Abstract: This study examined the association between the E23K allele variant of the KCNJ11 gene with type 2 diabetes mellitus in a Nigerian population and the possible complications that may arise from the variant. The E23K polymorphism of the KCNJ11 gene results from a substitution of the amino acid lysine to glutamate at codon 23. This alteration causes a critical inhibition of glucose-induced insulin secretion thereby resulting in hyperglycaemia. Hundred consenting Nigerian adults (73 diabetics and 27 non-diabetic subjects) aged at least 40 participated in this study. Genotyping was carried out with the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique using BanII restriction digestion enzyme. The restriction fragments were then electrophoresed on DNA grade.....
Key Word: Diabetes, Complications, E23K, Polymorphism, KCNJ11 gene.
[1]. Abdelhamid, I., Lasram, K., Meiloud, G., Ben Halim, N., Kefi, R., Samb, A., Abdelhak, S., & Houmeida, A. (2014). E23K variant in KCNJ11 gene is associated with susceptibility to type 2 diabetes in the Mauritanian population. Primary Care Diabetes, 8, 171-175.
[2]. Alsmadi, O., Al-Rubeaan, K., Wakil, S. M., Imtiaz, F., Mohamed, G., Al-Saud, H., Al-Saud, N., Aldaghri, N., Mohammad, S. & Meyer, B.F. (2008). Genetic study of Saudi diabetes (GSSD): significant association of the KCNJ11 E23K polymorphism with type 2 diabetes. Diabetes/Metabolism Research and Review, 24, 137-140.
[3]. Asaf, A., Ayesh, B.M. & Humdona, O.M. (2013). Single nucleotide polymorphism of E23K of KCNJ11 gene and other risk factors associated with type 2 diabetes mellitus in Gaza. International Journal of Chemical and Life Sciences, 2,1146-52.
[4]. Assman, T.S., Duarte, G.C., Rheinheimer, J., Cruz, L.A., Canani, L.H. & Crispim, D. (2014). The TCF7L2 rs7903146 (C/T) polymorphism is associated with risk to type 2 diabetes mellitus in Southern-Brazil. Brazillian Society of Endocrinology and Metabolism, 58(9), 918-25.
[5]. Basile, K. J., Guy, V. C., Schwartz, S. & Grant, S. F. (2014). Overlap of genetic susceptibility to type 1 diabetes, type 2 diabetes, and latent autoimmune diabetes in adults. Current Diabetes Reports, 14(11), 550.