iosr-JDMS   Volume-19 ~ Issue-5 ~ May 2020

Abstract: Objectives and Background:To describe clinical outcomes and prognosis i.e overall survival and relapse in the patients with paediatric B cell ALL (pBALL )with respect to minimal residual disease detection on day 15, day 29 and post consolidations in a tertiary care centre in eastern India. Minimal Residual disease (MRD) refers to the presence of disease in cases deemed to be in complete remission by conventional pathologic analysis. Prognostic importance of MRD in paediatric ALL is well accepted all over the world. This is the study where 8 colour flow cytometry (FCM) is used to detect MRD to assestreatment, diagnosis and prognosis of BcellALL. Method:Our Study had been running.....

KEY WORD: Paediatric ALL(pALL), MRD, Flowcytometry(FCM), Clinical Outcomes, Prognosis, overall survival

[1]. T Terwilliger, M abdul Hay. Acute lymphoblastic leukemia: a comprehensive review and 2017 Blood Cancer J. 2017 Jun; 7(6): e577.
[2]. Ampatzidou M et al. Prognosis significance of flowcytometry MRD long reduction during induction treatment of childhood ALL Leuk lymphoma 2019 Jan 60(1) 258-261
[3]. Conter et al Molecular response to treatment redefines all prognostic factors in children and adolescents with B‐cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP‐BFM ALL 2000 studyBlood/115,3206-3214
[4]. Marshal GM et al High‐risk childhood acute lymphoblastic leukemia in first remission treated with novel intensive chemotherapy and allogeneic transplantation, Leukemia,27,1497-1503
[5]. Pieter R et al, Successful therapy reduction and intensification for childhood acute lymphoblastic leukemia based on minimal residual disease monitoring: study ALL10 from the Dutch Childhood Oncology Group Journal of Clinical Oncology,34,2591-2601

Abstract: The advances in digital imaging systems combined with the availability to register CBCT data with digital models had made possible in fabrication of orthognathic surgery, CAD/CAM designed splints ,customized brackets ,and indirect bonding systems. Thusstereo lithography is used in wide range of dentistry, which helps in creating asymmetries ,fabricating, coating and land marking synthetic mandible. This article describes about stereo lithography and its application in various fields of dentistry.

[1]. Hourfar J, Kanavakis G, Goellner P, Ludwig B. Fully customized placement of orthodontic miniplates: a novel clinical technique. Head & face medicine. 2014 Dec 1;10(1):14.
[2]. Ercoli F, Tepedino M, Parziale V, Luzi C. A comparative study of two different clear aligner systems. Progress in orthodontics. 2014 Dec;15(1):1-5.
[3]. Russett S, Major P, Carey J, Toogood R, Boulanger P. An experimental method for stereolithic mandible fabrication and image preparation. The open biomedical engineering journal. 2007;1:4.
[4]. Guo, Q.Y., Zhang, S.J., Liu, H., Wang, C.L., Wei, F.L., Lv, T., Wang, N.N. and Liu, D.X., 2011. Three-dimensional evaluation of upper anterior alveolar bone dehiscence after incisor retraction and intrusion in adult patients with bimaxillary protrusion malocclusion. Journal of Zhejiang University SCIENCE B, 12(12), pp.990-997.
[5]. Kwon SY, Kim Y, Ahn HW, Kim KB, Chung KR. Computer-aided designing and manufacturing of lingual fixed orthodontic appliance using 2D/3D registration software and rapid prototyping. International journal of dentistry. 2014;2014..

Abstract: Introduction: All medical procedures involve some complications, even when they are performed by experts. The rate and severity of these complications depend on patient's state of health, age or general lifestyle. Even though the use of general anesthesia is considered safe, but it comes with certain complications. The risks of unexpected and potentially life threatening complications such as hypersensitivity or severe heart or lung problem can make the surgery difficult. Aim of the study:The aim of this study was to evaluate thecomplications of general anesthesia in different surgeries.

Keywords: General Anesthesia, Complications, Pain.

[1]. McCracken G, Houston P, Lefebvre G (2008) Guideline for the Management of Postoperative Nausea and Vomiting. J ObstetGynaecol Can 30: 600-607.
[2]. Gan TJ (2006) Risk Factors for Postoperative Nausea and Vomiting. AnesthAnalg 102: 1884-1898.
[3]. Miller RD, Eriksson LI, Fleisher LA, Wiener-Kronish JP, Young WL (2010) Miller's Anaesthesia. (7thedn), Churchill Livingstone Elsevier, Philedelphia, 2: 2728-2755.
[4]. Gan TJ, Meyer T, Apfel CC, Chung F, Davis JP, et al. (2003) Consensus Guidelines for Managing Postoperative Nausea and Vomiting. AnesthAnalg 97: 62-71.
[5]. Harris, M. & Chung, F. 2013. Complications of General Anesthesia. Accessed on 13 October 2016. Retrieved from http://tinyurl.com/j48qmvd.

Abstract: Background: After myocardial infarction, inflammation is the important key factor involved in cardiac remodelling. Continuous activation of inflammatory markers like interleukins and tumour necrosis factors will leads to myocardial damage which ultimately results in heart failure. Very few studies have been done so far in relation to various inflammatory markers in relation to left ventricular function in cardiac patients. Aim: To determine serum levels of interleukin-1β, interleukin-2, interleukin-6, interleukin-8, interleukin-10 and tumour necrosis factor-α inrelation to left ventricular function in cardiac patients. Methods:We studied 229 cases of CVDs who were enrolled at Cardiology and Medicine at a tertiary care hospital, Mumbai. We further categorized above.......

Keywords: ELISA, cardiac diseases, LVEF, serum interleukins, serum TNF-α.

[1]. Shrivastava AK, Singh HV, Raizada A, Singh SK. C-reactive protein, inflammation and coronary heart disease. Egypt Hear J. 2015;67:89–97.
[2]. Huffman MD, Prabhakaran D. Heart failure: epidemiology and prevention in India. Natl Med J India. 2010;23(5):283–8.
[3]. Dinarello CA, Simon A, M van der Meer JW. Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases. Nat Rev | DRUG Discov. 2012;11:633–52.
[4]. Karpiński Ł, Płaksej R, Kosmala W, Witkowska M. Serum levels of interleukin-6, interleukin-10 and C-reactive protein in relation to left ventricular function in patients with myocardial infarction treated with primary angioplasty. Kardiol Pol. 2008;66(12).
[5]. Deokar SA, Dandekar SP, Shinde GA, Prabhu SS, Patawardhan M. Role of serum interleukin-6 in heart failure. Int J Adv Med. 2018;5(4):936–40.

Abstract: Renal cell carcinomas (RCCs) metastasize to the adrenal glands via various mechanisms, including lymphatic vessel ,arterial embolism and retrograde venous embolism. The rate of ipsilateral metastasis is 3-5% and the rate of contralateral metastasis is ~0.7%, however, synchronous bilateral adrenal metastases are extremely rare. Therefore, the optimal diagnosis and treatment strategy for this condition is yet to be thoroughly defined.Renal cell carcinoma (RCC) is a common malignancy with high metastatic potential,primarily due to its extensive vascularity. Common sites of metastasis include lungs, bone,lymph nodes, liver, and brain. However, rare cases of metastasis to other sites including inguinal lymph nodes, peritoneum/mesentery, and orbit have been published in the literature. Here in is a rare case involving metastasis of RCC to the soft palate is presented.In the present study, a 39-year-old male patient presented with left flank pain and hematuria. Ultrasonography (US) revealed a left renal mass.......

[1]. Ljungberg B, Bensalah K, Bex A, et al; European Association of Urology: Guidelines on renal cell carcinoma. http://www.
guideline.gov/content.aspx?id=45321. Accessed February 2, 2014.
[2]. Lau WK, Zincke H, Lohse CM, et al: Contralateral adrenal metastasis of renal cell carcinoma: treatment, outcome and a review.
BJU Int 91: 775-779, 2003.
[3]. Koutalellis GE, Felekouras E, Evangelou C, et al: Renal cell carcinoma with bilateral synchronous adrenal gland metastases: a case
report. Cases J 2: 7298, 2009.
[4]. Siemer S, Lehmann J, Kamradt J, et al: Adrenal metastases in 1635 patients with renal cell carcinoma: outcome and indication for
adrenalectomy. J Urol 171: 2155-2159, 2004.
[5]. Zornoza J, Bernardino ME: Bilateral adrenal metastases. "Head light‟ sign. Urology 1980, 15:91-92

Abstract: Introduction: Allergic Rhinitis is considered to be one of the most common diseases affecting a wide range of people barring age. Approximately 20% of adults and children have seasonal or perennial allergic rhinitis. Allergic rhinitis patients often suffer from like asthma, sinusitis ,otitis media and decreased hearing. So we decided to do study of eustachian tube function and middle ear ventilation in patients of allergic rhinitis. Aims:The purpose of this study was to assess the effect of allergic rhinitis on Eustachian tube function (ETF) and middle ear ventilation......

Keywords:Eustachian tube,allergicrhinitis,middle ear ventilation,impedance tympanometry

[1]. Settipane GA. Allergic rhinitis—update. Otolaryngol Head Neck Surg1986;94:470-5.
[2]. Viswanathan R. Definition, incidence, aetiology and natural history of asthma. Indian J Chest Dis. 1964;6:108-24.
[3]. Tomonaga K, Kurono Y, Mogi G. The role of nasal allergy in otitis media with effusion.ActaOtolaryngol (Stockh) 1988;458(suppl):41-7.
[4]. Glasscock-Shambaugh SURGERY of the EAR Endoscopic Diagnosis of Eustachian Tube Dysfunction, Dennis S. Poe, MD, FACS pag2214
[5]. Fireman P. Otitis media and Eustachian tube dysfunction: connection to allergic rhinitis. J Allergy ClinImmunol 1981; 99:S787–S79776.1980. p. 83–1085.

Abstract: Background: Gallstone disease is the most common biliary pathology and is a major health problem worldwide. Gallbladder cancer is the most common malignancy of the biliary tract but extremely variable by geographical region and racial ethnic group. Material and Methods: A total of 120 resected cholecystectomy specimens with gallstone received during the period of six months were included. Clinical details and other relevant information were collected from the records. Statistical correlation was calculated using chi-square test and p value was calculated. value of p<0.05 was considered statistically significant....

Key Word: Gallbladder, stones, carcinoma, Histopathology.

[1]. Unisa S, Jagannath P, Dhir V, Khandelwal C, Sarangi L, Roy TK. Population-based study to estimate prevalence and determine risk factors of gallbladder diseases in the rural Gangetic basin of North India. HPB. 2011;13(2):117-25.
[2]. Das A. Epidemiology of Gallbladder cancer among North-Eastern states of India: A review. Int. Res. J. Medical Sci. 2016;4(6):11-5.
[3]. Pradhan SB, Joshi MR, Vaidya A. Prevalance of different type of gallstone in the patients with cholelithiasis at Kathmandu Medical College, Nepal. Kathmandu University Medical Journal.2009;7(3):268-71.
[4]. Idris SA, Shalayel MHF, Elsidding KE, Hamza AA, Hafiz MM. Prevalence of different types of gallstone in relation to age in sudan. Sch. J. App. Med. Sci.2013;1(6):664-67.
[5]. Aslam HM,Saleem S, Edhi MM, Shaikh HA, Khan JD, Hafiz M et al.; Assessment of gallstone predictor: comparative analysis of ultrasonographic and biochemical parameters. International Archives of Medicine,2013;6(1):17.

Abstract:Background: Sleep problems may have a great impact on the Physiotherapy students' daily life. The aim of the present study was to find out sleep disorders amongst undergraduate Physiotherapy students at Nootan College of Physiotherapy, Visnagar, Gujarat, India 384 315. Methods: Sixty five undergraduate Physiotherapy students (42 females and 23 males) participated in this study. An investigator developed mixed questionnaire was used to assess the sleep disorders amongst the physiotherapy under graduate students. Results: Only 20% (13/65) of participants reported that they had disturbed sleep and 80 % of participants had reported no trouble in sleep.....

Keywords: physiotherapy, students, sleep and insomnia.

[1]. Ritchie E. Brown, Radhika Basheer, James T. McKenna, Robert E. Strecker, and Robert W. McCarley: Control of sleep and wakefulness: Physiol Rev: 2012: 7: 92(3): 1087-1187.
[2]. Dauvilliers Y, Maret S, Tafti M. Genetics of normal and pathological sleep in humans. Sleep Med Rev. 2005; 9:91-100.
[3]. Itani O, Jike M, Watanabe N, Kaneita Y: Short sleep duration and health outcomes: a systematic review, meta-analysis, and meta-regression. Sleep Medicine.2017: 32:4:246-256.
[4]. Paula Alhola and Päivi Polo-Kantola: Sleep deprivation: Impact on cognitive performance. Neuropsychiatr Dis Treat. 2007:10: 3(5): 553-567.
[5]. Jensen GM, Nordstrom T, Segal RL, McCallum C, Graham C, Greenfield B: Education Research in Physical Therapy: Visions of the Possible: Phys Ther: 2016:12:96:1874-1884.

Abstract: Mucoceles are benign, mucus-containing cystic lesions of the minor salivary glands. These are not true cysts while most of them lack an epithelial lining. Most commonly the lesion occur in the lower lip. This case report presents two cases of mucocele on the lower lip. This lesion was diagnosed based on Clinical finding , history, and histopathological examination. The expurgation of the lesion was planed using diode laser and surgical excision method using scalpel blade.

Keywords: Mucoceles, Diode laser, Surgical excision and lower lip

[1]. A. Qafmolla, M. Bardhoshi, N. Gutknecht, and E. Bardhoshi, "Evaluation of early and long term results of the treatment of mucocele of the lip using 980 nm diode laser ," European Scientific Journal, vol. 10, no. 6, 2014
[2]. Langlais RP, Miller CS. Nodules of the lip. Color Atlas of Common Oral Diseases. 1st ed. Philadelphia: Lippincott Williams and Wilkins. 1992;32.
[3]. Laller S, Saini RS, Malik M, Jain R. An Appraisal of Oral Mucous Extravasation cyst case with Mini Review. J Adv Med Dent Sci Res 2014;2:166-70.
[4]. Madan N, Rathnam A. Excision of Mucocele: A surgical Case Report. Bio Biomed Rep. 2012;2:115-8.
[5]. L. J.Walsh, "The current status of laser applications in dentistry," Australian Dental Journal, vol. 48, no. 3, pp. 146–155, 2003

Abstract: Background: The variations of the uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) gene has been reported as risk factors associated with neonatal hyperbilirubinemia. Among UGT1A1 polymorphisms, the 211G>A, promoter A(TA)nTAA and c.-3279T>G mutations are common in Asian population. However, studies on frequency and co-expression patterns of these variants in Indian Malaysian newborns with significant hyperbilirubinemiaare limited. Objective: This study aims at determining the frequency pattern of 211G>A, promoter A(TA)nTAA and c.-3279T>G mutations in Indian Malaysian newborns with significant neonatal hyperbilirubinemia (SigNH). Methods: A total of 1121 hyperbilirubinemic......

Key words: UGT1A1, significant neonatal hyperbilirubinemia.

[1]. Watchko JF. Identification of neonates at risk for hazardous hyperbilirubinemia: Emerging clinical insights. Pediatr Clin N Am 2009; 56:671-687.
[2]. Keren R, Tremont K, Luan X, Cnaan A. Visual assessment of jaundice in term and late preterm infants. Arch Dis Child Neonatal Ed 2009; 94:F317-F322.
[3]. Bhutani VK, Johnson LH, Jeffery Maisels M, Newman TB, Phibbs C, Stark AR,et al,. Kernicterus: epidemiological strategies for its prevention through system-based approaches. Journal of Perinatology 2004; 24:650-662.
[4]. Servedio V, d'Apolito M, Maiorano N, Minuti B, Torricelli F, Ronchi F, Zancan L, Perrotta S, Vajro P, Boscetto L, Iolascon. A spectrum of UGT1A1 mutations in Crigler-Najjar (NS) syndrome patients: identification of twelve novel alleles and genotype-phenotype correlation. Hum Mutat 2005; 25:325.
[5]. Halamek LP, Stevenson D. Neonatal jaundice and liver disease. In: Fanaroff AA, Martin RJ (eds). Neonatal-Perinatal Medicine. Diseases of the fetus and infants. St Louis: C.V Mosby, 1997; 1345-89.

Abstract: Cyst within breast parenchyma is fluid filled epithelial lined cavities that vary in size from microscopic to large palpable masses [1]. The term "blue dome cyst" was first employed to designate a benign cyst filled with straw-colored fluid that showed a blue color when cut down on [2]. Breast cyst are usually small and multiple, Here we present a case of a large cyst in the right breast measuring about 15x10 cm clinically and containing about 500ml of fluid measured intra-operatively in a 60 year old. A Bluedome cyst of bloodgood this large has been rarely reported in this age group. Fewer than 5% of cysts occur in women over the age of 60 years [3].

Keywords: Breast Cyst, Breast lump, Bluedome cyst, benign breast disease, breast swelling, simple cyst

[1]. Courtney M. Townsend Jr, R. Daniel Beauchamp, B. Mark Evers, Kenneth L. Mattox. Sabiston The biological basis of Modern Surgical Practice, First South Asian Edition pg 835.
[2]. BARTLETT EI. THE TREATMENT OF BLUE DOME CYST. JAMA. 1924;83(5):343–348. doi:10.1001/jama.1924.02660050029006
[3]. Rodrigues G, Prabhu R, Nair R, Thinda R. A blue-domed cyst of bloodgood. Eurasian J Med. 2011;43(2):132. doi:10.5152/eajm.2011.30
[4]. Sriram Bhatt M. SRB's Manual of Surgery, 5th Edition pg 526; 2016.
[5]. Cardenosa G. Breast imaging companion. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2008. pp. 314–367.

Abstract: Background: Traumatic brain injury (TBI) is a significant public health problem and is a leading cause of mortality in India. Incidence of Head injuries in increasing over the years may be due to increase in vehicular traffic and non adherence to traffic rules. Materials and Methods: This is a retrospective and prospective study of all the patients admitted to Government general hospital, Guntur between June 2019 and August 2019, with TBI and GCS at admission of 12 or less. Results: The Total number of cases admitted with moderate to severe TBI were 136 during period of 3 months. 42.7 years was the mean age of TBI patients and male to female ratio was 6.5:1. Mortality rate was 38.2% and majority(88%) of them belonged to severe TBI group.....

Key Word: Head Injury; Moderate to Severe TBI; Impact score; Mortality.

[1]. Stein, S.C. (1996) Classification of head injury. In: R. K. Narayan, J. T. Povlishock, &E. Wilberger (eds), Neurotrauma, pp. 31–42. McGraw Hill, New York.
[2]. Long term outcome after traumatic brain injury. Fleminger S, Ponsford J BMJ. 2005 Dec 17; 331(7530):1419-20.
[3]. Marshall, L.F., Eisenberg, H.M., Jane, J.A., et al.(1991). A new classification of head injury based on computerizedtomography. J. Neurosurg. 75, s14–s20.
[4]. Tolias CM, Bullock MR. Critical appraisal of neuroprotectiontrials in head injury: what have we learned? NeuroRx. 2004;1(1):71–79.
[5]. Juan Jose Egea-Guerrero, IMPACT Score for Traumatic BrainInjury: Validation of the PrognosticTool in a Spanish CohortJ Head Trauma Rehabil,2017:1-7.

Abstract: Background: Preoperative medication of patients undergoing ambulatory operations in oral surgery is a serious problem widely studied over the years. However, in practice there are many situations in which some difficulties can be encountered. This study attempts to clarify this problem by outlining clear guidelines for clinical management. Materials and Methods: Indirect observations were performed in 98 cases for the period from 2017 to 2019. We had done full preliminary blood and urine tests. They were recorded and arranged all indicators according to their groups.We recorded also patient's preoperative status and functional evaluations using the SCI gen scale (MIT) were done. Statistical data.....

Key Word: patients' preparation, ambulatory surgery, third molar removal

[1]. Muralikrishna C, Rambabu C. Determination of Candesartan Cilexetil in Bulk and Pharmaceutical Dosage Forms by Visible Spectrophotometric Methods. International Journal of Science and Research. 2015;4(8):492–495.
[2]. Surajo AZ, Karim AZ. Youth unemployment and poverty in Nigeria: A threat to sustainable growth and development. International Journal of scientific research and management. 2016;4(12):4919–4928.
[3]. Shetty R, Verma S. Fenton's reagent for the treatment of pharmaceutical industry wastewater. International Journal of Science and Research. 2015;4(7):3093–3096.
[4]. Syaifullah II, Titisari P, Puspitasari N. Work Satisfaction In Compensation Mediation and Motivation on Productivity Permanent Employees of Pt. Sinergi Mitra Utama in Bandung. International Journal of Scientific Research and Management (IJSRM). 2019;7(03):1031–1038.
[5]. Baranwal HC, Pandiar D, Singh TB. Pattern of dental carries among adults purvanchal region of Utter Pradesh, India. Int J Sci Res. 2015;4:323–6..

Abstract: Background: Sexually transmitted infections (STIs) pose a major health problem worldwide and even more so in the developing countries like ours. Due to the lack of adequate laboratory infrastructure in the country, information regarding the profile of STIs relies essentially on syndromic diagnosis. Knowledge about its current patterns is very essential to formulate an effective control strategy, particularly in a resource constrained country like ours. Aims: to study the patterns of STIs in patients attending the STI clinic of a tertiary care hospital using a syndromic approach. Materials and Methods: A retrospective analysis of the data of 1200 consecutive STI patients attending STI clinic from January to June 2019 was carried out. The demographic data of all cases, the syndromic diagnoses and the laboratory reports for.....

Key Words –Sexually transmitted infections (STI), Human immunodeficiency virus (HIV) infection

[1]. Marfatia YS, Sharma A, Joshipura SP. Overview of sexually transmitted diseases. In: Valia RG, Valia AR, editors. IADVL Textbook of Dermatology. 3rd ed., Vol. 59. Mumbai: Bhalani Publishing House; 2008. p. 1766-78.
[2]. UNAIDS. AIDS Epidemic Update: December 2005. Geneva: UNAIDS; 2005.
[3]. National AIDS Control Organization, Ministry of Health and Family Welfare. Operational Guidelines for Programme Managers and Service Providers for Strengthening STI/RTI Services. New Delhi: Government of India; 2007. p. 18.
[4]. NACO. Department of AIDS Control-Ministry of Health and Family Welfare. Current Epidemiological Situations of HIV/AIDS. Annual Report 2011-2012
[5]. Sarkar S, Shrimal A, Das J, Choudhury S. Pattern of sexually transmitted infections: A profile from a sexually transmitted infections clinic of a tertiary care hospital of Eastern India. Ann Med Health Sci Res 2013;3:206-9.