iosr-JDMS   Volume-20 ~ Issue-2 ~ February 2021

Abstract: Background: Over the last few centuries, medicine has seen so many advances, in spite of which, the management of leg ulcer remains a very difficult challenge. In order to tackle this, many modalities of wound dressings and topical applicants have been developed and a lot of research are still going on. It is therefore essential to introduce new techniques in the management of these wounds to make them more accessible and affordable especially to the less privileged economic class of patients. The method of evaluating the wound is of prime importance to develop a good therapeutic plan. In this study, we aimed to describe the course of evolution in the healing of chronic leg ulcers by utilising the Pressure Ulcer Scale for Healing (PUSH) tool. Materials and methods......

Key Word: Chronic wounds, diabetic ulcer, PUSH score, ulcer complications, observational study

[1]. Stotts, N.A., Rodeheaver, G.T., Thomas, D.R., Frantz, R.A., Bartolucci, A.A., Sussman, C., … Maklebust, J. (2001). An instrument to measure healing in pressure ulcers development and validation of the pressure ulcer scale for healing (PUSH). The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 56(12), M795– M799.
[2]. Proposed Fiscal Year 2009 Payment, Policy Changes for Inpatient Stays in General Acute Care Hospitals. Available at: http://www.cms.hhs.gov/apps/media/press/factsheet.asp?COUNTER3045&intNumPerPage10&checkDate& checkKey&srchType1&numDays3500&srchOpt0&srchData& keywordTwpeAll&chkNewsType6&entPage&showAll&pYear &yeardesc&cboOrderdate. Accessed May 13, 2008.
[3]. Günes UY. A prospective study evaluating the Pressure Ulcer Scale for Healing (PUSH Tool) to assess stage II, stage III, and stage IV pressure ulcers. Ostomy Wound Manage. 2009 May 1;55(5):48-52. PMID: 19471048.
[4]. Thomas DR, Rodeheaver GT, Bartolucci AA, et al. Pressure ulcer scale for healing: derivation and validation of the PUSH tool. Adv Wound Care. 1997;10:96-101.
[5]. Berlowitz DR, Brandeis GH, Anderson J, et al. Effect of pressure ulcers on the survival of long-term care residents. J Gerontol A Biol Sci Med Sci 1997;52A:106–110. 8. Centers for Medicare and Medicaid Services..

Abstract: We are reporting a case of pulmonary epithelioid hemangioenthothelioma (PEH) diagnosed in 39 year old female patient, presented with dyspnoea on exertion and CT chest showed bilateral pleural effusion. The pathological diagnosis was made on a pleural biopsy.

Key Words: Epithelioid hemangioenthothelioma, Immunohistochemistry, Chemotherapy, Tumour markers

[1]. Dail DH, Liebow AA. Intravascular bronchioloalveolar tumor. Am J Pathol 1975;78:6a-7a.
[2]. Weiss SW, Ishak KG, Enzinger FM, et al. Epithelioid hemangioendothelioma and related lesions. Semin Diagn Pathol 1986;3:259-87.
[3]. Lau K, Massad M, Weinberg G, et al. Clinical patterns and outcome in epithelioid hemangioendothelioma with or without pulmonary involvement. Chest 2011;140:1312-8.
[4]. WWTR1-CAMTA1 gene fusion is a consistent abnormality in epithelioid hemangioendothelioma of different anatomic sites. Genes Chromosomes Cancer. 2011 Aug;50(8):644-53. doi: 10.1002/gcc.20886. Epub 2011 May 16. PMID: 21584898; PMCID: PMC3264678.
[5]. Antonescu CR, Le Loarer F, Mosquera JM, Sboner A, Zhang L, Chen CL, Chen HW, Pathan N, Krausz T, Dickson BC, Weinreb I, Rubin MA, Hameed M, Fletcher CD. Novel YAP1-TFE3 fusion defines a distinct subset of epithelioid hemangioendothelioma. Genes Chromosomes Cancer. 2013 Aug;52(8):775-84. doi: 10.1002/gcc.22073. Epub 2013 Jun 5. PMID: 23737213; PMCID: PMC4089994.

Abstract: Background Nasal reconstruction was one of earliest performed plastic surgical procedures. Reconstruction of nasal defects must preserve the integrity of complex facial functions and expressions and a pleasing aesthetic outcome. Location,size ,shape and orientation of the defects are important factors in determing the method used in reconstruction. Individualized therapy is the best course and numerous flaps has been designed to provide coverage of a variety of nasal specific defects. Methods The Study done at Sawai Man Singh hospital, Jaipur from January 2019 to October 2020 . A total of 85 patients having nasal defects were included. Reconstruction with local flaps was performed in all cases........

Key Word: 'Plastic Surgery, Nasal defect, Reconstruction, Local flaps, Aesthetic outcome

[1]. Bhrany AD. Complex nasal reconstruction: a case study: reconstruction of full thickness nasal defect. .Facial plast surg clin north am 2011: 19:183-95
[2]. Zaoli G. La chirurgia riconstruttiva nei carcinoma del distretto cervico-facciale.
[3]. Godoy A. Ishil M, Byme PJet al. How facial lesions impact attractiveness and perception: differential effects of size and location. Laryngoscope 2011:121(12) :2542-7
[4]. Conley J. Cancer of the skin of the nose. Annals Otol. Rhinol. Laryngol 1974:83:2
[5]. Burget GC. Aesthetic restoration of the nose. Clin Plast Surg. 1985; 12: 463-80
[6]. L. Guo, J.R. Pribaz and J.J.Pribaz, Nasal reconstruction with local flaps Plastic and reconstructive surgery, vol 122 no.5. pp 130e-139e,2008

Abstract: Dyke-Davidoff-Masson syndrome (DDMS) is one of the disease processes that present with cerebral hemiatrophy. It may be characterized by contralateral hemiparesis, seizure, mental retardation, facial asymmetry and learning disabilities. Thrombotic thrombocytopenic purpura (TTP) is a rare blood disorder though to be characterized by thromboses resulting in a low platelet count consisting of fever, renal disease, neurological symptoms, thrombocytopenic purpura and microangiopathic haemolytic anaemia. This case report illustrates the complexity of syndrome of Dyke–Davidoff–Masson and thrombotic thrombocytopenic purpura which can constitute a diagnostic and therapeutic challenge in an emergency setting when evaluating a patient with recurrent seizures.....

Key Word: Seizure, Dyke-Davidoff-Masson syndrome, Thrombotic thrombocytopenic purpura

[1]. Arora R., Rani J.Y. Dyke–Davidoff–Masson syndrome: imaging features with illustration of two cases. Quant Imaging Med Surg. 2015;5(3):469–471.
[2]. Piro E, Piccione M, Marrone G, Giuffrè M, Corsello G. DykeDavidoff-Masson syndrome: case report of fetal unilateral ventriculomegaly and hypoplastic left middle cerebral artery. Ital J Pediatr 2013; 39: 32.
[3]. Narain NP, Kumar R, Narain B. Dyke-Davidoff-Masson syndrome. Indian Pediatr 2008; 45: 927-928.
[4]. Shrestha B. Acquired cerebral hemiatrophy: Dyke-DavidoffMasson Syndrome - a case report. Turk Neurosurg 2013; 23: 117-121.
[5]. Zilkha A. CT of cerebral hemiatrophy. AJR Am J Roentgenol 1980; 135: 259-262.
[6]. Behera MR, Patnaik S, Mohanty AK. Dyke-Davidoff-Masson syndrome. J Neurosci Rural Pract 2012; 3: 411-413.

Abstract: Introduction: Premedication is an important step before giving anaesthesia to patient. Midazolam, a benzodiazepine, has short duration of action, causes anxiolysis, muscular relaxation, amnesia in lower doses and sedation, hypnosis in higher ones. Clonidine, an alpha-2 agonist, causes reduction of anaesthetic and analgesic requirements, haemodynamic stability, sedation, antisialogogue effect. Materials and Methods: A comparative study between midazolam and Clonidine as a premedication for general anesthesia was conducted on 50 patients of either cases at Department of Anaesthesia, Calcutta Medical College, Kolkata, and West Bengal. All the patients belongs to ASA I or II. The age of patients ranged from 15-65 years. On the day before the operation pre-operative assessment was carried out. Results: Majority of cases in both the groups were in the age group of 16.......

Key Word: Premedication, midazolam, Clonidine, benzodiazepine

[1]. Montazeri K, Kashefi P, Honarmand A, Safavi M, Hirma npour A. Attenuation of the pressor response to direct laryngoscopy and tracheal Intubation: oral Clonidine vs. oral gabapentin premedication. J Res Med Sci 2011; 16 (Suppl1): S377–S386.
[2]. Abdul-Latif MS, Putland AJ, McCluskey A, Meadows DP, Remington SA. Oral Midazolam premedication for day case breast surgery, a randomised prospective double-blind placebo-controlled study. Anaesthesia 2001;56 (10):990–994.
[3]. Frank T, Wehner M, Heinke W, Schmadicke I. Clonidine vs. Midazolam for premedication - comparison of the anxiolytic effect by using the STAI-test. Anasthesiologie Intensivmedizin Not fallmedizin Schmerztherapie 2002;37(2):89-93.
[4]. Chaurasia SK, Kane DG, Chaudhari LS. A comparative study of Clonidine versus a combination of diazepam and atropine for premedication in orthopaedic patients. J Postgrad Med 1999;45(3):74-78.
[5]. Henderson John. Airway Management in the Adult. In Ronald Miller (ed). Miller's Anaesthesia, seventh edition. Philadelphia, Churchill Livingstone, 2010; volume2, 50:p1599..

Abstract: Introduction: Surgical site infections (SSIs) are the most common nosocomial infection, accounting for 38% of all infections among surgical patients Studies corroborate that increased length of hospital stay and cost are associated with SSIs. A patient who develops an SSI while hospitalized has a greater than 60% greater risk of being admitted to the intensive care unit, is 15 times more likely to be readmitted to the hospital within 30 days after discharge, and incurs and attributable extra hospital stay of 6.5 days, leading to a direct cost of an additional $3000 per infection. SSIs due to Methicillin-resistant S. aureus (MRSA) in particular have also been shown to have a higher mortality than those due......

Key Words: Surgical site infections, MRSA, nosocomial infection

[1]. Zumla A. Mandell, Douglas, and Bennett's principles and practice of infectious diseases. The Lancet Infect Diseases. 2010;10(5):303-4.
[2]. 2. Boyce JM, Potter-Bynoe G, Dziob ek L. Hospital reimbursement patterns among patients with surgical wound infections following open heart surgery. Infect Control Hosp Epidemiol. 1990;11(2):89-93.
[3]. Hidron AI, Edwards JR, Patel J, Horan TC, Sievert DM, Pollock DA, et al. Antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007. Infect Control Hosp Epidemiol. 2008;29(11):996-1011.
[4]. Anderson DJ, Sexton DJ, Kanafani ZA, Auten G, Kaye KS. Severe surgical site infection in community hospitals: epidemiology, key procedures, and the changing prevalence of methicillin-resistant Staphylococcus aureus. Infect Control Hosp Epidemiol. 2007;28(9):1047-53.
[5]. Steinberg JP, Braun BI, Hellinger WC, Kusek L, Bozikis MR, Bush AJ, et al. Timing of antimicrobial prophylaxis and the risk of surgical site infections. Ann Surg. 2009;250(1):10-6..

Abstract: Introduction: Laparoscopic cholecystectomy is gold standard surgery for symptomatic gall stone disease which is the commonest disease needs surgical management. Cholecystectomy can be curative only whose symptoms are due to gallstones, and not due to other upper GI pathologies. It causes unnecessary burden of cost and surgical risk to patient, it also delays definitive treatment for the actual cause.
Materials and methods: The present cohort study conducted in the Department of General Surgery, Osmania Medical College and Osmania General Hospital, Koti, Hyderabad from January 2020 to December 2020 (prospective study). 50 Patients presenting with single or multiple symptomatic gallstone disease confirmed by the ultrasound findings admitted in......

Key Word: Laparoscopic cholecystectomy, endoscopy, gallstone disease

[1]. Berger MY, Hartman TC, Vander VJJM, Bohnen A. Is biliary pain exclusively related to gall bladder stone.? A controlled prospective study. Br J Gen Pract. 2004;54(303):574-9.
[2]. Schirmer BD, Winters KL, Edlich RF. Cholelithiasis and cholecystitis. J Long Term Eff Med Implants. 2005;15(3):329-38.
[3]. Conte D, Fraquelli M, Giunta M, Conti CB. Gall stones and Liver disease; an overview. J Gastrointestin Liver Dis. 2011;20:9-11.
[4]. Berger MY, olde Hartman TC, Van der Velden JJ, Bohnen AM. Is biliary pain exclusively related to gallbladder stones? A controlled prospective study. Br J Gen Pract. 2004;54(505):574-9.
[5]. Kraag N, Thijs C, Knipschild P. Dyspepsia-how noisy are gallstones? A meta-analysis of epidemiologic studies of biliary pain, dyspeptic symptoms, and food intolerance. Scand J Gastroenterol. 1995;30(5):411-21..

Abstract: INTRODUCTION: COVID-19 is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Monitoring ofbiochemical parameters in COVID-19 patients is criticalfor assessing disease severity and progression as well asmonitoring therapeutic interventionMATERIAL & METHODS: It was a hospital based retrospective study conducted at a tertiary care hospital from Vijayawada. A pre designed schedule was designed to get the relevant data. Data on 200 admitted COVID-19 patients was taken from the hospital case records using that schedule. Studyvariables included demographic characteristicslike age, sex, biochemical parameters and outcome. RESULTS: A total of 200 hospital case records data was analyzed. Mean age of the study population...

Key Word: Covid-19, biochemical parameters, outcome

[1]. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. (February 2020). "Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study". Lancet. 395 (10223): 507–513. doi:10.1016/S0140-6736(20)30211-7.
[2]. World Health Organization (WHO) onCoronavirus disease (COVID-19) pandemic. Accessed from https://www.who.int/emergencies/diseases/novel-coronavirus-2019 [Last accessed on 01-02-2021].
[3]. COVID-19 Guidelines. Govt.of India. Ministry of Health & Family welfare (MOHFW). Accessed from https://www.mohfw.gov.in/ [Last accessed on 01-02-2021].
[4]. Henry BM, de Oliveira MHS, Benoit S, Plebani M, Lippi G.Hematologic, biochemical and immune biomarker abnormalitiesassociated with severe illness and mortality in coronavirus disease2019 (COVID-19): a meta-analysis. Clin Chem Lab Med.2020;58(7):1021–8.
[5]. Tan L, Wang Q, Zhang D, Ding J, Huang Q, Tang YQ, et al.Lymphopenia predicts disease severity of COVID-19: a descriptiveand predictive study. Signal Transduct Target Ther. 2020;5(1):1–3..

Abstract: Cystic hygroma is a benign lymphatic malformation most commonly occurring in the cervico-facial region. It arises from sequestered lymphatic sacs that fail to communicate with the lymphatico-venous system. Although commonly presenting in paediatric age, cystic hygroma can occur at any age. Recurrent cystic hygroma is a known entity and can result from inadequate excision or specific tumour characteristics. We report such a case of giant recurrent cystic hygroma in the neck in a 15 years old male the surgical management of which was challenging due to the large size, previous adhesions and proximity to vital structures.

Key Word: Recurrent cystic hygroma, Large size, Surgical challenges, India

[1]. Fonkalsrud EW, Grosfeld, JL; O'Neill, JA Jr; Coran, JA; Fonkalsrud, EW; Caldamone, AA; Pediatric surgery. 6th edition. Chicagor: Mosby Elsevie; 2006. Lymphatic disorders. pp. 2137–2145. [Google Scholar]
[2]. Kaur N, Gupta A, Amratash, Singh N. Giant cystic hygroma of the neck with spontaneous rupture. J Indian AssocPediatr Surg. 2007;12:154–155. [Google Scholar]
[3]. Kraus J, Plzak J, Bruschini R. Cystic lymphangioma of the neck in adults: a report of three cases. Wiener KlinWochenschr. 2008;120:242–245. doi: 10.1007/s00508-008-0950-4. [PubMed] [CrossRef] [Google Scholar]
[4]. de CassoMoxo C, Lewis NJ, Rapado F. Lymphangioma presenting as a neck mass in the adult. Int J ClinPract . 2001;55:337–338. [PubMed] [Google Scholar]
[5]. Cheng LHH, Wells FC. A multidisciplinary approach to recurrent cervicothoracic cystic hygroma in an adult. Br J Oral Maxillofacial Surg. 2004;42:66–68. doi: 10.1016/S0266-4356(03)00173-6. [PubMed] [CrossRef] [Google Scholar]

Abstract: Introduction: Ovarian fibroma is a solid stromal tumor of the sex cord of the ovary, which accounts for 1-4% of benign ovarian tumors. It is sometimes associated with the Demons-Meigs syndrome, leading to suspicion of malignancy' at the clinical and paraclinical levels. Observation. We report two observations of ovarian fibroma Diagnosed and treated in our department associated with Demons-Meigs syndrome in one case, with suspicion of a malignant ovarian pathology, given the clinical signs and the radiological aspect, the treatment was radical surgery in both patients and it is the histological.....

Key Word: Fibroma, Ovary, Meigs' syndrome

[1]. H. Boufettala,*, F. Essodeguib, Z. Jeddaouia, S. Mahdaouia, M. Nouna, S. Hermasa, N. Samouh Fibrome ovarien Feuillets de radiologie 2013;53:215-218
[2]. V C Lema, A.N.Masside et al: bizarre presentation of bilateral ovarian leiomyoma: a case report; Tanzania journal of health research, 2013; 3:vol 15, Num 4.
[3]. C-T.Cissé, P-M.Ngom et al :fibrome de l'ovaire associé à un syndrome de Demons-Meigs et à une élévation du CA 125 ; j gynecol obstet biol reprod, 2004 ;1 :251-254.
[4]. Minutoli F, Blandino A, Gaeta M, Lentini M, Pandolfo I. Twisted ovarian fibroma with high signal intensity on T1-weighted MR image: a new sign of torsion of ovarian tumors? Eur Radiol 2001;11:1151–4.
[5]. Boufettal H, Zaghba N, Morad S, Bakhatar A, Yassine N, Bahlaoui A, et al. Syndrome de Demons-Meigs : une nouvelle observation. Rev Pneumol Clin 2011;67:121–3.

Abstract: Background: Because of the widespread prevalence of dermatophytosis in India, it is important to know their regional prevalence and clinical presentations along with the efficacy of the commonly prescribed topical medications. Aims: To study the prevalence, clinical presentation, age and sex distribution of superficial dermatophytic infections in a rural area along with clinicomycological correlation with the efficacy, safety and tolerability of topical terbinafine 1% vs topical fluconazole 0.5% vs topical miconazole 2%. Material and methods: The study a randomized controlled clinical trialwas carried out in the department of dermatology for the duration of one year after ethical clearance, in patients with a confirmed diagnosis of dermatophytosis. A total of......

Key Word: Dermatophytosis, terbinafine, fluconazole, miconazole

[1]. Kanwar AJ, Mamta, Chander J. Superficial fungal infections. In: Valia GR, editor. IADVL Text book and Atlas of Dermatology 2nd Edition Mumbai Bhalani Publishing House 2001 p 215-58
[2]. Seebacher C, Bouchara JP, Mignon B. Updates on the epidemiology of dermatophyte infections. Mycopathologia 2008;166:335-52
[3]. Gorbach SL, Bartlett JL, Blacklow NR. Infectious disease. 3rd ed. Philadelphia: Lippincott Williams and Wilkins; 2004. p. 1162-80.
[4]. Madhavi S, Rama Rao MV, Jyothsna K. Mycological study of Dermatophytosis in rural population. Ann Biol Res 2011;2:88-93.
[5]. Mahmoud A. Ghannoum; John R. Perfect (24 November 2009). Antifungal Therapy. CRC Press. p. 258.

Abstract: Introduction: Age-related cervical degeneration is evident in over 50% of the middle-aged population and is the most common cause of neural dysfunction. Cervical spine anteriorly stabilised by use of anterior cervical plate, strut graft, standalone cage or combination to maintain curvature and facilitate arthrodesis. Standalone strut graft has high rate of complications such as graft subsidence, dislodgement, non-union and donor site morbidities. Anterior plating has inherent deficiencies like plate loosening, screw pull out, breakage, trachea-oesophageal irritation, has increased operation time. Intervertebral cages avoid some of these difficulties due to their self-fixing construct, ability to contain graft or graft substitute in it. The aim of this study is to compare the clinical and radiological outcome of stand-alone cage in single level anterior cervical discectomy and fusion used to treat cervical degenerative disc disease......

Key Word: anterior cervical discectomy and fusion, Japanese orthopaedic association

[1]. Chau AM, Mobbs RJ. Bone graft substitutes in anterior cervical discectomy and fusion. Eur Spine J. 2009; 18(4):449-464.
[2]. Burkhardt JK, Mannion AF, Marbacher S, Kleinstück FS, et al. The influence of cervical plate fixation with either autologous bone or cage insertion on radiographic and patient-rated outcomes after two-level anterior cervical discectomy and fusion. European Spine Journal. 2014, 1-7.
[3]. Zhou J, Xia Q, Dong J, Li X, Zhou X, Fang T, et al. Comparison of stand-alone polyetheretherketone cages and iliac crest autografts for the treatment of cervical degenerative disc diseases. Acta Neurochir. 2010; 153:115-22.
[4]. Hacker RJ. A randomised prospective study of an anterior cervical fusion device with a minimum of 2 years follow-up results. J Neurosurg (Spine 2) 2000; 93:222-226.
[5]. Meier U, Grave A, Hajdukova A. Clinical experience with Cespace, the new intervertebral disc spacer by Aesculap for spondylodesis of the cervical spine in comparision with similar products by Weber, Intromed and AcroMed. Neurosurg Q. 2003; 13:40-50. doi: 10.1097/00013414-200303000-00004.