iosr-JDMS   Volume-20 ~ Issue-1 ~ January 2021

Abstract: Background: Anthracycline induced cardiac complications are one of the most common causes of morbidity and mortality in childhood hemato-oncological malignancies despite recent advances in the diagnosis and treatment. Anthracycline causes cardio toxic effects during treatment when its level exceeds the cumulative dose. Aims and Objectives: This was aimed to evaluate cardiac complications with anthracycline and to determine associated electrocardiogram (ECG) and echocardiogram (ECHO) change with anthracycline in the hemato-oncological malignancies. Materials and Methods: The present study was conducted from January 2018 to December 2018 on sixty-nine diagnosed hemato-oncological malignancies between five to fifteen years irrespective of sex. A detailed history along with a complete blood count, biochemical investigations, chest x-ray, bone marrow aspiration, immunophenotype...........

Key Words: Anthracycline; Electrocardiography; Echocardiography; Ejection fraction; Cumulative dose; Hematological malignancies.

[1]. Adams MJ, Lipshultz SE. Pathophysiology of anthracycline and radiation-associated cardiomyopathies: implications for screening and prevention. Pediatr Blood Cancer, 2005; 44(7):600-06.
[2]. Barry E, Alvarez JA, Scully RE, Miller TL, Lipshultz SE. Anthracycline-induced cardio toxicity: course, pathophysiology, prevention and management. Expert Opin Pharmacother, 2007; 8(8):1039-58.
[3]. Giantris A, Abdurrahman L, Hinkle A, Asselin B, Lipshultz SE. Anthracycline-induced cardio toxicity in children and young adults. Crit Rev Oncol Hematol, 1998; 27(1):53–68.
[4]. Lipshultz SE, Lipsitz SR, Mone SM, Goorin AM, Sallan SE, Sanders SP, Orav EJ, Gelber RD, Colan SD. Female sex and drug dose as risk factors for late cardio toxic effects of doxorubicin therapy for childhood cancer. N Engl J Med, 1995; 332(26):1738-43.
[5]. Simbre VC, Duffy SA, Dadlani GH, Millet TL, Lipshultz SE. Cardio toxicity of cancer chemotherapy: implications for children. Pediatr Drugs, 2005; 7(3):187-02.

Abstract: Background: Currently in the world there is a tendency of continuous growth in the incidence of cancer of the rectum and colon. The tendency to a continuous increase in the incidence is especially pronounced in industrialized countries. Within this re-search we have set to establish MSCT criteria for the infiltration and exophytic growth of colon cancer, to establish the capabilities of DWI and PET / CT in the diagnosis of to establish criteria for the invasion of tumor intestinal walls, to de-termine the effectiveness of chemoradiation and surgical treatment, as well as to determine the radiological criteria for recurrent tumors. Materials and Methods: MSCT colonoscopy was performed in 345 patients (240 with suspected cancer, 105 with polyps). Patients underwent standard preparation.......

Keywords- colon cancer MSCT criteria, DWI, PET / CT, diagnosis of colon and rectal cancer, recurrent tumors

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[2]. Sokolov V.N. Use of virtual CT endoscopy of large vessels, bronchi, and colon with the use of an AsteionSuper 4 computer tomograph and a Vitrea-2 station.J Clinical inform. Telemedicen. Ukraine, 2008, vol. 6, issue. 7, pp. 37-41.
[3]. Atlas of abdominal surgery. Volume 3. Surgery of the small and large intes-tine, rectum and anal area. EmilioItala / Medical literature. 2008, 448 p.
[4]. Kishkun A.A. Biological age and aging: possibilities of definition and ways of correction: a guide. 208.976 p.
[5]. Johnson C.D., Chen M.QH., Toledano A.Y. et al. Accuracy of CT Colonogra-phy for Detection of Large Adenomas and Cancers. N. Eng. J. Med. 2008, no. 359, pp. 1207-1217

Abstract: Carcinoma of buccal mucosa is the most common cancer of the oral cavity in India. Treatment of oral cancer poses unique reconstructive challenges, owing to the dynamic architecture of the oral cavity. Despite current progress in various treatment modalities, over the past 50 years survival rates have not improved drastically. This study provides a detailed insight on each of the options from the myriad of reconstruction modalities that have been instituted for the reconstruction of post-ablation defects which includes free tissue transfer with microvascular anastomosis, regional and local tissue transfer, skin grafting and use of alloplastic materials in a defect based approach for reconstruction of a post ablation defect of buccal mucosa in oral oncosurgery.

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[2]. Byakodi, r., byakodi, s., Hiremath, s., byakodi, j., adaki, s., marathe, k., & mahind, p. (2011). Oral cancer in India: an epidemiologic and clinical review. Journal of community health, 37(2), 316–319. Doi:10.1007/s10900-011-9447-6
[3]. M.a. Kuriakose (ed.), contemporary oral oncology vol3 ch 8, doi 10.1007/978-3-319-43854-2_8
[4]. Orthop clin north am. 1993 jul;24(3):393-409, the reconstructive ladder. An orthoplastic approach, l. Levin
[5]. Wound closure and the reconstructive ladder in plastic surgery, Richard simman 2009

Abstract: Since novel corona virus outbreak emerged as a pandemic in December, 2019 it has infected many people globally. Thrombocytopenia during pregnancy is quite common, with as many as 5-10% of patients being affected[1].In the initial data from China, mild thrombocytopenia is seen in 1/3rd of non pregnant patients admitted in hospital, more recent meta analysis found that thrombocytopenia is associated with 3-fold greater risk of COVID19 infection[2]. According to UNICEF, an estimated 116million babies will be born under the shadow of COVID19,with India expecting to have one of the highest births(20.1million).[3] Due to paucity of data about pregnant women infected with covid-19, it is essential......

[1]. Cines DB, Levine LD. Thrombocytopenia in pregnancy. Blood 2017;130:2271–7.
[2]. Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis. Clin Chim Acta 2020;506:145-8. 3
[3]. Pregnant mothers and babies born during COVID‑19 pandemic threatened by strained health systems and disruptions in services.UNICEF. Available from:
https://www.unicef.org/press‑releases/pregnant‑mothers‑and‑babies‑born‑during‑covid‑19‑pandemicthreatened‑strained‑health.[Last accessed on 2020 Jun 29].
[4]. Xu P, Zhou Q, Xu J. Mechanism of thrombocytopenia in COVID-19 patients. Ann Hematol 2020;99:1205-8.
[5]. Gouez AL, Vivanti AJ, Benhamou D, Desconclois C, Mercier FJ. Thrombocytopenia in pregnant patients with mild COVID-19. Int J Obstet Anesth 2020. doi: 10.1016/j.ijoa. 2020.05.010

Abstract: Introduction: Hepatitis B is a major health problem inIndia. To prevent transmission and progression of the disease in the community, proper community awareness about the disease, including prevention, is necessary. Our objective was to study the awareness amongst the health care workers(undergraduates) about hepatitis B virus, including knowledge regarding vaccine.Aim: To assess the level of awareness, and knowledge of the health care providers (undergraduates) toward Hepatitis B virus and vaccination. Methods: After obtaining approval from the IEC and valid informed consent, the participants were recruited into the study. A cross-sectional descriptive questionnaire-based study was conducted amongst health care providers, i.e., MBBS students.....

Keywords- Awareness, education, hepatitis B, hepatitis B virus, hepatitis B vaccine, knowledge, medical students.

[1]. Schillie S, Murphy TV, Sawyer M, Ly K, Hughes E, Jiles R, et al. CDC guidance for evaluating health‑care personnel for hepatitis B virus protection and for administering postexposuremanagement. MMWR Recomm Rep 2013;62:1‑19.
[2]. Abedi F, Madani H, Asadi A, Nejatizadeh A. Significance of blood‑related high‑risk behaviors and horizontal transmission of hepatitis B virus in Iran. Arch Virol2011;156:629‑35.
[3]. Wilkins T, Zimmerman D, Schade RR. Hepatitis B: Diagnosis and treatment. Am Fam Physician 2010;81:965‑72.
[4]. Causse X, Delaunet A, Si Ahmed SN. Anaes practice guidelines for vaccination against hepatitis B virus: Impact on general practitioners. GastroenterolClinBiol 2009;33:1166‑70.
[5]. Ahmed MS, Chowdhury OA, Chowdhury AR, Khatoon M. Seroprevalence of HBs antibody among the newly admitted medical students in Bangladesh and seroconversion one year after vaccination. Bangladesh Med Res Counc Bull 2010;36:41‑2.

Abstract: The present retrospective study is undertaken to analyze the prevalence of periodontal abscess and its incidence in Diabetic mellitus patients of various age groups in Tirupur population from the data available from the records of Department of Dental surgery, Government Headquarters Hospital, Tirupur during the period from January 2019 to December 2019. In total, 353 patients with periodontal abscess were analysed. Among them, 225 patients (63.74%) had Diabetic mellitus, who were mostly male patients in their fifth decade followed by sixth and fourth-decade patients. Multiple periodontal abscess formation was frequently encountered in Diabetes mellitus patients (71.12 %). Periodontal abscess was commonly found affecting the Molar teeth (62.88%) region, followed by incisor teeth region (21.81%) and the least affected area was the canine region (5.94%). This article revealed considerable incidence of periodontal abscess in Diabetes mellitus patients, especially multiple in number. These multiple.....

Keywords- Diabetes mellitus, periodontal abscess, Oral hygiene, tooth loss.

[1]. AlGhamdi, A. S. T., Bukhari, S. M., Elias, W. Y., Merdad, K., & Sonbul, H. (2013). Dental clinics as potent sources for screening undiagnosed diabetes and prediabetes. The American journal of the medical sciences, 345(4), 331-334.
[2]. Al-Khabbaz, A. K., & Al-Shammari, K. F. (2011). Diabetes mellitus and periodontal health: dentists' knowledge. Medical Principles and Practice, 20(6), 538-544.
[3]. Ojehanon, P. I., Azodo, C. C., Erhabor, P., & Orhue, V. (2017). Periodontal characteristics of diabetic patients with tooth mobility. Journal of Social Health and Diabetes, 5(02), 094-099.
[4]. Herrera, D., Roldán, S., & Sanz, M. (2000). The periodontal abscess: a review. Journal of Clinical Periodontology: Review article, 27(6), 377-386.
[5]. McLeod, D. E., Lainson, P. A., & Spivey, J. D. (1997). Tooth loss due to periodontal abscess: a retrospective study. Journal of periodontology, 68(10), 963-966.

Abstract: Background: Rheumatoid arthritis (RA) is a chronic multisystem disease affecting joints, connective tissues and fibrous tissues. Methotrexate (MTX) is a folate antagonist used as a first line treatment in RA. Hepatotoxicity is a common side effect of MTX. This study was done to evaluate abnormalities of liver function with respect to cumulative dose and duration of MTX.
Materials and methods: In this cross sectional analytical study 109 patients of RA aged ≥18years on methotrexate therapy were analyzed for abnormal liver profile by using Liver Function Test (LFT), Ultrasonography (USG) abdomen. The weekly dose, cumulative dose and duration of treatment were compared between patients with and without elevated liver enzymes.
Results: Of 109 patients, transaminitis was observed in 22 patients (20.1%,95% CI: 13.3%-29.2%). The mean SGOT and SGPT were 44.04 ± 29.15 IU/L and 35.85 ± 23.26 IU/L respectively. The mean weekly dose, cumulative dose and duration of MTX therapy were......

[1]. Cutolo M, Sulli A, Pizzorni C, Seriolo, Straub RH. Anti-inflammatory mechanisms of methotrexate in rheumatoid Arthritis. Ann Rheum Dis 2001;60:729–35.
[2]. Singh JA, Saag KG, Bridges Jr SL, Akl EA, Bannuru RR, Sullivan MC, et al. American College of Rheumatology guideline for the treatment of rheumatoidarthritis. Arthritis Rheum 2016;68:1–26.
[3]. Shinde CG, Venkatesh MP, Pramod Kumar TM, Shivakumar HG. Methotrexate: a gold standard for treatment of rheumatoid arthritis. J Pain Palliat Care Pharmacother2014;28:351–8.
[4]. Lopez-Olivo MA, Siddhanamatha HR, Shea B, Tuqwell P, Wells GA, Suarez-Almazor ME. Methotrexate for treating rheumatoid arthritis. CochraneDatabaseSyst Rev 2014;(6):CD000957.
[5]. Gossec L, Smolen JS, Ramiro S, de Wit M, Cutolo M, Dougados M, et al. European League against Rheumatism (EULAR) recommendations for the managementof psoriatic arthritis with pharmacological therapies: 2015 update. Ann RheumDis 2016;75:499–510.

Abstract: Background:The purpose of this prospective study is to compare the functional outcomes of method of fixation (dynamic compression plating and interlocking nailing) for the fracture shaft of humerus and to analyze the difference in the results of these two methods. Materials and Methods: A prospective comparative study of 26 patients with diaphyseal fracture of humerus (age range18-60), half of the patients (group A) treated with Intramedullary Interlocking Nailing and another half group of patients (group B) treated with Narrow DCP in the Department of Orthopaedics, Jhalawar Medical College, Jhalawar between January 2018 to June 2019. Results:The functional outcome and range of motion of shoulder.......

Keywords- Humerus fracture, IMIL nail, narrow DCP

[1]. Rose SH, Melton LJ, Morrey BF, Ilstrup DM, Riggs BL. Epidemiologic features of Humeral fractures. Clin Orthop 1982; 168; 24-30.
[2]. Buckholz RW, Heckman JD, Court-Brown CM, Koval KJ, Tornetta P, Wirth MA. Rockwood and Green's Fractures in Adults, Vol 1, 6th Edition, Lippincott Williams and Wilkins, 2006.
[3]. Bohler L (1965) Conservative treatment of fresh closed fractures of humerus. J Trauma 5:464–468
[4]. Sarmiento A, Zagorski JB, Zych DO, Latta LL, Capps CA (2000) Functional bracing for the treatment of fractures of humeral diaphysis. J Bone Joint Surg Am 82:478–486
[5]. Koch PP, Gross DF, Gerber C (2002) The results of functional (Sarmiento) bracing of humeral shaft fractures. J Shoulder Elbow Surg 11:143–150

Abstract: Background: Lipomas are the most common mesenchymal soft tissue tumours encountered in surgical practice. They can occur anywhere in the body, but the common sites are subcutaneous tissue of trunk, nape of the neck and limbs. Giant lipomas measure more than 10cm in diameter and are very rarely seen in the axillary region.
Case Report: We hereby report a case of 35-year-old woman who presented with huge asymptomatic bilateral axillary mass that had been enlarging for 18 years. She underwent surgical excision, and the masses were found on histopathological examination to be benign lipomas.
Discussion: Lipomas are not frequently seen in the axilla. Clinically, malignancy should always be considered in tumours around the axilla, especially.....

Keywords- axilla, lipoma, axillary mass.

[1]. Schwartz's Principles of Surgery, 10th Edition, Part II Specific Considerations: Soft tissue tumours; 486.
[2]. Sabiston's Textbook of Surgery, 1st SAE Edition, Section V: Surgical Oncology, Chapter 31: Soft tissue Sarcoma 754-770.
[3]. Bailey & Love's Short Practice Of Surgery, 27th Edition. Soft tissue tumours; 544-546.
[4]. E. Vandeweyei & I. ScagnoI (2005) Axillary Giant Lipoma: a Case Report, Acta 1.Chirurgica Belgica, 105:6, 656-657, DOI: 10.1080/00015458.2005.11679797
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Abstract: Background: Though titanium is considered as the best for the rehabilitation of edentulous space TITANIUM based implant systems have been condemn for many disadvantages. The onset of hypersensitive reactions, incompatibility, and an unaesthetic gray discoloration raised the demand` for alternative material with more aesthetically appealing, natural, and tissue compatibility for fabrication of implants[18].
Subsequently, Zirconia (ZrO2) with its physical and mechanical properties like high corrosion resistance, hardness, low thermal conduction, high flexure.......

Keywords- Word:'zirconia,' 'zirconia implant,' 'zirconia and its biocompatibility,' 'zirconia and its marginal esthetics', 'zirconia and its bone-implant contact (BIC)/osseointegration,' and 'zirconia and its plaque.

[1]. Yilmaz H, Aydin C, Gul BE. Flexural strength and fracture toughness of dental core ceramics. The Journal of prosthetic dentistry. 2007 Aug 1;98(2):120-8.
[2]. Kohal RJ, Papavasiliou G, Kamposiora P, Tripodakis A, Strub JR. Three-Dimensional Computerized Stress Analysis of Commercially Pure Titanium and Yttrium--Partially Stabilized Zirconia Implants. International Journal of Prosthodontics. 2002 Mar 1;15(2).
[3]. Kohal RJ, Weng D, Bächle M, Strub JR. Loaded custom‐made zirconia and titanium implants show similar osseointegration: an animal experiment. Journal of Periodontology. 2004 Sep;75(9):1262-8.
[4]. Depprich R, Ommerborn M, Zipprich H, Naujoks C, Handschel J, Wiesmann HP, Kübler NR, Meyer U. Behavior of osteoblastic cells cultured on titanium and structured zirconia surfaces. Head & Face Medicine. 2008 Dec 1;4(1):29.
[5]. Schultze-Mosgau S, Schliephake H, Radespiel-Tröger M, Neukam FW. Osseointegration of endodontic endosseous conesZirconium oxide vs titanium. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2000 Jan 1;89(1):91-8.