iosr-JDMS   Volume-18 ~ Issue-9 ~ November-2019

Abstract: Study was carried out at Malda Medical college, Malda amongst 40 patients of pre- eclampsia to find out role of different oxidative radicals & antioxidants and compared with the levels in same number of normal pregnant mothers. Serum uric acid, MDA(malondialdehyde), thiol status and catalase levels were analyzed. Serum uric acid level was found significantly increased in cases of pre-eclampsia in comparison to normal pregnancy. The level of total thiol which is protective against ROS (reactive oxidative stress) molecules was found to be significantly lowered in the cases pre-eclampsia in comparison to control. No significant changes were observed in catalase levels between the two groups. Serum Malondialdehyde (MDA) were found significantly raised in pre-eclampsia patients than in controls..........

[1]. Lindherimer MD: introduction, history, controversies and definitions in hypertensive disorders in pregnancy 92nd ed.): Appleton & Lange,pp3 - 41,1999.
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Abstract: As emergence of multi drug resistance, MRSA and resistant to existing therapies like fusidic acid and mupirocin is increasing prevalence, it is necessary to evaluate the efficacy of new drugs like retapamulin in treatment of resistant strains in impetigo. An open label, prospective, parallel group study was conducted in out-patient department of Dermatology in Osmania General Hospitalto compare Retapamulin ointment 1% twice daily with Fusidic acid 2% cream thrice daily for 7 days treatment of 100 impetigo patients of age group 2-60 years of either sex, divided in to two groups of 50 patients each. Number of the lesions counted, size of the lesions measured, and culture of the samples taken from the lesions done before and after treatment. Anyadverseeffectsofthe treatmentwere alsorecorded.Chi-square and student's unpaired........

Key words: Retapamulin, Fusidic acid, Impetigo, Clinical response,Bacteriological response

[1]. Brown J, Shriner DL, Schwartz RA, Janniger CK. Impetigo: an update. Int J Dermatol 2003;42:251-5.
[2]. Sladden MJ, Johnston GA. Common skin infections in children. BMJ 2004;329:95-9.
[3]. Vos, T (Dec 15, 2012). "Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.". Lancet. 380 (9859): 2163–96.
[4]. Altabax (retapamulin) ointment [package insert]. Research Triangle Park, N.C.: GlaxoSmithKline; 2010.
[5]. Weinberg JM, Tyring SK. Retapamulin: an antibacterial with a novel mode of action in an age of emerging resistance to Staphylococcus aureus. J Drugs Dermatol. 2010;9(10):1198-1204.

Abstract: Background: Thyroid hormones have an essential role in metabolism and proliferation of blood cells. Thyroid dysfunction causes anemia by effecting erythrocytosis. In severe cases it can cause leucopenia, thrombocytopenia, and rarely it causes pancytopenia. Glycated hemoglobin (HbA1c) levels differ in disorders of thyroid gland. Aim :The objective of this study is to measure HbA1c levels and to know its importance in recently diagnosed hyper and hypothyroidism individuals without diabetes. Methods&Materials: This study was performed in 60 Euglycemic individuals with overt hypo/ hyper-thyroidism at OGH in Dec 2018 to Jan 2019 (30 hypothyroid and 30 hyperthyroid) and 30 controls were selected. Baseline HbA1c was estimated by HPLC method and thyroid status was measured by CLIA in all patients and controls and then compared......... .

Key words: HbA1C interpretation, Hypothyroidism, Hyperthyroidism

[1]. Trbojević B. Tiroidna žlezda: Patofiziološke osnove i klinički pristup, Beograd, 1998; 305-310.
[2]. Manojlović D, Bogić M, Bošković D, Bulajić M, Čolović M, ĐorĎević P. i ost. Bolesti žlezda sa unutrašnjim lučenjem. U: Interna medicina. Bjeletić D. Ed. Zavod za udžbenike i nastavna sredstva Beograd, Beograd, 1998: 1140-1158.
[3]. Diez JJ, Iglesias P, Burman KD, Spontaneous normalization of thyrotropin concentations in patients with subclinical hypothyreoidism. J Clin Endocrinol Metab. 2005, 90: 4124-4127.
[4]. Milošević DP, Đurica S, Davidović M, Stević R, Rajić M, Marković N. Subclinical and manifested hypothyroidism as a consequence of thyroid autoimmune disease. Serbian archives of medicine, Journal of the Serbian medical society. 2005; Suppl 1: 34-39.
[5]. Bakker SJL, Ter Matten JC, Popp-Snijders C, Slaets JPJ, Heine RJ, Gans ROB. The relationship between thyrotropin and low density lipoprotein cholesterol is modified by insulin sensitivity in healthy euthyroid subjects. J Clin Endocrinol Metab. 2001; 86: 1206–1211.

Abstract: Cervical cancer remains the most common cancer in women of the developing world, largely as a result of a lack of screening. The gold standard screening test for cervical cancer, the Pap smear, has been effective in reducing cervical cancer incidence and mortality by identifying precancerous and cancerous lesions; however, little is known about quality assurance practices for gynecologic cytopathology in resource-limited settings. The goal of this study was to document baseline clinical andlaboratory characteristics in the hope of improving the efficacy of cervical cancer screening and informingfuture quality improvement initiatives. Patients in the age group 15-45 and 50-70years with various............

Keywords- PAP smear,Bethesdastudy,screening,premalignant lesion..

[1]. Rejendra A Kalkar, YogeshKulkarini. Screening forcervical cancer: an overview. ObstetGynecol India vol.56 no. 2: March / April 2006.
[2]. Mohammed Shaoaib Khan, FohadiyaYasin Raja at el.Pap smear Screening for Precancerous conditions ofthe cervical cancers. Pak J. Med. Res.; vol. 44 no. 3,2005:111-3
[3]. Parkin M, Bray F, Ferlay J, Pisani P. Global Cancer Statistics. CACancer J Clin 2005:74-108.
[4]. Anttila A, Pukkala E, Soderman B, Kallio M, Nieminen PA, Hakama M.Effect of organized screening on cervical cancer incidence and mortalityin Finland, 1963-1995: Recent increase in cervical cancer incidence. IntJ Cancer 1999;83:59-65
[5]. Valdespino VM, Valdespino VE. Cervical cancer screening: State of theart. CurrOpinObstetGynecol 2006;18:35-40.

Abstract: Mentat, a polyherbal psychotropic preparation, is mostly used for its memory enhancing property. Only limited studies established that mentat possesses sleep promoting property. The present study was carried out to evaluate sleep promoting property of mentat in animal models of diazepam induced sleeping time. Sleep promoting effect of mentat was assessed in three groups of rats (n=6). The animals were treated orally (p.o.) with 300 and 600 mg/kg of mentat one hour before administering diazepam intraperitoneally (i.p). Sleep latency and total sleep time were used as parameters for evaluation. Mentat exhibits dose dependent sleep promoting effect in diazepam induced sleeping time...........

Keywords: Mentat, Insomnia, GABAergic, Diazepam induced sleep.

[1]. Morin, Charles M. "The Nature of Insomnia and the Need to Refine Our Diagnostic Criteria". Psychosomatic Medicine 2000;62 (4): 483–485.
[2]. Anita Verma and Kulkarni S K. Pharmacological profile of BR-16A (mentat). Probe 1995; 34(2): 124-39.
[3]. Anil kumar, kulkarni S K. Effect of BR-16A(mentat),a polyherbal formulation on drug induced catalepsy in mice. Indian journal of Experimental Biology 2006 ;44:45-48. [4]. Kulkarni S K, and George B. Pentylenetetrazol-induced kindling in Animals: Protective Effect of BR-16A. Indian Journal of Experimental Biology 1995; 33: 424-427.
[5]. Kulkarni S K and Anita Verma. Protective Effect of Mentat (BR-16A) A Herbal Preparation, on Alcohol Abstinence-Induced Anxiety and Convulsions. Indian Journal of Experimental Biology. 1993; 31: 435-440.

Abstract: Introduction : Le cancer du col utérin etla condylomatose génitale sont des affections stigmates de l'infection à Human Papillomavirus (HPV) les plus communes. L'objectif de cette étude est de recenser lesdites affections stigmates de l'infection à HPV et d'en analyser le profil épidémio-clinique ainsi que leur prise en charge à Lubumbashi, deuxième ville en termes de population de la République Démocratique du Congo. Méthodologie : Il s'agit d'une étude transversale descriptive dans laquelle 122 patientes pour cancer du col utérin et 54 patientes pour condylomatose génitale ont été reçues parmi les 3650 patientes ayant bénéficié d'un examen gynécologique du 01 janvier 2012 au 31 décembre 2018 dans les sept hôpitaux généraux de référence du district sanitaire de la ville de Lubumbashi et à l'hôpital général provincial de référence Jason Sendwe. Les variables sociodémographiques, les aspects de prise en charge et l'issue des patientes ont été analysés...........

Keywords: cancer du col utérin, condylomatose génitale, Human papillomavirus, dépistage, Lubumbashi

[1]. Human papillomavirus (HPV) and cervical cancer [Internet]. [Cité 2 mai 2019]. Disponible sur : https://www.who.int/fr/news-room/fact-sheets/detail/human-papillomavirus-(hpv)-and-cervical-cancer
[2]. Yoo W, Kim S, Huh WK, Dilley S, Coughlin SS, Partridge EE, et al. Recent trends in racial and regional disparities in cervical cancer incidence and mortality in United States. PLoS ONE [Internet]. 2017 [cité 2 mai 2019] ;12(2). Disponible sur : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325259/
[3]. Wang H, Lee D, Park S, Kim G, Kim S, Han L, et al. Diagnostic Performance of HPV E6/E7 mRNA and HPV DNA Assays for the Detection and Screening of Oncogenic Human Papillomavirus Infection among Woman with Cervical Lesions in China. Asian Pac J Cancer Prev. 2015;16(17):7633‑40.
[4]. Dareng EO, Adebamowo SN, Famooto A, Olawande O, Odutola MK, Olaniyan Y, et al. Prevalence and incidence of genital warts and cervical Human Papillomavirus infections in Nigerian women. BMC Infect Dis [Internet]. 2019 [cité 14 juill 2019] ;19. Disponible sur : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323853/

Abstract: Aims: To study the various urological abnormalities in children with renal ectopia. Materials and methods: Retrospective review of patients of renal ectopia between 2008 to 2017. Results: 36 patients of renal ectopia ( RE) : 20 boys and 16 girls, with a mean age of 13 months( range at birth-8.5 yrs) underwent clinical and radiological evaluation. 28 patients were asymptomatic. 4 pts had crossed and 3 bilateral renal ectopia. The most common associated urological abnormality was vesicoureteric reflux( VUR), present in 25% cases of crossed renal ectopia( CRE), 40% cases of simple renal ectopia ( SRE) which increased to 70% in bilateral ectopia. Orthotopic kidney was involved in 80% cases in unilateral ectopia. Other documented abnormalities were: renal dysplasia in orthotopic kidney in 40% , hypospadias in 2% and undescended testes in 2% cases...........

Keywords: renal ectopia, urological abnormalities, vesicoureteric reflux

[1]. Gleason PE, Kelalis PP, Husman DA, Kramer SA. Hydronephrosis in renal ectopia: incidence, etiology and significance. J Urol 1994; 151: 1660.
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[3]. Schlussel RN. Disorders of rena position and parenchymal development. In: Pediatric urology practice. Gonzalez ET and S.B. Bauer( Ed). Lippincott Williams and Wilkins, Philadelphia 1999; 17:285-93.
[4]. Guarino N, Tadini B, Camardi P, Silvestro L, Lace R, Bianchi M. The incidence of associated urological abnormalities in children with renal ectopia. J Urol 2004; 172: 1757-9.
[5]. Kramer SA, Kelalis P. Ureteropelvic junction obstruction in children with renal ectopia. J Urol 1984; 90: 331

Abstract: SSIs are associated with an increased risk of morbidity, readmission, intensive care unit stay, and mortality. Hence the need to prevent SSIs is ubiquitous. Several earlier publications have alluded to the benefits of using triclosan coated sutures. Our study adds to the wealth of evidence from an Indian perspective. The present study aims to assess the efficacy of TCS in reducing the incidence of SSI in a tertiary care setting in Northern India and the risk factors associated with it. Methods: This is a retrospective 'real-world' study of 306 patients who underwent surgery and wound closure withtriclosan-coated suture from (month, year) to (month, year) at (Hospital), Jaipur. Incidence of SSI was recorded and association with various factors like age, gende...........

Keywords: Triclosan coated suture, Antibiotic coated sutures, Surgical site infection, Age, Gender, Wound class

[1]. Horan TC, Gaynes RP, Martone WJ, Jarvis WR, Emori TG. CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. Infect Control HospEpidemiol. 1992;13(10):606–608.
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[4]. Malik S, Gupta A, Singh PK, Agarwal J, Singh M. Antibiogram of aerobic bacterial isolates from post- operative wound infections at a tertiary care hospital in india. Journal of Infectious Diseases Antimicrobial Agents. 2011;28:45–51.
[5]. Lilani SP, Jangale N, Chowdhary A, Daver GB. Surgical site infection in clean and clean- contaminated cases. Indian J Med Microbiol. 2005;23:249–52.

Abstract: Diabetic nephropathy is usually found in persons who have had diabetes for 10-20 years. Numerous physiological and biochemical mechanisms could explain the protective effect of RAS inhibition against the development of type 2 diabetes in individuals with arterial hypertension. An open label, prospective comparative clinical study was conducted in out-patient and in-patient department of Nephrology in Osmania General Hospital to compare the effect of Enalapril and Telmisartan on Glycosylated Haemoglobin and Liver Function Test in 100 patients of Diabetic Nephropathy. They were divided in to two groups of 50 patients of age group 18-65years of either sex. Group A received Enalapril 5mg orally once a day daily for 3 months. Group B received Telmisartan...........

Keywords: Enalapril, Telmisartan, Diabetic nephropathy, HbA1C, Liver Function Test

[1]. Danaei G et al (2011) National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participa0nts. Lancet 378(9785):31–40
[2]. Xu Y et al (2013) Prevalence and control of diabetes in Chinese adults. JAMA 310(9):948–959

Abstract: Nose and paranasal sinuses are aptly called air conditioner for lung.Various authors have studied lesions of nose and paranasal sinuses in different aspects.The present study includes 100 cases of nasal cavity and paranasal sinuses presented to Department of Pathology, Government medical college, Patiala from December 2010 to October 2012. In this study of 100 cases, 81 were non-neoplastic and 19 were neoplastic lesions forming a ratio of non-neoplastic to neoplastic lesions as 4.2: I and the ratio of benign neoplastic and malignant lesions as 2.1:1. The incidence of nasal polyps in our study is 81% of all the non-neoplastic lesions of nasal cavity and PNS thus forming the commonest nasal lesion in this study. Allergic polyps were much more common than inflammatory polyps............

Keywords: sino-nasal lesions, histopathological spectrum

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Abstract: Introduction: To evaluate the effect of ozonated water with and without nano-hydroxyapatite (NHA) paste on remineralizing artificially created initial enamel caries around orthodontic brackets using polarized light microscopy and Vickers microhardness tester Material and Methods: A total of 120 extracted human premolar sound teeth were collected and coded from 1 to 120. Metallic brackets were bonded to the buccal surface of the teeth, then specimens were divided into 4 groups following different remineralization regimen: ozonated water, ozonated water + 10 % NHA paste, 10 % NHA paste alone, and control (saliva). The surface microhardness (SMH) was measured using HVS-50 Digital Display Vickers microhardness tester at baseline. The specimens were subjected to demineralizing solution to create initial enamel caries and enamel SMH was recorded. The specimens were subjected to pH cycling model then enamel SMH was recorded............

Keywords: demineralization, hardness, polarized light microscopy, tooth remineralization, ozone

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[4]. Huth KC, Paschos E, Brand K, et al. Effect of ozone on non-cavitated fissure carious lesions in permanent molars. A controlled prospective clinical study. Am J Dent. 2005;18(4):223-228.
[5]. Ximenes M, Cardoso M, Astorga F, et al. Antimicrobial activity of ozone and NaF-chlorhexidine on early childhood caries. Braz Oral Res. 2017;31.