% convenient.........

Keywords –Fever cases, Antibiotic treatment, Pediatric Out Patient Department, Kolkata

[1]. Harrison‟s Principles of Internal Medicine, 19th Edition, p-123, Mc Graw Hill Education, 2015.
[2]. Nelson Textbook of Pediatrics, 20th Edition, Vol-I, P-173, Elsevier, Philadelphia, 2016.
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[5]. Jane M Gould , MD, FAAP; Chief Editor: Russell W Steele, MD. Medscape. Fever in the Infant and Toddler, Sep 13, 2017

Abstract: The incidence of extended spectrum beta-lactamases (ESBL)-producing strains has been steadly increasing during the past few years, and remains an important cause of treatment failures with cephalosporin. This study intended to investigate the antibiotic resistance patterns and gene types of ESBL-producing Klebsiella pneumoniae isolates in Dr. H. Abdul Moeloek Hospital, Lampung, Indonesia.Klebsiella pneumoniae isolates (N=90) collected from various clinical samples such as pus, sputum, blood, wound swab, urine and body fluids were subjected to usual antibiotics using disc diffusion methods according to NCCLS criteria for resistance analysis.To determine the minimum inhibitory concentration (MIC) and identify the ESBL-producing strains, the isolates were confirmed with........

Keywords: Antibiotic resistance Pattern, Klebsiella pneumoniae, ESBL, blaTEM, blaSHV, blaCTX

[1]. Shaikh,S., Fatima, J., Shakil, S., Rizvi, S.M.D., Kamal, M.A., 2015. Antibiotic resistance and extended spectrum beta-lactamases:
Types, epidemiology and treatment. Saudi Journal of Biological Sciences 22,90-101.
[2]. Bradford PA: Extended spectrum beta lactamases in the 21st century: characterization, epidemiology, and detection of this
important resistance threat. Clin Microbiol Rev 2001, 14:933-51.
[3]. Paterson DL and Bonomo RA: Extended spectrum beta-lactamases: a clinical update. Clin Microbiol Rev 2005, 18:657-86.
[4]. Cao X, Xu X, Zhang Z, Shen H, et al. 2014. Molecular characterization of clinical multidrug resistant Klebsiella pneumoniae
isolates. Ann. Clin Microbiol. Antimicrob. 13: 16.
[5]. Gumke S, Kohler C, Steinmetz I, et al. Molecular epidemiology of Extended spectrum betalactamase positive Klebsiella
pneumoniae from bloodstream infections and risk factors for mortality. J Infect Chemother. 2014, 20(12). 817-9.Pubmed PMID.

Abstract: The World Health Organization has highlighted the emergence of non-communicable chronic diseases, including stroke, in developing countries. As a cause of death, stroke ranks fourth in India. Stroke is the foremost cause of neuropsychiatric disorder, including Post Stroke Depression (PSD) which is a very common disorder. The objectives of this study were to identify the prevalence and severity of depression in patients with stroke and to assess its relationship with demographic variables and stroke characteristics. It was a cross sectional study and was conducted at the Neurology Out Patient Department of Thanjavur Medical College Hospital, Thanjavur, Tamil Nadu. Screening for depression was carried out for patients with stroke (N=52), who visited the Neurology Out Patient.........

Keywords: Stroke, post stroke depression, left middle cerebral artery infarction

[1]. World Health Report 2007. Geneva: World Health Organization. (Cited 2011 August 23), available at:(http://www.who.int/whr/2007/whr07_en.pdf) And http://www.who.int/topics/cerebrovascular_accident/en
[2]. Wayne Rosamond; Katherine Flegal, Gary Friday ;Karen Furie; Alan Go; Kurt Greenlund; et al. Heart Disease and Stroke Statistics,
A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee; 2007 update. (Cited 2011
August 28), available at: http://circ.ahajournals.org/content/115/5/e69.full
[3]. T Truelsen, P U Heuschmann, R Bonita, G Arjundas, P Dalal, A Damasceno, et al. Standard method for developing stroke registers
in low-income and middle income countries: experiences from a feasibility study of a stepwise approach to stroke surveillance
(STEPS Stroke); 2007 ; The Lancet Neurology, 6, P 134-139.
[4]. J. Mackay; G. Mensah, The Atlas of Heart Disease and Stroke, World Health organization, 2004.
[5]. Feigin, V.L., Lawes, C.M.M., Bennett, D.A., and Anderson C.S; Stroke epidemiology: e-review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century; 2003; Lancet Neurology, 2, 43-53..

Abstract: Background and Objectives : Hydro therapy is a system of Naturopathic medicine where treatment is given using various forms of water. Spinal spray is one of the treatment used in hydro therapy for the management of various disorders. Hence present study aims to evaluate the physiological effects of cold and neutral spinal spray and measure the difference among them. Materials and Methodology: 90 male healthy volunteers were recruited for the study. Subjects were randomly allocated into three groups, cold spinal spray (Group 1), neutral spinal spray (Group 2), and control (Group 3). Intervention was given for the duration of 20 minutes. Assessments were done 5 minutes before and 5 minutes immediately after the intervention. Results: Results of individually groups are shown some changes.........

Keywords: Hydro therapy, Spinal spray, Heart rate variability, Autonomic Nervous System, Naturopathy

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Abstract: L'observance du régime hyposodé chez les hypertendus est un élément déterminant dans la prise en charge. L'objectif de notre étude était de déterminer la valeur prédictive des outils d'évaluation du respect du régime hyposodé d'une part et les facteurs de risque de mauvaise observance de ce régime d'autre part. Méthodes : Nous avons mené une étude transversale sur une durée de 15 jours chez des patients suivis en consultation de néphrologie ayant une hypertension artérielle sous régime hyposodé. Nous avons coté l'observance du régime hyposodé en se basant sur des questionnaires pour le patient, l'accompagnant et le médecin. L'observance du traitement anti-hypertenseur s'est basée sur le score de Girerd. Une enquête diététique a permis d'estimer les apports quotidiens en sel. Enfin, nous avons utilisé un automate en salle de consultation pour la mesure systématique..........

Keywords: Hypertension artérielle, Natriurèse, Observance thérapeutique, Régime hyposodé

[1]. Kearney PM, Whelton M, Reynolds K et coll. Global burden of hypertension: analysis of worldwide data. Lancet 2005 ; 365 : 217-23.
[2]. Mancia G, et coll. 2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens, 2013 ; 31(7): 1281-357.
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Abstract: Internal fixation with hook plate has been used to treat acromioclavicular joint dislocation. This study aims to evaluate the effect of its use on shoulder function, to further analyze the contributing factors, and provide a basis for selection and design of improved internal fixation treatment of the acromioclavicular joint dislocation in the future. Methods: A prospective analysis was performed on patients treated with a hook plate for acromioclavicular joint dislocation in our hospital from January 2014 to February 2016. There were 15 cases in total, including 9 males and 6 females, with mean age of 48.27 ± 8.7 years. There were 10 cases of Rockwood type IVacromioclavicular dislocation, 5 cases of type V...........

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[2]. Arenas AJ, Pampliega T, Iglesias J. Surgical management of bipolar clavicular dislocation. Acta Orthop Belg. 1993;59:202–205.

[3]. Trainer G, Arciero RA, Mazzocca AD. Practical management of grade III acromioclavicular separations. Clin J Sport Med. 2008;18(2):162–166. doi: 10.1097/JSM.0b013e318169f4c1.

[4]. Motta P, Bruno L, Maderni A, et al. Acromioclavicular motion after surgical reconstruction. Knee Surg Sports Traumatol Arthrosc. 2012;20(6):1012–1018. doi: 10.1007/s00167-011-1627-5.

[5]. Mazzocca AD, Arciero RA, Bicos J. Evaluation and treatment of acromioclavicular joint injuries. Am J Sports Med. 2007;35(2):316–329. doi: 10.1177/0363546506298022..

Abstract: Formaldehyde is extensively used to preserve cadavers in departments of anatomy. This study investigated the effect of short-term exposure to formalin on male sex hormones levels of College of Health Sciences' students in Nnewi, Anambra State, Nigeria. There is paucity of information on this experimental design study in Nnewi hence the research. Forty (40) apparently healthy male students aged 18-30 years, were randomly recruited into the pre and post experimental design study. Five milliliters (5mls) each of baseline and post-formalin exposure blood samples were collected from each participant and used for the analysis of biochemical parameters. Serum Testosterone, Luteinizing..........

Keywords: Formalin, Testosterone, Follicle stimulating hormone, Luteinizing hormone, Estradiol, Prolactin, Student, Dissection Laboratory...

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and health effects, Environment International, 35, 2009, 1210–1224.
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Abstract: DKA is an acute life threatening condition with mortality of 3.4% to 13.4% in developing countries like India. Objective: Utilise PRISM III score for triage and prognostication in DKA. Methodology: It is a cross sectional hospital based study conducted on 50 DKA patients of age 1 month to 12 years, fulfilling the criteria (ISPAD guidelines) for 2 years duration at Department of Pediatrics, Niloufer Hospital, Osmania Medical College. PRISM III score was used to triage these children with DKA which comprised of 17 physiologic variables............

Keywords: Diabetic Ketoacidosis, Pediatric Risk of Mortality, Triaging.

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Lawson Wilkins Pediatric Endocrine Society consensus statement on diabetic ketoacidosis in children and adolescents. Pediatrics
2004; 113: e133-40
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Res 1991; 29: Abstract A195
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Abstract: Diabetes mellitus is a metabolic disorder in which there is increased level of blood glucose because of insulin deficiency leading to significant morbidity and mortality1. Global prevalence of diabetes is 6.3% in the general population and 8.7% among persons aged 20 years and older, corresponding to total number of 171 million of patients, this number will double and reach 366 million in 20302. Diabetic foot ulceration and infections are a major medical, social, economic problem and a leading cause of morbidity and mortality, especially in developing countries like India3............

[1]. Johar A, Waqas A and Ali A, Diabetic Foot Ulcer Grades; Correlation with ankle brachial pressure index. Professional Med J, 15(1): 133-136, (2008).
[2]. 2. Ako-Nai AK, Ikem IC, Akinloye OO, Aboderin AO, Ikem RT, Kassim OO, 2006. Characterization of bacterial isolates from diabetic foot infections in Ile-Ife, Southwestern Nigeria. The Foot, 16 (3): 158-164.
[3]. Lipsky BA, Itani K, Norden C, 2004 b. Linezolid Diabetic Foot Infections Study Group. Treating foot infections in diabetic patients: a randomized, multicenter, open-label trial of linezolid versus ampicillin sulbactam/ amoxicillin- clavulanate. Clinical Infectious Diseases. 38: 17-24.
[4]. Viswanathan V, Jasmine JJ, Snehalatha C, Ramachandran A. Prevalence of pathogens in diabetic foot infection in South India type 2 diabetic patients. Journal of Associations of Physicians in India, 2002; 50: 1013-6.
[5]. Ikem RT., Kolawole BA., Ikem IC. The prevalence, presentation and outcome of diabetic foot lesions in a Nigerian teaching hospital, Trop Doct, 32: 226-227, (2002).

Abstract: Glomus tumor is a benign tumour arising from the neuromyoarterial plexus concentrated beneath the nail and arises from digital Glomus body. It is more common in females, however extra digital tumours are common in males. It is common in elderly, but can occur in young individuals. Exact aetiology is not known. Common sites within the nail unit are the nail bed, subungual region, nail root and laterally. A 60 year old woman presented with slow growing swelling on the dorsal aspect of great toe for 5years. It was 4X3 cm in size, lying over extensor hallucis longus tendon. It was hard in consistency, lobulated surface with a small cystic area where a discharging puncture wound was present and the discharge was scanty and serosanguinous. The swelling was moving freely side to side with restricted...........

Keywords: Glomus tumour, Histopathological examination (HPE), ultra sonogram (USG), magnetic resonance Imaging (MRI)

[1]. Banavasi S Girisha, Manjunath M Shenoy, Michelle Mathias, and Rajashekar Mohan; Glomus tumor of the nail unit.

[2]. Heys SD, Brittenden J, Atkinson P, Eremin, Glomus tumour: an analysis of 43 patients and review of the literature; O Br J Surg. 1992 Apr; 79(4):345-7.

[3]. Weiss SW, Goldblum JR, editors. Enzinger and Weiss's Soft Tissue Tumors. 5th edition.Mosby; Maryland Heights,MO:2007. Perivascular tumors; pp. 751-756

[4]. Domínguez-Cherit J, Chanussot-Deprez C, Maria-Sarti H, Fonte-Avalos V, Vega-Memije E, Luis-Montoya P; Nail unit tumors: a study of 234 patients in the dermatology department of the "Dr Manuel Gea González" General Hospital in Mexico City. Dermatol Surg. 2008 Oct; 34(10):1363-71
[5]. Lee DW, Yang JH, Chang S, Won CH, Lee MW, Choi JH, Moon KC, Clinical and Pathological characteristics of extradigital Glomus tumors: a retrospective comparative study. J EUR ACAD Dermatol Venereol. 2011:25:1392-1397.

Abstract: Oral squamous cell carcinoma (OSCC) is widely recognized as the most common type of head and neck cancer and is an important cause of death and morbidity . In Indian population, the situation is more alarming since nearly 10% of the cancers that develop annually belongs to this category. Deactivation and unregulated expression of oncogenes and tumor suppressor genes may be involved in the pathogenesis of oral squamous cell carcinoma. The genomic change results in numerical aberrations in chromosomes 17 & p53 gene. The aim of our study was to identify numerical aberrations of chromosome 17, deletion or amplification of p53 gene. This study was performed retrospectively...........

Keywords: Oral squamous cell carcinoma, FISH, Chromosome 17, p53 gene

[1]. Wei Liu, Yu-Feng Wang, Hai-Wei Zhou, Peng Shi, Zeng-Tong Zhou, Guo-Yao Tang. "Malignant transformation of oral
leukoplakia: a retrospective cohort study of 218 Chinese patients". Liu et al. BMC Cancer 2010; 10: 685.
[2]. S. Warnakulasuriya, "Global Epidemiology of Oral and Oropharyngeal Cancer," Oral Oncology 2009; 45(4): 309-316.
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[5]. Meszaros N, Belengeanu D, Stoicanescu D, Andreescu N, Farcas S, Stoian M, Cevei M. "Analyses Of Numerical Aberrations Of
Chromosome 17 And TP53 Gene Deletion / Amplification In Human Oral Squamous Cell Carcinoma Using Dual-Color
Fluorescence In Situ Hybridization". Tom 2010; 17: 142-146.

Abstract: The non-traumatic perforations of the small intestine are pathological entities.The primary sources of the perforation might be foreign bodies, inflammatory diseases, tumors, infectious diseases, etc. In most cases intestinal perforation is discovered only by laparotomy and the definitive diagnosis is made only after histopathologic examination. Small bowel malignancies are rare; among them, lymphomas rank third in frequency, being mostly B-cell non Hodgkin lymphomas.Primary non-Hodgkin's lymphoma of the small bowel with hepatitis B presenting as a perforated viscus entity with peritonitis is extremely rare. A 58 year old man presented with pain abdomen and distension. An emergency laparotomy revealed a perforation in jejunum with enlarged mesenteric lymph nodes and mesenteric thickening which required segmental resection and anastomosis. Histopathological examination of the........

Keywords: perforation, small intestine, hepatitis B, extra nodal follicular lymphoma, peritonitis

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[4]. Chuang SS, Ye H, Yang SF, Huang WT, Chen HK, Hsieh PP, Hwang WS, Chang KY, Lu CL, Du MQ. Perforation predicts poor prognosis in patients with primary intestinal diffuse large B‐cell lymphoma. Histopathology. 2008 Oct 1;53(4):432-40.

[5]. Marcucci F, Spada E, Mele A, Caserta CA, Pulsoni A. The association of hepatitis B virus infection with B-cell non-Hodgkin lymphoma–a review. American journal of blood research. 2012; 2(1):18.

Abstract: Actinomycosis is a rare and insidious disease. The most common etiologic organism is the anaerobic, gram positive bacterium, Actinomyces israelii. It is invasive and spreads by direct extension across the tissue planes with the formation of multiple abscesses. Abdominopelvic actinomycosis is rare but its prevalence has increased with the increasing use of (Intrauterine devices) IUDs. Aims and Objectives: the aim of this study is to find out the association of Actinomycosis infection mongst IUD users. Material and Methods: this retrospective study is based on abdominal hysterectomies operated for Pelvic Inflammatory Disease in a two years period. In Five Hysterectomy specimens out of 100 cases, Copper T (Cu T) was present in situ as an incidental finding in...........

[1]. Simsek A, Perek A, Cakcak EI, Durgun VA. Pelvic actinomycosis presenting as a malignant pelvic mass. Journal of Medical Case
Reports. 2011; 5: 40.
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Abstract: Thepresence of peripheral arterial disease (PAD) is associated with higher cardiovascularmorbidity and mortality, regardless of gender or its clinical form of presentation (symptomatic orasymptomatic). The ankle brachial index (ABI) is a sensitive and cost-effective screening tool for PAD. ABI is valuable for screening of peripheral artery disease in patients at risk and for diagnosing the disease in patients who present with lower-extremity symptoms.Normal cut-off values for ABI are between 0.9 and 1.4. Therefore, ABI can be considered as a generalized atherosclerotic predictor, identifying patients at high risk for developing cardio or cerebrovascular events and should be incorporated into routine clinical practice.........

Keywords:- Ankle Brachial Index (ABI); Peripheral Arterial Disease (PAD).

[1]. Hiatt WR, Goldstone J, Smith SC Jr, et al. – Atherosclerotic PeripheralVascular Disease SymposiumII: Nomenclature for vascular
diseases.Circulation 2008;118:2826.
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Cardiol. 2002; 5:119-130.
[3]. Diehm C, Lange S, Darius H, et al. – Association of low ankle brachialindex with high mortality in primary care. Eur Heart J.
2006;27:1743-1749.
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peripheral artery diseases. Eur Heart J.2011; 32: 2851- 2906..

Abstract: Head and neck cancers represent a significant treatment challenge because the disease is located within an anatomical area that contains several critical tissues. With development of modern radiotherapy techniques, precise delivery of adequate dose of radiation to the tumor while sparing organs at risk has become possible. Aims: The present retrospective study was done to compare toxicity profile of IMRT versus 3DCRT in ocally advanced head and neck cancer. Methods and Material: A total of 150 patients of histologically confirmed stage III to IVB squamous cell carcinoma of the oral cavity and oropharynx of either sex were evaluated in the study from July 2015 to June 2016; 58 in IMRT group and 92 in 3DCRT group. All patients received 70 Gy in 35 fractions with 2 Gy per fraction in both groups with 6MV photon beam concurrent with weekly cisplatin 30 mg/m...........

Keywords: 3DCRT, Head and neck, IMRT, Locally advanced, Squamous cell carcinoma

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2003;30:2089-115...

Abstract: Preterm premature rupture of membranes (PPROM) is one of the most important complications of the pregnancy and cause perinatal morbidity and mortality. Iron, Folic acid, Vitamin B Complex and Vitamin C plays an important role in collagen metabolism and increases resistance maintenance of the chorioamniotic membranes. Objectives: The aim of this study is to assess the effectiveness of Iron, Folic acid, Vitamin B Complex and Vitamin C for reducing the risk of Pre-mature Ruptures of membrane in pregnancy. Patients and Methods: This clinical trial study was performed on 200 pregnant women with the history of PPROM, with singleton pregnancy and gestational age 14 weeks in a hospital...............

Keywords: PPROM, Ascorbic Acid, Pregnancy, Collagen, Premature Rupture, Prevention and Control

[1]. Premature rupture of membrane: Allahyar Jazayeri, MD, PhD, FACOG, DACOG, FSMFM Medical Director of Perinatal Services,
Aspirus Hospital; Consulting Staff and Owner, Women's Specialty Care and NEWMOMS of Green Bay
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Abstract: The Traditional Siddha system of medicine has a vast documentation of herbs in its ancient literature for the treatment Neerizhivu/Madhumegham (Diabetes milletus). Many of these formulations are clinically effective but they lack in scientific evidence which is the chief present day challenge faced by the traditional system of medicine. Pungampoo Chooranam is one such formulation which has been indicated for thr treatment of diabetes millets in the Siddha Classical literature Boga Munivar Vaithiyam – 700. The present study was aimed to screen the oral antihyperglycemic activity of Pungampoo Chooranam (PC ) (200 and 400 mg/kg) against streptozotocin (45 mg/kg i.p.) induced diabetes mellitus in rat models. The animals were grouped into four groups of 6 animals each. Group I (Control group)-received normal saline, Group II rats were administered with 45 mg/kg,i.p of STZ, Group III received 45 mg/kg,i.p of STZ + 200mg/kg of Pungampoo Chooranam and group IV received 45 mg/kg,i.p of STZ + 400mg/kg..........

Keywords: Siddha medicine, Diabetes mellitus, Pungampoo Chooranam, Pongamia glabra

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[2]. Kazi S. Use of traditional plants in diabetes mellitus. Int J Pharm. 2014; 4(4):283–9.
[3]. Y. Sachdev, Clinical endocrinology and diabetes mellitus: A comprehensive (Jaypee brothers Medical Publishers P Ltd), 2008, 2, 871-905.
[4]. Rajalakshmi K , Christian GJ , Shanmuga Priya P , Jeeva Gladys R. Validation of Anti-diabetic Potential of Avirai kudineer a Siddha herbal formulation-A Review (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 14, Issue 7 Ver. V (July. 2015), PP 07-15 [5]. Parasuraman S, Kumar E, Kumar A, Emerson SFree radical scavenging property and diuretic effect of triglize, a polyherbal formulation in experimental models.J Pharmacol Pharmacother. 2010 Jan; 1(1):38-41.