Abstract: Detecting patients with active Tuberculosis (TB) disease is an important component of tuberculosis control programs, as early diagnosis and treatment of tuberculosis is essential in reducing the morbidity, mortality and the escalating costs associated with advanced disease. We conducted this study to access the usefulness of Gene Xpert MTB/RIF assay technique in the diagnosis of childhood tuberculosis. We retrospectively reviewed the clinical records and rapid diagnostic results of children less than 14 yrs of age with suspected Tuberculosis who visited the pulmonary clinic of Government Rajaji Hospital (GRH), Madurai from January 2017 to June 2017. Various pulmonary and extra pulmonary specimens were collected under aseptic precautions. These Xpert MTB/RIF.............
Keywords: Gene-Xpert, tuberculosis, children
[1]. Detjen, Anne K et al. "Xpert MTB/RIF Assay for the Diagnosis of Pulmonary Tuberculosis in Children: A Systematic Review and Meta-Analysis." The Lancet. Respiratory medicine 3.6 (2015): 451–461. PMC. Web. 2 Aug. 2017.
[2]. Bates M1, O'Grady J, Maeurer M, Tembo J, Chilukutu L, Chabala C, Kasonde R, Mulota P, Mzyece J, Chomba M, Mukonda L, Mumba M, Kapata N, Rachow A, Clowes P, Hoelscher M, Mwaba P, Zumla A. Assessment of the Xpert MTB/RIF assay for diagnosis of tuberculosis with gastric lavage aspirates in children in sub-Saharan Africa: a prospective descriptive study.Lancet Infect Dis. 2013 Jan;13(1):36-42. doi: 10.1016/S1473-3099(12)70245-1. Epub 2012 Nov 5.
[3]. Raizada, Neeraj et al. "Piloting Upfront Xpert MTB/RIF Testing on Various Specimens under Programmatic Conditions for Diagnosis of TB & DR-TB in Paediatric Population." Ed. Delmiro Fernandez-Reyes. PLoS ONE 10.10 (2015): e0140375. PMC. Web. 2 Aug. 2017.
[4]. Sekadde, MoorinePenninah et al. "Evaluation of the Xpert MTB/RIF Test for the Diagnosis of Childhood Pulmonary Tuberculosis in Uganda: A Cross-Sectional Diagnostic Study." BMC Infectious Diseases 13 (2013): 133. PMC. Web. 2 Aug. 2017.