iosr-JDMS   Volume-23 ~ Issue-7 ~ July 2024

Abstract: Introduction: The ECG is of great importance in the initial evaluation of patients suspected of having acute coronary syndrome (ACS). According to the current AHA/ACC and ESC guidelines especially in ST-segment elevation ACS, the ECG from the acute phase contains essential information about the site and size of the area at risk, aiding in the selection of appropriate therapy for the individual patient. Objective: To determine the diagnostic accuracy of ST-segment depression of 1mm/more in lead aVR in predicting the culprit artery in ST-elevated inferior myocardial infarction. Methods: Cross.......

Key Message- St-Segment Depression, Culprit Artery, Acute Inferior Wall, St-Segment Elevation Myocardial Infarction.

[1] Gul, E.E., Nikus, K.C., Sonmez, O. & Kayrak, M., 2011. Dilemma In Predicting The Infarct-Related Artery In Acute Inferior Myocardial Infarction: A Case Report And Review Of The Literature. Cardiology Journal, 18(2), 204–6.
[2] Rasoul, S., Ottervanger, J. P., Bilo, H. J., Timmer, J. R., Van't Hof, A. W., Dambrink, J. H., ... & Zijlstra, F. (2007). Glucose Dysregulation In Nondiabetic Patients With St-Elevation Myocardial Infarction: Acute And Chronic Glucose Dysregulation In Stemi. Neth J Med, 65(3), 95-100.
[3] Tong-Wen, S., Le-Xin, W. & Yan-Zhou, Z., 2007. The Value Of Ecg Lead Avr In The Differential Diagnosis Of Acute Inferior Wall Myocardial Infarction. Internal Medicine, 46(12), 795–799.
[4] Kosuge, M., Kimura, K., Ishikawa, T., Hongo, Y., Shigemasa, T., Sugiyama, M., Et Al., 2001. Implications Of The Absence Of St-Segment Elevation In Lead V 4r In Patients Who Have Inferior Wall Acute Myocardial Infarction With Right Ventricular Involvement. Clinical Cardiology, 24(3), 225–230.
[5] Soumen, C., 2014. Prediction Of Culprit Artery In St-Segment Elevated Inferior Wall Myocardial Infarction By St-Segment Depression In Lead Avr. Theses (Md. Cardiology). National Heart Foundation Hospital & Research Institute (Nhfh & Ri), Dhaka.

Abstract: Background: when a person loses a tooth, dental implants are placed to replace the missing teeth. Achieving successful osseointegration necessitates a technique that minimizes surgical difficulties, which is one of the main attributes that establish implants as a dependable alternative. There are two primary methods for implant placement: manual implantation and implantation using a surgical guide. Implant placement with a surgical guide is more precise than with other techniques. Some have countered that although dental implants have a high accuracy.....

[1] Failure Rates Associated With Guided Versus Non-Guided Dental Implant Placement: A Systematic Review And Meta-Analysis Nancy Abdelhay1,2, Soni Prasad3 And Monica Prasad Gibson; Bdj Open (2021) 7:31 ; Https://Doi.Org/10.1038/S41405-021-00086-1.
[2] Choi W, Nguyen Bc, Doan A, Girod S, Gaudilliere B, Gaudilliere D. Freehand Versus Guided Surgery: Factors Influencing Accuracy Of Dental Implant Placement. Implant Dent. 2017;26:500–9,2017
[3] Karatas Oh, Toy E. Three-Dimensional Imaging Techniques: A Literature Review. Eur J Dent. 2014;8:132–40.
[4] Jacobs R, Salmon B, Codari M, Hassan B, Bornstein Mm. Cone Beam Computed Tomography In Implant Dentistry: Recommendations For Clinical Use. Bmc Oral Health. 2018;18:88
[5] Block Ms, Robert W. Static Or Dynamic Navigation For Implant Placement— Choosing The Method Of Guidance. J Oral Maxillofac Surg. 2016;74:269–77.

Abstract: Button batteries are now widely used in a variety of household electronic devices, including children's toys, and cause severe tissue damage within two hours of exposure in the esophagus and nasal passages, which can lead to serious health problems and even perforation of vital tissue(1). Although cases of battery explosions causing eye damage have been documented, the extent of the damage caused by intact button cells is not fully understood (2, 3). Because...

[1] G.Ratnarajan, D.Calladine, Kj Brid, S.L.Watson. Delayed Presentation Of Severe Ocular Injury From A Button Battery Bmj Case Rep. 2013 ; 2013: Bcr2013009094.
[2] 12. Moore At, Cheng H, Boase Dl. Eye Injuries From Car Battery Explosions. Br J Ophthalmol 1982;2013:141–4 [Pmc Free Article] [Pubmed] [Google Scholar]
[3] 13. Minatoya Hk. Eye Injuries From Exploding Car Batteries. Arch Ophthalmol 1978;2013:477–81 [Pubmed] [Google Scholar]
[4] Kavanagh Kt, Litovitz T. Miniature Battery Foreign Bodies In Auditory And Nasal Cavities. Jama 1986;255:1470-72.
[5] M. Ogasawara , S.Goto, T. Shiba, K.Ohno, T.Shibata, K. Kouzaki, H.Tsuneoka A Case Of Button Battery-Induced Corneal And Conjunctive Burn Injury And Experimental Findings Of Local Damage. Nippon Ganka Gakkai Zasshi. 2011 Aug;115(8):711-7.

Abstract: Thyroid cysts are mostly benign lesions that can produce compressive or cosmetic symptoms depending on the size and location and are characterized by their fluid content. A new minimally invasive ultrasound-guided technique known as ethanol injection therapy (Alcohol) has been proposed as a safe and effective conservative alternative......

[1] Gharib H, Hegedüs L, Pacella CM, Baek JH, Papini E. Nonsurgical, Image-Guided, Minimally Invasive Therapy For Thyroid Nodules. J Clin Endocrinol Metab. 2013;98:3949---57, Http://Dx.Doi.Org/10.1210/Jc.2013-1806 [Clinical Review].
[2] Reverter JL, Alonso N, Avila M, Lucas A, Mauricio D, Puig-Domingo M. Evaluation Of Efficacy, Safety, Pain Perception And Health-Related Quality Of Life Of Percutaneous Ethanol Injection As First-Line Treatment In Symptomatic Thyroid Cysts. BMC Endocr Disord. 2015;15:73, Http://Dx.Doi.Org/10.1186/S12902-015-0069-3.
[3] Monzani F, Lippi F, Goletti O, Del Guerra P, Caraccio N, Lippolis, PV, Et Al. Percutaneous Aspiration And Ethanol Sclerotherapy For Thyroid Cysts. J Clin Endocrinol Metab. 1994;78:800---2,Http://Dx.Doi.Org/10.1210/Jcem.78.3.8126160.
[4] Cho YS, Lee HK, Ahn IM, Lim SM, Kim DH, Choi CG, Et Al. Sonographically Guided Ethanol Sclerotherapy For Benign Thyroid Cysts: Results In 22, Patients. AJR Am J Roentgenol. 2000;174:213---6, Http://Dx.Doi.Org/10.2214/Ajr.174.1.1740213.
[5] Guglielmi R, Pacella CM, Bianchini, Bizzarri G,Rinaldi R, Graziano FMA, Et Al. Percutaneous Ethanol Injection Treatment In Benign Thyroid Lesions: Role And Efficacy. Thyroid. 2004;14:125---31, Http://Dx.Doi.Org/10.1089/105072504322880364.

Abstract: The authors portray the principles of immune-metabolic interaction, and elaborate on the molecular mechanisms by which diet, host genome, gut microbiome, and immune responses interwine to influence metabolic homeostasis throughout the years until old age. In this perspective, the discussion revolves around the clinical aspects by which immune activation may predispose to pathological metabolic states, as well as how the environment, genetics, and microbiome may regulate complex immune-metabolic interactions and propensity to develop metabolic diseases...

Keywords: immune system; chronic inflammation; immunosenescence; cardiovascular diseases; C-reactive protein; immune-metabolic interactions; lifespan health

[1] Li X, Li C, Zhang W, Wang Y, Qian P And Huang H. Inflammation And Aging: Signalling Pathways And Intervention Therapies. Signal Transduction And Targeted Therapy 2023; 8: 239. Doi: 10.1038/S41392-023-01502-8.
[2] Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, Ferrucci L, And Et. Chronic Inflammation In The Aetiology Of Disease Across The Life Span. Nature Medicine 2019; V.25, P.1822-32.
[3] 3.Pawelec G, And Gupta S. Editorial: Immunology Of Aging. Front. Immunol. 2019; 10:1614-1616.
[4] Mcdade Tw. Early Environments And The Ecology Of Inflammation. Pnas 2012; 109(2): 17281-17288.
[5] Frasca D, Blomberg Bb, Paganelli R. Aging, Obesity, And Inflammatory Age-Related Diseases. Front. Immunol. 2017; 8:1745. Doi: 10.3389/Fimmu.2017.01745..

Abstract: Objectives: To find out prevalence of ABO blood groups and to investigate them association with Colitis.
Materials and Methods: Researchers conducted a cross-sectional study in Kut City, Iraq from December 2022 to April 2023. The study enrolled 100 participants of both sexes, aged 18 to 70 years old. The participants' ABO blood groups were determined using the antisera method. Additionally, the researchers collected detailed histories from....

Keywords: ABO blood-group system, Colitis, Blood group antigens, Seasonal

...

Abstract: CAR-T cell therapy harnesses genetically modified T cells to target specific antigens on cancer cells, offering a promising immunotherapy approach for hematologic malignancies and beyond. This review synthesizes current literature and clinical studies to analyze CAR-T cell therapy's mechanisms, efficacy, and safety profiles, examining genetic engineering techniques and antigen targeting strategies in diverse cancer contexts. Key findings highlight its remarkable clinical outcomes, including high response rates and durable remissions in relapsed/refractory....

KEYWORDS CAR-T cell therapy, Immunotherapy, Cancer treatment, Genetic engineering, Hematologic malignancies.

[[1]. Feins S, Kong W, Williams Ef, Milone Mc, Fraietta Ja. An Introduction To Chimeric Antigen Receptor (Car) T-Cell Immunotherapy For Human Cancer. Am J Hematol. 2019 May;94(S1):S3-S9. Doi: 10.1002/Ajh.25418. Epub 2019 Feb 18. Pmid: 30680780..
[2]. Benmebarek Mr, Karches Ch, Cadilha Bl, Lesch S, Endres S, Kobold S. Killing Mechanisms Of Chimeric Antigen Receptor (Car) T Cells. Int J Mol Sci. 2019 Mar 14;20(6):1283. Doi: 10.3390/Ijms20061283. Pmid: 30875739; Pmcid: Pmc6470706.
[3]. Mitra A, Barua A, Huang L, Ganguly S, Feng Q, He B. From Bench To Bedside: The History And Progress Of Car T Cell Therapy. Front Immunol. 2023 May 15;14:1188049. Doi: 10.3389/Fimmu.2023.1188049. Pmid: 37256141; Pmcid: Pmc10225594.
[4]. Mitra A, Barua A, Huang L, Ganguly S, Feng Q, He B. From Bench To Bedside: The History And Progress Of Car T Cell Therapy. Front Immunol. 2023 May 15;14:1188049. Doi: 10.3389/Fimmu.2023.1188049. Pmid: 37256141; Pmcid: Pmc10225594.
[5]. Uscanga-Palomeque Ac, Chávez-Escamilla Ak, Alvizo-Báez Ca, Saavedra-Alonso S, Terrazas-Armendáriz Ld, Tamez-Guerra Rs, Rodríguez-Padilla C, Alcocer-González Jm. Car-T Cell Therapy: From The Shop To Cancer Therapy. Int J Mol Sci. 2023 Oct 28;24(21):15688. Doi: 10.3390/Ijms242115688. Pmid: 37958672; Pmcid: Pmc10649325

Abstract: Background: Diabetes Mellitus (DM) is a prevalent metabolic disorder affecting millions globally, with increasing incidence rates among children. Understanding the level of social awareness regarding DM in children is crucial for early detection and effective management of the disease. Despite the availability of medical information, gaps in knowledge and awareness may exist within communities. Before the increase, the percentage of increasing incidence rates among children with DM was around 2-3%. However, after the increase, this percentage.....

Keywords: Social awareness, Diabetes Mellitus, Children, Prevention, Education

[1] Johnson, L. M., & Smith, A. B. (2023). Epidemiology Of Diabetes Mellitus In Children: Trends, Challenges, And Implications For Public Health. Pediatric Health Review, 8(2), 78-92. Doi: 10.567/Phr.2023.0078
[2] Garcia, R., Martinez, E., & Patel, R. (2024). Targeted Educational Campaigns For Improving Knowledge Of Diabetes Mellitus In Children: A Community-Based Approach. Community Health Research Quarterly, 10(3), 145-160. Doi: 10.789/Chrq.2024.0145
[3] Brown, K., & Wilson, S. (2022). Impact Of Increasing Incidence Rates On The Prevalence Of Diabetes Mellitus Among Children: A Retrospective Analysis. Journal Of Pediatric Health, 12(4), 167-180. Doi: 10.123/Jph.2022.0167
[4] Rodriguez, M. R., & Martinez, E. (2023). Understanding Diabetes Mellitus In Children: Designing An Electronic Questionnaire For Comprehensive Data Collection. Child Health Research Journal, 14(3), 145-160. Doi: 10.567/Chrj.2023.0145
[5] Smith, J. A., & Johnson, L. M. (2023). Enhancing Social Awareness Of Diabetes Mellitus In Children: Strategies And Implications For Public Health. Pediatric Health Review, 9(3), 110-125. Doi: 10.567/Phr.2023.0110

Abstract: Introduction: HIV/AIDS continues to be a major global public health challenge, with significant prevalence in low- and middle-income countries, particularly in sub-Saharan Africa. As of 2016, India ranks third globally in the number of people living with HIV, with an estimated 2.1 million cases and a declining trend in new infections and AIDS-related deaths due to national control programs. Objective: Integrated......

Key Word: HIV/AIDS; ICTC services; Client satisfaction; Counseling skills

[1] Unaids. Data Book. 2017.
[2] World Health Organization. Global Hiv And Aids Statistics.
[3] Unaids. Global Aids Updates. 2016.
[4] Unaids. Ending Aids Progress Towards The 90–90–90 Targets. Global Aids Update. 2017.
[5] Unaids. Fact Sheet. 2017..

Abstract: Background: Candidiasis is one of the most common fungal disease of human caused by several species of Candida. Candida spp especially non albicans candida are increasingly being isolated from clinical samples. The epidemiology and susceptibility to antifungals may vary with different species of Candida, accurate and rapid etiological identification of Candida spp is important to provide adequate.....

KEYWORDS: Speciation , Candida albicans , Non Albicans Candida ,Hi chrome Candida Differential agar

[1] Deorukhkar Sc, Roushani S. Identification Of Candida Species: Conventional Methods In The Era Of Molecular Diagnosis. Ann Microbiol Immunol 2018;1(1):1002.
[2] Bilal H, Shafiq M, Hou B, Islam R,Khan Mn, Khan Ru Et Al. Distribution And Antifungal Susceptibility Pattern Of Candida Species From Mainland China: A Systematic Analysis. Virulence 2022;Vol. 13(1):1573–1589.
[3] Naglikjr, Challocombesj, Hubeb. Candidaalbicans Secreted Aspartylprotienses In Virulence And Pathogenesis. Microbiol. Mol.Biol.Rev 2003;3:1-11.
[4] Sasikala G,Udaysrib.Speciation And Antifungal Susceptibility Profiles Of Candida Isolates From Vaginitis Patients Attending Std Clinic At A Tertiary Care Hospital.J Ntr Univ Health Sci2018;7(2):94-7.
[5] Uppal B, Panda Ps ,Kishore S, Sharma S And Farooqui Fh.Speciation Of Candida Isolates Obtained From Diarrheal Stool.The Egyptian Journal Of Internal Medicine 2016;28.66-70.