iosr-JDMS   Volume-15 ~ Issue-12 ~ December-2016

Abstract: The significance of palmar and digital ridges have brought into light by Cummins and Midlowin 1943, since then the field of dermatoglyphics has improved a lot in the field of personal identification. Now a day's its use as a tool in early diagnosis of various psychological, medical and genetic conditions. But it could be implemented only by taking print of the hand by a conventional method called 'ink method'. But it has so many many disadvantages which is the main barrier for its wide use. Inorder to overcome this barrier we implemented a way new stain less, strain less, user and subject friendly method – 'Photographic Method

Keywords: Dermatoglyphics,imagej, ink method, photographic

[1]. Cummins, H., &Midlow, C. (1943). Finger prints, palms and soles: An introduction to dermatoglyphics. Philadelphia: The Blakiston Company. Philadelphia.
[2]. Cotterman C. W., A scotch-tape India-ink method for recording dermatoglyphics, Am J Hum Genet. 1951 December; 3(4): 376–379.
[3]. Misumi Y, Akiyoshi T. Scanning electron microscopic structure of the finger print as related to the dermal surface. Anat Rec.1984 Jan;208(1):49-55.
[4]. Okajima M,., Development of dermal ridges in the foetus,J Med Genet. 1975 Sep;12(3):243-50.
[5]. Roopam K Gupta and Aruna K Gupta, New, easy and effective method to take dermatoglyphic prints, National journal of medical research, Jan – March 2013:3(1) Page 45-47

Abstract: Majority of Skull bones are held together by fibrous joints termed as sutures. At birth the two halves of frontal bone remain separate as the metopic suture which is replaced by bone at about 2 years. The persistence of this suture beyond 8 years of age is termed as metopism. The study was conducted on 90 adult human dry skulls. Among them 55 were obtained from department of anatomy RIMS Ongole, A.P. and 35 from department of Forensic Medicine, RIMS Ongole..........

Keywords: Bregma , frontalbone, metopic suture, metopism, nasion

[1]. Guerram A, Le Minor JM, Renger S, Bierry G. Brief communication: The size of the human frontal sinuses in adults presenting
complete persistence of the metopic suture. American Journal of Physical Anthropology. 2014;154:621-627.
[2]. A.K.Dutta, Essentials of Human anatomy, Head & Neck, 5th edn Current books International pp 14
[3]. Gray's Anatomy 40th Edn – The Anatomical basis of Clinical Practice, Churchill Livingstone, elsevier PP 409,472.
[4]. Romanes G.J.Cunninghams Textbook of Anatomy 11th edn London, Oxford University Press, pp 133
[5]. Merrits neurology,11thedition, Lippincott williams & wilkins.

Abstract: The replacement of a single tooth is a common procedure performed in contemporary implant dentistry. Placement of implant immediately following tooth extraction provides several advantages to the patient compared with a staged approach. This case presentation illustrates a case of an extraction and immediate implant placement in the maxillary second premolar region.

Keywords: Immediate implant, Implant

[1]. Brånemark PI, Hansson BO, Adell R, et al. Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period. Scand J Plast Reconstr Surg Suppl 1977;16:1–132.
[2]. Adell R, Lekholm U, Rockler B, Brånemark PI. A 15-year study of osseointegrated implants in the treatment of the edentulous jaw. Int J Oral Surg 1981;10:387–416.
[3]. Paolantonio M, Dolci M, Scarano A, et al. Immediate implantation in fresh extraction sockets. A controlled clinical and histological study in man. J Periodontol 2001;72:1560–1571.
[4]. Schropp L, Kostopoulos L, Wenzel A. Bone healing following immediate versus delayed placement of titanium implants into extraction sockets: A prospective clinical study. Int J Oral Maxillofac Implants 2003;18:189–199.
[5]. Schulte W. The intraosseous Al2O3 (Frialit) Tuebingen implant. Developmental status after eight years (II). Quintessence Int 984;15:19-35.

Abstract: Introduction: The commonest swelling in the neck worldwide is a lymph nodal enlargement. The commonest cause of cervical lymphadenopathy varies from country to country and include Tuberculosis, Lymphomas, and metastatic cancers. However, there are a variety of less common causes of neck swellings, which are encountered in clinical practice. Because of their rarity, clinical diagnosis is rarely attained and they are often histological surprises after incisional or excision biopsy. Objective and Methods: It is useful to know the uncommon causes of neck swellings as they present a diagnostic dilemma as well as a therapeutic challenge. In this article, we document the clinical features of a few uncommon neck swellings.........

Keywords: Neck swellings, Castleman's disease, chondrosarcoma, ectopic hamartomatous thymoma, extra-cranial meningioma , cervical germ cell tumour, Infantile myofibroma

[1]. Rosai J, Limas C, Husband EM. Ectopic hamartomatous thymoma. A distinct benign lesion of the lower neck. Am J Surg Pathol. July 8(7), 1984, 501-513.
[2]. Fetsch JF, Laskin WB, Michal M, Remotti F, Heffner D, Ellis G, Furlong M, Miettinen M. Ectopic hamartomatous thymoma. A clinico pathological and immunohistochemical analysis of 21 cases with data supporting reclassification as a mixed branchial anlage tumour. Am J Surg Pathol 28(10),2004 Oct,1360-70. [3]. Marschall J, Kanthan R. The sarcomatous guise of ectopic hamartomatous thymoma. Head Neck 24(8),2002 Aug,800-4.
[4]. Wang J, Zhang RY. Ectopic hamartomatous thymoma. A clinicopathological and immunohistochemical study of two cases. Zhanghua Bing Li Xue Za Zhi. 34(7),2005 Jul,397-401.
[5]. Castleman B, Towne V. Case records of the Massachusetts General Hospital weekly clinicopathological exercises: case 40011. N Engl J Med. 250(1),1954, 26-30.

Abstract: Stroke is the leading cause of death and the most common cause of severe disability. World Health Organization defines clinical diagnosis of stroke as."Rapidly developing clinical signs of focal or global disturbance of cerebral function with symptoms lasting for 24hours or longer or leading to death, with no apparent cause other than of vascular origin". This definition includes subarachnoid and intra cerebral haemorrhage but excluding syndromes mimicking stroke resulting from trauma, CNS infections, tumours etc.Much of our current knowledge.........

Keywords: Clinical features, Lacunar infract, Risk factors, stroke, tumours.

[1]. sethi P K. Incidence in India and management of ischemic stroke Neuroscience today 2002; 6:139-143.
[2]. Stroke Vol 24, No 1 January 1993.
[3]. Sacco S, Marini C, Totaro R, et al. A population-based study of the incidence and prognosis of lacunar stroke. Neurology May 9,2006;66(9): 1335-8.
[4]. Poiner J. Derouesre C. Le concept de lacunecerebrale de 1838 a nosjourns. Rev Neurol (Paris)1985;141:3-17.
[5]. Donnan GA Lacunes& Lacunar syndromes In: Ginsberg MD, Bogousslavsky J. (eds) cerebrovascular Disease Pathophysiology, Diagnosis & Treatment. Malden, MA Blackwell science, 1998, 1090-102.

Abstract: Background:The presence of a lump in the breast is a cause of anxiety and fear to most patients. This may be due to the increased awareness of breast cancer which is the commonest malignancy affecting females worldwide. . Objective:To determine the clinic demographic and histologic pattern of benign breast diseases as seen in University of Port Harcourt Teaching Hospital (UPTH)............

Keywords: Benign, Breast, lumps, Nigeria, Tertiary

[1]. A. Sharma, R. Bandari, D. Gilbert, AK Sharma. Benign and malignant breast disease presenting to Bhaktapur Cancer Hospital.
Kathmandu Univ Med J (KUMJ), 3(4), 2005, 384-387.
[2]. C. Goehring, A. Morabia, Epidemiology of benign breast disease with special attention to histologic types. Epidemiol Rev 19(2),
1997, 310-327
[3]. J.W. Berg, R.V. Hutter. Breast cancer. Cancer, 75(1 Suppl), 1995, 257-269.
[4]. D. M. Parkin, F.Bray, J. Ferlay, P. Pisani. Global cancer statistics, 2002.CA Cancer J Clin, 55(2), 2005, 74-108.
[5]. 5 O. Ochicha, S.T.Edino, A.Z. Mohammed, S.N. Amin. Benign breast lesions in Kano. Nig J Surg Res, 4(1-2) 2002, 1-5.

Abstract: Aim: To compare the outcome of post-operative astigmatism produced in superior straight type of incision and temporal straight type of incision in patients who underwent manual SICS with PCIOL implantation Methods: A total of 80 patients with unilateral or bilateral uncomplicated cataract were taken for the study. Informed consent was obtained after informing the patient about the study, details of the procedure and possible complications. Only after obtaining the informed consent from the patient, he/she was included in the study. The study group was randomly selected and was divided into two groups of 40 subjects each. For each group.........

Keywords: Manual small incision cataract surgery; incisions; surgically induced astigmatism

[1]. Roman SJ e al,Surgically induced astigmatism with superior and temporal incisions in cases of with therule preoperative astigmatism.J Cataract and ref surgery, 1998.
[2]. Gokhale NS,Sawhney S, Reduction in astigmatism in manual small incision cataract surgery through change of incision site.Indian j ophthalmology 2005;53:201-3.
[3]. Malik VK et al, Comparison of astigmatism followingmanual small incision cataract surgery:superior versus temporal approach,Nepal J Ophthalmology,2012 jan-jun.

Abstract: Mucocele is a common , benign, mucous containing cystic lesion of the minor salivary glands in the oral cavity, resulting from the retention or extravasation of mucous into the surrounding tissues of lamina propria. They occur in various anatomical locations but the occurrence in the ventral aspect of tongue is rarely seen. This article, reports a case of mucocele of the glands of Blandin and Nuhn in a 13 year old female patient and its management.

Keywords: Mucocele, Extravasation, Retention, Glands of Blandin Nuhn, Ventral aspect of tongue.

[1]. Adachi & AMP Soubhia & F K Horikawa and E h Shinohara. Mucocele of the glands of Blandin Nuhn clinical, pathological, and
therapeutical aspects. Oral Maxillofac Surg 2011; 15:11- 13.
[2]. Baurmash HD. Mucoceles and Ranula. J oral maxillofac Surg 2003; 61: 369 -378.
[3]. Daniels JSM and Al Bakri IM. Mucoceles of lingual glands of Blandin Nuhn: A report of 5 cases. Saudi Dental Journal
2005;17(3):154-61.
[4]. Ellis E, Scott R, Upton LG. An unusual complication after excision of a mucocele of the anterior lingual gland. Oral Surg Oral Med
Oral pathol 1983; 56: 467 – 471.
[5]. Gupta B, Rajesh A, sudha P, Gupta M. Mucocele: Two case reports. J Oral health comm Dent 2007; 1(3): 56 – 58.

Abstract: The term uveitis, derived from uva, the Latin word for grape, encompasses a broad range of disease processes involving the uveal tract and its associated ocular structures. This study was done to find the patterns of uveitis among the patients attending a tertiary care facility in Imphal, Manipur during the period from September 2012 to August 2014. Patients were grouped according to the anatomical classification of uveitis based on the International Uveitis study group classification system. Ophthalmological work-up were done after obtaining prior informed consent..........

Keywords: Anterior uveitis, Intermediate uveitis, Panuveitis, Posterior uveitis

[1]. Yeh S, Grace A, Clarke L, Nussenblatt RB, Introduction to Uveitis, in Daniel AM, Miller JW, Azar TD, Blodi BA, Cohan JE,
Perkins T(ed), Albert and Jakobiec's Principles and Practice of Ophthalmology,3( Toronto, Elsevier, 2008)1113.
[2]. Nussenblatt RB, The natural history of uveitis, Int Ophthalmol14(5-6),1990,303-8.
[3]. Cannel CA, Causes of uveities in the general practise of ophthalmology, Am J Ophthalmol114, 1996, 35-46.
[4]. Khairallah M, Ben S, Yahia, Ladjimi A, Messaoud R, Pattern of Uveitis in Tunisia, North Africa, Eye (Lon)21(1), 2007, 33-9.
[5]. Rathinam SR, Global variation and pattern changes in epidemiology of uveitis, Indian J Ophthalmol, 55(3), 2007, 173-183.

Abstract: Background: We conducted a retrospective study to evaluate the incidence of tympanosclerosis (TS), degree of resulting deafness, the required surgical stratergies and their outcome in patients with tympanic membrane perforation. Material and methods: A retrospective study was done in 500 patients (14 – 45 yrs) with ear discharge attending the out patient department (OPD) in the last 3 years. Data regarding incidence of TS, location of perforation, degree of deafness, association with repeated cold, headaches and sinusitis; history of grommet insertion or trauma to the tympanic membrane (TM) and the surgical stratergy required was compiled..........

Keywords: Tympanosclerosis (TS), Sinusitis, Tympanic membrane (TM)

[1]. Forseni M, Bagger-Sjoback D, Hultcrantz M. A study of inflammatory mediators in the human tympanosclerotic middle ear. Arch
Otolaryngol Head Neck Surg 2001;127(5):559-64.
[2]. Asiri S, Hasham A, al Anazy F, Zakzouk S, Banjar A. Tympanosclerosis: review of literature and incidence among patients with
middle-ear infection. J Laryngol Otol 1999;113(12):1076-80.
[3]. Isaacon JE, Vora NM. Differential diagnosis and treatment of hearing loss. Am Fam Physician 2003;68(6):1125-32.
[4]. Hampal S, Flood LM, Kumar BU. The mini-grommet and tympanosclerosis. J Laryngol Otol 1991;105(3):161-4.
[5]. Ferri M, Faggioli GL, Ferri GG, Pirodda A. Is carotid stenosis correlated with tympanosclerosis. Int Angiol 2004;23(2):144-6.

Abstract: Adenoid cystic carcinoma (ACC), is one of the most common primary malignant tumors of the lacrimal gland. It accounts for less than 4% of all lacrimal gland tumours. Mean age of incidence is 40 years1. It has a poor prognosis, in view of its locally invasive and metastatic potential.2-7. Radical Excision with negative margin is the treatment of choice. However, the complex anatomy of orbital narrows the extent of radical resection in many cases. We report a case of a 16 year old boy in whom ACC of the lacrimal gland recurred locally in a multifocal pattern following a 3 year disease free interval, after initial excision and adjuvant radiation therapy. The case is unique due to its rarity in the age group as well as successful application of conservative approach in the extent of salvage surgery

Keywords: Adenoid Cystic Carcinoma, Cylindroma, Orbital Tumours

[1]. Font RL Gamel JW Adenoid cystic carcinoma of the lacrimal gland: a clinicopathologic study of 79 cases. Nicholson DHed. Ocular Pathology Update. New York, NY Masson Publishing USA1980;277- 283
[2]. Henderson JW Adenoid cystic carcinoma of the lacrimal gland: is there a cure? Trans Am Ophthalmol Soc. 1987;85312- 334
[3]. Jakobiec FA Discussion of Henderson JW. Adenoid cystic carcinoma of the lacrimal gland: is there a cure? Trans Am Ophthalmol Soc. 1987;85314- 337
[4]. Lee DACampbell RJ Waller RR Ilstrup DM. A clinicopathologic study of primary adenoid cystic carcinoma of the lacrimal gland. Ophthalmology. 1985;9212- 34
[5]. Byers RM Berkeley RG Luna M Hesse R. Combined therapeutic approach to malignant lacrimal gland tumors. Am J Ophthalmol. 1975;7953- 55

Abstract: Pregnancy is considered the greatest physiological stress to which females are subjected to during their lives. Owing to that fact, they should maintain their nutritional status by consuming complementary supplements that helps in preventing the risk of developing pregnancy related disorders. This study is evaluating the compliance of pregnant ladies in KSA towards supplements. 200 Women attending the antenatal clinics in (King Fahad University Hospital, Procare, and Air Base Hospital) in AlKhobar – KSA were randomly selected to participate in a self-filled questionnaire.........

Keywords: Antenatal clinics, Compliance, KSA, Pregnant ladies, Supplements

[1]. F. Strauss Jerome and L. B. Robert, Yen & Jaffe's reproductive endocrinology: physiology, pathophysiology, and clinical
management (Elsevier Health Sciences, 2013).
[2]. J. A. Cramer, A. Roy, A. Burrell, C. J. Fairchild, M. J. Fuldeore, D. A. Ollendorf and P. K. Wong, Medication compliance and
persistence: terminology and definitions, Value Health, 11, 2008, 44-47.
[3]. S. Al Faraj and K. Al Mutairi, Vitamin D deficiency and chronic low back pain in Saudi Arabia. Spine, 28, 2003, 177–179.
[4]. R. S. Al-Ahmadi, Use of folic acid among pregnant women attending antenatal care clinic at Al-Hejrah primary health care center,
Makkah Al-Mokarramah, Saudi Arabia, International Journal of Medical Science and Public Health, 3(8), 2014, 963-969.
[5]. F. Habib, E. H. Alabdin, M. Alenazy and R. Nooh, Compliance to iron supplementation during pregnancy, Journal of Obstetrics &
Gynaecology, 29(6), 2009, 487-492.

Abstract: Hypoxic-ischemic encephalopathy (HIE) due to birth asphyxia is an important etiology of neonatal morbidity and mortality and is conventionally diagnosed on the basis of clinical features and promptly classified by various classifications and treated accordingly. By this protocol, often the cases are diagnosed late and this leads to increased mortality and morbidity. The aim of this study was to investigate the predictive values of biochemical parameters, like serum creatine kinase (CK), lactate dehydrogenase (LDH), uric acid (UA) in newborns with HIE. A total of 42patients were diagnosed with HIE.............

Keywords: Hypoxic-ischemic encephalopathy, creatine kinase, lactate dehydrogenase, uric acid.

[1]. Cloherty, John P, Eichenwald Eric C, Stark Ann R ,manual of neonatal care, 6th Edition chapter 27C , 518-527 ( Philadelphia ,USA : Lippincott Williams & Wilkins).
[2]. Joseph Volpe ,Harvard University, Boston, U.S.A. Pathophysiology of Birth Asphyxia: A Review of the Clinical Problem; Programme for Global Paediatric Research convened a symposium and workshop on the global crisis of birth asphyxia ,May 17 and 18, 2005. [3]. Sarnat H, Sarnat M. Neonatal encephalopathy following fetal distress. Arch Neurol. 33: 1976, 695 - 705
[4]. Levene ML, Kornberg J, Williams TH. Theincidence and severity of post-asphyxial encephalopathyin full-term infants. Early Hum Dev; 11:1985, 21-26.
[5]. CM Thompson,, AS Puterman, LL Linley, FM Hann, CW van der Elst, CD Molteno and AF Malan , The value of a scoring system for hypoxic ischaemic encephalopathy in predicting neurodevelopmental outcome, Acta Paediatrica Volume 86, Issue 7, July 1997, 757–761, .

Abstract: We report the observation of a patient aged 45, treated for trabeculo vesicle carcinoma of thyroid. A year later, the patient had a local recurrence, cervical lymph node metastases and bone with the finding of a central diabetes insipidus and a dissociated hypopituitarism .Magnetic resonance imaging revealed metastasis of pituitary. The treatment consisted of a pituitary hormone replacement deficits and cervical and pituitary radiotherapy

Keywords: Thyroid cancer; Pituitary metastases; Diabetes insipidus; Pituitary RMI

[1]. Kovacs, K : Metastatic cancer of the pituitary gland. Oncology 1973; 27(6): 533-42
[2]. Nugent, JL, Bunn, PA, Matthews, MJ Idhe, DC, Cohen, MH, Gazdar, A Central nervous system metastases in small cell bronchogenic carcinoma. Cancer 1979; 44: 1885-93.
[3]. Ntyonga-Pono MP, Thomopoulos P, Luton JP. the metastases Hypophysaires. Presse Med, 1999;28:1567-71.
[4]. Teears RJ, Silverman, EM :Clinicopathologic review of 88 cases of carcinoma metastatic to the pituitary gland. Cancer 1975; 36: 216-20.
[5]. Halpert, B, Erickson, EE, Fields, WS Intracranial involvement from carcinoma of the lung. Arch Pathol 1960; 69: 93-103

Abstract: KlippelFeil syndrome (SKF) is a rare congénital disease. It is characterized mainly by the incorrect union or fusion of two cervical vertebrae or more. This malformation is responsible for limitation of movement of the head and a significant risk of spinal cord injury. Other variable anomalies may be associated with increased morbidity . We report the case of a child who consulted us for short stature with abnormal sexual differentiation. The existence of short and palmed neck associated with congenital strabismus oriented diagnosis and has linked abnormalities present to KlippelFeil syndrome

Keywords: Cervical vertebrae; short neck; radiography of the cervical spine; malformative anomalies

[1]. Behrman RE, et al., eds. Nelson Textbook of Pediatrics. 15th ed. Philadelphia, PA: W.B. Saunders Company; 1996:1950.
[2]. Gorlin RJ, et al., eds. Syndromes of the Head and Neck. 3rd Ed. New York, NY: Oxford University Press; 1990:886-89.
[3]. Buyse ML. Birth Defects Encyclopedia. Dover, MA: Blackwell Scientific Publications, Inc.; 1990:653-54, 1015-16.
[4]. Isidor B, David A. Two girls with Short Stature, Short neck, vertebral anomalies, Sprengel deformity and Intellectual disability. Eur J Med Genet 2014 Nov 18. pii: S1769-7212(14)00204-3.Doi: 10.1016/j.ejmg.2014.11.001.
[5]. Clarke RA, et al. Heterogeneity in Klippel-Feil syndrome: a new classification. PediatrRadiol. 1998; 28:967-74.

Abstract: Differential carcinoma is the most common cancer of the thyroid. Usually of good prognosis, it is characterized by mostly locoregional locations1. Remote metastasis are mainly lung and bone. The other locations are much rarer (brain, mediastinum, skin, liver, eye, adrenal ...). In our study, they were found in 1.85% of cases. Predominant in the female sex (67%), they are more common in vesicular carcinomas (77%) than in pure papillary carcinomas (22%) (p = 0001). The average age of diagnosis of metastasis is 53 ± 4.2 years with an average of 3 ± 0.5 years after the diagnosis of thyroid carcinoma.........

Keywords: Unusual metastases ; vesicular carcinomas; radioactive iodine

[1]. Troutoux J., Aidan D. -Tumors The Thyroid . Emc, Orl, 20-875-A-10, 1997, 12p.
[2]. Shaha Ar, Ferlito A, Rinaldo A. Distant Metastases From Thyroid And Parathyroid Cancer. Orl J Otorhinolaryngeal Relat Spec. 2001;63:243- 249.
[3]. Ahmadi M.A., Nicholes D., Esmaeli B. Late Choroidal Metastasis Secondary To Papillary Thyroid Carcinoma. Am J Ophthalmol 2001;132:796-8.
[4]. Dahl Pr, Brodland Dg, Goellner Jr, Hay Id. Thyroid Carcinoma Metastatic To The Skin: A Cutaneous Manifestation Of A Widely Disseminated Malignancy. Jam Acad Dermatol. 1997;36:531-7.
[5]. Ferry A.P, Font R. -Dcarcinoma Metastatic To The Eye And Orbit. I.A Clinicopathologic Study Of 227 Cases. Arch Ophthalmol., 1974; 92: 276-286.

Abstract: A comparative study was conducted between sporadic CMT ( CMTS , n : 19) and heritable ( CMT H , n = 22) integrated within a MEN2A . The diagnosis of CMT in CMTH group was made rather than the CMTS group It was revealed by a thyroid nodule in CMTS and family screening in CMTH . the CMTH were stage I TNM in 78.9 %, while the CMTS is almost equally divided between stage II ( 26.31% ) I and IV (21.05 %) . Genotypically , two mutations were observed 634 mutation and618 RET gene mutation . A genotype-phenotype correlation was observed

Keywords: medullary thyroid carcinoma, MEN2A , RET protooncogene , genotype- phenotype

[1]. Clark OH, Kebebew E, Ituarte PHG, Siperstein AE, Duh QY(2000) Medullary thyroid carcinoma—clinical characteristics,treatment, prognostic factors, and a comparison of staging systems.Cancer 88(5):1139-1148
[2]. Pelizzo MR, Boschin IM, Bernante P, et al. Natural history, diagnosis, treatment and outcome of medullary thyroid cancer: 37 years experience on 157 patients. Eur J Surg Oncol. 2007;33:493-497
[3]. Guliana JM, Franc B et Duron F. Cancer médullaire de la thyroïde. Encycl Méd Chir (Editions Scientifiques et Médicales Elsevier SAS, Paris, tous droits réservés)Endocrinologie-Nutrition, 10-008-B-10, 2001, 15 p.
[4]. Mulligan LM, Eng C, Healey CS, et al. Specific mutations of the RET protooncogene are related to disease phenotype in MEN 2A and FMTC. Nat Genet. 1994;6:70-74.
[5]. Kebebew E, Ituarte PH, Siperstein AE, Duh QY, Clark OH, Medullary thyroid carcinoma: clinical characteristics, treatment, prognostic factors, and a comparison of staging systems, Cancer. 2000 Mar 1;88(5):1139-48.

Abstract: Cushing's syndrome is a rare condition. it is much less frequent to diagnosis it during pregnancy. We report the cases of three patients in whom Cushing's syndrome appeared during pregnancy and revealed by hypertension associated with diabetes mellitus and signs of endogenous catabolic. Hormonal balance was in favor of a non- ACTH -dependent hypercortisolism and MRI revealed a unilateral adrenal tumor in the three cases: Adrenocortical carcinoma (n = 2) and adrenal adenoma (n = 1)...........

Keywords: Cushing's syndrome; pregnancy; Adrenocortical adenoma, adrenocortical carcinoma

[1]. Vilar L, Freitas Mda C, Lima LH, Lyra R, Kater CE. Cushing's syndrome in pregnancy: an overview. Arq Bras Endocrinol Metabol. 2007;51:1293-1302.
[2]. Terhune KP, Jagasia S, Blevins LS, Phay JE. Diagnostic and therapeutic dilemmas of hypercortisolemia during pregnancy: a case report. Am Surg. 2009;75:232-4.
[3]. Lindsay JR, Jonklaas J, Oldfield EH ,Nieman LK. Cushing's syndrome during pregnancy: personal experience and review of the literature. Journal of Clinical Endocrinology and Metabolism 2005 90 3077-30.
[4]. Beucher MA, McClamrock HD, Adashi EY. Cushing syndrome in pregnancy. Obstet Gynecol. 1992;79:130-7.
[5]. Chico A, Manzanares JM, Halperin I, Martinez de Osaba MJ, Adelantado J, Webb SM. Cushing's disease and pregnancy: report of six cases. Eur J Obstet Gynecol Reprod Biol. 1996;64:143-146.

Abstract: Glycogen storage diseases are pathologies that affect the glycogen metabolism. Several types were identified. The most common one is glycogen storage disease type 1 (GSD I) also called Von Giereke disease. It results from deficiency of the enzyme glucose-6-phosphatase, and it is observed in one of 100,000 births. Clinically it includes hepatomegaly that give an appearance of abdominal distension contrasting with slender limbs, fasting intolerance, epistaxis and repeated infections. Growth retardation and delayed puberty can frequently be observed in this pathology. We report the cases of two sibling children admitted to ourdepartment for evaluation of short stature which proved to be secondary to.

Keywords: Hypoglycemia, delaystature, glycogen storage diseases, hepatomegaly, CT-guided biopsy

[1]. Roach PJ. Glycogen and its metabolism. Curr Mol Med 2002; 2:101-120
[2]. Chen YT. Glycogen storage diseases. In: Scriver CR, Beaudet AL, Sly WS, Vale D, Childs B, Kinzler KW, Vogelstein B. The metabolic & molecular basis of inherited diseases. New York: McGraw-Hill, 2001: 1521-1552
[3]. Applegarth DA, Toone JR, Lowry RB. Incidence of inborn errors of metabolism in British Columbia, 1969-1996. Pediatrics 2000; 105: e10
[4]. Weinstein DA, Correia CE, Saunders AC, Wolfsdorf JI. Hepatic glycogen synthase deficiency: an infrequently recognized cause of ketotic hypoglycemia. Mol Genet Metab 2006; 87: 284-288
[5]. CORI GT, CORI CF. Glucose-6-phosphatase of the liver in glycogen storage disease. J Biol Chem 1952; 199: 661-667

Abstract: Lymphoma adrenal is a rare cause of adrenal tumor(0,5% ). Bilateral primary lymphoma adrenal phenotypeT is exceptional. We report observation of a patient 56 years old hospitalized for exploration and therapeutic management of two large adrenal masses discovered on CT imaging after back pain, and weight loss. Physical examination revealed a patient asthenic, with no signs of hypersecretion. The rest of the examination was unremarkable and research call signs primary neoplasm was negative. A hormonal balance showed a low cortisol with a hight ACTH level.This which required start hormone replacement therapy to hydrocortisone..........

Keywords: Adrenal masses;Bilateral primary lymphoma adrenal; phenotype T; chemotherapy

[1] Nicolas M, Tissier S, Béot S, Laurent V,Meyer Bisch L, Régent D. Quel est votre diagnostic? J Radiol 2004;85:1081-3.
[2] Mignon F, Aix P, Mesurolle B, Sissa-kian JF, Bruckert F, et al. QUID ? J Radiol 1999;80:1583-6
[3] Wen-chiuan T, Cheng-da H, Ming-fang C, Chih-kung L. Adrenal insuffi-ciency in T-cell lymphoma. Int J Urol 2006;13:794-7.
[4] M. Sfaxi et al. / Annales d'Endocrinologie 69 (2008) 249-253.
[5] Edderai et al./ Lymphome surrénalien primitif bilatéral : à propos de deux observations. J Radiol 2009;90:832-5.

Abstract: A retrospective study of 30 patients with sexual differentiation 46XY abnormality collected over 19 years to assess the clinical and etiological characteristics. The disease is rare; the age at diagnosis is in generally late at 8.5 years (02 months - 25 years). However the defect is found at birth in most cases (82.5%). In half of the cases, the first Endocrinology consultation is done between the second and the sixth year. Sexual ambiguity is severe in 10% of cases. We discerned three predominant etiologies: the androgen resistance (26.6%) gonadal dysgenesis (20%) and the enzyme block (20%). In nearly a third (26.6%) no etiology was found.

Keywords: Sexual differentiation, Quigley classification, androgen resistance, enzymatic block, gonadal dysgenesis, sexual ambiguity

[1] Yves Morel, Delphine Mallet, Rita Menassa: La différenciation sexuelle. P. Chanson. Médecine Clinique endocrinologie & diabète. 2006. [64] Yves
[2] Dewing. P, Bernard. P, Vilain. E. Disorders of gonadal development. In : Seminars in Reproductive Medecine. New York. Thieme, 2002 ; 20 : 189-198.
[3] JOB JC. PIERSON M: Endocrinologie pédiatrique et croissance. Les états intersexuels. Médecine/sciences 1978, 2, 273-293. [35] Jones.
[4] Migeon. CJ, Berkovitz. GD, Brown. TR. Sexual differenciation and ambiguity. In : Kappy MS, Blizzard. RM, Migeon. CJ eds. The diagnosis and adolescence springfield : Charles Thomas, 1994 : 573 - 681.
[5] Thyen. U, Richter-Appel. H, Wiesemann. C.Deciding on gender with intersex conditions : considerations and controversies. Treat Endocrinol 2005 ; 4 : 1-8

Abstract: We report the original observation of the adrenal metastasis of a renal clear cell carcinoma on ipsilateral cortisolic adenoma in a patient aged 59 who had a radical nephrectomy. The preoperative assessment revealed an ipsilateral adrenal lesion measured at 20 mm having radiological features in favor of the benign character (lower density 10UH). Six months later, an abdominal CT scan revealed an increase of the adrenal mass size (31X42X53 mm). She was then heterogeneous and took the contrast. Hormonal balance and radiological suggest a corticosurrenaloma. A left adrenalectomy was performed. Histological and immunohistochemical study revealed that the mass was the metastasis of a the renal clear cell carcinoma among a cortisolic adenoma

Keywords: Kidney cancer, surgery, adrenalectomy; cortisolic adenoma; CT scan

[1]. Coulange C., Rambeaud J.J., 1997, Cancer Du Rein De L'adulte. Prog. Urol, 7,Pp. 723-909.
[2]. Lieber M.M., Tomera F.M., William F.T., Farrow G., 1981,Renal Adenocarcinoma In Young Adults: Survival And Variables Affecting Prognosis. J. Urol., ,125, Pp.164-168. [3]. Kessler O. J., Mukamel E., Weinstein R., Weinstein E.
[4]. Gayer M ., Konichezky C., 1998, Servadio Metachronous Renal Cell Carcinoma Metastasis To The Contralateral Adrenal Gland Urology 51, Pp. 539- 43
[5]. Scatarige J.C., Sheth S., Corl F.M., Fishman E., 2001, Patterns Of Recurrence In Renal Cell Carcinoma : Manifestations On Helical Ct. Ajr Am J Roentgenol;177. Pp.653-58.

Abstract: Primary hyperparathyroidism (PHPT) is a disease whose incidence has increased considerably. The systematic and automated assay of serum calcium since the 70's has allowed a major evolution of the clinical picture of classical form with asymptomatic forms which represent 80% of cases diagnosed in industrialized countries. In poor countries, primary HPT continues to be diagnosed at the stage of complications. 38 cases of PHPT were recorded in 18 years with an average incidence of two cases per year. The average age of patients was 50.7 years (16 -75 years). 68% were aged over 46 years and 82% were female with a sex ratio (female / male sex ratio 4.4)..............

Keywords: Primary hyperparathyroidism, hypercalcemia, PTH , sporadic, genetics

[1]. Heath H 3rd, Hodgson SF, Kennedy MA. Primary hyperparathyroidism. Incidence, morbidity, and potential economic impact in a community. N Engl J Med 1980;302:189-93.
[2]. Houillier P, Maruani G, Eladari D, Paillard M. Hyperparathyroïdie primitive. Encl Méd Chir (Editions Scientifiques et Médicales Elsevier SAS, tous droits réservés), Endocrinologie-Nutrition, 10-012-B-10, 2002, 9 p
[3]. Bilezikian JP, Potts JT Jr, Fuleihan Gel-H et al. Summary statement from a workshop on asymptomatic primary hyperparathyroidism: a perspective for the 21st century. J Clin Endocrinol Metab. 2002;87:5353-61
[4]. Wémeau JL, Gilliot-Valtille E, Bizard JP et al. Current concepts in primary hyperparathyroidism. Horm Res 1989;32:93-6
[5]. Silverberg SJ, Shane E, de la Cruz L et al. : Skeletal disease in primary hyperparathyroidism. J Bone Miner Res 1989 ; 4 : 283-91 14.

Abstract: The Insulin like Growth Factors (IGFs = essentially IGFI and IGFII) play a key role in many physiological processes. Therefore, they are involved in numerous pathologies including stunting. A comparative study on the determination of IGFI was made between a group of healthy normal sized Algerian children (n = 266) and a group of Algerian children with a deficit in growth hormone (n = 107) and another Western healthy normal size children group (Rosenfeld Series). The results are as follows: Before 04 years, there is a large overlap of results between IGFI of deficient children...........

Keywords: Delay stature, GH deficiency, IGFI, IGFBP3, Nutrition

[1]. DAUGHADAY WH, ROTWEIN P Insulin-Like Growth Factors I And II Peptides, Messenger Ribonucleic Acid And Gene Structures, Serum, And Tissue Concentrations. Endocr Rev 1989 ; 10 : 68-91
[2]. HARDOUIN. S, GOURMELEU. M, NOGUIEZ. P, SEURIN. D, ROGHANI.M, LEBOUC. Y, POVOA. G, MERIMEE. T.J, HOSSENLOPP. P, BINOUX. M. Molecular Formes Of Serum Insulin-Like Growth Factor (IGF) = Binding Proteins In Man = Relation Ships With Growth Hormone And IGF S And Phsyiological Significance.J. Clin. Endocrinol. Metab. 1989 ; 69 = 1291 - 1301
[3]. BLUM. W.F, RANKE . M.B, KIETZMANN. K, GAUGGEL. E, ZEISEL. H.J, BEIRICH. J.R. Aspecific Radio-Immuno-Assay For The Growth Hormone (GH) Dependent Somatomedin Binding Protein : Its Use For Diagnosis Of GH Deficiency.J. Clin. Endocrinol. Metab. 1990 ; 70 = 1292 - 1298.
[4]. BLUM. W.F. Insulin Like Growth Factors And Their Binding Proteins. In : Ranke MB (Ed) Functionnal Endocrinologic Diagnostics In Children And Adolescents Verlag. Mann Heim, Germanyu 1992 ; Pp = 102 - 117.
[5]. BINOUX M, GOURMELEN M, GIRARD F Serum Levels Of Insulin-Like Growth Factor (IGF) And IGF-Binding Protein In Constitutionally Short Children And Adolescents. Acta Endocrinol 1986 ; 113 : 145-152

Abstract: Peutz - Jeghers syndrome ( PJ S ) is an autosomal dominant disease that combines hamartomatous polyposis ,a peri- orificial lentiginose and a high risk of associated cancers. We report the observation of a girl 07 years old of personal historyof acute intestinal intussusception occurred a year ago who consults for signs of early puberty and the onset of vaginal bleeding up to 06 months . The child has a sexual stage development S3P3R (+) , an advance of height (11 years) and bone age ( 12years) and the presence of brownish macules on the buccal mucosa . During her hospitalization, she developed severe abdominal pain predominant in the right iliac region

Keywords: Peutz jeghers;polyps ;peri oral lentiginose; hamartoma ;neoplasia

[1]. Tovar J.A., Eizaguirre I., Albert A., Jimenez J., 1983 , Peutz-Jeghers Syndrome in Children: Report of Two Cases and Review of the Literature. J Pediatr Surg ,Feb;18(1) pp.1–6
[2]. Bouraoui S., Azouz H., Kecherid H ., Lemaiem F.,Mzabi Regaya.S. , 2008, Dégénérescence inaugurale d'un polype hamartomateux au cours du syndrome de peutz jeghers .gastroentérologie clinique et biologique ,32, pp.250-254.
[3]. McGarrity T.J., Amos C., . 2006, Peutz-Jeghers syndrome: Clinicopathology and molecular alterations. Cell Mol Life Sci,Sep;63(18), pp.2135–44
[4]. Heymann W.R., 2007, Peutz-Jeghers syndrome. J Am Acad Dermatol, pp.57:513–4.
[5]. Tovar J.A., Eizaguirre I., Albert A., Jimenez J., 1983, Peutz-Jeghers Syndrome in Children: Report of Two Cases and Review of the Literature. J Pediatr Surg ,Feb;18(1) pp.1–6