iosr-JDMS   Volume-22 ~ Issue-10 ~ October 2023

Abstract: BACKGROUND - Adenosine deaminase (ADA) is suggested to modulate the bioactivity of insulin. The present study was undertaken to evaluate serum ADA activity and serum uric acid levels in patients of Type 2 DM. AIM: To evaluate the serum ADA level and to correlate ADA levels with Blood Glucose, Glycated Hemoglobin (HbA1c) levels in Type-2 DM patients. MATERIAL AND METHOD: It is a case control study. The subjects in this study were divided into 3 groups. Group I consisted of 50 normal healthy......

Key Word: Type 2 diabetes mellitus , Serum ADA , HbA1c , serum uric acid

[1]. Fu, Y., Wu, Y., Liu, E. C?Reactive Protein And Cardiovascular Disease: From Animal Studies To The Clinic (Review). Exp Ther Med. 2020 Jun 4;20(2):1211-1219.
[2]. Sapkota, L. B., Thapa S, Subedi N. Correlation Study Of Adenosine Deaminase And Its Isoenzymes In Type 2 Diabetes Mellitus. BMJ Open Diabetes Res Care. 2017 Mar;5(1):E000357.
[3]. Hariprasath, G., Ananthi, N. Glycemic Control And Raised Adenosine Deaminase Activity In Type 2 Diabetes Mellitus. IOSR J Dent Med Sci. 2017 Jan;16(01):53-56
[4]. Goodrich K. M., Crowley S. K., Lee D.-C., Sui X. S., Hooker S. P., Blair S. N. Associations Of Cardiorespiratory Fitness And Parental History Of Diabetes With Risk Of Type 2 Diabetes. Diabetes Research And Clinical Practice. 2012;95(3):425–431. Doi: 10.1016/J.Diabres.2011.10.045.
[5]. Czupryniak L. Guidelines For The Management Of Type 2 Diabetes: Is ADA And EASD Consensus More Clinically Relevant Than The IDF Recommendations? Diabetes Research And Clinical Practice. 2009;86(1):S22–S25. Doi: 10.1016/S0168-8227(09)70005-1.

Abstract: The field of healthcare is an ever evolving landscape, constantly revealing intricate connections between different aspects of the body. One such intriguing link that has garnered attention in recent years is the relationship between oral health and eye health. Glaucoma and periodontitis, two seemingly unrelated conditions, have been the subject of research aiming to understand how one can influence the other. In this article, we delve into the fascinating connection between glaucoma and periodontitis and explore the potential implications for dental and eye care professionals........

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Abstract: Hyperreaction luteinalis is most often bilateral and found incidentally at the time of ovarian cystectomy.. There are multiple benign ovarian lesions including hyperreactio luteinalis that can mimic ovarian neoplasms. However, HL may presents as an abdominal mass or acute abdomen. Hyperreactio luteinalis (HL) refers to moderate to marked cystic enlargement of the ovaries due to multiple benign theca lutein .The cause of this condition is unknown, but is believed to be related to elevated levels of, or abnormal ovarian response to, human chorionic and pituitary......

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Abstract: Background: The increased risk of cardiovascular disease is attributed to the cluster of metabolic abnormalities known as hypothyroid patients affected with type 2 diabetes mellitus (T2DM). Most people with hypothyroid patients affected with T2DM also have several other metabolic problems, including high blood sugar, insulin resistance, and high blood pressure. Aim: To assess the effect of free T3 (FT3), free T4 (FT4), thyroid stimulating hormone (TSH), glucose profile, insulin, and Homoeostasis model assessment- estimated insulin resistance (HOMA-IR) in hypothyroid patients affected with T2DM........

Keywords: Hypothyroid patients affected with T2DM; Homeostasis Model Assessment of Insulin Resistance (HOMA-IR); Hyperglycemia; Insulin; Insulin resistance.

[1] Duntas LH, Orgiazzi J, Brabant G. The Interface Between Thyroid And Diabetes Mellitus. Clinical Endocrinology. 2011 Jul;75(1):1-9.
[2] Kar K, Sinha S. Variations Of Adipokines And Insulin Resistance In Primary Hypothyroidism. Journal Of Clinical And Diagnostic Research: JCDR. 2017 Aug;11(8):BC07.
[3] Biondi B, Kahaly GJ, Robertson RP. Thyroid Dysfunction And Diabetes Mellitus: Two Closely Associated Disorders. Endocrine Reviews. 2019 Jun;40(3):789-824.
[4]. Wang C. The Relationship Between Type 2 Diabetes Mellitus And Related Thyroid Diseases. Journal Of Diabetes Research. 2013 Oct;2013.
[5]. Abdullah JN, Mohammed SB, Al-Auqbi TF. Evaluation Of The Osteoprotegerin And Insulin Levels In Patient's Serum With Hypothyroid And Hypothyroid With Type 2 Diabetes Mellitus. Eurasian Chemical Communications.. 2021;3(11):9-854.

Abstract: Extra Mammary Pagets Disease(EMPD) mostly involves areas rich in apocrine glands such as perianal area, perineum, vulva, axilla, mons pubis, glans penis and eyelids and rarely scrotum . EMPD is often seen in concurrence with an underlying visceral carcinoma but can also arise de novo. EMPD lesions may also be accompanied by adenocarcinoma in situ or invasive adenocarcinoma of the apocrine glands . The average age of presentation is usually between 58 and 67 and also has more preponderance to post menopausal women. Lesions clinically present as erosive plaques, scaly, eczematous and erythematous ulcers. Early identification is vital and requires high index of suspicion or else diagnosis is usually delayed. Here, we present a patient who had scrotal lesion with bilateral inguinal lymphnodal metastasis.

Key Words: Extramammary Paget's Disease (EMPD), Adenocarcinoma, inguinal lymphadenopathy

[1]. Isrow D, Oregel KZ, Cortes J, Gomez H, Milikowski C, Feun L, Et Al. Advanced Extramammary Paget's Disease Of The Groin, Penis, And Scrotum. Clin Med Insights Oncol. 2014;8:87–90.Doi: 10.4137/CMO.S13107
[2]. Kanitakis J. Mammary And Extramammary Paget's Disease. J Eur Acad Dermatol Venereol. 2007 May;21(5):581–90. Doi:
10.1111/J.1468-3083.2007.02154.X
[3]. Hatta N, Yamada M, Hirano T, Fujimoto A, Morita R. Extramammary Paget's Disease: Treatment, Prognostic Factors And Outcome In 76 Patients. Br J Dermatol. 2008 Feb;158(2):313–8. Doi: 10.1111/J.1365-2133.2007.08314.X
[4]. Park S, Grossfeld GD, Mcaninch JW, Santucci R. Extramammary Paget's Disease Of The Penis And Scrotum: Excision, Reconstruction And Evaluation Of Occult Malignancy. J Urol. 2001 Dec;166(6):2112–6; Discussion 2117. Doi: 10.1016/S0022-5347(05)65516-4
[5]. Chanda JJ. Extramammary Paget's Disease: Prognosis And Relationship To Internal Malignancy. J Am Acad Dermatol. 1985
Dec;13(6):1009–14. Doi: 10.1016/S0190-9622(85)70254-X

Abstract: Adenomyosis is ectopic endometrial tissue in myometrium and is a common occurrence. Endomyometritis is usually seen in postpartum period. A few cases of abscess formation in adenomyotic foci have been reported in literature, but very few reports of endomyometritis arising within adenomyosis appears in the literature. Here, we present a 50 year old female who was admitted with anemia and heavy menstrual bleeding. The hysterectomy specimen revealed myometrial trabeculations and extruded frank pus on cutting open. Microscopically the myometrium showed areas of adenomyosis with transmural dense neutrophilic cell infiltration. The lumen of the endometrial glands showed neutrophilic exudates. Final report of Acute endomyometritis with adenomyosis was made. The postoperative period of the patient was uneventful.

Key Words: Adenomyosis; Endometrium, Myometrium, Infection

[1]. Taran FA, Stewart EA, Brucker S. Adenomyosis: Epidemiology, Risk Factors, Clinical Phenotype And Surgical And Interventional Alternatives To Hysterectomy. Geburtshilfe Frauenheilkd. 2013; 73: 924-931.
[2]. Rezzan E, Mehmet MM, Alpay A, Mehmet NE, Hasan G, Kafkasli A. Abscess In Adenomyosis Mimicking A Malignancy In A 54-Year-Old Woman. Infect Dis Obstet Gynecol. 2003;11:59-64.
[3]. Katherine L, Williams, Joseph G, Pastorek II. Postpartum Endomyometritis. Infectious Diseases In Obstetrics And Gynecology. 1995;3(5):210-16.
[4]. Lipscomb GH, Ling FW, Photopulos GJ. Ovarian Abscess Arising Within An Endometrioma. Obstet Gynecol. 1991;78(5):951-54.
[5]. Milman T, Shivji A, Edwards D, Solnik MJ. Myometrial Abscess In The Noninstrumented Uterus. J Minim Invasive Gynecol. 2022 Feb;29(2):190-192

Abstract: The surgical removal of head and neck tumors frequently results in significant abnormalities, functional impairment, and deformity. The provision of a prosthesis is a crucial strategy for regaining physical and mental function. For patients with missing teeth, it has been claimed that the use of Osseo-integrated implants will increase retention and stability in the traditional obturator prosthesis. At the end of the follow-up periods, the clinical observations showed that inflammation had increased around implants with magnet attachments more than it had around implants with ball and socket attachments

Key words: Acquired maxillary defects, obturator, implant, attachments

[1].
Ahila SC, Anitha KV, ThulaSingam C. Comparison of obturator design for acquired maxillary defects in completely edentulous patients. Ind J Dent Res. 2011; 22:161–163.
[2].
Akinmoladun V , Akinamoju CA, Olaniran FO, Olaopa OI. Maxillectomy and quality of life; Experience from a Nigerian tertiary institution. Nig J Surg. 2018; 24: 125–130
[3].
Bou C, Pomar P, Miquel JL, Poissan P. Maxillofacial prostheses: an issue in public health. Odontostomal Trop. 2006; 29:34–40
[4].
Keyf F. Obturator prosthesis for hemimaxillectomy patients. J.Oral Rehab. 2001; 28:821–829
[5].
Arigbede AO, Dosumu OO, Shaba OP, Esan TA. Evaluation of speech in patients with partial surgically acquired defects: pre and post prosthetic obturation. J Contemp Dent Pract. 2006; 7:89–96

Abstract: Background: Oral diseases present an overwhelming burden among the elderly population, coupled with other existing comorbidities provide a public health challenge that impairs the quality of life. Objectives: To assess the oral health related quality of life using the Geriatric Oral Health Assessment Index-Hi (GOHAI-Hi) amongst elderly population visiting the geriatric day care centers in New Delhi. Methods: A cross‑sectional study was conducted among seven purposively selected geriatric day care centers in New Delhi, and a convenience sample of 518 elderly patients was obtained. OHRQoL was measured using a pre-validated instrument (GOHAI-Hi) along with other variables. Statistical analysis was done using Statistical Package for the Social Sciences software version 28, and descriptive results were obtained.........

Key Words: Geriatric Dentistry; Oral Health; Quality of Life; Homes for the Aged

[1]. Khosrozadeh H, Alavi NM, Gilasi H, Izadi M. Oral Health‑Related Quality Of Life In Older People In Kashan/Iran 2015.Nurs Midwifery Stud 2017;6:182-8.
[2]. Petersen PE, Yamamoto T. Improving The Oral Health Of Older People: The Approach Of The WHO Global Oral Health Programme. Community Dent Oral Epidemiol 2005; 33:81‑92.
[3]. Parth Patel B, Shivakumar KM, Patil S, Suresh KV, Kadashetti V. Association Of Oral Health‑Related Quality Of Life And Nutritional Status Among Elderly Population Of Satara District, Western Maharashtra, India. J Indian Assoc Publ Health Dent 2015; 13:269‑73.
[4]. Irudaya RS. The National Policy For Older Persons: Critical Issues In Implementation BKPAI\Working Paper No. 5. New Delhi, US: United Nations Population Fund (UNFPA); 2011.
[5]. Singh A, Purohit BM. Addressing Geriatric Oral Health Concerns Through National Oral Health Policy In India. Int J Health Policy Manag. 2015; 4:39–42. Doi:10.15171/Ijhpm.2014.126

Abstract: Background: L'antibioprophylaxie chirurgicale(ABP) a fait l'objet d'une priorité de l'Organisation mondiale de la santé (OMS). Une évaluation de la conformité de la prescription des antibiotiques en prophylaxie pour les actes opératoires a été réalisée avec mesure du taux d'incidence des infections du site opératoire (ISO) et recherché des facteurs de risque liés à leur survenue.......

Key Words: antibioprophylaxie en chirurgie; conformité; infections du site opératoire (ISO); étude prospective.

[1]. Organisation Mondiale De La Santé Plan D'action Mondial Sur La Résistance Aux Antimicrobiens 2015.
[2]. Organisation Mondiale De La Santé Directives Mondiales Pour La Prévention Des Infections Du Site Opératoire 2016.
[3]. SI Berrios-Torres Et Al. Lignes Directrices Des Centers For Disease Control And Prevention Pour La Prévention Des Infections Du Site Opératoire, 2017.
[4]. Société Française D'anesthésie Et De Réanimation. Recommandations Pour La Pratique De L'antibioprophylaxie En Chirurgie : Actualisation 2018.Https://Sfar.Org/Wp-Content/Uploads/2018/07/Antibioprophylaxie-RFE-Mise-A-Jour-2018.Pdf.
[5]. Seltzer S, Rapenne T, Aho S, Freysz M, Wilkening M, Chava- Net P. Antibioprophylaxie En Chirurgie Dans Un CHU En 1996. SFAR Septembre 1998 : R381.

Abstract: Introduction: The liver is the organ most prone to abscess formation. Amoebic liver abscess a major health and socioeconomic problem in many parts of Africa, Asia, and Latin America.5 Amoebiasis is a common tropical disease characterized by dysentery caused by Entamoeba histolytica contamination of foods and water. Amoebic dysentery may occasionally complicate and create an abscess in the liver, resulting in an amoebic liver abscess.12 The diagnosis of ameobic liver abscess is based on clinical suspicion, laboratory findings, serologic tests, and a hepatic imaging examination. In only half of the cases, the protozoon is separated from the faeces.13,14,17
Aim of the study: The aim of this cross-sectional study was to assess the clinical profile of liver abscess in patients attending a tertiary referral hospital..........

Key Words: Amoebic Liver Abscess, Predisposing Factors, Patient Demographics, Alcoholism.

[1]. Baron M J, Kasper D L. Intra-Abdominal Infections And Abscesses. In: Infectious Diseases. In : Fauci A S, Braunwald E, Kasper D L, Hauser S L, Longo D L, Jamson J L, Loscalzo J. Harrison's Principles Of Internal Medicine. Mcgraw Hill Medical.17th Ed. 2008; 807-812..
[2]. Krige J E, Beckingham I J. ABC Of Diseases Of Liver, Pancreas, And Biliary System. BMJ 2001; 322(7285):537-40.
[3]. Dykes A C, Ruebush T K, Gorelkin L, Lushbaugh W B, Upshur J K, Cherry J D. Extraintestinal Amebiasis In Infancy. Pediatrics. 1980; 65:799-803.
[4]. Hughes M A, Petri W A Jr. Amebic Liver Abscess. Infect Dis Clin North Am 2000; 14:565-582.
[5]. Martinez-Palomo A. Public Health Significance Of Amoebiasis. World Health Organisation 1986; Draft Agenda Item 5.

Abstract: BACKGROUND: Neck swellings need quick diagnostic & therapeutic approach. USG has proven to be a diagnostic modality of choice in this condition. AIM: This study aims to evaluate the efficacy of the USG to depict benign and malignant potential of lymph nodal lesions. MATERIALS &METHODS: A prospective analytical study was done. USG findings of 40 patients who presented with neck swelling, throat pain, difficulty in swallowing and fever were analyzed. This data for morphology of lymphnodes on USG was compared with biopsy findings.........

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Abstract: Introduction:-Hemophilia is a severe bleeding disorder, primarily caused by the inactivity of factor VIII and is inherited as an X-linked recessive trait. Although most cases are hereditary, 30% result from new mutations. Gastrointestinal stromal tumors (GISTs) are most common mesenchymal tumors of gastrointestinal tract and are derived from interstitial cells of Cajal (ICC) - GI pacemaker cells. We present rare case of a 44 year old male who presented with upper GI bleed to emergency care. On evaluation he was diagnosed with hemophilia A and D2 duodenal GIST.......

[1]. Kumar, V., Abbas, A., & Aster, J. C. (2020). Robbins & Cotran Pathologic Basis Of Disease E-Book. Elsevier Health Sciences.
[2]. Sabiston Text Book Of Surgey: 21 Edition: Stomach: David A Mahvi, David M Mahvi Pg 1233-34
[3]. Lee SJ, Song KB, Lee YJ, Et Al. Clinicopathologic Characteristics And Optimal Surgical Treatment Of Duodenal Gastrointestinal Stromal Tumor. J Gastrointest Surg. 2019;23(2):270-279. Doi:10.1007/S11605-018-3928-1
[4]. Yıldız A, Şahin O, Yayar O, Et Al. The Rare Coexistence Of High Titer Inhibitor Development And Gastrointestinal Stromal Tumor In A Patient With Severe Hemophilia: A Case Report. Transfus Apher Sci. 2018;57(3):398-400.
Doi:10.1016/J.Transci.2018.04.023
[5]. C. D. Forbes, R. D. Barr, C. R. M. Prentice, A. S. Douglas, Gastrointestinal Bleeding In Haemophilia, Qjm: An International Journal Of Medicine, Volume 42, Issue 3, July 1973, Pages 503–511.

Abstract: Tuberculosis of the upper aerodigestive tract is a rare form of extrapulmonary tuberculosis. Miliary tuberculous is the most serious form and is life-threatening. We report a case of bacilliferous tubercular miliary revealed by a pharyngolaryngeal location......

Key Words: Tuberculosis, pharynx, larynx, miliary

[1]. Kulkarni NS, Gopal GS, Ghaisas SG, Gupte NA. Epidemiological Considerations And Clinical Features Of ENT Tuberculosis. J Laryngol Otol. 2001; 115:555-8
[2]. Oudidi A, Ridal M, Cherkaoui A, El Alami MN. Tuberculose Laryngée. À Propos De Neuf Cas Laryngeal Tuberculosis: A Nine Case Report. La Lettre d'Oto-Rhino-Laryngologie Et De Chirurgie Cervico-Faciale. 2005(296)
[3]. Carette MF, Azeucot N, Le Blanche A, Le Breton C, Bigot JM. Apport De L'imagerie Dans Le Diagnostic Et Le Suivi De La Tuberculose Thoracique. Rev Pneumol Clin. 1994; 50:229-39
[4]. Stelianides S, Belmatoug N, Fantin B. Manifestations Et Diagnostic De La Tuberculose Extrapulmonaire. Rev Mal Respir. 1997; 14(5):72-87
[5]. Ben Gamra O, M'Barek CH, Khammassi K, Ben Hamouda R, L. Hariga L, Ben Amor M, Zribi S, El Khedim A. La Tuberculose Des Voies Aérodigestives Supérieures. Service D'orl Et De Chirurgie Cervico-Faciale Hopital Habib Thameur. Tunis-Tunisie. Rev Tun Infectiol, 2008 ; 2(3):21-25

Abstract: Introduction: Currently, available data indicates that long-term health risks associated with donor nephrectomy are pretty low. However, since live related donors form a formidable pool of kidney donors in our country & no available study from our country throws light on the incidence of potential complications like hypertension, proteinuria, and metabolic and renal functions post-donation, there is a need for a prospective study of living related kidney donors.........

Key Words: Renal transplant; Live donor; End-stage renal disease

[1]. Richet G. Hamburgerʹs achievement with early renal transplants. Am J Nephrol. 1997;17: 315-7.
[2]. Merill JP, Murray JE, Takacs FJ, et al. Successful transplantation of a kidney from a human cadaver. JAMA. 1963;185: 347-53.
[3]. Koller AH, Mayer G. Evaluation of the living kidney donor. Nephrol Dial Transplant. 2004;19: 41-4.
[4]. Textor SC, Taler SJ, Driscoll N, et al. Blood pressure and renal function after kidney donation from hypertensive living donors. Transplantation. 2004;78: 276-82.
[5]. Fehrman-Ekholm I, Elinder G, Stenbeck M, Tydén G, Groth C. Kidney donors live longer. Transplantation. 1997;64: 976-8.