iosr-JDMS   Volume-22 ~ Issue-1 ~ January 2023

Abstract: Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) is a rare autosomal dominant disorder characterized by orbito-palpebral anomalies. Other ophthalmic manifestations can be associated with BPES including ,euryblepharon, strabismus, microphthalmos, lacrimal drainage abnormality, and optic disc coloboma . We reporttwo case of BPES in both eyes .Referedfor a congenital ptosis reported by their parents . No other ophthalmologic manifestations wasassociated with this syndrome.

Keywords: congenital ptosis ,pediatric ophthalmology , Blepharophimosis

[1]. T. Cai, D.A. Tagle, X. Xia, P. Yu, X.X. He, L.Y. Li, A novel case of unilateral blepharophimosis syndrome and mental retardation associated with de novo trisomy for chromosome 3q, J Med Genet. 34 (9) (1997) 772–776.
[2]. P. Strømme, F. Sandboe, Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES), Acta Ophthalmol. Scand. 74 (1) (mai 2009) 45–47.
[3]. Mari F, Giachino D, Russo L, Pilia G, Ariani F, Scala E, et al. Blepharophimosis, Ptosis, and Epicanthus Inversus Syndrome: Clinical and Molecular Analysis of a Case. Journal of American Association for Pediatric Ophthalmology and Strabismus. juin 2006;10(3):279‑80.
[4]. Uhlenhaut N. Foxl2 function in ovarian development. Mol Genet Metab. 2006;88: 225–234.
[5]. Allen CE, Rubin PAD. Blepharophimosis-ptosis-epicanthus Inversus Syndrome (BPES): Clinical Manifestation and Treatment. International Ophthalmology Clinics. 2008;48(2):15‑23.

Abstract: Objective: To evaluate the diagnostic accuracy of multiparametric magnetic resonance imaging (mpMRI) of prostate in patients with raised prostate specific antigen (PSA). Design and Methods: The studyconducted on 31 patients in Department of Radiodiagnosis in collaboration with Urology department, Regional Institute of Medical Sciences (RIMS), Imphal, Manipur from January 2021 to December 2022 and analysed for sensitivity and specificity of the test (mpMRI) was calculated to find out its accuracy. Conclusion:Multi-parametric MRI PIRADS scoring in patients with raised PSA levels is an invaluable, non-invasive and feasible option to detect carcinoma prostate with a high sensitivity and specificity besides high predictive values and can help in identifying patients in need of biopsy and also helps in targeted biopsy and characterizing the extent and aggressiveness of the prostate cancer.

Keywords: multiparametric magnetic resonance imaging (mpMRI), prostate specific antigen (PSA), Multi-parametric MRI,PIRADS scoring

[1]. Siegel RL, Miller KD, Jemal A. Cancer statistics. 2019. CA Cancer J Clin. 2019 Jan;69(1):7-34 [2]. Mathur P, Sathishkumar K, Chaturvedi M, Das P, Sudarshan KL, Santhappan S et al. ICMR-NCDIR-NCRP Investigator Group. Cancer Statistics, 2020: Report From National Cancer Registry Programme, India. JCO Glob Oncol. 2020 Jul;6:1063-1075 [3]. Catto JW et al.ProtecT study group. Suitability of PSA-detected localised prostate cancers for focal therapy: experience from the ProtecT study. Br J Cancer. 2011 Sep 27;105(7):931-7 [4]. Roehl KA, Antenor JA, Catalona WJ. Serial biopsy results in prostate cancer screening study. J Urol. 2002 Jun;167(6):2435-9 [5]. Hambrock T, Somford DM, Hoeks C, Bouwense SA, Huisman H, Yakar D et al. Magnetic resonance imaging guided prostate biopsy in men with repeat negative biopsies and increased prostate specific antigen. J Urol. 2010 Feb;183(2):520-7

Abstract: Aim:To find out the demographic characteristics, co- morbid conditions, clinical course and outcomes among COVID- 19 patients with renal disease admitted at in a tertiary care hospital in north east India. Materials and Method:It is a prospective observational study conducted in the department of nephrology, Regional Institute of Medical Sciences (RIMS), Imphal, during the period between 1st of March 2020 and 31st of April 2021. All adult patients of both the sexes with COVID-19 infectionwith kidney diseaseswere included in the study. Result:During the study period, out of 2287 patient with COVID-19 infection, 103 (4.50%) patients had kidney disease either at the time of admission or developed later on during hospital stay. The incidence of renal dysfunction in males and females were 62.14% and 37.86% respectivelyand.......

Keywords: COVID-19, chronic kidney disease, acute kidney injury, hemodialysis.

[1]. World Health Organization: Corona virus disease (COVID-19) pandemic, Available at: who.int/emergencies/disease/novel-corona virus 2019 Accessed 13th August.
[2]. Wang L, LiX, Chen H, Yan S,LiD,Gan Z. Corona virus disease 19 infection does not result in acute kidney injury: an analysis of 116 hospitalized patient from Wuhan, China. Am JNephrol 2020;51: 343-48.
[3]. Cheng Y, Lou R, Wang K, Zhang M, Wang Z, Dong L etal. Kidney disease is associated with in hospital death of patient with COVID-19. Kidney Int 2020;97: 829-38.
[4]. Guan WJ, Ni ZY, HuY, Liang WH, Ou CQ, He JX etal. Clinical characteristics of corona virus disease 2019 in China. N Engl J Med 2020;382:1708-20.
[5]. Huang C, Wang Y, LiX, Ren L, Zhau J, HuY etal. Clinical features of patient infected with 2019 novel corona virus in Wuhan, China. Lancet 2020;395:497-506.

Abstract: Objective: To describe the profile of common low back pain in nursing staff working at the University Hospital of Brazzaville. Patients and method This is a cross-sectional, descriptive study conducted at the CHUB from March 1 to October 1, 2021 (8 months). It focused on health care personnel with low back pain who agreed to participate in the study. Epidemiological, professional, clinical, morphological, therapeutic and evolutionary study variables. Data were collected using a form administered in French and in national languages........

Keywords: common low back pain, triggering factor, nursing staff, Brazzaville University Hospital

[1]. Duquesnoy B, De fontaine MC, Grardel B, Maigne JY, Simonin A, Thevenon A, et al. Définition de la lombalgie chronique. Rev Rhum. 1994 ;61(4bis) : 9S-10S.
[2]. Haute Autorité de Santé (HAS). Prise en charge Masso-kinésithérapique dans la lombalgie commune, modalités de prescription. 2005 ; 31(5) :11-24.
[3]. Vignier C, Brenier E, Carie S. Conséquences socioprofessionnelles des lombalgies en milieu de travail. Document pour le médecin de travail (INRS), Paris 1987 ; 29 :17-24.
[4]. De Gaudemaris R, Blatier JF, Quinton B, Piazza E, Gallin-Martel C, et al. Analyse du risque lombalgique en milieu professionnel. Rev Epi S Pub. 986 ;34 :308–17.
[5]. Leger D, Voisin C, Conso F. Handicaps et incidences socioéconomiques dans la pathologie lombaire commune. Techniques Appareil Locomoteur 1994 :1-8 EMC Editions 15-841-A-10.

Abstract: Calcifying Epithelial odontogenic tumor(CEOT) is a rare benign odontogenic neoplasm described in 1955 by Danish pathologist Jens J.Pindborg and is now known as Pindborg tumour. It representing less than 1% of all odontogenic tumors. I am reporting a case of CEOT in a 33-years-old male patient with painful bony swelling in the mandible on left side with embedded permanent canine. The clinical, radiographic, and histopathologic features are discussed with relevant references.

Keywords: Calcifying epithelial odontogenic tumor, odontogenic epithelial tumor, pindborg tumor,CEOT.

[1]. Pindborg JJ. Calcifying epithelial odontogenic tumors. Acta Pathol Microbiol Scand 1956;71:111.
[2]. Pindborg JJ. A calcifying epithelial odontogenic tumor. Cancer 1958;11:838-43.
[3]. Bouckaert MM, Roubenheimer EJ, Jacobs FJ. Calcifying epithelial odontogenic tumor with intracranial extension: Report of a case and review of literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;90:656-62.
[4]. Philipsen HP, Reichart PA. Calcifying epithelial odontogenic tumor: Biological profile based on 181 cases from the literature. Oral Oncol 2000;36:17-26.
[5]. Goldenberg D, Sciubba J, Koch W, Tufano RP. Malignant odontogenic tumors: A 22-year experience. Laryngoscope 2004;114:1770-4.

Abstract: The American Diabetes Association (ADA) endorsed using HbA1C for diagnosing diabetes and pre-diabetes. HbA1C is commonly used for assessing glycemic control.Normal HbA1c values are 4% to 5.7%.Pre-diabetes 5.7%–6.5%; diabetes mellitus > 6.5%.(1) It depends on both the RBC turnover from the bone marrow and the average levels of glycemia during the previous two to three months. In circumstances of altered erythrocyte turnover, the level of glycemia may not be accurately reflected by HbA1c.A falsely increased HbA1c is linked to diseases that have a limited RBC turnover (hypo proliferative anaemias).One of the causes of hypo proliferative anaemia, hypothyroidism, may induce a misleading rise of HbA1c, leading to a false diagnosis of pre-diabetes or diabetes.(2,3)

Keywords: Thyroxine replacement, HbA1c, Diabetes

[1]. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2010 Jan;33 Suppl 1(Suppl 1):S62-69.
[2]. Anantarapu S, Vaikkakara S, Sachan A, Phaneendra BV, Suchitra MM, Reddy AP, et al. Effects of thyroid hormone replacement on glycated hemoglobin levels in non diabetic subjects with overt hypothyroidism. Arch Endocrinol Metab. 2015 Dec;59(6):495–500.
[3]. Kim MK, Kwon HS, Baek KH, Lee JH, Park WC, Sohn HS, et al. Effects of thyroid hormone on A1C and glycated albumin levels in nondiabetic subjects with overt hypothyroidism. Diabetes Care. 2010 Dec;33(12):2546–8.
[4]. [Anemia in hypothyroidism]. - Abstract - Europe PMC [Internet]. [cited 2022 Dec 8]. Available from: https://europepmc.org/article/med/10518398
[5]. Christy AL, Manjrekar P, Babu RP, M S R, Hegde A. Elevation of HbA1C in Non-diabetic Hypothyroid Individuals: Is Anaemia the Connecting Link? -A Preliminary Study. J Clin Diagn Res JCDR. 2013 Nov;7(11):2442–4.

Abstract: Hearing impairment is common in chronic kidney disease (CKD)patients. Studies have observed that when diabetes coexists with CKD, the auditory thresholds become still worse. However, certain other studies differ and claim that CKD, Hypertension and Diabetes independently impact the hearing capacity. Hence, there is a need for further studies. The aim of our study was to find out 'whether among CKD patients, there is an association of diabetes on hearing impairment'. If so, whether other parameters confound the association. The design of the study was simple and focussed. It had a large sample. In this study, we had taken care to employ the current and latest definitions and guidelines for hearing impairment, diabetes and CKD........

Keywords: We conclude that routine audiometry must become a part of periodic assessment protocol for dialysis patients and for diabetes patients.

[1]. Olusanya BO, Davis AC, Hoffman HJ (2019) Hearing loss grades and the International classification of functioning, disability and health. Bull World Health Organ. 2019 Oct 1; 97(10): 725-728. doi: 10.2471/BLT.19.230367 [2]. WHO Global Health Estimates 2020: Disease burden by Cause, Age, Sex, by Country and by Region 2000-2019. WHO, Geneva: WHO. Available at www.who.int/data/gho/data/themes/mortality-and-global-health-estimates/global-health-estimates-leading-causes-of-dalys (accessed on 1 Dec 2020) [3]. NSSO 75th Round Report No. 586 ((Jul 2017-Jun 2018). Health in India. National Sample Survey Organization, Ministry of Statistics & Programme Implementation, Govt of India 2020 http://www.mospi.gov.in/sites/default/files/publication_reports [4]. Gatland, D., Tucker, B., Chalstrey, S., Keene, M., & Baker, L. (1991). Hearing loss in chronic renal failure-hearing threshold changes following haemodialysis. Journal of the Royal Society of Medicine, 84(10), 587–589.
[5]. Pereira CV, Leite IC. Health-related quality of life of patients receiving hemodialysis therapy. Acta Paul Enferm. 2019;32(3):267-74. DOI: http://dx.doi.org/10.1590/1982-0194201900037

Abstract: Thiel Behnke corneal dystrophy is an autosomal dominant corneal disorder1. It is also known as honeycomb corneal dystrophy1. A 28-year-old male came to OPD with chief complaint of defective vision in both eyes since childhood. On detailed ophthalmological examination, both eyes showed subepithelial irregular gray opacities arranged in honeycomb pattern, suggestive of Thiel Behnke corneal dystrophy.

[1]. Yanoff Myron and Duker Jay. Yanoff&Duker: Ophthalmology, 4th Ed. Mosby, 2014 [2]. Thiel HJ, Behnke H. Ein bisherunbekannte, subepithelialehereditareHornhautdystrophie. KlinMonstsblAugenheilkd1967;150:862–74. [PubMed] [Google Scholar] [3]. Perry HD, Fine BS, Caldwell DR. Reis-Bucklers' dystrophy. A study of eight cases. Arch Ophthalmol1979;97:664–70. [PubMed] [Google Scholar]
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Abstract: statement of problem: Rapid increase in using digital systems with monolithic restorations had occurred. Either intraoral scanning can produce reliable results or not must be carefully assessed. Purpose: The purpose of this study was to compare the marginal adaptation of implant retained zirconia bridges scanned with the use of intraoral digital scanner with those scanned by the conventional impression technique followed by scanning using desktop scanner. Material and methods: 14 monolithic implant supported zirconia bridges were constructed, either using intraoral scanner (Group A) or desktop scanner (Group B) The marginal adaptation of each specimen was measured with a light microscope at 40X magnification. Paired t test was used for statistical analysis. Results: Statistically in-significant differences were found between the 2 scanning protocols.......

[1]. Glossary of Prosthodontic Terms. J Prosthet Dent 2005; 94: 92.
[2]. Holmes JR, Bayne SC , Holland GA, Sulik WD. Consid- erations in measurement of marginal fit. J Prosthet Dent 1989; 62: 405–408.
[3]. Tinschert J, Natt G, Hassenpflug S, Spiekermann H. Status of current CAD/CAM technology in dental medicine. Int J Comput Dent 2004;92:25-45.
[4]. Ng J, Ruse D, Wyatt C (2014) A comparison of the mar- ginal fit of crowns fabricated with digital and conventional methods. J Prosth Dent 112(3):555–60.
[5]. Tidehag P, Ottosson K, Sjogren G (2013) Accuracy of ce- ramic restorations made using an in-office optical scanning technique: an in vitro study. Oper Dent 39(3):308–316.

Abstract: We report a case of Stargardt's disease in eleven-year-old male presented with decreased vision in both eyes since childhood. On fundus examination circular lesion is seen at macula with beaten bronze appearance suggesting Stargardt's disease.

Keywords: Stargardt's disease, macular dystrophy

[1]. American Academy of Ophthalmology 2014-2015. Vitreous and Retina. San fransisco. American Academy of Ophthalmology. 2014.
[2]. Deutman, AF, Hoyng, CB, et al. Macular Dystrophies. In: Retina 4th ed. New York; Elsevier.
[3]. Telander, DG, Small, KW. Macular Dystrophies. In: Ophthalmology 4th ed. 2014. New York; Elsevier.
[4]. Kanski, Jack. Clinical Ophthalmology A Systematic Approach. Seventh edition. 2011. Elsvier.
[5]. McBain, VA, Townend, J, Lois, N. Progression of Retinal Epithelial Atrophy in Stargardt Disease. Am J Ophthalmol 2012;154:146–154.

Abstract: Introduction - Covid 19 infection has emerged as serious health problem in the world since its emergence. The disease has affected worst to human race because of the unexpected virulence of the disease, lack of preparedness for the pandemic and severe contagious nature of the disease. World Health Organization declared Covid 19 as global pandemic on 11th march 2020.India is among most severely affected countries in this Covid - 19 pandemic with more than 4,58,000 deaths reported by November 2021.The disease spread around the world with 5.9% case fatality rate.Since then multiple peaks of disease has affected the health system and led to morbidity and mortality.........

Keywords: SARS CoV 2, Children, India.

[1]. Sarangi B, Reddy VS, Oswal JS,MalsheN,Patil A,Chakraborty Met al.Epidemiological and clinical characteristics of COVID-19 in Indian children in the initial phase of the pandemic. Indian Pediatrics2020; 57: 914-7.
[2]. Mahase E. Covid 19: WHO declares Pandemic because of 'alarming levels' of spread , severity and inaction. BMJ 2020;368:m1036
[3]. Lewnard JA, Mahmud A, Narayan T, Wahl B, Selvavinayagam TS, Mohan C et al. All- cause mortality during Covid 19 pandemic in Chennai, India. An observational study.Lancet Infect Dis. 2022;22:463-472.
[4]. WHO. Coronavirus disease 2019(COVID 19) situation report 137.https://www.who.int/docs/default – source/Srilanka documents/20200605-covid 19-sitrep-137
[5]. Guidelines for management of COVID 19 in children below 18 years, Ministry of health and family welfare. Government of India. https://www.mohfw.gov.in. 18 June 2021 and revised comprehensive guidelines for management of COVID 19 in children. 20 January 2022.

Abstract: Background: The COVID-19 pandemic has inarguably shattered the medical community into bits and pieces. With infecting more than 10% of the global population, it has established itself as the "Disease of the Century." While attempts are being made to control the spread of virus, it can take up to several years to break the chain and put an end to this pandemic. Objective: To evaluate the knowledge among dental students regarding use of mouthwash as a pre-prophylactic rinse to reduce oral viral load among the patients. Methods: The study is based on the reports collected via a questionnaire survey conducted from June 2021 to September 2021 among 300+ dental students from over 5 different colleges in Bengaluru, India. The study protocol was designed with the help of Department of Public Health Dentistry, NSVK Sri Venkateshwara Dental College and Hospital.........

Keywords: prophylaxis, mouthwash, SARS-CoV-2 virus, COVID-19, screening.

[1]. Chetty, R. et al. (2020), The Economic Impacts of COVID-19: Evidence from a New Public Database Built from Private Sector Data, Harvard University and Opportunity Insight, https://opportunityinsights.org/paper/tracker/. [2]. 2.Jum'ah AA, Elsalem L, Loch C, Schwass D, Brunton PA. Perception of health and educational risks amongst dental students and educators in the era of COVID-19. Eur J Dent Educ. 2021;25(3):506-515. doi:10.1111/eje.12626 [3]. Burton MJ, Clarkson JE, Goulao B, et al. Antimicrobial mouthwashes (gargling) and nasal sprays to protect healthcare workers when undertaking aerosol-generating procedures (AGPs) on patients without suspected or confirmed COVID-19 infection. Cochrane Database Syst Rev. 2020;9(9):CD013628. Published 2020 Sep 16. doi:10.1002/14651858.CD013628.pub2 [4]. Vergara-Buenaventura A, Castro-Ruiz C. Use of mouthwashes against COVID-19 in dentistry. Br J Oral Maxillofac Surg. 2020;58(8):924-927. doi:10.1016/j.bjoms.2020.08.016 [5]. Yoon JG, Yoon J, Song JY, et al. Clinical Significance of a High SARS-CoV-2 Viral Load in the Saliva. J Korean Med Sci. 2020;35(20):e195. Published 2020 May 25. doi:10.3346/jkms.2020.35.e195

Abstract: Introduction: An acute febrile illness known as scrub typhus is prevalent in many parts of India. Patients with scrub typhus who are not diagnosed and treated in the early stages of the disease are more likely to suffer from acute kidney injury (AKI). Electrolyte abnormalities can also be associated with these patients. Objectives: The purpose of this study was to determine the correlation between the severity of acute kidney injury (AKI) and electrolyte abnormalities in scrub typhus patients.........

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