iosr-JDMS   Volume-21 ~ Issue-12 ~ Dec. 2022

Abstract: La neurofibromatose de type 1 (NF1) ou maladie de Von Recklinghausen est l'une des maladies génétiques les plus fréquentes. Le diagnostic se base sur les 7 critères diagnostiques de la conférence de consensus du National Institute of Heath. Si la sphère crânio-faciale n'est atteinte que dans 10% des cas, elle représente la localisation la plus fréquente dans notre consultation à cause du retentissement psychologique majeur. C'est aussi la localisation où la chirurgie est la plus décevante. Sur le plan thérapeutique, il n'existe aucun traitement contre la maladie, La chirurgie reste actuellement le seul moyen, souvent itérative, de réduction tumorale et non d'exérèse complète. Les résultats restent décevants, la maladie est toujours en évolution entrainant des relâchements, c'est une chirurgie à risque hémorragique important en rapport avec la dysplasie vasculaire. Nous exposons notre expérience dans la prise en charge de la neurofibromatose type 1.

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[5]. Uusitalo E, Rantanen M, Kallionpää Ra, Pöyhönen M, Leppävirta J, Ylä-Outinen H, Riccardi Vm, Pukkala E, Pitkäniemi J, Peltonen S, Peltonen J. Distinctive Cancer Associations in Patients with Neurofibromatosis Type 1. J Clin Oncol. 2016; 34:1978–86.

Abstract: Pain sensation involves multiple signaling and modulatory pathways, employing a variety of neurotransmitters and other mediators. Inhibitory and facilitatory mechanisms affect the perception of stimuli as painful or non-painful, and in addition may affect the perceived intensity of pain. Endogenous opioids are key mediators in the descending pain suppression pathways. Additionally, monoaminergic neurotransmitters such as norepinephrine, serotonin and dopamine positively or negatively modulate pain signaling, depending on receptor type and location. The various mediators involved in pain signaling provide potential targets for pharmacological interventions. Single analgesic therapies may be limited in their ability to comprehensively target these complex pain signaling pathways. Therapeutic approaches acting on multiple pain transmission pathways through different mechanisms of action provide an opportunity to maximize efficacy and tolerability in the treatment of pain.

Keywords: Pain, signalling pathway, modulatory pathway,pharmacological and non pharmacological method, analgesic, non steroidal anti inflammatory, neuroimaginary method

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Abstract: Dental caries is a pathologic process which is multifactorial and causes the destruction of the dental tissues and produces local and general complications.Fluoride involves inhibition of tooth demineralization, promotion of incipient lesion remineralization. Even though fluoride had a profound effect on the level of caries prevalence but non-fluoride agents can enhance fluoride action. There are various steps that have been taken in the prevention of dental caries, out of which fluoride tops the list. Non-fluoride agents like, arginine, plant extracts, probiotics, novamin, dentrifrices, antimicrobials, CPP- ACP etc are commonly used in prevention of dental caries. This paper reviews about these non-fluoride agents in the prevention of dental caries.

Keywords: dental caries, fluoride, non-fluoride agents, prevention

[1]. Singh ML, Papas AS. Long-term clinical observation of dental caries in salivary hypofunction patients using a supersaturated calcium-phosphate remineralizing rinse. The Journal of clinical dentistry. 2009;20(3):87-92.
[2]. Dawes C. Fluorides: mechanisms of action and recommendations for use. Journal (Canadian Dental Association). 1989 Sep;55(9):721.
[3]. Chhabra KG, Shetty PJ, Prasad KV, Mendon CS, Kalyanpur R. The beyond measures: Non flouride preventive measures for dental caries. J Int Oral Health. 2011 Apr 1;3(2):1-8.
[4]. Philip N, Suneja B, Walsh LJ. Ecological approaches to dental caries prevention: paradigm shift or shibboleth?. Caries research. 2018;52(1-2):153-65.
[5]. Chhabra KG, Shetty PJ, Prasad KV, Mendon CS, Kalyanpur R. The beyond measures: Non flouride preventive measures for dental caries. J Int Oral Health. 2011 Apr 1;3(2):1-8.

Abstract: Background: Eating disorders are characterized by irregular eating habits and distress or concern about bodyweight or shape. Medical students are exposed to high levels of stress and burnout which acts as a risk factor for eating disorders.The aim of the study is to identify the risk of eating disorders and body shape concern among undergraduate medical students. Materials and Methods: A cross sectional study design was used to collect data from the undergraduate medical students. Study instruments include proforma for age, gender, height, weight; Eating Attitude Test (EAT 26) and Body Shape Questionnaire (BSQ 16). Analysis of the data was done using SPSS software. Results: A total of 146 students were....

Keywords: Eating disorders, Eating attitudes, Body shape concern.

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Abstract: Introduction-Vitamin D is avidly involved in the process of innate and adaptive immune activation. A fall in vitamin D levels leads to the activation of tissue-damaging autoimmunity.Serum vitamin D levels are observed to be reduced in RA, however, to date there is still a paucity of literature on its correlation with markers of disease including ESR. Aims and objectives- 50 newly diagnosed cases of RA were included to assess vitamin D3 levels. The levels were correlated with disease duration, markers of disease activity, disease severity, and level of hemoglobin in RA patients.......

Key words: vitamin D3, Rheumatoid arthritis, ESR, DAS 28 ESR

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[4]. Anić B, Mayer M. Pathogenesis of rheumatoid arthritis [Article in Croatian]. Reumatizam. 2014, 61:19-23.
[5]. Weiss S. Bacterial components plus vitamin D: the ultimate solution to asthma (autoimmune disease) epidemic? J Allergy Clin Immunol. 2011;127: 1128–30

Abstract: Sebaceous carcinoma of the eyelid frequently present with metastatic disease involving regional lymph nodes. However, the metastasis to parotid gland is very rare and can be mistaken for primary parotid gland tumor.We present a case of 53-year-old female who presented with right parotid swelling. MRI was suggestive of a pleomorphic adenoma. She was operated for sebaceous carcinoma of the eyelid four years back. Characteristic cytological findings of a mixture of high-grade malignant cells with vacuolated cells along with clinical correlation were helpful in the diagnosis of this tumor following which the patient underwent parotidectomy

Keywords: Sebaceous carcinoma, Eyelid sebaceous carcinoma, parotid metastatic malignancy

[1]. Agnihotri MA, Kothari KS, Naik LP. Sebaceous carcinoma of upper eyelid presenting as submandibular lymphadenopathy Cytol 2019;36:73-74.
[2]. Margarita V, Vaia-Aikaterini A, Maria K, Loanna K, Konstantinos A. Recurrent Sebaceous Gland Carcinoma of the Eyelid with Metastasis to the Parotid Gland and the Regional Lymph Nodes: Case Report and Review of the Literature. Journal of Head and neck Surgery;2019: 13-17.
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[5]. Seenu, V., Misra, M. C., Khazanchi, R. K., Goel, A. K., & Prakash, M. B. (1997). An eyelid swelling with a parotid mass. Postgraduate medical journal; 73:123–125.

Abstract: Background : Ectopic pregnancy is an emergency condition threatening mothers life. This has increased recently due to various early diagnostic modalities . This study aims to analyze the maternal characteristics , clinical presentation , management in a tertiary care hospital . Methods : This study was carried out in a tertiary care hospital at Kallakurichi , Tamil Nadu. All the cases of ectopic pregnancies admitted and managed in the Department of Obstetrics and Gynecology at GMCH , Kallakurichi between the period of July 2021 to June 2022 has taken for the study . Results : Total ectopic pregnancies admitted during the study period was 24. This accounts for about 0.2% of total obstetric admissions and 1.......

Keywords: Ectopic pregnancy , sterilization failure, laparotomy

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[4]. Clinical study of Ectopic pregnancy , Meenakshi T . Chate , Bhagyashree Chate , Kranti Chate . IJRCOG 2017 Aug;6(8):3498-3501.
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Abstract: Background and objectives: post-recoverysequelae have become a major concern in patients who have recovered from coronavirus disease 2019 (COVID‐19). Many reports have shown that COVID‐19 has a variety of long‐term manifestations on almost all systems including respiratory, cardiovascular, gastrointestinal, neurological, psychiatric, and dermatological systems. Our objective is to investigate the prevalence and characteristics of post‐COVID complications among COVID‐19 survivors. Material and methods: We performed a semi-structured questionnaire to inquire about the presence of persistent symptoms beyond......

Keywords: Post COVID-19 syndrome, Long COVID, Post COVID sequelae, Complications after COVID, manifestations after COVID recovery

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[5]. Aiyegbusi, O. L., Hughes, S. E., Turner, G., Rivera, S. C., McMullan, C., Chandan, J. S., Haroon, S., Price, G., Davies, E. H., Nirantharakumar, K., Sapey, E., Calvert, M. J., & TLC Study Group (2021). Symptoms, complications, and management of long COVID: a review. Journal of the Royal Society of Medicine, 114(9), 428–442. https://doi.org/10.1177/01410768211032850