iosr-JDMS   Volume-23 ~ Issue-3 ~ March 2024

Abstract: Background: Hypertension and type 2 diabetes mellitus co-morbidity significantly impact on the left ventricular function with diastolic dysfunction being the earliest and commonest complication. The prevalence and risk factors for diastolic dysfunction in this subset of patients are understudied. Methodology: This is a cross-sectional descriptive study carried out in the Department of Internal Medicine of University of Port-Harcourt Teaching Hospital Rivers State, Nigeria. The study population consisted of 160 hypertensive patients.....

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Abstract: Fahr syndrome (FS) is a rare entity, characterized by phosphocalcic metabolism disorders and clinical polymorphism of which neuropsychological symptoms are the most common. We report the case of a 42-year-old woman presented for a generalized tonic-clonic seizure and for whom the diagnosis of FS secondary to primary hypoparathyroidism with severe hypocalcemia was retained.

Keywords: Fahr syndrome; Epileptic seizure; Brain imaging; Hypocalcemia; Hypoparathyroidism

[1]. Fahr T. Idiopathische Verkalkung Der Hirngefässe. Zentrabl Allg Pathol. 1930; 50:129-33. Chevalier D, Marie I, Tillon J, Lévesque H. Une Cause De Calcifications Intracérébrales A Ne Pas Méconnaître : Le Syndrome De Fahr. Rev Med Interne 2005; 26: 668-77.
[2]. Boukhrissi Fe, Zoulati G, En-Nafaa I, Ouleghzal H, Derrou S, Safi S Et Al. Syndrome De Fahr Secondaire A Une Hyperparathyroïdie Primaire: A Propos D´Un Cas. Pamj. 2017;26:2.
[3]. Bhadada Sk, Bhansali A, Upreti V, Subbiah S, Khandelwal N. Spectrum Of Neurological Manifestations Of Idiopathic Hypoparathyroidism And Pseudohypoparathyroidism. Neurol India 2011;59:586–9.
[4]. Riggs Je. Neurologic Manifestations Of Electrolyte Disturbances. Neurol Clin 2002;20:227–39.
[5]. Esselmani H, Yassine A, Fatihi T, Touzani O, Bounsir A, Lfakir A. Hypocalcémie Sévère Chez Un Patient Traité Pour Epilepsie Pendant Huit Ans Révélatrice Du Syndrome De Fahr Avec Hyperparathyroïdie. Sanmt 2022 ; Xx(X) : 1-3

Abstract: Platelet – Rich – Plasma (PRP) therapy has been effective in treating injuries and orthopaedic issues. Diabetic Foot Ulcer (DFU) needs to be studied since the population of diabetics suffering from chronic wounds is high. 85% of lower limb amputation begin with foot ulcers. Over and above this chronic leg ulcers cannot heal thus, becoming a major cause for concern for the patients and doctors too. Leg amputation becomes the only solution to fall back on in such cases. Diabetic Foot Ulcer majorly affects diabetics with devastating implications. With high mortality and disability rates it is a huge health challenge.......

[1] Martin Pera, Stem Cells And Regenerative Medicines. Maine: The Jackson Laboratory.
[2] What Is Regenerative Medicine? (20th July, 2023), Https://Mirm-Pitt.Net/About-Us/What-Is-Regenerative-Medicine/ [3]
Varghese, J., & Acharya, N. (2022). Platelet-Rich Plasma: A Promising Regenerative Therapy In Gynecological Disorders. Cureus, 14(9): E28998. Doi:10.7759/Cureus.28998
[4] Hara, G., & Basu, T. (2014). Platelet-Rich Plasma In Regenerative Medicine. Vietnamese Journal For Medical Biotechnology And Medicine Incorporating Advances In Regenerative Medicine, 1(1), 25-31. Retrieved From Http://Bmrat.Org/Index.Php/Bmrat/Article/View/14
[5] Suresh, D.H., Suryanarayan, S., Sarvajnamurthy, S., & Puvvadi, P. (2014). Treatment Of A Non-Healing Diabetic Foot Ulcer With Platelet-Rich Plasma. Journal Of Cutaneous And Aesthetic Surgery, 7(4), 229–231. Doi: 10.4103/0974-2077.150786.

Abstract: le kératocône est la maladie oculaire invalidante la plus fréquente chez l'enfant et l'adolescent. La plupart des cas apparaissent à l'adolescence et se stabilisent entre 30 et 40 ans. Le cross linking est actuellement le seul traitement capable d'arrêter ou de retarder la progression du kératocône. Le but de notre travail est de décrire l'aspect clinique des infiltrats cornéens stériles post cross linking ainsi que d'évaluer les facteurs de risque incriminés a leurs survenus.....

[1] Profile Of Infectious And Sterile Keratitis After Accelerated Corneal Collagen Cross-Linking For Keratoconus Shreesha Kumar Kodavoor, Nitin Narendra Tiwari, Dandapani Ramamurthy Feb 2020
[2] Atypical Sterile Infiltrates After Corneal Crosslinking Seiler, Theo G. Md; Kozhaya, Karim Md; Seiler, Theo Md, Phd; Awwad, Shady T. Jcrs Online Case Reports 10(2):P E00081, April 2022.
[3] Profile Of Infectious And Sterile Keratitis After Accelerated Corneal Collagen Cross-Linking For Keratoconus ;S. Kodavoor, N. Tiwari, D. Ramamurthy .Published 1 January 2020.

Abstract: This is a 59-year-old patient, with a pathological history of diabete and hypertension under treatment who consulted for a progressive decrease in visual acuity in both eyes, more marked on the left. On clinical examination, the corrected visual acuity was 6/10 in the right eye and 5/10 in the left. The examination of the anterior segment was normal. The fundus examination showed a loaded vitreous, revealing scynchisis scntillans (figure1). Macular OCT showed some hyper-reflective material at the vitreoretinal interface. (figure 2)

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Abstract: The present study was conducted to study the effect of graded doses of Sodium fluoride on the microanatomy of the heart of Albino rats over different periods. Sixty male adult albino rats taken from the animal house of Govt. Medical College Srinagar were divided randomly into four groups of 15 animals each. Animals of the first three groups were given fluorinated water in various concentrations to drink and the fourth group served as the control group getting plain tap water to drink. Animals from each group were sacrificed and examined after 30, 60, and 90 days of therapy and....

Keywords: Sodium Fluoride, Edema, Necrosis, Fluorosis, Eco toxins

[1] Abukurrah A R "Acute Sodium Fluoride Poisoning" Jama 222: 816-17 1972.
[2] Alfred Taylor "Research Paper "University Of Texas 1965.
[3] Call Ra 1965 "Histological And Chemical Studies In Man On Effects Of Fluoride". Public Health Reporter 529-38-1965.
[4] Jd Ebert 2003 Cited By Fluoride Adverse Health Effect Httm. 2003
[5] Johnson W 1974 "Exposure To Excessive Fluorides" Kid International 5-457, 1974.

Abstract: Background Systemic hypertension is a major risk factor for cardiovascular diseases. Electrocardiographic (ECG) abnormalities have been found to be associated with higher cardiovascular events in several studies. In the present study we evaluated the prevalence of ECG conduction abnormalities in patients with Systemic hypertension in different age groups and their relation with Left Ventricular (LV) function. Materials and Methods This study is a cross......

Key Word: Conduction abnormalities, Electrocardiographic (ECG) abnormalities, Left ventricular (LV) dysfunction, Systemic hypertension

[1] Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age-Specific Relevance Of Usual Blood Pressure To Vascular Mortality: A Meta-Analysis Of Individual Data For One Million Adults In 61 Prospective Studies. Lancet. 2002;360: 1903–1913
[2] Global Burden Of 87 Risk Factors In 204 Countries And Territories, 1990-2019: A Systematic Analysis For The Global Burden Of Disease Study 2019: Gbd 2019 Risk Factors Collaborators, The Lancet, 396, 10258, 1223-1249.
[3] Worldwide Trends In Hypertension Prevalence And Progress In Treatment And Control From 1990 To 2019 : A Pooled Analysis Of 1201 Population Representative Studies With 104 Million Participants. Ncd Risk Factor Collaboration, The Lancet,398, 10304, 957-980.
[4] Lee Sr, Park Cs, Choi Ek, Ahn Hj, Han Kd, Oh S, Lip Gyh. Hypertension Burden And The Risk Of New-Onset Atrial Fibrillation: A Nationwide Population-Based Study.Hypertension. 2021; 77:919–928.
[5] Auer R, Bauer Dc, Marques-Vidal P, Et Al.; Health Abc Study. Association Of Major And Minor Ecg Abnormalities With Coronary Heart Disease Events. Jama. 2012;307: 1497–505.

Abstract: Background: Neuroendocrine carcinoma of the Breast is a rare subtype of Breast cancer, comprising less than 1% of all breast malignancies. Due to its rarity, there is limited data on optimal management strategies, including the role of radiotherapy. Here we present a case report of a 68 year old female presented with a palpable lump initially suspected to be a benign lesion. However subsequent imaging and histopathological analysis revealed features......

Keywords: Primary neuroendocrine carcinoma breast, breast lump

[1] Righi L, Sapino A, Marchiò C, Papotti M, Bussolati G. Neuroendocrine Differentiation In Breast Cancer:Established Facts And Unresolved Problems Semin Diagn Pathol. 2010;27(1):69-76.
[2] Zhu Y, Li Q, Gao J, He Z, Sun R, Shen G,Et Al. Clinical Features And Treatment Response Of Solid Neuroendocrine Breast Carcinoma To Adjuvant Chemotherapy And Endocrine Therapy. Breast J. 2013;19(4):382-7.
[3] Tan Ph, Schnitt Sj, Van De Vijver Mj, Ellis Io, Lakhani Sr. Review Papillary And Neuroendocrine Breast Lesions: The Who Stance. Histopathology. 2015;66(6):761-70.
[4] Wang J, Wei B, Albarracinct, Hu J, Abraham Sc, Wu Y. Invasive Neuroendocrine Carcinoma Of The Breast: A Population-Based Study From The Surveillance, Epidemiology And End Results (Seer) Database. Bmc Cancer. 2014;14:147.
[5] Yildirim Y, Elagoz S, Koyuncu A, Aydin C, Karadayi K. Management Of Neuroendocrine Carcinomas Of The Breast: A Rare Entity. Oncol Lett. 2011;2(5):887-90

Abstract: .India is considered as the Diabetes capital of the world due to high prevalence of Diabetes including Gestational Diabetes Mellitus. We undertook this study to find the prevalence of GDM in North East India. Method: It was a hospital based study conducted at a tertiary care centre in North East India.

1) Metzger BE, Coustan DR, Organizing Committee. Summary and recommendations of the fourth international workshop-conference on gestational diabetes mellitus. Diabetes care. 1998 Aug 1;21:B161.
2) Federation ID. IDF diabetes atlas. Brussels: International Diabetes Federation. 2013;128:40-50.
3) Hunt KJ, Schuller KL. The increasing prevalence of diabetes in pregnancy. Obstet Gynecol Clin North Am. 2007 Jun;34(2):173-99, vii.

Abstract: Introduction: Blistering following lower limb procedures, including arthroplasty, arises from multifactorial causes categorized into patient and surgical factors. Patient factors involve obesity, age, vascular conditions, and diseases impacting wound healing, while surgical factors encompass tourniquet time, dressings, and skin preparation. Skin blistering, characterized by epidermal separation from the dermal layer, is a potential complication of total knee arthroplasty, though significant blistering remains rare despite its reported incidence.........

[1] Sharma, A., Subramanian, P., Shah, S., Remani, M., & Shahid, M. (2018). Massive Haemorrhagic Blister Formation Following Total Knee Arthroplasty. Jrsm Open, 9(5), 205427041875856. Https://Doi.Org/10.1177/2054270418758569
[2] Bohensky Ma, Ackerman I, Desteiger R, Gorelik A, Brand Ca. Lifetime Risk Of Total Knee Replacement And Temporal Trends In Incidence By Health Care Setting, Socioeconomic Status, And Geographic Location. Arthritis Cae Res (Hoboken) 2014; 66: 424–431.
[3] Culliford Dj, Maskell J, Kiran A, Judge A, Javaid Mk, Cooper C, Et Al. The Lifetime Risk Of Total Hip And Knee Arthroplasty: Results From The Uk General Practice Research Database. Osteoarthritis Cartilage 2012; 20: 519–524.
[4] Ravenscroft Mj, Harker J, Buch Ka. A Prospective, Randomised, Controlled Trial Comparing Wound Dressings Used In Hip And Knee Surgery: Aquacel And Tegaderm Versus Cutiplast. Ann R Coll Surg Engl 2006; 88: 18–22.
[5] Varela Cd, Vaughan Tk, Carr Jb, Slemmons Bk. Fracture Blisters: Clinical And Pathological Aspects. J Orthop Trauma 1993; 7: 417–427.

Abstract: Background- Burnout, defined by emotional exhaustion, cynicism, and reduced professional efficacy, is prevalent in medical residents due to prolonged working hours, administrative responsibilities, and relentless time constraints. Burnout is a work-related stress syndrome resulting from chronic exposure to job stress. Aim (a) Assess the impact of the COVID-19 pandemic on burnout levels among healthcare professionals, focusing on emotional exhaustion, depersonalization, and personal accomplishment, by comparing responses during and post-COVID-19. (b) Find out the demographic and professional factors associated with burnout among healthcare professionals, (c) Assess the self-care practices adopted by doctors to cope with burnout and identify the most commonly utilized stress reducing activities.......

Keywords: Burnout, residents, coping strategy, stress-busters

[1] Sanghera, J.; Pattani, N.; Hashmi, Y.; Varley, K.F.; Cheruvu, M.S.; Bradley, A.; Burke, J.R. The Impact Of Sars-Cov-2 On The Mental Health Of Healthcare Workers In A Hospital Setting-A Systematic Review. J. Occup. Health 2020, 62, E12175.
[2] De Hert S. Burnout In Healthcare Workers: Prevalence, Impact And Preventative Strategies. Local Reg Anesth. 2020 Oct 28; 13:171-183. Doi: 10.2147/Lra.S240564. Pmid: 33149664; Pmcid: Pmc7604257.
[3] Kesarwani V, Husaain Zg, George J. Prevalence And Factors Associated With Burnout Among Healthcare Professionals In India: A Systematic Review And Meta-Analysis. Indian J Psychol Med. 2020 Mar 9;42(2):108-115.
Doi: 10.4103/Ijpsym.Ijpsym_387_19. Pmid: 32346250; Pmcid: Pmc7173664.
[4] Https://Www.Who.Int/News/Item/28-05-2019-Burn-Out-An-Occupational-Phenomenon-International-Classification-Of-Diseases.
[5] Maya Romani & Khalil Ashkar (2014) Burnout Among Physicians, Libyan Journal OfMedicine, 9:1, Doi: 10.3402/Ljm.V9.23556

Abstract: Prostate cancer is the most common cancer in nigeria with increasing morbidity and mortalities. Radiation therapy is a major modality of management. Radiation therapy is used in the management of organ confined prostate cancer with both low and high risks. It is used in locally advanced disease and in disease recurrence after radical prostatectomy. It is also used on palliative basis for metastatic prostate cancer. Useful as it is in the management of various stages of prostate cancer, it produces deleterious effects to the body......

Keywords: Prostate cancer, radiation therapy, adverse effects and aba

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Abstract: This in vitro study aimed to compare the microleakage of self-adhesive and conventional composite restorations in class V cavities. Forty freshly extracted human mandibular premolars were randomly divided into two groups (n=20): Group A restored with conventional composite (Omnichroma, Tokuyama, Japan) and Group B restored with self-adhesive composite (Constic, DMG, Germany). Class V cavities were prepared, adhesive applied, and composites restored. Teeth were immersed in methylene blue dye, sectioned, and evaluated for microleakage. Kruskal-Wallis and......

Keywords: class V, microleakage, self-adhesive composite, conventional composite , scanning electron microscope.

[1] Muhamad A-H, Nezar W, Azzaldeen A, Hanali A-S: Anterior Dental Esthetics In Primary Teeth. Int J Public Health Res. 2015, 3:25-36.
[2] Cacciafesta V: Bonding Problems Related To Adult Reconstructed Dentitions. Adult Orthodontics. 2022, 181 215. 10.1002/9781119775805.Ch9
[3] Soares Fzm, Rocha Rdo, Raggio Dp, Sadek Ft, Cardoso Pec: Microtensile Bond Strength Of Different Adhesive Systems To Primary And Permanent Dentin. Pediatr Dent. 2005, 27:457-62.
[4] Eick Jd, Robinson Sj, Chappell Rp, Cobb Cm, Spencer P: The Dentinal Surface: Its Influence On Dentinal Adhesion Part Iii. Quintessence Int. 1993, 24:571-582.
[5] Fusayama T, Nakamura M, Kurosaki N, Iwaku M: Non-Pressure Adhesion Of A New Adhesive Restorative Resin. J Dent Res. 1979, 58:1364-70. 10.1177/00220345790580041101

Abstract: Peter's Plus syndrome is an infrequent genetic disease , characterised by low height , peculiar facial appearance, eye anomalies and mental retardation. We report here a rare case of bilateral corneal opacity in 5 month old infant with ocular features of Peter's anomaly. Our case is of Peter's plus anomaly as it is associated with acyanotic heart disease and dysmorphic facial features.

[1] Peters A. Über Angeborene Defektbildung Der Descemetschen Membran. Klin Monbl Augenheilkd. 1906;44:27–40.
[2] The Portal For Rare Diseases And Orphan Available At
Http://Www.Orpha.Net/Consor/Cgibin/Disease_Search.Php?Lng=En&Data_Id=2590&Disease=Peters-Anomaly&Search=Disease_Search_Simple.
[3] Bhandari R, Ferri S, Whittaker B, Liu M, Lazzaro Dr. Peters Anomaly: Review Of The Literature. Cornea. 2011 Aug. 30(8):939-44. [Medline].
[4] Parul Ichhpujani, Suresh Kumar Gupta, Surinder Singh Pandav,9.3.3 Congenital And Developmental Glaucoma: Clinical Profile, Postgraduate Ophthalmology Volume 1, First Edition, Jaypee Brothers Medical Publishers (P) Ltd, 2012;866-19
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Abstract: Acute pancreatitis is an inflammation of the pancreas following self-destruction by its own enzymes responsible for local lesions and systemic response. In rarely cases, several drugs are described as having adverse effects causing acute pancreatitis outside of a context of drug intoxication. Classically, drug-induced acute pancreatitis tends to be edematous and has a relatively limited course over time. Several cases of pancreatitis due to sodium valproate are described in the literature. We describe a first clinical case in Morocco of an epileptic adolescent treated with sodium valproate......

Keywords: acute pancreatitis, drug-induced, valproic acid, Moroccan case

[1] Bischof Mcm, Stadelmann Mie, Janett S, Bianchetti Mg, Camozzi P, Goeggel Simonetti B, Lava Sag, Milani Gp. Valproic Acid-Associated Acute Pancreatitis: Systematic Literature Review. J Clin Med. 2023 Sep 19;12(18):6044. Doi: 10.3390/Jcm12186044. Pmid: 37762984; Pmcid: Pmc10531745.
[2] Lankisch P, Dröge M, Gottesleben F. Drug-Induced Pancreatitis: Incidence And Severity. Gut 1995 ; 37 : 565-7
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[4] Rünzi R, Layer P. Drug-Associated Pancreatitis: Facts And Fiction. Pancreas 1996 ; 13 : 100-9.
[5] Banerjee A, Patel K, Grainger S. Druginduced Pancreatitis. A Critical Review. Med. Toxicol. Adverse Drug Exp 1989 ; 4 : 186-98.

Abstract: Background: For a dental restoration to be successful, one needs to take several factors into account however, prosthetic precision is largely affected by marginal fit of the restoration as it directly influences the longevity and clinical success of the dental restoration. Reason being, increased marginal discrepancy leading to cement dissolution which in turn leads to accumulation of the tooth biofilm, hypersensitivity, marginal discoloration, microleakage, caries, endodontic and periodontal diseases.....

Keywords: All ceramic restorations, marginal fit, lithium disilicate, zirconia, CAD/CAM, Scanning electron microscope.

[1] Succaria F & Morgano Sm. Prescribing A Dental Ceramic Material: Zirconia Vs Lithiumdisilicate. Saudi Dent J 2011;23(4):165-6.
[2] Zarone F, Di Mauro Mi, Ausiello P, Ruggiero G, & Sorrentino R. Current Status On Lithium Disilicate And Zirconia: A Narrative Review. Bmc Oral Health 2019;19:134-147.
[3] Bona A, Pecho O, & Alessandretti R. Zirconia As A Dental Biomaterial. Materials (Basel)2015; 8(8):4978–91.
[4] Ivoclar Vivadent. Ips E.Max Lithium Disilicate: The Future Of All-Ceramic Dentistry – Material Science, Practical Applications, Key To Success. Amherst, N.Y.: Ivoclar Vivadent;2009:1-15
[5] Baig Mr, Tan Kb, Nicholls Ji. Evaluation Of The Marginal Fit Of A Zirconia Ceramic Computer-Aided Machined (Cam) Crown System. J Prosthet Dent 2010;104(4):216-27.